PharmaCoNets of Dihydroergocornine (SPCN: 48.50 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dihydroergocorninehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Dihydroergocorninehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Dihydroergocorninehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Dihydroergocorninehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Dihydroergocorninehsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Dihydroergocorninehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Dihydroergocorninehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Dihydroergocorninehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Dihydroergocorninehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Dihydroergocorninehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Dihydroergocorninehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Dihydroergocorninehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Dihydroergocorninehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Dihydroergocorninehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Dihydroergocorninehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Dihydroergocorninehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Dihydroergocorninehsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Dihydroergocorninehsa04064NF-kappa B signaling pathway2.63E-0311P10415, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q13315, P24522, P09341BCL2, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, ATM, GADD45A, CXCL1More
Dihydroergocorninehsa04071Sphingolipid signaling pathway6.19E-058P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Dihydroergocorninehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Dihydroergocorninehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Dihydroergocorninehsa04140Autophagy - animal4.55E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Dihydroergocorninehsa04145Phagosome3.69E-027O75015, Q15080, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Dihydroergocorninehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Dihydroergocorninehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Dihydroergocorninehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Dihydroergocorninehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Dihydroergocorninehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Dihydroergocorninehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Dihydroergocorninehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Dihydroergocorninehsa04612Antigen processing and presentation3.33E-048P13765, P48382, Q14953, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Dihydroergocorninehsa04613Neutrophil extracellular trap formation6.68E-0417O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Dihydroergocorninehsa04640Hematopoietic cell lineage4.72E-028P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Dihydroergocorninehsa04650Natural killer cell mediated cytotoxicity5.26E-0510P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Dihydroergocorninehsa04657IL-17 signaling pathway5.38E-048O00463, Q16539, P49841, P19875, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL2, MMP9, ANAPC5, LCN2, TNFMore
Dihydroergocorninehsa04658Th1 and Th2 cell differentiation4.78E-038Q04759, P20963, P09693, P06239, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, LCK, STAT4, GATA3, TBX21, HLA-DOBMore
Dihydroergocorninehsa04659Th17 cell differentiation2.11E-028Q04759, P06239, P13765, Q9HBE5, Q9UL17, P23771, P09693, P20963PRKCQ, LCK, HLA-DOB, IL21R, TBX21, GATA3, CD3G, CD247More
Dihydroergocorninehsa04660T cell receptor signaling pathway4.75E-0310P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCKMore
Dihydroergocorninehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Dihydroergocorninehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Dihydroergocorninehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Dihydroergocorninehsa04742Taste transduction1.01E-021P30939HTR1FMore
Dihydroergocorninehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Dihydroergocorninehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Dihydroergocorninehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Dihydroergocorninehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Dihydroergocorninehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Dihydroergocorninehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Dihydroergocorninehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Dihydroergocorninehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Dihydroergocorninehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Dihydroergocorninehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Dihydroergocorninehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Dihydroergocorninehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Dihydroergocorninehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Dihydroergocorninehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Dihydroergocorninehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Dihydroergocorninehsa05133Pertussis4.20E-021P0C0L4C4AMore
Dihydroergocorninehsa05140Leishmaniasis3.53E-026P13612, O75015, P13765, O60603, P01375, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, NCF4More
Dihydroergocorninehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Dihydroergocorninehsa05144Malaria8.10E-057P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Dihydroergocorninehsa05146Amoebiasis1.64E-039P09341, P19875, P27930, P01375, O60603, P05089, P30679, P22694, P08311CXCL1, CXCL2, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, CTSGMore
Dihydroergocorninehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Dihydroergocorninehsa05202Transcriptional misregulation in cancer1.13E-0316Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Dihydroergocorninehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Dihydroergocorninehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Dihydroergocorninehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Dihydroergocorninehsa05310Asthma1.92E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Dihydroergocorninehsa05321Inflammatory bowel disease1.17E-057O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Dihydroergocorninehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Dihydroergocorninehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Dihydroergocorninehsa05332Graft-versus-host disease7.00E-055P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Dihydroergocorninehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Dihydroergocornine (SDC: 5.25)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P30939HTR1F5Nonehydroxytryptamine receptor 1FReported00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)