PharmaCoNets of Diflunisal (SPCN: 34.24 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Diflunisalhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Diflunisalhsa00190Oxidative phosphorylation3.56E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Diflunisalhsa00230Purine metabolism1.81E-022P20839, Q02153IMPDH1, GUCY1B3More
Diflunisalhsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Diflunisalhsa00565Ether lipid metabolism3.00E-031Q8N661TMEM86BMore
Diflunisalhsa00983Drug metabolism - other enzymes3.59E-023P04183, P32320, P05164TK1, CDA, MPOMore
Diflunisalhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Diflunisalhsa03008Ribosome biogenesis in eukaryotes1.46E-024Q9NYH9, P78345, Q9BVP2, Q9GZY0UTP6, RPP38, GNL3, NXF2; NXF2BMore
Diflunisalhsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Diflunisalhsa03013RNA transport3.88E-0312P52298, Q09161, O14893, P61326, Q9GZY0, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5, Q53GS7NCBP2, NCBP1, GEMIN2, MAGOH, NXF2; NXF2B, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3, GLE1More
Diflunisalhsa03015mRNA surveillance pathway9.78E-036O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1More
Diflunisalhsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Diflunisalhsa04064NF-kappa B signaling pathway4.09E-038P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Diflunisalhsa04071Sphingolipid signaling pathway1.05E-038P17252, P21453, Q9H228, Q13362, Q16537, Q9BX95, P04637, P10415PRKCA, S1PR1, EDG8, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2More
Diflunisalhsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Diflunisalhsa04120Ubiquitin mediated proteolysis2.89E-022O95071, P0CG47UBR5, UBBMore
Diflunisalhsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Diflunisalhsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Diflunisalhsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Diflunisalhsa04145Phagosome4.34E-0710P63261, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Diflunisalhsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Diflunisalhsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Diflunisalhsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Diflunisalhsa04540Gap junction3.53E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Diflunisalhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Diflunisalhsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Diflunisalhsa04613Neutrophil extracellular trap formation4.29E-0313P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P21730, P21462, P63261PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, C5AR1, FPR1, ACTG1More
Diflunisalhsa04650Natural killer cell mediated cytotoxicity2.96E-026O60880, P20963, Q13241, P26718, P26717, P26715SH2D1A, CD247, KLRD1, KLRK1, KLRC2, KLRC1More
Diflunisalhsa04657IL-17 signaling pathway4.87E-022P07900, P01584HSP90AA1, IL1BMore
Diflunisalhsa04658Th1 and Th2 cell differentiation1.07E-037Q04759, P20963, P09693, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, STAT4, GATA3, TBX21, HLA-DOBMore
Diflunisalhsa04659Th17 cell differentiation1.90E-026Q04759, P13765, Q9UL17, P23771, P09693, P20963PRKCQ, HLA-DOB, TBX21, GATA3, CD3G, CD247More
Diflunisalhsa04660T cell receptor signaling pathway1.00E-027Q9UDY8, Q04759, P10747, Q08881, P20963, P09693, P01732MALT1, PRKCQ, CD28, ITK, CD247, CD3G, CD8AMore
Diflunisalhsa04666Fc gamma R-mediated phagocytosis6.51E-046P23528, P49006, P06396, O14494, P14598, P17252CFL1, MARCKSL1, GSN, PLPP1, NCF1, PRKCAMore
Diflunisalhsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Diflunisalhsa04744Phototransduction2.80E-022P62873, P0DP23GNB1, CALM1More
Diflunisalhsa04916Melanogenesis4.80E-024P0DP23, Q9UJU2, P17252, P04628CALM1, LEF1, PRKCA, WNT1More
Diflunisalhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Diflunisalhsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Diflunisalhsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Diflunisalhsa04932Non-alcoholic fatty liver disease9.70E-034P18848, P01584, P13073, O15239ATF4, IL1B, COX4I1, NDUFA1More
Diflunisalhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Diflunisalhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Diflunisalhsa04972Pancreatic secretion1.99E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Diflunisalhsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Diflunisalhsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Diflunisalhsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Diflunisalhsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Diflunisalhsa05132Salmonella infection1.94E-0311P51617, Q9UJU2, P63261, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, LEF1, ACTG1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Diflunisalhsa05133Pertussis4.20E-021P0C0L4C4AMore
Diflunisalhsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Diflunisalhsa05140Leishmaniasis4.13E-025P14598, P13765, O60603, P49006, Q15080NCF1, HLA-DOB, TLR2, MARCKSL1, NCF4More
Diflunisalhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Diflunisalhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Diflunisalhsa05152Tuberculosis5.68E-039Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Diflunisalhsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Diflunisalhsa05170Human immunodeficiency virus 1 infection5.94E-0312P62873, P0DP23, P17252, O00463, Q14643, P01568, P51617, O60603, P23528, P10415, Q93034, Q9Y6Q5GNB1, CALM1, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, CFL1, BCL2, CUL5, AP1M2More
Diflunisalhsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Diflunisalhsa05202Transcriptional misregulation in cancer9.64E-0516Q12778, Q15532, Q13315, P41732, P14780, P14923, Q16548, Q13489, Q13077, O15550, P04637, P35226, P05164, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, JUP, BCL2A1, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, ELA2, BCL11B, GADD45AMore
Diflunisalhsa05205Proteoglycans in cancer9.14E-0412Q13009, Q12955, Q14643, O75369, P63261, P04637, P14780, P17252, O60603, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, ACTG1, TP53, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63More
Diflunisalhsa05216Thyroid cancer3.59E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Diflunisalhsa05217Basal cell carcinoma1.46E-024Q13635, Q9UJU2, P04637, P24522PTCH1, LEF1, TP53, GADD45AMore
Diflunisalhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.84E-025P20963, P09693, O60603, P10747, Q04759CD247, CD3G, TLR2, CD28, PRKCQMore
Diflunisalhsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Diflunisalhsa05321Inflammatory bowel disease1.17E-035O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Diflunisalhsa05323Rheumatoid arthritis1.45E-034P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Diflunisalhsa05332Graft-versus-host disease3.45E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Diflunisalhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Diflunisalhsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore
Diflunisalhsa05418Fluid shear stress and atherosclerosis4.26E-026P14598, P14780, P63261, P04637, P10415, Q92974NCF1, MMP9, ACTG1, TP53, BCL2, ARHGEF2More

Community members of Diflunisal (SDC: 3.68)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
Q13093PLA2G7PlateletNoneactivating factor acetylhydrolasePredicted00.05050.20960.15580.6001
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)