PharmaCoNets

PharmaCoNets of Dienestrol (S_PCN: 115.73 )

Dienestrol regulated-network (S_DN: 19.29)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Dienestrol

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Dienestrol

hsa00220

Arginine biosynthesis

3.83E-02

P05089, P49448

ARG1, GLUD2

Dienestrol

hsa00310

Lysine degradation

1.98E-03

Q96KQ7, Q02809, P51648

EHMT2, PLOD1, ALDH3A2

Dienestrol

hsa00480

Glutathione metabolism

3.29E-04

Q9UJ14, Q16772, P09211, P30041

GGTL3, GSTA3, GSTP1, PRDX6

Dienestrol

hsa00512

Mucin type O-glycan biosynthesis

3.19E-03

O95395, Q8N4A0, Q9NY28

GCNT3, GALNT4, GALNT8

Dienestrol

hsa00532

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

3.56E-02

Q9Y2C2

UST

Dienestrol

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Dienestrol

hsa00562

Inositol phosphate metabolism

2.00E-02

P27987, P19174, P42338, Q02252

ITPKB, PLCG1, PIK3CB, ALDH6A1

Dienestrol

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Dienestrol

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Dienestrol

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Dienestrol

hsa00630

Glyoxylate and dicarboxylate metabolism

1.59E-04

P40925, P15104

MDH1, GLUL

Dienestrol

hsa00830

Retinol metabolism

3.93E-02

P00352, Q9BPW9, O75911

ALDH1A1, DHRS9, DHRS3

Dienestrol

hsa00970

Aminoacyl-tRNA biosynthesis

2.24E-03

O95363, P14868, Q15046

FARS2, DARS, KARS

Dienestrol

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-05

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Dienestrol

hsa00982

Drug metabolism - cytochrome P450

1.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Dienestrol

hsa00983

Drug metabolism - other enzymes

1.72E-02

Q16772, P09211

GSTA3, GSTP1

Dienestrol

hsa01100

Metabolic pathways

8.43E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1

Dienestrol

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Dienestrol

hsa01522

Endocrine resistance

2.16E-02

P08069

IGF1R

Dienestrol

hsa01524

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Dienestrol

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Dienestrol

hsa03013

RNA transport

5.01E-03

P52298, O14893, P61326, P38919, P37198, Q7Z3B4, P35658, Q14152, P55884, O75822, P78345, Q9Y6A5

NCBP2, GEMIN2, MAGOH, EIF4A3, NUP62, NUP54, NUP214, EIF3A, EIF3B, EIF3J, RPP38, TACC3

Dienestrol

hsa03040

Spliceosome

5.53E-08

Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.888
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.775
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.953
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.871
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O60508	CDC40	Pre-mRNA-processing factor 17	0.838
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O60508	CDC40	Pre-mRNA-processing factor 17	0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.788
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.935
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.882
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.886
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.746
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Dienestrol

hsa03060

Protein export

4.22E-02

P37108, Q15005

SRP14, SPCS2

Dienestrol

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Dienestrol

hsa04010

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Dienestrol

hsa04012

ErbB signaling pathway

2.00E-02

P16333, P17252, P19174, P42338

NCK1, PRKCA, PLCG1, PIK3CB

Dienestrol

hsa04014

Ras signaling pathway

1.86E-06

P42338, P20827, Q9NRA1, P49767, P08069, Q13009, P17252, P14921, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174

PIK3CB, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, PRKCA, ETS1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P20827	EFNA1	Ephrin-A1	-0.872
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.776
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.792
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14921	ETS1	Protein C-ets-1	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766

Dienestrol

hsa04015

Rap1 signaling pathway

2.09E-04

P20827, P49767, P08069, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P0DP23, P17252, P19174

EFNA1, VEGFC, IGF1R, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, CALM1, PRKCA, PLCG1

Dienestrol

hsa04020

Calcium signaling pathway

4.34E-02

P27987, P17252, O15399, P19174, P0DP23, P49767

ITPKB, PRKCA, GRIN2D, PLCG1, CALM1, VEGFC

Dienestrol

hsa04024

cAMP signaling pathway

4.34E-02

P42338, P0DP23, Q13370, O15399, P25963, Q13009

PIK3CB, CALM1, PDE3B, GRIN2D, NFKBIA, TIAM1

Dienestrol

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Dienestrol

hsa04061

Viral protein interaction with cytokine and cytokine receptor

9.72E-04

Q8NHW4, P09341, P25024, P61073, P47992, Q9UBD3, Q13651, P14784

CCL4L2, CXCL1, CXCR1, CXCR4, XCL1, XCL2, IL10RA, IL2RB

Dienestrol

hsa04062

Chemokine signaling pathway

9.40E-08

P25024, P09341, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, P14598, P42224, P25963, Q8WYR1

CXCR1, CXCL1, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, NCF1, STAT1, NFKBIA, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P43250	GRK6	G protein-coupled receptor kinase 6	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.792
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14598	NCF1	Neutrophil cytosol factor 1	0.908
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Dienestrol

hsa04064

NF-kappa B signaling pathway

1.90E-06

P10415, O00463, P14778, P01584, Q04759, Q9UDY8, P67870, Q16548, P07948, P06239, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7

BCL2, TRAF5, IL1R1, IL1B, PRKCQ, MALT1, CSNK2B, BCL2A1, LYN, LCK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763

Dienestrol

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Dienestrol

hsa04068

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Dienestrol

hsa04070

Phosphatidylinositol signaling system

2.81E-04

P19174, P0DP23, P42338, P23743, P27987, P17252

PLCG1, CALM1, PIK3CB, DGKA, ITPKB, PRKCA

Dienestrol

hsa04071

Sphingolipid signaling pathway

6.65E-04

P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Dienestrol

hsa04080

Neuroactive ligand-receptor interaction

1.00E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2

Dienestrol

hsa04110

Cell cycle

4.67E-03

Q09472, P24522, P49918, P42773, P01106

EP300, GADD45A, CDKN1C, CDKN2C, MYC

Dienestrol

hsa04114

Oocyte meiosis

2.99E-02

P08069

IGF1R

Dienestrol

hsa04140

Autophagy - animal

2.95E-02

P08069, P22694, Q14643, P10415, Q04759

IGF1R, PRKACB, ITPR1, BCL2, PRKCQ

Dienestrol

hsa04141

Protein processing in endoplasmic reticulum

8.60E-03

P30101, P60604, P11142, P08238, Q9H173, Q9UNL2

PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3

Dienestrol

hsa04142

Lysosome

1.96E-02

Q9UBR2, P34059, P17900

CTSZ, GALNS, GM2A

Dienestrol

hsa04145

Phagosome

9.44E-04

P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Dienestrol

hsa04146

Peroxisome

2.42E-02

O43933, P56589, Q9UKG9, O75521, P33121

PEX1, PEX3, CROT, ECI2, ACSL1

Dienestrol

hsa04150

mTOR signaling pathway

2.32E-02

P08069

IGF1R

Dienestrol

hsa04151

PI3K-Akt signaling pathway

2.03E-03

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, P14784, P01568, P17252, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, IL2RB, IFNA21, PRKCA, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P20827	EFNA1	Ephrin-A1	-0.872
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P16144	ITGB4	Integrin beta-4	-0.705
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O15335	CHAD	Chondroadherin	-0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13751	LAMB3	Laminin subunit beta-3	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.865
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Dienestrol

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Dienestrol

hsa04210

Apoptosis

3.44E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1

Dienestrol

hsa04211

Longevity regulating pathway

2.16E-02

P08069

IGF1R

Dienestrol

hsa04213

Longevity regulating pathway - multiple species

1.66E-02

P08069

IGF1R

Dienestrol

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Dienestrol

hsa04217

Necroptosis

3.30E-02

P01568, Q13489, P42224, P08238, P15104, Q6FI13, O43633

IFNA21, BIRC3, STAT1, HSP90AB1, GLUL, H2AC18; H2AC19, CHMP2A

Dienestrol

hsa04260

Cardiac muscle contraction

4.49E-02

P67936, P13073, P12074

TPM4, COX4I1, COX6A1

Dienestrol

hsa04330

Notch signaling pathway

2.77E-02

Q92542, P49768

NCSTN, PSEN1

Dienestrol

hsa04340

Hedgehog signaling pathway

3.09E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Dienestrol

hsa04360

Axon guidance

5.10E-04

P16333, P20827, O95631, P17252, P42338, P07332, P23528, P19174

NCK1, EFNA1, NTN1, PRKCA, PIK3CB, FES, CFL1, PLCG1

Dienestrol

hsa04370

VEGF signaling pathway

7.68E-03

P19174, P42338, P17252

PLCG1, PIK3CB, PRKCA

Dienestrol

hsa04371

Apelin signaling pathway

3.84E-05

P62873, P63218, P50151, Q8WYR1, Q13370, Q14814, Q14344, Q13485, P84022, P0DP23

GNB1, GNG5, GNG10, PIK3R5, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CALM1

Dienestrol

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Dienestrol

hsa04510

Focal adhesion

2.69E-03

P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, Q13489, P08069, P49767

ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, BIRC3, IGF1R, VEGFC

Dienestrol

hsa04520

Adherens junction

8.29E-03

P08069

IGF1R

Dienestrol

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Dienestrol

hsa04540

Gap junction

1.08E-02

Q13509, P68371, Q71U36, Q9NRA1

TUBB3, TUBB2C, TUBA1A, PDGFC

Dienestrol

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P08069

IGF1R

Dienestrol

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Dienestrol

hsa04612

Antigen processing and presentation

2.20E-03

P13765, P01730, P26715, P26717, Q13241, P01732

HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8A

Dienestrol

hsa04613

Neutrophil extracellular trap formation

1.20E-04

O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767

Dienestrol

hsa04623

Cytosolic DNA-sensing pathway

5.86E-05

P01584, P01568, P25963, Q8NHW4

IL1B, IFNA21, NFKBIA, CCL4L2

Dienestrol

hsa04630

JAK-STAT signaling pathway

4.43E-02

P01106, Q09472, P16871

MYC, EP300, IL7R

Dienestrol

hsa04640

Hematopoietic cell lineage

6.15E-06

P13612, P14778, P27930, P20023, P25063, P07766, P09693, P01732, P01730, P09564, P16871, P13765

ITGA4, IL1R1, IL1R2, CR2, CD24, CD3E, CD3G, CD8A, CD4, CD7, IL7R, HLA-DOB

Dienestrol

hsa04650

Natural killer cell mediated cytotoxicity

3.08E-04

P06239, O60880, P20963, Q13241, P26718, O14931, P26717, P26715

LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, KLRC2, KLRC1

Dienestrol

hsa04657

IL-17 signaling pathway

4.98E-02

O00463, Q16539, P14780, Q9UJX4, P80188, P01375

TRAF5, MAPK14, MMP9, ANAPC5, LCN2, TNF

Dienestrol

hsa04658

Th1 and Th2 cell differentiation

1.77E-09

Q04759, P07766, P20963, P09693, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Dienestrol

hsa04659

Th17 cell differentiation

1.18E-10

P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.865
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.748
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Dienestrol

hsa04660

T cell receptor signaling pathway

3.19E-05

Q9UDY8, Q04759, P10747, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239

MALT1, PRKCQ, CD28, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK

Dienestrol

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Dienestrol

hsa04664

Fc epsilon RI signaling pathway

2.89E-05

P04141, P42338, P17252, P07948, P19174, P09917

CSF2, PIK3CB, PRKCA, LYN, PLCG1, ALOX5

Dienestrol

hsa04666

Fc gamma R-mediated phagocytosis

8.08E-03

P42338, P19174, P23528, P14598, P17252

PIK3CB, PLCG1, CFL1, NCF1, PRKCA

Dienestrol

hsa04713

Circadian entrainment

7.16E-04

O15399, P0DP23, P17252, P62873, P63218, P50151

GRIN2D, CALM1, PRKCA, GNB1, GNG5, GNG10

Dienestrol

hsa04724

Glutamatergic synapse

3.33E-04

O15399, P17252, P62873, P63218, P50151, P15104

GRIN2D, PRKCA, GNB1, GNG5, GNG10, GLUL

Dienestrol

hsa04725

Cholinergic synapse

4.26E-02

P17252, P62873, P50151, P42338

PRKCA, GNB1, GNG10, PIK3CB

Dienestrol

hsa04726

Serotonergic synapse

2.52E-03

P17252, P62873, P63218, P50151, P33260, P09917

PRKCA, GNB1, GNG5, GNG10, CYP2C18, ALOX5

Dienestrol

hsa04727

GABAergic synapse

1.33E-04

P62873, P63218, P50151, P15104, P17252

GNB1, GNG5, GNG10, GLUL, PRKCA

Dienestrol

hsa04730

Long-term depression

1.95E-02

Q14344, P08069, P07948

GNA13, IGF1R, LYN

Dienestrol

hsa04744

Phototransduction

1.59E-04

P62873, P0DP23

GNB1, CALM1

Dienestrol

hsa04913

Ovarian steroidogenesis

1.16E-02

P08069

IGF1R

Dienestrol

hsa04914

Progesterone-mediated oocyte maturation

7.95E-03

P08069, P42338, Q13370, Q9UJX4, P30304, P08238

IGF1R, PIK3CB, PDE3B, ANAPC5, CDC25A, HSP90AB1

Dienestrol

hsa04922

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Dienestrol

hsa04924

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Dienestrol

hsa04926

Relaxin signaling pathway

1.53E-02

P25963, P42338, P62873, P50151, P49767, P17252

NFKBIA, PIK3CB, GNB1, GNG10, VEGFC, PRKCA

Dienestrol

hsa04928

Parathyroid hormone synthesis, secretion and action

4.23E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Dienestrol

hsa04932

Non-alcoholic fatty liver disease

1.24E-02

O43521, O75460, P01584, P13073, P12074, O15239

BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFA1

Dienestrol

hsa04933

AGE-RAGE signaling pathway in diabetic complications

2.17E-04

P84022, Q13485, P42224, P10415, P42338, P49767, P17252, P19174

SMAD3, SMAD4, STAT1, BCL2, PIK3CB, VEGFC, PRKCA, PLCG1

Dienestrol

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Dienestrol

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Dienestrol

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Dienestrol

hsa05010

Alzheimer disease

2.21E-02

O15239, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P67870, P28070

NDUFA1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, CSNK2B, PSMB4

Dienestrol

hsa05012

Parkinson disease

1.77E-02

P60604, P19174, P0DP23, Q71U36, Q13509, P68371

UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C

Dienestrol

hsa05032

Morphine addiction

7.16E-04

P62873, P63218, P50151, Q13370, P17252, P43250

GNB1, GNG5, GNG10, PDE3B, PRKCA, GRK6

Dienestrol

hsa05034

Alcoholism

9.40E-05

P07101, Q93077, P62807, P33778, O60814, P68431

TH, HIST1H2AC, HIST1H2BC, H2BC3, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Dienestrol

hsa05110

Vibrio cholerae infection

3.15E-02

Q13488, P17252, P19174

TCIRG1, PRKCA, PLCG1

Dienestrol

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.08E-02

P25963, Q13488, P19174, P07948

NFKBIA, TCIRG1, PLCG1, LYN

Dienestrol

hsa05130

Pathogenic Escherichia coli infection

3.19E-02

Q71U36, P16333, Q13509, P68371, Q14344, P25963

TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA

Dienestrol

hsa05132

Salmonella infection

2.19E-03

P25963, P08238, Q13489, P10415, O75369, Q9BQS8, Q71U36, Q13509, P68371, P49754

NFKBIA, HSP90AB1, BIRC3, BCL2, FLNB, FYCO1, TUBA1A, TUBB3, TUBB2C, VPS41

Dienestrol

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Dienestrol

hsa05134

Legionellosis

4.75E-02

P25963, P11215, P11142

NFKBIA, ITGAM, HSPA8

Dienestrol

hsa05140

Leishmaniasis

4.82E-02

P14598, P11215, P42224, P25963

NCF1, ITGAM, STAT1, NFKBIA

Dienestrol

hsa05143

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Dienestrol

hsa05144

Malaria

3.09E-02

P69905, P68871

HBA2, HBB

Dienestrol

hsa05145

Toxoplasmosis

3.86E-03

P25963, P10415, Q13489, P42224, P09917, Q13751, P11142

NFKBIA, BCL2, BIRC3, STAT1, ALOX5, LAMB3, HSPA8

Dienestrol

hsa05146

Amoebiasis

9.73E-03

P09341, P14778, P27930, P05089, P12814, P08311

CXCL1, IL1R1, IL1R2, ARG1, ACTN1, CTSG

Dienestrol

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Dienestrol

hsa05163

Human cytomegalovirus infection

1.70E-05

P42338, P25963, P62873, P63218, P50151, P0DP23, Q14344, Q8NHW4, Q08828, P23458, P01584, P61073, P17252, Q13651, P30101, P01568

PIK3CB, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, CCL4L2, ADCY1, JAK1, IL1B, CXCR4, PRKCA, IL10RA, PDIA3, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P0DP23	CALM1	Calmodulin-1	0.762
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q08828	ADCY1	Adenylate cyclase type 1	0.829
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P23458	JAK1	Tyrosine-protein kinase JAK1	0.847
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P30101	PDIA3	Protein disulfide-isomerase A3	0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733

Dienestrol

hsa05166

Human T-cell leukemia virus 1 infection

2.13E-02

P01106, P09693, Q09472, P42773, P01730

MYC, CD3G, EP300, CDKN2C, CD4

Dienestrol

hsa05167

Kaposi sarcoma-associated herpesvirus infection

2.15E-06

P01568, P42224, P25963, P42338, P40189, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23

IFNA21, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.748
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	-0.79
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775

Dienestrol

hsa05168

Herpes simplex virus 1 infection

8.25E-04

P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q13398, Q03923, O75820, Q9UDV6

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF85, ZNF189, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.935
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.882
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.886
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.747
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P30101	PDIA3	Protein disulfide-isomerase A3	0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13398	ZNF211	Zinc finger protein 211	0.956
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13398	ZNF211	Zinc finger protein 211	0.849
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q03923	ZNF85	Zinc finger protein 85	-0.731
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O75820	ZNF189	Zinc finger protein 189	-0.756
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75820	ZNF189	Zinc finger protein 189	-0.766
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q9UDV6	ZNF212	Zinc finger protein 212	0.798

Dienestrol

hsa05169

Epstein-Barr virus infection

1.57E-04

P20023, P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, Q14790, P07766, P09693, P20963

CR2, HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CASP8, CD3E, CD3G, CD247

Dienestrol

hsa05170

Human immunodeficiency virus 1 infection

3.04E-04

P42338, P62873, P63218, P50151, P0DP23, P17252, P30101, P01568, P25963, P19174, P23528

PIK3CB, GNB1, GNG5, GNG10, CALM1, PRKCA, PDIA3, IFNA21, NFKBIA, PLCG1, CFL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P30101	PDIA3	Protein disulfide-isomerase A3	0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P23528	CFL1	Cofilin-1	-0.853

Dienestrol

hsa05171

Coronavirus disease - COVID-19

3.30E-02

P25963, P42224, P01568, P40189, P42338, P19174, P17252

NFKBIA, STAT1, IFNA21, IL6ST, PIK3CB, PLCG1, PRKCA

Dienestrol

hsa05200

Pathways in cancer

5.45E-08

Q13751, P42338, P08238, P42224, P25963, P19174, P17252, P43246, P84022, Q13485, P20585, Q13547, P10826, P14923, P30281, Q13489, P49767, P14921, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P40189

LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, HDAC1, RARB, JUP, CCND3, BIRC3, VEGFC, ETS1, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13751	LAMB3	Laminin subunit beta-3	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P43246	MSH2	DNA mismatch repair protein Msh2	0.925
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P43246	MSH2	DNA mismatch repair protein Msh2	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P20585	MSH3	DNA mismatch repair protein Msh3	0.825
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P10826	RARB	Retinoic acid receptor beta	0.779
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14923	JUP	Junction plakoglobin	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.747
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14921	ETS1	Protein C-ets-1	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P78417	GSTO1	Glutathione S-transferase omega-1	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.919
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.865
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.748

Dienestrol

hsa05202

Transcriptional misregulation in cancer

8.83E-05

Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P08069, P35226, P05164, P08246, Q9C0K0, P24522

FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, IGF1R, BMI1, MPO, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Dienestrol

hsa05203

Viral carcinogenesis

1.45E-04

Q14790, Q12933, P42229, Q09472, Q15283, P62807, P33778, O60814

CASP8, TRAF2, STAT5A, EP300, RASA2, HIST1H2BC, H2BC3, H2BC12

Dienestrol

hsa05204

Chemical carcinogenesis

1.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Dienestrol

hsa05205

Proteoglycans in cancer

3.48E-02

P08069

IGF1R

Dienestrol

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Dienestrol

hsa05212

Pancreatic cancer

5.76E-04

P42338, P42224, P84022, Q13485, O75293

PIK3CB, STAT1, SMAD3, SMAD4, GADD45B

Dienestrol

hsa05213

Endometrial cancer

3.77E-02

P01106, P24522

MYC, GADD45A

Dienestrol

hsa05214

Glioma

6.23E-05

P08069, P0DP23, P17252, P42338, P19174, O75293

IGF1R, CALM1, PRKCA, PIK3CB, PLCG1, GADD45B

Dienestrol

hsa05215

Prostate cancer

1.33E-02

P08069

IGF1R

Dienestrol

hsa05216

Thyroid cancer

1.68E-02

P01106, P24522

MYC, GADD45A

Dienestrol

hsa05218

Melanoma

6.63E-03

P08069

IGF1R

Dienestrol

hsa05220

Chronic myeloid leukemia

1.44E-03

Q13547, Q13485, P25963, P84022, P42338, O75293

HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B

Dienestrol

hsa05222

Small cell lung cancer

6.98E-04

P10826, P42338, Q13751, Q13489, P10415, P25963, O75293

RARB, PIK3CB, LAMB3, BIRC3, BCL2, NFKBIA, GADD45B

Dienestrol

hsa05223

Non-small cell lung cancer

4.91E-03

P17252, P42338, P19174, P10826, O75293

PRKCA, PIK3CB, PLCG1, RARB, GADD45B

Dienestrol

hsa05224

Breast cancer

1.49E-02

P08069

IGF1R

Dienestrol

hsa05225

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Dienestrol

hsa05226

Gastric cancer

2.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Dienestrol

hsa05231

Choline metabolism in cancer

4.91E-03

P42338, Q9Y259, P19174, P23743, P17252

PIK3CB, CHKB, PLCG1, DGKA, PRKCA

Dienestrol

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

7.87E-04

P07766, P20963, P09693, P06239, O60603, P10747, Q04759, P01730

CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, CD4

Dienestrol

hsa05321

Inflammatory bowel disease

1.17E-03

O60603, P13765, Q14765, Q9UL17, P23771

TLR2, HLA-DOB, STAT4, TBX21, GATA3

Dienestrol

hsa05322

Systemic lupus erythematosus

2.30E-05

P09871, Q93077, P62807, P33778, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC3, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Dienestrol

hsa05323

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Dienestrol

hsa05332

Graft-versus-host disease

3.63E-04

P13765, P10747, P26715, Q13241

HLA-DOB, CD28, KLRC1, KLRD1

Dienestrol

hsa05340

Primary immunodeficiency

2.89E-03

P01730, P01732, P16871, P07766, P06239

CD4, CD8A, IL7R, CD3E, LCK

Dienestrol

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Community members of Dienestrol (S_DC: 6.00)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

O75469

NR1I2

Nuclear receptor subfamily 1 group I member 2

Predicted

0.0315

0.9493

1.9143

Q14376

GALE

UDPNoneglucose 4Noneepimerase

Predicted

0.0046

0.0309

0.2313

0.2953

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

O95271

TNKS

Poly [ADPNoneribose] polymerase tankyraseNone1

Predicted

0.1017

0.2224

0.4957

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P08069

IGF1R

InsulinNonelike growth factor 1 receptor

Predicted

0.2082

0.9561

0.9883

3.0047

P22748

CA4

Carbonic anhydrase 4

Predicted

0.0056

0.8267

0.1609

1.8171

P15121

AKR1B1

AldoNoneketo reductase family 1 member B1

Predicted

0.5683

0.629

0.214

1.7562

P08238

HSP90AB1

Heat shock protein HSP 90Nonebeta

Predicted

0.0611

0.5208

0.741

1.8131

P62942

FKBP1A

PeptidylNoneprolyl cisNonetrans isomerase FKBP1A

Predicted

0.432

0.2695

0.7551

P42330

AKR1C3

AldoNoneketo reductase family 1 member C3

Predicted

0.4017

0.8348

0.1748

2.0453

P49768

PSEN1

PresenilinNone1

Predicted

0.2677

0.6599

0.3308

1.7845

PharmaCoNets of Dienestrol (SPCN: 115.73 )

Dienestrol regulated-network (SDN: 19.29)

Community members of Dienestrol (SDC: 6.00)

PharmaCoNets of Dienestrol (S_PCN: 115.73 )

Dienestrol regulated-network (S_DN: 19.29)

Community members of Dienestrol (S_DC: 6.00)