PharmaCoNets of Dienogest (SPCN: 108.59 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dienogesthsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Dienogesthsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Dienogesthsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Dienogesthsa00071Fatty acid degradation3.77E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Dienogesthsa00190Oxidative phosphorylation4.36E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Dienogesthsa00220Arginine biosynthesis3.83E-022P05089, P49448ARG1, GLUD2More
Dienogesthsa00310Lysine degradation3.15E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Dienogesthsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Dienogesthsa00500Starch and sucrose metabolism2.10E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Dienogesthsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Dienogesthsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Dienogesthsa00630Glyoxylate and dicarboxylate metabolism5.35E-052P40925, P15104MDH1, GLULMore
Dienogesthsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Dienogesthsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Dienogesthsa00970Aminoacyl-tRNA biosynthesis2.34E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Dienogesthsa01200Carbon metabolism2.91E-021P11413G6PDMore
Dienogesthsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Dienogesthsa01230Biosynthesis of amino acids3.91E-023P51854, Q99707, P50213TKTL1, MTR, IDH3AMore
Dienogesthsa01240Biosynthesis of cofactors2.95E-022P13716, P14618ALAD, PKM2More
Dienogesthsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Dienogesthsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Dienogesthsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Dienogesthsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Dienogesthsa03040Spliceosome4.95E-0613Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, ASCC3L1More
Dienogesthsa03430Mismatch repair4.38E-021P20585MSH3More
Dienogesthsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Dienogesthsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Dienogesthsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Dienogesthsa04015Rap1 signaling pathway5.18E-043P08069, P06213, O00522IGF1R, INSR, KRIT1More
Dienogesthsa04024cAMP signaling pathway4.25E-037P63092, P42338, P26678, P0DP23, P61586, Q13370, Q13009GNAS, PIK3CB, PLN, CALM1, RHOA, PDE3B, TIAM1More
Dienogesthsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Dienogesthsa04061Viral protein interaction with cytokine and cytokine receptor1.32E-026P09341, P25024, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RBMore
Dienogesthsa04062Chemokine signaling pathway6.73E-039P25024, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881CXCR1, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITKMore
Dienogesthsa04064NF-kappa B signaling pathway2.21E-0412Q13489, O00463, Q13546, P14778, Q04759, Q9UDY8, P07948, P06239, P24522, P09341, Q06643, Q9UNE0BIRC3, TRAF5, RIPK1, IL1R1, PRKCQ, MALT1, LYN, LCK, GADD45A, CXCL1, LTB, EDARMore
Dienogesthsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Dienogesthsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Dienogesthsa04070Phosphatidylinositol signaling system4.86E-023P0DP23, P42338, P27987CALM1, PIK3CB, ITPKBMore
Dienogesthsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Dienogesthsa04080Neuroactive ligand-receptor interaction3.70E-027P08311, P48058, Q15722, Q9H228, P43657, P21730, P35318CTSG, GRIA4, LTB4R, EDG8, P2RY5, C5AR1, ADMMore
Dienogesthsa04114Oocyte meiosis3.19E-035P51812, Q02750, P16298, Q17RY0, P08069RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1RMore
Dienogesthsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Dienogesthsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Dienogesthsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Dienogesthsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Dienogesthsa04144Endocytosis2.81E-026Q13191, P11142, P25024, P43250, P14784, Q9Y5X3CBLB, HSPA8, CXCR1, GRK6, IL2RB, SNX5More
Dienogesthsa04150mTOR signaling pathway7.74E-034P08069, Q02750, Q9NQL2, P51812IGF1R, MAP2K1, RRAGD, RPS6KA3More
Dienogesthsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Dienogesthsa04211Longevity regulating pathway1.34E-034Q12778, P08069, Q9UEF7, Q96KQ7FOXO1, IGF1R, KL, EHMT2More
Dienogesthsa04213Longevity regulating pathway - multiple species2.83E-033P08069, Q9Y4H2, Q13547IGF1R, IRS2, HDAC1More
Dienogesthsa04217Necroptosis1.85E-037P01375, P01568, P48023, Q13489, Q13546, Q14765, Q99878TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT4, H2AC14More
Dienogesthsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Dienogesthsa04360Axon guidance7.48E-045P20827, O95631, P42338, P23528, Q06124EFNA1, NTN1, PIK3CB, CFL1, PTPN11More
Dienogesthsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Dienogesthsa04510Focal adhesion8.84E-034O14986, P61586, Q16363, P08069PIP5K1B, RHOA, LAMA4, IGF1RMore
Dienogesthsa04512ECM-receptor interaction1.90E-022P26012, P16070ITGB8, CD44More
Dienogesthsa04520Adherens junction1.65E-054P08069, P19784, P67870, P61586IGF1R, CSNK2A2, CSNK2B, RHOAMore
Dienogesthsa04530Tight junction2.08E-023P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Dienogesthsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Dienogesthsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Dienogesthsa04612Antigen processing and presentation1.75E-026P13765, P01730, P26715, P26717, Q13241, P01732HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8AMore
Dienogesthsa04613Neutrophil extracellular trap formation1.23E-035P11215, Q13547, P58876, Q16778, O60814ITGAM, HDAC1, H2BC5, HIST2H2BE, H2BC12More
Dienogesthsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Dienogesthsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Dienogesthsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Dienogesthsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Dienogesthsa04640Hematopoietic cell lineage9.22E-0611P13612, P14778, P27930, P15144, P25063, P07766, P09693, P01732, P01730, P09564, P13765ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOBMore
Dienogesthsa04650Natural killer cell mediated cytotoxicity1.02E-0613P16298, P50591, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715PPP3CB, TNFSF10, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Dienogesthsa04658Th1 and Th2 cell differentiation5.96E-1112Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Dienogesthsa04659Th17 cell differentiation2.09E-1116Q04759, Q16539, P01730, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, Q13485, P08238, P07766, P09693, P20963PRKCQ, MAPK14, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Dienogesthsa04660T cell receptor signaling pathway1.95E-0611Q04759, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841PRKCQ, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Dienogesthsa04662B cell receptor signaling pathway4.07E-024P42338, P60033, P07948, Q8N149PIK3CB, CD81, LYN, LILRA2More
Dienogesthsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Dienogesthsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Dienogesthsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Dienogesthsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Dienogesthsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Dienogesthsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Dienogesthsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Dienogesthsa04724Glutamatergic synapse2.19E-036O15399, P63092, P62873, P63218, P50151, P15104GRIN2D, GNAS, GNB1, GNG5, GNG10, GLULMore
Dienogesthsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Dienogesthsa04727GABAergic synapse4.42E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Dienogesthsa04730Long-term depression1.16E-021P08069IGF1RMore
Dienogesthsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Dienogesthsa04914Progesterone-mediated oocyte maturation9.67E-047P08069, Q17RY0, P42338, Q13370, P08238, P51812, Q02750IGF1R, CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1More
Dienogesthsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Dienogesthsa04922Glucagon signaling pathway4.18E-022P14618, P06737PKM2, PYGLMore
Dienogesthsa04923Regulation of lipolysis in adipocytes3.76E-021P06213INSRMore
Dienogesthsa04924Renin secretion3.77E-022Q13370, P0DP23PDE3B, CALM1More
Dienogesthsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Dienogesthsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Dienogesthsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Dienogesthsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Dienogesthsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Dienogesthsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Dienogesthsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Dienogesthsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Dienogesthsa05017Spinocerebellar ataxia2.22E-024Q92915, O15399, P42338, P21796FGF14, GRIN2D, PIK3CB, VDAC1More
Dienogesthsa05032Morphine addiction2.47E-033P62873, P48169, P63092GNB1, GABRA4, GNASMore
Dienogesthsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Dienogesthsa05120Epithelial cell signaling in Helicobacter pylori infection3.76E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Dienogesthsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Dienogesthsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Dienogesthsa05133Pertussis4.20E-021P0C0L4C4AMore
Dienogesthsa05135Yersinia infection1.52E-026P13612, P06239, Q16539, P49841, P01730, P01732ITGA4, LCK, MAPK14, GSK3B, CD4, CD8AMore
Dienogesthsa05140Leishmaniasis4.50E-035P14598, O60603, P25963, P29350, Q15080NCF1, TLR2, NFKBIA, PTPN6, NCF4More
Dienogesthsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Dienogesthsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Dienogesthsa05146Amoebiasis6.00E-046P09341, P14778, P27930, P05089, P12814, P08311CXCL1, IL1R1, IL1R2, ARG1, ACTN1, CTSGMore
Dienogesthsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Dienogesthsa05163Human cytomegalovirus infection2.09E-024P62873, P61586, P63092, P61769GNB1, RHOA, GNAS, B2MMore
Dienogesthsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Dienogesthsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Dienogesthsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Dienogesthsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Dienogesthsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Dienogesthsa05202Transcriptional misregulation in cancer8.55E-045P27930, P11215, P08069, Q13547, P12980IL1R2, ITGAM, IGF1R, HDAC1, LYL1More
Dienogesthsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Dienogesthsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Dienogesthsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Dienogesthsa05212Pancreatic cancer1.72E-023P42338, P42224, O75293PIK3CB, STAT1, GADD45BMore
Dienogesthsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Dienogesthsa05214Glioma1.88E-034P08069, P0DP23, P42338, O75293IGF1R, CALM1, PIK3CB, GADD45BMore
Dienogesthsa05215Prostate cancer1.33E-021P08069IGF1RMore
Dienogesthsa05218Melanoma6.63E-031P08069IGF1RMore
Dienogesthsa05224Breast cancer1.49E-021P08069IGF1RMore
Dienogesthsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Dienogesthsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Dienogesthsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Dienogesthsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.38E-047P07766, P20963, P09693, P06239, Q04759, Q16539, P01730CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, CD4More
Dienogesthsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Dienogesthsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Dienogesthsa05332Graft-versus-host disease3.75E-035P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Dienogesthsa05340Primary immunodeficiency2.04E-034P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Dienogesthsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Dienogesthsa05415Diabetic cardiomyopathy3.59E-021P11413G6PDMore
Dienogesthsa05418Fluid shear stress and atherosclerosis3.73E-024P42338, P14598, P0DP23, P08238PIK3CB, NCF1, CALM1, HSP90AB1More

Community members of Dienogest (SDC: 6.89)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Predicted00.32530.5650.15791.4506
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
O43451MGAMMaltaseNoneglucoamylasePredicted10.19540.16780.1910.6242
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)