PharmaCoNets of Diazoxide (SPCN: 25.52 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Diazoxidehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Diazoxidehsa00071Fatty acid degradation2.32E-034O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Diazoxidehsa00500Starch and sucrose metabolism1.07E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Diazoxidehsa00520Amino sugar and nucleotide sugar metabolism3.76E-021Q13231CHIT1More
Diazoxidehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Diazoxidehsa00630Glyoxylate and dicarboxylate metabolism4.12E-032P40925, P15104MDH1, GLULMore
Diazoxidehsa00730Thiamine metabolism8.96E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Diazoxidehsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Diazoxidehsa00770Pantothenate and CoA biosynthesis2.27E-022O95498, O95497VNN2, VNN1More
Diazoxidehsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Diazoxidehsa00970Aminoacyl-tRNA biosynthesis2.77E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Diazoxidehsa01100Metabolic pathways3.52E-0223P05089, O95455, P21953, P32320, P11766, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, Q08477, P15907, Q9UNP4, P37837, P32321, Q9BPW9, Q9UHY7, P43490, P46976, P06737ARG1, TGDS, BCKDHB, CDA, ADH5, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, CYP4F3, ST6GAL1, ST3GAL5, TALDO1, DCTD, DHRS9, ENOPH1, PBEF1, GYG1, PYGLMore
Diazoxidehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Diazoxidehsa03013RNA transport7.23E-0413P52298, Q09161, O14893, P61326, P38919, P37198, Q7Z3B4, P35658, Q14152, P55884, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, NUP62, NUP54, NUP214, EIF3A, EIF3B, EIF3J, RPP38, TACC3More
Diazoxidehsa04060Cytokine-cytokine receptor interaction4.71E-022P78552, O75509IL13RA1, TNFRSF21More
Diazoxidehsa04064NF-kappa B signaling pathway1.31E-0518P10415, Q13489, P25963, P51617, O00463, P14778, P01584, P01375, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, IL1B, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CYLDMore
Diazoxidehsa04071Sphingolipid signaling pathway5.94E-048P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Diazoxidehsa04072Phospholipase D signaling pathway9.70E-032Q92529, Q14344SHC3, GNA13More
Diazoxidehsa04080Neuroactive ligand-receptor interaction1.18E-027P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1More
Diazoxidehsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Diazoxidehsa04145Phagosome1.98E-028Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Diazoxidehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Diazoxidehsa04150mTOR signaling pathway2.23E-023P42338, Q13322, P49841PIK3CB, GRB10, GSK3BMore
Diazoxidehsa04210Apoptosis1.52E-029Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1More
Diazoxidehsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Diazoxidehsa04380Osteoclast differentiation4.45E-0414Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P42338, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, PIK3CB, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Diazoxidehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Diazoxidehsa04613Neutrophil extracellular trap formation3.09E-0619P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Diazoxidehsa04614Renin-angiotensin system7.75E-034P50052, P15144, P08311, O75787AGTR2, ANPEP, CTSG, ATP6AP2More
Diazoxidehsa04621NOD-like receptor signaling pathway1.90E-0414Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4More
Diazoxidehsa04625C-type lectin receptor signaling pathway8.11E-039Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Diazoxidehsa04640Hematopoietic cell lineage4.31E-0210P13612, P14778, P27930, P15144, P11836, P09693, P01732, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD3G, CD8A, HLA-DOB, TNF, IL1BMore
Diazoxidehsa04650Natural killer cell mediated cytotoxicity2.99E-0210P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Diazoxidehsa04657IL-17 signaling pathway9.30E-059O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF, IL1BMore
Diazoxidehsa04658Th1 and Th2 cell differentiation1.26E-0210Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765, P23458PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOB, JAK1More
Diazoxidehsa04659Th17 cell differentiation2.09E-0313Q04759, Q16539, P06239, P14784, P13765, P14778, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458PRKCQ, MAPK14, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1More
Diazoxidehsa04660T cell receptor signaling pathway1.46E-0314P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Diazoxidehsa04662B cell receptor signaling pathway7.25E-034P49841, P42338, P21854, Q8N149GSK3B, PIK3CB, CD72, LILRA2More
Diazoxidehsa04668TNF signaling pathway2.59E-027P01375, O00463, Q13489, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9More
Diazoxidehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Diazoxidehsa04730Long-term depression3.52E-021Q14344GNA13More
Diazoxidehsa04750Inflammatory mediator regulation of TRP channels1.36E-0310P14778, P01584, P51828, P22694, Q16539, P42338, Q14643, P24723, Q04759, P0DP24IL1R1, IL1B, ADCY7, PRKACB, MAPK14, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2More
Diazoxidehsa04912GnRH signaling pathway4.33E-026P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACBMore
Diazoxidehsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Diazoxidehsa04929GnRH secretion3.63E-022P42338, P49407PIK3CB, ARRB1More
Diazoxidehsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Diazoxidehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Diazoxidehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Diazoxidehsa04970Salivary secretion4.49E-024P22694, Q14643, P17252, P49913PRKACB, ITPR1, PRKCA, CAMPMore
Diazoxidehsa04973Carbohydrate digestion and absorption4.12E-032O43451, P42338MGAM, PIK3CBMore
Diazoxidehsa05120Epithelial cell signaling in Helicobacter pylori infection2.27E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Diazoxidehsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Diazoxidehsa05132Salmonella infection2.98E-0211P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3More
Diazoxidehsa05133Pertussis4.20E-021P0C0L4C4AMore
Diazoxidehsa05140Leishmaniasis7.48E-0513P13612, O75015, P14598, P23458, P13765, O60603, P25963, P01375, P01584, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, JAK1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, MARCKSL1, MAPK14, IRAK1, NCF4More
Diazoxidehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Diazoxidehsa05144Malaria3.81E-038P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1More
Diazoxidehsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Diazoxidehsa05146Amoebiasis5.47E-039P01584, P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311IL1B, CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Diazoxidehsa05152Tuberculosis2.07E-029Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Diazoxidehsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Diazoxidehsa05163Human cytomegalovirus infection3.28E-027P01375, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Diazoxidehsa05170Human immunodeficiency virus 1 infection1.06E-0313P01375, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5TNF, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2More
Diazoxidehsa05202Transcriptional misregulation in cancer3.33E-0722Q12778, Q15532, Q13315, P41732, P17844, P14780, P27930, P14923, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Diazoxidehsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Diazoxidehsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Diazoxidehsa05225Hepatocellular carcinoma1.85E-022Q92529, P51531SHC3, SMARCA2More
Diazoxidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.10E-028O95267, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539RASGRP1, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14More
Diazoxidehsa05310Asthma3.88E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Diazoxidehsa05321Inflammatory bowel disease4.27E-047O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Diazoxidehsa05322Systemic lupus erythematosus4.20E-027P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Diazoxidehsa05332Graft-versus-host disease9.30E-035P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Diazoxidehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Diazoxidehsa05418Fluid shear stress and atherosclerosis2.43E-037Q16539, P42338, P10599, P14780, P01375, P14778, P27930MAPK14, PIK3CB, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Diazoxide (SDC: 2.82)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Reported10.112510.22152.2778
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
P78508KCNJ10ATPNonesensitive inward rectifier potassium channel 10Predicted00.07310.08780.20670.4189
Q99712KCNJ15ATPNonesensitive inward rectifier potassium channel 15Predicted00.15870.07790.12670.3619
O75493CA11Carbonic anhydraseNonerelated protein 11Predicted00.07450.061200.1597
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)