PharmaCoNets of Dimethyl-fumarate (SPCN: 1.10 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dimethyl-fumaratehsa00520Amino sugar and nucleotide sugar metabolism1.68E-022Q14376, O60701GALE, UGDHMore
Dimethyl-fumaratehsa04110Cell cycle2.57E-024O43913, Q9UNH5, Q09472, Q14683ORC5, CDC14A, EP300, SMC1AMore
Dimethyl-fumaratehsa04120Ubiquitin mediated proteolysis2.57E-024Q14145, Q13042, Q93034, Q15751KEAP1, CDC16, CUL5, HERC1More
Dimethyl-fumaratehsa04612Antigen processing and presentation4.12E-023O43908, P30511, P01375KLRC4, HLA-F, TNFMore
Dimethyl-fumaratehsa04621NOD-like receptor signaling pathway3.24E-024P52630, P10599, P01375, P12838STAT2, TXN, TNF, DEFA4More
Dimethyl-fumaratehsa04625C-type lectin receptor signaling pathway2.17E-023P52630, P20749, P01375STAT2, BCL3, TNFMore
Dimethyl-fumaratehsa04657IL-17 signaling pathway3.06E-023P49841, P80188, P01375GSK3B, LCN2, TNFMore
Dimethyl-fumaratehsa04940Type I diabetes mellitus1.58E-022P30511, P01375HLA-F, TNFMore
Dimethyl-fumaratehsa04962Vasopressin-regulated water reabsorption1.52E-021Q9UJW0DCTN4More
Dimethyl-fumaratehsa05014Amyotrophic lateral sclerosis1.35E-022Q9UJW0, Q99567DCTN4, NUP88More
Dimethyl-fumaratehsa05132Salmonella infection9.14E-032P51617, Q9UJW0IRAK1, DCTN4More
Dimethyl-fumaratehsa05133Pertussis4.01E-021P51617IRAK1More
Dimethyl-fumaratehsa05160Hepatitis C9.27E-034P52630, P60033, P49841, P01375STAT2, CD81, GSK3B, TNFMore
Dimethyl-fumaratehsa05165Human papillomavirus infection1.76E-025P49841, P24821, P01375, P52630, P30511GSK3B, TNC, TNF, STAT2, HLA-FMore
Dimethyl-fumaratehsa05310Asthma9.71E-032P12724, P01375RNASE3, TNFMore
Dimethyl-fumaratehsa05330Allograft rejection2.30E-022P30511, P01375HLA-F, TNFMore
Dimethyl-fumaratehsa05332Graft-versus-host disease3.14E-022P30511, P01375HLA-F, TNFMore
Dimethyl-fumaratehsa05418Fluid shear stress and atherosclerosis4.70E-023Q14145, P10599, P01375KEAP1, TXN, TNFMore

Community members of Dimethyl-fumarate (SDC: 0.36)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)