PharmaCoNets of Diethylcarbamazine (SPCN: 7.79 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Diethylcarbamazinehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Diethylcarbamazinehsa00600Sphingolipid metabolism4.50E-021P15289ARSAMore
Diethylcarbamazinehsa00920Sulfur metabolism3.18E-021Q16762TSTMore
Diethylcarbamazinehsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Diethylcarbamazinehsa03040Spliceosome1.28E-0513O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Diethylcarbamazinehsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Diethylcarbamazinehsa04015Rap1 signaling pathway2.69E-0311P20827, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P08514, P19174EFNA1, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, ITGA2B, PLCG1More
Diethylcarbamazinehsa04062Chemokine signaling pathway9.23E-0310P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Diethylcarbamazinehsa04120Ubiquitin mediated proteolysis1.68E-022O00762, Q14139UBE2C, UBE4AMore
Diethylcarbamazinehsa04122Sulfur relay system3.18E-021Q16762TSTMore
Diethylcarbamazinehsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Diethylcarbamazinehsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Diethylcarbamazinehsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Diethylcarbamazinehsa04512ECM-receptor interaction3.73E-022P07359, P08514GP1BA, ITGA2BMore
Diethylcarbamazinehsa04514Cell adhesion molecules8.19E-033P16109, P56750, O00501SELP, CLDN17, CLDN5More
Diethylcarbamazinehsa04530Tight junction1.38E-045Q8TEU7, P16989, P56750, O00501, Q14247RAPGEF6, CSDA, CLDN17, CLDN5, CTTNMore
Diethylcarbamazinehsa04610Complement and coagulation cascades4.47E-022P25116, P09871F2R, C1SMore
Diethylcarbamazinehsa04611Platelet activation5.18E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Diethylcarbamazinehsa04613Neutrophil extracellular trap formation3.07E-024P16109, O60814, P08514, P07359SELP, H2BC12, ITGA2B, GP1BAMore
Diethylcarbamazinehsa04659Th17 cell differentiation1.70E-027P19174, P14784, P14778, P84022, Q13485, P08238, P07766PLCG1, IL2RB, IL1R1, SMAD3, SMAD4, HSP90AB1, CD3EMore
Diethylcarbamazinehsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Diethylcarbamazinehsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Diethylcarbamazinehsa04810Regulation of actin cytoskeleton2.58E-023Q15746, P08514, P25116MYLK, ITGA2B, F2RMore
Diethylcarbamazinehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Diethylcarbamazinehsa04976Bile secretion4.50E-021Q9BY07SLC4A5More
Diethylcarbamazinehsa05130Pathogenic Escherichia coli infection7.39E-034Q14247, P56750, O00501, P25116CTTN, CLDN17, CLDN5, F2RMore
Diethylcarbamazinehsa05133Pertussis2.41E-022P09871, Q02556C1S, IRF8More
Diethylcarbamazinehsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Diethylcarbamazinehsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Diethylcarbamazinehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore

Community members of Diethylcarbamazine (SDC: 1.72)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenaseReported00.382210.27012.4612
P18054ALOX12Polyunsaturated fatty acid lipoxygenase ALOX12Predicted00.00750.37030.24160.986
O75342ALOX12BArachidonate 12Nonelipoxygenase, 12RNonetypePredicted00.0750.03990.15890.2762
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)