PharmaCoNets of Dimenhydrinate (SPCN: 36.82 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dimenhydrinatehsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Dimenhydrinatehsa00500Starch and sucrose metabolism1.47E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Dimenhydrinatehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Dimenhydrinatehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Dimenhydrinatehsa00600Sphingolipid metabolism2.77E-023Q9BX95, Q8TCT0, P15289SGPP1, CERK, ARSAMore
Dimenhydrinatehsa00630Glyoxylate and dicarboxylate metabolism4.29E-032P40925, P15104MDH1, GLULMore
Dimenhydrinatehsa00730Thiamine metabolism4.07E-022P05186, P24666ALPL, ACP1More
Dimenhydrinatehsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Dimenhydrinatehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Dimenhydrinatehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Dimenhydrinatehsa00983Drug metabolism - other enzymes1.64E-023P04183, P32320, P05164TK1, CDA, MPOMore
Dimenhydrinatehsa01040Biosynthesis of unsaturated fatty acids2.92E-022P22307, Q9H5J4SCP2, ELOVL6More
Dimenhydrinatehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Dimenhydrinatehsa01522Endocrine resistance4.48E-024P22694, Q02750, Q9UM47, P46527PRKACB, MAP2K1, NOTCH3, CDKN1BMore
Dimenhydrinatehsa03020RNA polymerase1.81E-021P24928POLR2AMore
Dimenhydrinatehsa03040Spliceosome6.28E-036Q14562, O43143, O60508, Q07955, Q01130, Q13243DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5More
Dimenhydrinatehsa04012ErbB signaling pathway3.31E-021Q13153PAK1More
Dimenhydrinatehsa04014Ras signaling pathway4.04E-026Q02750, Q15389, P17252, P21359, P62879, P22694MAP2K1, ANGPT1, PRKCA, NF1, GNB2, PRKACBMore
Dimenhydrinatehsa04024cAMP signaling pathway1.05E-025P42338, P0DP23, Q13370, Q13009, Q13153PIK3CB, CALM1, PDE3B, TIAM1, PAK1More
Dimenhydrinatehsa04064NF-kappa B signaling pathway1.01E-0312O00463, P14778, P01584, P01375, Q04759, Q13077, Q16548, P06239, Q8WV28, P24522, P09341, Q9NQC7TRAF5, IL1R1, IL1B, TNF, PRKCQ, TRAF1, BCL2A1, LCK, BLNK, GADD45A, CXCL1, CYLDMore
Dimenhydrinatehsa04066HIF-1 signaling pathway4.48E-024P17252, Q15389, Q02750, P46527PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Dimenhydrinatehsa04070Phosphatidylinositol signaling system4.86E-023P0DP23, P42338, P27987CALM1, PIK3CB, ITPKBMore
Dimenhydrinatehsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Dimenhydrinatehsa04380Osteoclast differentiation2.05E-0312Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Dimenhydrinatehsa04392Hippo signaling pathway - multiple species1.51E-021Q13153PAK1More
Dimenhydrinatehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Dimenhydrinatehsa04540Gap junction2.03E-024P17252, P22694, P68371, Q02750PRKCA, PRKACB, TUBB2C, MAP2K1More
Dimenhydrinatehsa04613Neutrophil extracellular trap formation4.05E-0318O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q93077, P62807, O60814, P68431, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Dimenhydrinatehsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Dimenhydrinatehsa04625C-type lectin receptor signaling pathway2.53E-0310Q9ULY5, Q13153, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, PAK1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Dimenhydrinatehsa04640Hematopoietic cell lineage4.31E-0210P13612, P14778, P27930, P15144, P11836, P09693, P01732, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD3G, CD8A, HLA-DOB, TNF, IL1BMore
Dimenhydrinatehsa04650Natural killer cell mediated cytotoxicity7.86E-0311P01375, P78314, P06239, O60880, P20963, Q13153, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, PAK1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Dimenhydrinatehsa04657IL-17 signaling pathway2.25E-038O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Dimenhydrinatehsa04658Th1 and Th2 cell differentiation1.26E-0210Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765, P23458PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOB, JAK1More
Dimenhydrinatehsa04659Th17 cell differentiation2.17E-0315Q04759, Q16539, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P01584, P08238, P09693, P20963, P23458PRKCQ, MAPK14, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, IL1B, HSP90AB1, CD3G, CD247, JAK1More
Dimenhydrinatehsa04660T cell receptor signaling pathway2.12E-0312P01375, Q04759, O95267, Q08881, Q13153, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, PAK1, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Dimenhydrinatehsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Dimenhydrinatehsa04720Long-term potentiation1.09E-024P17252, P51812, P22694, Q02750PRKCA, RPS6KA3, PRKACB, MAP2K1More
Dimenhydrinatehsa04725Cholinergic synapse2.43E-024P22694, P17252, P62879, Q02750PRKACB, PRKCA, GNB2, MAP2K1More
Dimenhydrinatehsa04726Serotonergic synapse2.43E-024P22694, P17252, P62879, Q02750PRKACB, PRKCA, GNB2, MAP2K1More
Dimenhydrinatehsa04727GABAergic synapse2.03E-024P62879, P22694, O60296, P17252GNB2, PRKACB, TRAK2, PRKCAMore
Dimenhydrinatehsa04750Inflammatory mediator regulation of TRP channels1.17E-028P14778, P01584, P51828, P22694, Q16539, Q14643, Q04759, P0DP24IL1R1, IL1B, ADCY7, PRKACB, MAPK14, ITPR1, PRKCQ, CALM2More
Dimenhydrinatehsa04912GnRH signaling pathway4.33E-026P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACBMore
Dimenhydrinatehsa04914Progesterone-mediated oocyte maturation3.92E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Dimenhydrinatehsa04919Thyroid hormone signaling pathway2.22E-025P17252, Q02750, P22694, Q12778, Q9UM47PRKCA, MAP2K1, PRKACB, FOXO1, NOTCH3More
Dimenhydrinatehsa04924Renin secretion3.77E-022Q13370, P0DP23PDE3B, CALM1More
Dimenhydrinatehsa04928Parathyroid hormone synthesis, secretion and action4.48E-024P22694, Q02750, P17252, Q9Y5Q3PRKACB, MAP2K1, PRKCA, MAFBMore
Dimenhydrinatehsa04970Salivary secretion4.22E-023P22694, P17252, P49913PRKACB, PRKCA, CAMPMore
Dimenhydrinatehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Dimenhydrinatehsa05120Epithelial cell signaling in Helicobacter pylori infection3.10E-035Q16539, Q13153, P09341, P25024, P25025MAPK14, PAK1, CXCL1, CXCR1, CXCR2More
Dimenhydrinatehsa05140Leishmaniasis1.93E-0310P13612, O75015, P23458, P13765, O60603, P01375, P01584, P49006, Q16539, Q15080ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MARCKSL1, MAPK14, NCF4More
Dimenhydrinatehsa05144Malaria2.43E-026P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Dimenhydrinatehsa05146Amoebiasis5.82E-039P01584, P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311IL1B, CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Dimenhydrinatehsa05163Human cytomegalovirus infection3.64E-027Q14643, P49841, P14778, P25025, Q16539, P04637, O00463ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Dimenhydrinatehsa05165Human papillomavirus infection4.71E-0310P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATMMore
Dimenhydrinatehsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Dimenhydrinatehsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Dimenhydrinatehsa05202Transcriptional misregulation in cancer9.53E-0419Q12778, Q13315, P17844, P14780, P27930, Q15744, Q16548, Q13077, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, ATM, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Dimenhydrinatehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Dimenhydrinatehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Dimenhydrinatehsa05206MicroRNAs in cancer3.66E-026P46527, Q9UM47, P16070, Q13315, P17252, Q02750CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1More
Dimenhydrinatehsa05211Renal cell carcinoma2.42E-021Q13153PAK1More
Dimenhydrinatehsa05212Pancreatic cancer1.72E-023P42338, P42224, O75293PIK3CB, STAT1, GADD45BMore
Dimenhydrinatehsa05214Glioma1.72E-023P0DP23, P42338, O75293CALM1, PIK3CB, GADD45BMore
Dimenhydrinatehsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Dimenhydrinatehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Dimenhydrinatehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Dimenhydrinatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer5.71E-039O95267, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539, P01730RASGRP1, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14, CD4More
Dimenhydrinatehsa05321Inflammatory bowel disease1.21E-027O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Dimenhydrinatehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Dimenhydrinatehsa05418Fluid shear stress and atherosclerosis2.84E-0310Q16539, P42338, P14598, P10599, P14780, P04637, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, NCF1, TXN, MMP9, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Dimenhydrinate (SDC: 4.14)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)