PharmaCoNets of Dimetindene (SPCN: 94.56 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dimetindenehsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Dimetindenehsa00190Oxidative phosphorylation3.92E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Dimetindenehsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Dimetindenehsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Dimetindenehsa00620Pyruvate metabolism3.90E-022P07195, P11766LDHB, ADH5More
Dimetindenehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Dimetindenehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Dimetindenehsa00830Retinol metabolism3.15E-021P00325ADH1BMore
Dimetindenehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Dimetindenehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Dimetindenehsa01230Biosynthesis of amino acids2.22E-034P51854, P60891, Q99707, P37837TKTL1, PRPS1, MTR, TALDO1More
Dimetindenehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Dimetindenehsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Dimetindenehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Dimetindenehsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Dimetindenehsa03020RNA polymerase1.91E-074P24928, P62487, Q9GZM3, P52435POLR2A, POLR2G, POLR2J2, POLR2JMore
Dimetindenehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Dimetindenehsa03050Proteasome1.21E-021P28074PSMB5More
Dimetindenehsa03060Protein export5.30E-044Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Dimetindenehsa03430Mismatch repair4.38E-021P20585MSH3More
Dimetindenehsa04015Rap1 signaling pathway9.14E-032P06213, O00522INSR, KRIT1More
Dimetindenehsa04020Calcium signaling pathway2.28E-039P27987, Q08828, P30679, P19174, P61073, P0DP23, P51828, P23634, P49767ITPKB, ADCY1, GNA15, PLCG1, CXCR4, CALM1, ADCY7, ATP2B4, VEGFCMore
Dimetindenehsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Dimetindenehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Dimetindenehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Dimetindenehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Dimetindenehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Dimetindenehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Dimetindenehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Dimetindenehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Dimetindenehsa04114Oocyte meiosis1.10E-025Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Dimetindenehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Dimetindenehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Dimetindenehsa04145Phagosome2.57E-024Q15080, P14598, Q13488, O60603NCF4, NCF1, TCIRG1, TLR2More
Dimetindenehsa04151PI3K-Akt signaling pathway7.39E-037P62753, O43521, P27348, Q8WYR1, P18848, O00141, Q6ZUJ8RPS6, BCL2L11, YWHAQ, PIK3R5, ATF4, SGK, PIK3AP1More
Dimetindenehsa04210Apoptosis3.63E-023O75460, O43521, P18848ERN1, BCL2L11, ATF4More
Dimetindenehsa04213Longevity regulating pathway - multiple species4.41E-034P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Dimetindenehsa04217Necroptosis4.76E-0617P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q9H444, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP4B, CHMP2A, PPIDMore
Dimetindenehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Dimetindenehsa04261Adrenergic signaling in cardiomyocytes4.66E-039P09493, P07550, Q08828, P51828, P22694, P18848, Q13362, P0DP23, P23634TPM1, ADRB2, ADCY1, ADCY7, PRKACB, ATF4, PPP2R5C, CALM1, ATP2B4More
Dimetindenehsa04370VEGF signaling pathway4.50E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Dimetindenehsa04610Complement and coagulation cascades1.14E-052P00734, P0C0L4F2, C4AMore
Dimetindenehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Dimetindenehsa04613Neutrophil extracellular trap formation3.76E-0410P11215, Q13547, P04908, Q93077, P58876, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Dimetindenehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Dimetindenehsa04640Hematopoietic cell lineage1.54E-039P21926, P14778, P27930, P11215, P25063, P07766, P01732, P01730, P09564CD9, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD4, CD7More
Dimetindenehsa04650Natural killer cell mediated cytotoxicity5.49E-0612P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q14953, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1More
Dimetindenehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Dimetindenehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Dimetindenehsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Dimetindenehsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Dimetindenehsa04668TNF signaling pathway2.67E-036P01375, P18848, P19875, P01584, P14780, P20333TNF, ATF4, CXCL2, IL1B, MMP9, TNFRSF1BMore
Dimetindenehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Dimetindenehsa04720Long-term potentiation4.03E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Dimetindenehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Dimetindenehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Dimetindenehsa04750Inflammatory mediator regulation of TRP channels2.23E-049P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Dimetindenehsa04913Ovarian steroidogenesis2.45E-033P42330, P22694, P06213AKR1C3, PRKACB, INSRMore
Dimetindenehsa04914Progesterone-mediated oocyte maturation1.60E-024Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Dimetindenehsa04915Estrogen signaling pathway4.80E-026Q99527, Q08828, P51828, P11142, P0DP23, Q15788GPER1, ADCY1, ADCY7, HSPA8, CALM1, NCOA1More
Dimetindenehsa04923Regulation of lipolysis in adipocytes4.24E-034P07550, P06213, P42338, Q9Y4H2ADRB2, INSR, PIK3CB, IRS2More
Dimetindenehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Dimetindenehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Dimetindenehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Dimetindenehsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Dimetindenehsa04932Non-alcoholic fatty liver disease5.63E-0612P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHDMore
Dimetindenehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Dimetindenehsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Dimetindenehsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Dimetindenehsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Dimetindenehsa04970Salivary secretion1.60E-037P07550, Q08828, P51828, P22694, P23634, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ATP2B4, CALM1, CAMPMore
Dimetindenehsa04972Pancreatic secretion1.31E-022Q08828, P62491ADCY1, RAB11AMore
Dimetindenehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Dimetindenehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Dimetindenehsa05010Alzheimer disease2.78E-026P13073, O75460, P0DP24, P01584, P18848, P05141COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5More
Dimetindenehsa05012Parkinson disease3.89E-025P13073, P05141, O75460, P18848, P0DP24COX4I1, SLC25A5, ERN1, ATF4, CALM2More
Dimetindenehsa05016Huntington disease1.05E-048P13073, Q9GZM3, P24928, P62487, P52435, P05141, Q9NYC9, O75460COX4I1, POLR2J2, POLR2A, POLR2G, POLR2J, SLC25A5, DNAH9, ERN1More
Dimetindenehsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Dimetindenehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Dimetindenehsa05022Pathways of neurodegeneration - multiple diseases6.94E-0413P49841, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P20333, Q16539, P01584, Q08752, P0DP24GSK3B, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, IL1B, PPID, CALM2More
Dimetindenehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Dimetindenehsa05034Alcoholism4.57E-048Q13547, P0DP23, P63218, Q93077, P58876, P62807, Q16778, O60814HDAC1, CALM1, GNG5, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Dimetindenehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Dimetindenehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Dimetindenehsa05133Pertussis2.35E-032P0DP23, P0C0L4CALM1, C4AMore
Dimetindenehsa05134Legionellosis6.62E-046P01584, Q9NR31, P11215, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA8, CXCL1, CXCL2More
Dimetindenehsa05140Leishmaniasis5.18E-046P14598, P42224, O60603, P25963, P29350, Q15080NCF1, STAT1, TLR2, NFKBIA, PTPN6, NCF4More
Dimetindenehsa05143African trypanosomiasis3.01E-034P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Dimetindenehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Dimetindenehsa05146Amoebiasis2.05E-0511P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1More
Dimetindenehsa05150Staphylococcus aureus infection1.16E-036P0C0L4, P13646, Q14532, P59665, P59666, P49913C4A, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Dimetindenehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Dimetindenehsa05162Measles4.28E-027P23458, P14784, P11142, P01584, Q13191, P67870, Q9NP90JAK1, IL2RB, HSPA8, IL1B, CBLB, CSNK2B, RAB9BMore
Dimetindenehsa05168Herpes simplex virus 1 infection6.00E-0416P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, Q9Y2A4, Q13398, P51522, Q9HCX3, P17038, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, ZNF443, ZNF211, ZNF83, ZNF304, ZNF43, ZNF140, ZNF189, ZNF212More
Dimetindenehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Dimetindenehsa05203Viral carcinogenesis8.26E-0410P23458, P27348, P29083, Q7KZF4, Q13547, P12814, P58876, P62807, Q16778, O60814JAK1, YWHAQ, GTF2E1, SND1, HDAC1, ACTN1, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Dimetindenehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Dimetindenehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Dimetindenehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Dimetindenehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.99E-048P42338, P19174, P07766, P20963, P06239, Q04759, Q9HC35, P01730PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQ, EML4, CD4More
Dimetindenehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Dimetindenehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Dimetindenehsa05323Rheumatoid arthritis2.00E-023Q13488, P10747, O60603TCIRG1, CD28, TLR2More
Dimetindenehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Dimetindenehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Dimetindenehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Dimetindenehsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Dimetindenehsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Dimetindenehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore

Community members of Dimetindene (SDC: 6.24)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P12271RLBP1RetinaldehydeNonebinding protein 1Predicted00.0840.106200.2543
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P37840SNCAAlphaNonesynucleinPredicted10.08530.13240.33210.6395
P04156PRNPMajor prion proteinPredicted00.59090.173700.6429
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
Q08357SLC20A2SodiumNonedependent phosphate transporter 2Predicted00.08530.02700.0966
Q8WUM9SLC20A1SodiumNonedependent phosphate transporter 1Predicted00.69560.02700.4018
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)