PharmaCoNets

PharmaCoNets of Dicoumarol (S_PCN: 145.89 )

Dicoumarol regulated-network (S_DN: 23.23)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Dicoumarol

hsa00020

Citrate cycle (TCA cycle)

2.78E-02

O75390, P40926

CS, MDH2

Dicoumarol

hsa00051

Fructose and mannose metabolism

4.17E-02

P15121, P60174

AKR1B1, TPI1

Dicoumarol

hsa00052

Galactose metabolism

1.06E-03

P06280, O43451

GLA, MGAM

Dicoumarol

hsa00190

Oxidative phosphorylation

8.71E-03

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Dicoumarol

hsa00220

Arginine biosynthesis

1.36E-02

P15104, P49448

GLUL, GLUD2

Dicoumarol

hsa00250

Alanine, aspartate and glutamate metabolism

2.61E-02

P49448, P15104

GLUD2, GLUL

Dicoumarol

hsa00310

Lysine degradation

4.14E-02

Q02809

PLOD1

Dicoumarol

hsa00500

Starch and sucrose metabolism

2.71E-05

O43451, P46976, P35573, P06737

MGAM, GYG1, AGL, PYGL

Dicoumarol

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Dicoumarol

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Dicoumarol

hsa00561

Glycerolipid metabolism

2.51E-02

P51648, P23743

ALDH3A2, DGKA

Dicoumarol

hsa00562

Inositol phosphate metabolism

7.30E-04

P27987, Q96PE3, P19174, P42338

ITPKB, INPP4A, PLCG1, PIK3CB

Dicoumarol

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Dicoumarol

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Dicoumarol

hsa00620

Pyruvate metabolism

2.51E-02

P40925, P51648

MDH1, ALDH3A2

Dicoumarol

hsa00630

Glyoxylate and dicarboxylate metabolism

2.31E-04

P40925, P40926, P15104

MDH1, MDH2, GLUL

Dicoumarol

hsa00730

Thiamine metabolism

2.53E-04

P05186, P24666

ALPL, ACP1

Dicoumarol

hsa00750

Vitamin B6 metabolism

4.96E-02

O00764

PDXK

Dicoumarol

hsa00830

Retinol metabolism

3.15E-02

P00325

ADH1B

Dicoumarol

hsa00910

Nitrogen metabolism

2.61E-02

P15104, P49448

GLUL, GLUD2

Dicoumarol

hsa00970

Aminoacyl-tRNA biosynthesis

2.24E-03

O95363, P14868, Q15046

FARS2, DARS, KARS

Dicoumarol

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Dicoumarol

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Dicoumarol

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Dicoumarol

hsa01100

Metabolic pathways

4.12E-02

P15104, P51648, P42338, Q96PE3, P19174, P27987, Q13370, P40925, P23743, P43034, P09917, Q53FZ2

GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, PDE3B, MDH1, DGKA, PAFAH1B1, ALOX5, ACSM3

Dicoumarol

hsa01210

2-Oxocarboxylic acid metabolism

1.40E-02

P50213

IDH3A

Dicoumarol

hsa01521

EGFR tyrosine kinase inhibitor resistance

7.30E-04

Q92529, P19174, P42338, Q9NRA1

SHC3, PLCG1, PIK3CB, PDGFC

Dicoumarol

hsa01523

Antifolate resistance

1.68E-02

Q92820, P04818

GGH, TYMS

Dicoumarol

hsa03010

Ribosome

4.92E-05

P42677, P30050, P40429, P46776, Q9H0U6, Q07020, P62910, P36578, P05386, P62249, P23396

RPS27, RPL12, RPL13A, RPL27A, MRPL18, RPL18, RPL32, RPL4, RPLP1, RPS16, RPS3

Dicoumarol

hsa03013

RNA transport

6.43E-04

P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, Q14152, O75822, Q13310, P20042, Q14240, Q9Y6A5, P51114

RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EIF3A, EIF3J, PABPC4, EIF2S2, EIF4A2, TACC3, FXR1

Dicoumarol

hsa03015

mRNA surveillance pathway

4.25E-02

Q13310, Q13362, Q15287, Q9UBU9

PABPC4, PPP2R5C, RNPS1, NXF1

Dicoumarol

hsa03020

RNA polymerase

1.31E-02

P24928, P62487

POLR2A, POLR2G

Dicoumarol

hsa03040

Spliceosome

5.67E-07

O43143, O60508, P17844, P08579, P26368, P51991, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, DDX5, SNRPB2, U2AF2, HNRPA3, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Dicoumarol

hsa03410

Base excision repair

4.17E-02

P49005, P29372

POLD2, MPG

Dicoumarol

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Dicoumarol

hsa04010

MAPK signaling pathway

1.53E-02

Q9H2K8, Q12933

TAOK3, TRAF2

Dicoumarol

hsa04012

ErbB signaling pathway

9.49E-03

Q92529, P19174, P42338

SHC3, PLCG1, PIK3CB

Dicoumarol

hsa04014

Ras signaling pathway

7.65E-05

P42338, Q92529, P20827, Q9NRA1, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, SHC3, EFNA1, PDGFC, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Dicoumarol

hsa04015

Rap1 signaling pathway

2.22E-03

P20827, Q9NRA1, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174

EFNA1, PDGFC, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1

Dicoumarol

hsa04020

Calcium signaling pathway

2.85E-04

P27987, Q96DU7, Q08828, Q13557, P19174, P61073, P05141, P51828, Q9NRA1, P49767

ITPKB, ITPKC, ADCY1, CAMK2D, PLCG1, CXCR4, SLC25A5, ADCY7, PDGFC, VEGFC

Dicoumarol

hsa04062

Chemokine signaling pathway

2.01E-04

P09769, P07948, P42338, P19174, Q92529, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

FGR, LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Dicoumarol

hsa04064

NF-kappa B signaling pathway

3.99E-02

P10415, Q13489, P29965, Q9UDY8, Q8WV28, Q13315

BCL2, BIRC3, CD40LG, MALT1, BLNK, ATM

Dicoumarol

hsa04070

Phosphatidylinositol signaling system

7.63E-05

P19174, P0DP23, Q14643, P42338, P23743, Q96PE3, P27987, P17252

PLCG1, CALM1, ITPR1, PIK3CB, DGKA, INPP4A, ITPKB, PRKCA

Dicoumarol

hsa04071

Sphingolipid signaling pathway

1.07E-04

P17252, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2, Q12933, Q02156

PRKCA, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2, TRAF2, PRKCE

Dicoumarol

hsa04072

Phospholipase D signaling pathway

1.85E-04

P42338, Q92529, P19174, Q14344, P23743, Q9NRA1

PIK3CB, SHC3, PLCG1, GNA13, DGKA, PDGFC

Dicoumarol

hsa04110

Cell cycle

6.63E-04

P06493, O60566, P30304, P33981, P42773, P01106

CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC

Dicoumarol

hsa04114

Oocyte meiosis

1.13E-03

P51812, Q02750, Q13557, P16298, Q17RY0, Q08828, P51828, P27348, Q13362

RPS6KA3, MAP2K1, CAMK2D, PPP3CB, CPEB4, ADCY1, ADCY7, YWHAQ, PPP2R5C

Dicoumarol

hsa04120

Ubiquitin mediated proteolysis

4.82E-03

Q9UBT2, Q14669

SAE2, TRIP12

Dicoumarol

hsa04141

Protein processing in endoplasmic reticulum

1.91E-03

P18848, Q15437, Q99941, P11142, P07900, Q9NR31

ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1A

Dicoumarol

hsa04145

Phagosome

1.59E-03

Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOB

Dicoumarol

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Dicoumarol

hsa04151

PI3K-Akt signaling pathway

3.89E-06

P62753, P42338, P43657, P25116, P27348, P20827, Q9NRA1, P49767, Q13362, P07900, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, P22105, O60603, P14784, P01568, Q99941, P18848, P10415, P17252, O00141, P30281

RPS6, PIK3CB, P2RY5, F2R, YWHAQ, EFNA1, PDGFC, VEGFC, PPP2R5C, HSP90AA1, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, TNXB, TLR2, IL2RB, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGK, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P62753	RPS6	40S ribosomal protein S6	0.722
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P27348	YWHAQ	14-3-3 protein theta	0.833
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	1
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P22105	TNXB	Tenascin-X	0.777
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.709
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Dicoumarol

hsa04210

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Dicoumarol

hsa04211

Longevity regulating pathway

2.72E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Dicoumarol

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Dicoumarol

hsa04217

Necroptosis

9.14E-03

P01568, Q13489, P42224, Q6FI13, P10415, O43633, Q08752

IFNA21, BIRC3, STAT1, H2AC18; H2AC19, BCL2, CHMP2A, PPID

Dicoumarol

hsa04261

Adrenergic signaling in cardiomyocytes

1.69E-04

P09493, Q08828, P51828, Q99941, P18848, Q13362, P0DP23, Q13557, P17252, P10415

TPM1, ADCY1, ADCY7, CREBL1, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2

Dicoumarol

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Dicoumarol

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Dicoumarol

hsa04370

VEGF signaling pathway

8.20E-05

P19174, P16298, P42338, Q05397, Q02750

PLCG1, PPP3CB, PIK3CB, PTK2, MAP2K1

Dicoumarol

hsa04371

Apelin signaling pathway

4.48E-04

P63218, P50151, Q8WYR1, Q13370, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, PDE3B, MEF2D, GNA13, SMAD4, SMAD3

Dicoumarol

hsa04380

Osteoclast differentiation

1.02E-02

Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2

Dicoumarol

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Dicoumarol

hsa04510

Focal adhesion

1.55E-02

P42338, O15335, Q9NRA1, P49767, Q92529

PIK3CB, CHAD, PDGFC, VEGFC, SHC3

Dicoumarol

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Dicoumarol

hsa04540

Gap junction

1.29E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Dicoumarol

hsa04550

Signaling pathways regulating pluripotency of stem cells

2.16E-02

P04628, P40189

WNT1, IL6ST

Dicoumarol

hsa04611

Platelet activation

4.11E-02

P42338, Q14344, P07948

PIK3CB, GNA13, LYN

Dicoumarol

hsa04612

Antigen processing and presentation

8.00E-04

P04233, P25208, P26715, P26717, P10966, P01889, P10321, Q06323

CD74, NFYB, KLRC1, KLRC2, CD8B, HLA-B, HLA-C, PSME1

Dicoumarol

hsa04613

Neutrophil extracellular trap formation

2.54E-03

P17252, O60603, P08246, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P21462

PRKCA, TLR2, ELA2, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1

Dicoumarol

hsa04622

RIG-I-like receptor signaling pathway

2.47E-02

Q12933

TRAF2

Dicoumarol

hsa04625

C-type lectin receptor signaling pathway

3.87E-02

Q9ULY5, P20749, P01375, Q16539

CLEC4E, BCL3, TNF, MAPK14

Dicoumarol

hsa04630

JAK-STAT signaling pathway

3.09E-03

O75925, P40189, Q06124

PIAS1, IL6ST, PTPN11

Dicoumarol

hsa04640

Hematopoietic cell lineage

4.95E-02

P01730, P06127, P09564

CD4, CD5, CD7

Dicoumarol

hsa04650

Natural killer cell mediated cytotoxicity

2.94E-02

P16298, P50591, Q02750

PPP3CB, TNFSF10, MAP2K1

Dicoumarol

hsa04657

IL-17 signaling pathway

1.27E-03

O00463, Q16539, P49841, P14780, P01375

TRAF5, MAPK14, GSK3B, MMP9, TNF

Dicoumarol

hsa04658

Th1 and Th2 cell differentiation

2.56E-05

Q04759, P07766, P20963, P19174, P01730, P06239, P14784, Q13761

PRKCQ, CD3E, CD247, PLCG1, CD4, LCK, IL2RB, RUNX3

Dicoumarol

hsa04659

Th17 cell differentiation

1.43E-06

P25963, Q04759, P19174, P01730, P06239, P14784, P14778, P84022, Q13485, P08238, P07766, P20963

NFKBIA, PRKCQ, PLCG1, CD4, LCK, IL2RB, IL1R1, SMAD3, SMAD4, HSP90AB1, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	Q04759	PRKCQ	Protein kinase C theta type	0.726
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.73
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P01730	CD4	T-cell surface glycoprotein CD4	0.845
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P06239	LCK	Tyrosine-protein kinase Lck	0.799
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P14778	IL1R1	Interleukin-1 receptor type 1	-0.72
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.907
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.788

Dicoumarol

hsa04660

T cell receptor signaling pathway

2.78E-03

Q9UDY8, Q04759, P10747, Q08881, P19174, P07766, P20963, P01730, P10966, P06239

MALT1, PRKCQ, CD28, ITK, PLCG1, CD3E, CD247, CD4, CD8B, LCK

Dicoumarol

hsa04662

B cell receptor signaling pathway

1.52E-03

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Dicoumarol

hsa04664

Fc epsilon RI signaling pathway

1.42E-05

P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917

TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5

Dicoumarol

hsa04666

Fc gamma R-mediated phagocytosis

1.73E-02

P07948, P42338, P19174

LYN, PIK3CB, PLCG1

Dicoumarol

hsa04668

TNF signaling pathway

2.21E-02

P01375, O00463, Q16539, P20749, P14780

TNF, TRAF5, MAPK14, BCL3, MMP9

Dicoumarol

hsa04672

Intestinal immune network for IgA production

3.76E-03

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Dicoumarol

hsa04713

Circadian entrainment

2.60E-02

P0DP23, P17252, P62873, Q14643

CALM1, PRKCA, GNB1, ITPR1

Dicoumarol

hsa04714

Thermogenesis

3.31E-02

P51828, P62753, P12074, O15239

ADCY7, RPS6, COX6A1, NDUFA1

Dicoumarol

hsa04720

Long-term potentiation

1.95E-03

P17252, P16298, P0DP23, P51812, Q02750, Q14643

PRKCA, PPP3CB, CALM1, RPS6KA3, MAP2K1, ITPR1

Dicoumarol

hsa04722

Neurotrophin signaling pathway

4.87E-02

P42338, P19174, Q92529

PIK3CB, PLCG1, SHC3

Dicoumarol

hsa04723

Retrograde endocannabinoid signaling

1.88E-02

Q14643, P17252, P62873, Q16718

ITPR1, PRKCA, GNB1, NDUFA5

Dicoumarol

hsa04724

Glutamatergic synapse

1.73E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Dicoumarol

hsa04725

Cholinergic synapse

4.54E-06

Q08828, P51828, Q14643, P17252, P62873, P63218, P50151, P18848, Q13557, P42338, P10415

ADCY1, ADCY7, ITPR1, PRKCA, GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CB, BCL2

Dicoumarol

hsa04726

Serotonergic synapse

3.41E-02

P63218, P50151, P09917

GNG5, GNG10, ALOX5

Dicoumarol

hsa04727

GABAergic synapse

6.57E-03

P63218, P50151, P15104

GNG5, GNG10, GLUL

Dicoumarol

hsa04728

Dopaminergic synapse

4.76E-03

Q14643, P17252, P62873, Q99941, P18848, Q13557, Q13362, P0DP23

ITPR1, PRKCA, GNB1, CREBL1, ATF4, CAMK2D, PPP2R5C, CALM1

Dicoumarol

hsa04730

Long-term depression

1.56E-02

Q14344, P07948

GNA13, LYN

Dicoumarol

hsa04744

Phototransduction

1.02E-02

P62873, P0DP23

GNB1, CALM1

Dicoumarol

hsa04750

Inflammatory mediator regulation of TRP channels

1.77E-02

P01584, Q08828, P51828, Q13557

IL1B, ADCY1, ADCY7, CAMK2D

Dicoumarol

hsa04910

Insulin signaling pathway

2.44E-03

P22694, P06737, Q92529, Q13370, P42338, P49841

PRKACB, PYGL, SHC3, PDE3B, PIK3CB, GSK3B

Dicoumarol

hsa04911

Insulin secretion

6.99E-06

Q08828, P51828, Q99941, P18848, Q13557

ADCY1, ADCY7, CREBL1, ATF4, CAMK2D

Dicoumarol

hsa04912

GnRH signaling pathway

2.08E-04

P17252, Q08828, P51828, P18848, Q13557, Q14643, P0DP23

PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, ITPR1, CALM1

Dicoumarol

hsa04914

Progesterone-mediated oocyte maturation

1.58E-03

Q17RY0, P42338, Q13370, P08238, P51812, Q02750

CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1

Dicoumarol

hsa04915

Estrogen signaling pathway

3.83E-05

Q99941, P18848, P51828, P42338, Q92529, P07900, P08238, P11142

CREBL1, ATF4, ADCY7, PIK3CB, SHC3, HSP90AA1, HSP90AB1, HSPA8

Dicoumarol

hsa04916

Melanogenesis

3.73E-02

Q13557, Q08828, P51828

CAMK2D, ADCY1, ADCY7

Dicoumarol

hsa04918

Thyroid hormone synthesis

1.69E-03

P51828, Q99941, P18848, P02768

ADCY7, CREBL1, ATF4, ALB

Dicoumarol

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Dicoumarol

hsa04920

Adipocytokine signaling pathway

4.76E-03

Q06124, Q9Y478

PTPN11, PRKAB1

Dicoumarol

hsa04922

Glucagon signaling pathway

3.47E-02

Q12778, Q13370, P0DP23, Q14643

FOXO1, PDE3B, CALM1, ITPR1

Dicoumarol

hsa04923

Regulation of lipolysis in adipocytes

3.64E-02

Q13370, P42338

PDE3B, PIK3CB

Dicoumarol

hsa04924

Renin secretion

8.71E-03

Q14643, Q13370, P0DP23

ITPR1, PDE3B, CALM1

Dicoumarol

hsa04925

Aldosterone synthesis and secretion

1.18E-04

Q99941, P18848, Q08828, P51828, Q13557

CREBL1, ATF4, ADCY1, ADCY7, CAMK2D

Dicoumarol

hsa04926

Relaxin signaling pathway

1.31E-04

P42338, P63218, P50151, Q99941, P18848, P49767, P51828, Q92529

PIK3CB, GNG5, GNG10, CREBL1, ATF4, VEGFC, ADCY7, SHC3

Dicoumarol

hsa04927

Cortisol synthesis and secretion

3.17E-04

Q99941, P18848, Q08828, P51828

CREBL1, ATF4, ADCY1, ADCY7

Dicoumarol

hsa04928

Parathyroid hormone synthesis, secretion and action

2.17E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Dicoumarol

hsa04930

Type II diabetes mellitus

2.47E-02

Q02156

PRKCE

Dicoumarol

hsa04931

Insulin resistance

9.16E-04

P01375, P49841, Q06124, P06737, Q9Y478

TNF, GSK3B, PTPN11, PYGL, PRKAB1

Dicoumarol

hsa04932

Non-alcoholic fatty liver disease

2.07E-02

P18848, O75460, P01584, P12074, O15239

ATF4, ERN1, IL1B, COX6A1, NDUFA1

Dicoumarol

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.03E-05

P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174

SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1

Dicoumarol

hsa04934

Cushing syndrome

5.27E-05

Q99941, P18848, Q08828, P51828, Q13557

CREBL1, ATF4, ADCY1, ADCY7, CAMK2D

Dicoumarol

hsa04935

Growth hormone synthesis, secretion and action

1.84E-03

P19174, P51828, Q99941, P18848, P42338, Q92529

PLCG1, ADCY7, CREBL1, ATF4, PIK3CB, SHC3

Dicoumarol

hsa04964

Proximal tubule bicarbonate reclamation

2.61E-02

P49448, P40925

GLUD2, MDH1

Dicoumarol

hsa04966

Collecting duct acid secretion

2.86E-02

Q13488, Q9Y666

TCIRG1, SLC12A7

Dicoumarol

hsa04971

Gastric acid secretion

4.73E-03

Q08828, P51828, P15311, Q13557

ADCY1, ADCY7, VIL2, CAMK2D

Dicoumarol

hsa04972

Pancreatic secretion

1.31E-02

Q08828, P62491

ADCY1, RAB11A

Dicoumarol

hsa04974

Protein digestion and absorption

2.47E-02

Q7Z2H8

SLC36A1

Dicoumarol

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Dicoumarol

hsa04976

Bile secretion

2.44E-02

P22694, P08183

PRKACB, ABCB1

Dicoumarol

hsa05010

Alzheimer disease

1.68E-03

O15239, Q16718, O14521, P05496, P12074, Q14643, Q00535, O75460, P0DP23, P01584, P18848, Q13509, P68371, P05141, Q08752, P28070

NDUFA1, NDUFA5, SDHD, ATP5G1, COX6A1, ITPR1, CDK5, ERN1, CALM1, IL1B, ATF4, TUBB3, TUBB2C, SLC25A5, PPID, PSMB4

Dicoumarol

hsa05012

Parkinson disease

8.40E-04

O15239, Q16718, O14521, P12074, P05496, P05141, O75460, P18848, P28070, Q14643, P0DP23, Q13557, Q13509, P68371

NDUFA1, NDUFA5, SDHD, COX6A1, ATP5G1, SLC25A5, ERN1, ATF4, PSMB4, ITPR1, CALM1, CAMK2D, TUBB3, TUBB2C

Dicoumarol

hsa05016

Huntington disease

1.72E-02

O15239, P12074, P05496, P30876, P62487, P05141, O75460, P28070

NDUFA1, COX6A1, ATP5G1, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4

Dicoumarol

hsa05020

Prion disease

1.59E-03

P01584, P46531, O15239, Q16718, O14521, P05496, P12074, Q14643, P18848, P05141, P28070, Q13509, P68371, P14598, Q15080

IL1B, NOTCH1, NDUFA1, NDUFA5, SDHD, ATP5G1, COX6A1, ITPR1, ATF4, SLC25A5, PSMB4, TUBB3, TUBB2C, NCF1, NCF4

Dicoumarol

hsa05022

Pathways of neurodegeneration - multiple diseases

2.98E-04

Q14643, Q13509, P68371, P10415, O15239, Q16718, O14521, P12074, P05496, O75460, P18848, Q13561, P05141, P17252, Q00535, P01584, Q08752, P0DP23, Q13557, P28070

ITPR1, TUBB3, TUBB2C, BCL2, NDUFA1, NDUFA5, SDHD, COX6A1, ATP5G1, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, CDK5, IL1B, PPID, CALM1, CAMK2D, PSMB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P63279	UBE2I	SUMO-conjugating enzyme UBC9	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.736
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.752
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.768
P63279	UBE2I	SUMO-conjugating enzyme UBC9	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.737
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.708
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P05141	SLC25A5	ADP/ATP translocase 2	0.755
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P63279	UBE2I	SUMO-conjugating enzyme UBC9	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.739
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P01584	IL1B	Interleukin-1 beta	0.815
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P63279	UBE2I	SUMO-conjugating enzyme UBC9	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.743
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P28070	PSMB4	Proteasome subunit beta type-4	0.733

Dicoumarol

hsa05030

Cocaine addiction

4.87E-02

Q99941, P18848

CREBL1, ATF4

Dicoumarol

hsa05031

Amphetamine addiction

6.41E-03

Q13557, Q99941, P18848

CAMK2D, CREBL1, ATF4

Dicoumarol

hsa05032

Morphine addiction

2.22E-02

P63218, P50151, Q13370

GNG5, GNG10, PDE3B

Dicoumarol

hsa05034

Alcoholism

8.41E-04

Q02930, P50151, Q9BTM1, Q93077, P62807, Q16778, O60814, P68431

CREB5, GNG10, H2AFJ, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Dicoumarol

hsa05100

Bacterial invasion of epithelial cells

3.64E-02

P42338, Q92529

PIK3CB, SHC3

Dicoumarol

hsa05131

Shigellosis

3.33E-03

Q12933, P68431, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752

TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID

Dicoumarol

hsa05132

Salmonella infection

8.60E-04

P25963, Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371

NFKBIA, LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Dicoumarol

hsa05140

Leishmaniasis

2.17E-03

P14598, P42224, P13765, O60603, P29350, Q15080

NCF1, STAT1, HLA-DOB, TLR2, PTPN6, NCF4

Dicoumarol

hsa05145

Toxoplasmosis

1.02E-03

P25963, P10415, Q13489, P42224, P13765, O60603, P29965

NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Dicoumarol

hsa05152

Tuberculosis

7.93E-04

Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8

TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1

Dicoumarol

hsa05161

Hepatitis B

9.85E-04

Q99941, P18848, P25963, Q13485, P10415, P27348, P84022

CREBL1, ATF4, NFKBIA, SMAD4, BCL2, YWHAQ, SMAD3

Dicoumarol

hsa05162

Measles

3.91E-02

P14784, P07766, P42338, P11142

IL2RB, CD3E, PIK3CB, HSPA8

Dicoumarol

hsa05163

Human cytomegalovirus infection

8.13E-05

P42338, P01375, P63218, P50151, Q14344, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, P18848, O00463, P30101

PIK3CB, TNF, GNG5, GNG10, GNA13, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, ATF4, TRAF5, PDIA3

Dicoumarol

hsa05165

Human papillomavirus infection

3.10E-02

P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315

ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM

Dicoumarol

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.34E-04

P01568, P42224, P42338, P62873, P62879, P63218, P50151, P19174, P16298, Q14643, Q02750, P07948, P0DP23, P0CG47, Q9UJU2

IFNA21, STAT1, PIK3CB, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, ITPR1, MAP2K1, LYN, CALM1, UBB, LEF1

Dicoumarol

hsa05169

Epstein-Barr virus infection

4.01E-03

P01106, P42338, P07948, O00232, P30101, Q13761, P29728, P07766, P20963

MYC, PIK3CB, LYN, PSMD12, PDIA3, RUNX3, OAS2, CD3E, CD247

Dicoumarol

hsa05170

Human immunodeficiency virus 1 infection

2.49E-06

P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P17252, P30101, Q14643, P01568, O60603, Q13315, P19174, P07766, P10415, Q9Y6Q5, P20333

PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PRKCA, PDIA3, ITPR1, IFNA21, TLR2, ATM, PLCG1, CD3E, BCL2, AP1M2, TNFRSF1B

Dicoumarol

hsa05171

Coronavirus disease - COVID-19

9.07E-04

P23396, P62249, P42677, P40429, P36578, P30050, Q07020, P46776, P62910, P05386

RPS3, RPS16, RPS27, RPL13A, RPL4, RPL12, RPL18, RPL27A, RPL32, RPLP1

Dicoumarol

hsa05200

Pathways in cancer

2.05E-04

Q13751, P42338, P08238, P42224, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P49767, Q12778, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784

LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, FOXO1, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Dicoumarol

hsa05203

Viral carcinogenesis

5.01E-06

Q99941, P18848, Q02930, P23458, P06746, P07948, P27348, Q7KZF4, Q15283, P06396, P12814, P01889, P10321, P61978, P06493, P62807, Q16778, O60814

CREBL1, ATF4, CREB5, JAK1, POLB, LYN, YWHAQ, SND1, RASA2, GSN, ACTN1, HLA-B, HLA-C, HNRPK, CDK1, HIST1H2BC, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.708
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	Q02930	CREB5	Cyclic AMP-responsive element-binding protein 5	0.701
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P23458	JAK1	Tyrosine-protein kinase JAK1	0.756
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P06746	POLB	DNA polymerase beta	0.817
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P07948	LYN	Tyrosine-protein kinase Lyn	-0.752
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P27348	YWHAQ	14-3-3 protein theta	0.759
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P27348	YWHAQ	14-3-3 protein theta	0.833
P63279	UBE2I	SUMO-conjugating enzyme UBC9	Q7KZF4	SND1	Staphylococcal nuclease domain-containing protein 1	0.74
Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.718
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	P06396	GSN	Gelsolin	0.703
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P12814	ACTN1	Alpha-actinin-1	-0.876
Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.706
Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.706
P63279	UBE2I	SUMO-conjugating enzyme UBC9	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.7
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.827
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P06493	CDK1	Cyclin-dependent kinase 1	-0.702
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.764
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.764
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	Q16778	HIST2H2BE	Histone H2B type 2-E	-0.702
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Dicoumarol

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Dicoumarol

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Dicoumarol

hsa05212

Pancreatic cancer

4.45E-03

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Dicoumarol

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Dicoumarol

hsa05214

Glioma

9.49E-03

Q92529, P42338, P19174

SHC3, PIK3CB, PLCG1

Dicoumarol

hsa05215

Prostate cancer

4.87E-02

Q9NRA1, P08238, P42338

PDGFC, HSP90AB1, PIK3CB

Dicoumarol

hsa05218

Melanoma

3.64E-02

Q9NRA1, P42338

PDGFC, PIK3CB

Dicoumarol

hsa05220

Chronic myeloid leukemia

1.44E-03

Q13547, Q13485, P25963, P84022, P42338, O75293

HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B

Dicoumarol

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Dicoumarol

hsa05226

Gastric cancer

6.26E-04

Q02750, O15169, P04628, P84022, Q13485, P10415, P10826

MAP2K1, AXIN1, WNT1, SMAD3, SMAD4, BCL2, RARB

Dicoumarol

hsa05231

Choline metabolism in cancer

1.17E-03

P42338, Q9NRA1, P19174, P23743

PIK3CB, PDGFC, PLCG1, DGKA

Dicoumarol

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

8.54E-03

P19174, P07766, P20963, P06239, Q04759, P01730

PLCG1, CD3E, CD247, LCK, PRKCQ, CD4

Dicoumarol

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Dicoumarol

hsa05322

Systemic lupus erythematosus

4.80E-06

P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P62807, O60814, P68431

ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Dicoumarol

hsa05323

Rheumatoid arthritis

1.29E-02

P13765, Q13488, P10747, O60603

HLA-DOB, TCIRG1, CD28, TLR2

Dicoumarol

hsa05330

Allograft rejection

1.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Dicoumarol

hsa05332

Graft-versus-host disease

4.29E-02

P10747, P26715

CD28, KLRC1

Dicoumarol

hsa05340

Primary immunodeficiency

4.50E-02

P01730, P07766, P06239

CD4, CD3E, LCK

Dicoumarol

hsa05415

Diabetic cardiomyopathy

3.55E-02

P17252, P14598, Q15080, Q16718, O14521

PRKCA, NCF1, NCF4, NDUFA5, SDHD

Dicoumarol

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Dicoumarol

hsa05418

Fluid shear stress and atherosclerosis

1.08E-03

Q16539, Q14145, P10599, P14780, P01375, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2

Community members of Dicoumarol (S_DC: 6.28)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

VKORC1

Vitamin K epoxide reductase complex subunit 1

Reported

0.2806

0.04

0.1697

0.39

Q08257

CRYZ

Quinone oxidoreductase

Reported

0.0597

0.0067

0.0432

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

Q16549

PCSK7

Proprotein convertase subtilisin/kexin type 7

Predicted

0.2746

0.0279

0.1931

P21462

FPR1

fMetNoneLeuNonePhe receptor

Predicted

0.1205

0.3492

0.4378

1.1964

P06746

POLB

DNA polymerase beta

Predicted

0.4573

0.1868

0.4856

1.0878

O75469

NR1I2

Nuclear receptor subfamily 1 group I member 2

Predicted

0.0315

0.9493

1.9143

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

P07900

HSP90AA1

Heat shock protein HSP 90Nonealpha

Predicted

0.4727

0.6064

0.741

2.1901

P17252

PRKCA

Protein kinase C alpha type

Predicted

0.1409

0.6948

2.4601

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

Q15078

CDK5R1

CyclinNonedependent kinase 5 activator 1

Predicted

0.1358

0.5004

0.2575

1.3263

Q02763

TEK

AngiopoietinNone1 receptor

Predicted

0.3206

0.6236

0.4304

1.8379

Q02156

PRKCE

Protein kinase C epsilon type

Predicted

0.1175

0.5287

0.5377

1.6539

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P63279

UBE2I

SUMONoneconjugating enzyme UBC9

Predicted

0.2332

0.0512

0.4983

0.7173

Q9Y478

PRKAB1

5'NoneAMPNoneactivated protein kinase subunit betaNone1

Predicted

0.1478

0.1088

0.5564

0.8479

P16083

NQO2

Ribosyldihydronicotinamide dehydrogenase [quinone]

Predicted

0.2958

0.3134

0.7747

PharmaCoNets of Dicoumarol (SPCN: 145.89 )

Dicoumarol regulated-network (SDN: 23.23)

Community members of Dicoumarol (SDC: 6.28)

PharmaCoNets of Dicoumarol (S_PCN: 145.89 )

Dicoumarol regulated-network (S_DN: 23.23)

Community members of Dicoumarol (S_DC: 6.28)