PharmaCoNets of Diazepam (SPCN: 150.57 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Diazepamhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Diazepamhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Diazepamhsa00220Arginine biosynthesis1.43E-022P05089, P49448ARG1, GLUD2More
Diazepamhsa00240Pyrimidine metabolism3.59E-032P31350, P04818RRM2, TYMSMore
Diazepamhsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Diazepamhsa00500Starch and sucrose metabolism5.75E-063O43451, P46976, P06737MGAM, GYG1, PYGLMore
Diazepamhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Diazepamhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Diazepamhsa00670One carbon pool by folate4.14E-021P04818TYMSMore
Diazepamhsa00730Thiamine metabolism1.06E-042P05186, P24666ALPL, ACP1More
Diazepamhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Diazepamhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Diazepamhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Diazepamhsa00983Drug metabolism - other enzymes3.59E-023P04183, P32320, P05164TK1, CDA, MPOMore
Diazepamhsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Diazepamhsa01523Antifolate resistance1.01E-045P41439, P41440, Q92820, P04818, P01375FOLR3, SLC19A1, GGH, TYMS, TNFMore
Diazepamhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Diazepamhsa03008Ribosome biogenesis in eukaryotes2.86E-036Q9NYH9, P19784, P67870, P78345, Q9BVP2, Q9GZY0UTP6, CSNK2A2, CSNK2B, RPP38, GNL3, NXF2; NXF2BMore
Diazepamhsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Diazepamhsa03013RNA transport4.33E-0313P62826, P52298, P61326, Q9UBU9, Q9GZY0, P63279, P68104, Q14152, O75822, P78345, Q9Y6A5, Q14232, Q53GS7RAN, NCBP2, MAGOH, NXF1, NXF2; NXF2B, UBE2I, EEF1A1, EIF3A, EIF3J, RPP38, TACC3, EIF2B1, GLE1More
Diazepamhsa03015mRNA surveillance pathway9.78E-036O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1More
Diazepamhsa03020RNA polymerase6.08E-054P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Diazepamhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Diazepamhsa03050Proteasome1.14E-032P55036, P28074PSMD4, PSMB5More
Diazepamhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Diazepamhsa04020Calcium signaling pathway4.83E-024Q08828, P0DP23, P05141, P51828ADCY1, CALM1, SLC25A5, ADCY7More
Diazepamhsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Diazepamhsa04024cAMP signaling pathway4.18E-037P63092, Q08828, P51828, P31751, P26678, P0DP23, P61586GNAS, ADCY1, ADCY7, AKT2, PLN, CALM1, RHOAMore
Diazepamhsa04061Viral protein interaction with cytokine and cytokine receptor4.79E-037Q8NHW4, P09341, P19875, P25024, P25025, Q13651, P14784CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, IL10RA, IL2RBMore
Diazepamhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Diazepamhsa04064NF-kappa B signaling pathway5.76E-0719P10415, O00463, P14778, P01584, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, TRAF5, IL1R1, IL1B, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Diazepamhsa04070Phosphatidylinositol signaling system9.86E-034P0DP23, O14986, Q16760, P48426CALM1, PIP5K1B, DGKD, PIP4K2AMore
Diazepamhsa04071Sphingolipid signaling pathway1.05E-038P17252, P21453, Q9H228, Q13362, Q16537, Q9BX95, P04637, P10415PRKCA, S1PR1, EDG8, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2More
Diazepamhsa04072Phospholipase D signaling pathway5.40E-0513P31751, P42338, P61586, P43657, P25024, P25025, P19174, O14986, Q15438, P63092, Q08828, P51828, Q16760AKT2, PIK3CB, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, GNAS, ADCY1, ADCY7, DGKDMore
Diazepamhsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Diazepamhsa04110Cell cycle1.97E-057P06493, O60566, O75293, P30304, P33981, P42773, P01106CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Diazepamhsa04114Oocyte meiosis5.20E-049P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5DMore
Diazepamhsa04115p53 signaling pathway1.69E-022P31350, P06493RRM2, CDK1More
Diazepamhsa04120Ubiquitin mediated proteolysis1.44E-047Q9UBT2, Q14145, Q13042, Q13191, Q15751, Q14669, Q7Z6Z7SAE2, KEAP1, CDC16, CBLB, HERC1, TRIP12, HUWE1More
Diazepamhsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Diazepamhsa04140Autophagy - animal1.92E-039P31751, Q7L523, O75460, P22694, Q14643, P10415, Q04759, Q96GC9, Q8TEV9AKT2, RRAGA, ERN1, PRKACB, ITPR1, BCL2, PRKCQ, TMEM49, SMCR8More
Diazepamhsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Diazepamhsa04145Phagosome6.83E-059P63261, Q15080, P14598, Q13509, P68371, P05164, O60603, P35443, P13765ACTG1, NCF4, NCF1, TUBB3, TUBB2C, MPO, TLR2, THBS4, HLA-DOBMore
Diazepamhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Diazepamhsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Diazepamhsa04211Longevity regulating pathway1.88E-024P31751, Q08828, P51828, P18848AKT2, ADCY1, ADCY7, ATF4More
Diazepamhsa04213Longevity regulating pathway - multiple species4.29E-037P31751, P42338, Q9Y4H2, Q08828, P51828, P11142, Q13547AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA8, HDAC1More
Diazepamhsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Diazepamhsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Diazepamhsa04261Adrenergic signaling in cardiomyocytes4.98E-047Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Diazepamhsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Diazepamhsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Diazepamhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Diazepamhsa04371Apelin signaling pathway3.94E-024P31751, Q08828, P51828, P0DP23AKT2, ADCY1, ADCY7, CALM1More
Diazepamhsa04380Osteoclast differentiation5.27E-0410Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Diazepamhsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Diazepamhsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Diazepamhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Diazepamhsa04540Gap junction3.53E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Diazepamhsa04612Antigen processing and presentation1.28E-036P13765, P26715, P26717, Q07444, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRC3, KLRD1, CD8AMore
Diazepamhsa04613Neutrophil extracellular trap formation6.35E-0520P17252, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P21730, P21462, P63261, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, C5AR1, FPR1, ACTG1, AQP9, MAPK14More
Diazepamhsa04620Toll-like receptor signaling pathway2.54E-033P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Diazepamhsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Diazepamhsa04623Cytosolic DNA-sensing pathway2.21E-043P01584, Q9Y535, Q8NHW4IL1B, POLR3H, CCL4L2More
Diazepamhsa04625C-type lectin receptor signaling pathway1.14E-038Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Diazepamhsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Diazepamhsa04640Hematopoietic cell lineage2.46E-0410P21926, P14778, P27930, P11215, P25063, P07766, P01732, P01730, P06127, P09564CD9, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD4, CD5, CD7More
Diazepamhsa04650Natural killer cell mediated cytotoxicity5.16E-1017P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Diazepamhsa04657IL-17 signaling pathway1.62E-048P07900, O00463, Q16539, P49841, P09341, P14780, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNF, IL1BMore
Diazepamhsa04658Th1 and Th2 cell differentiation1.60E-1113Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Diazepamhsa04659Th17 cell differentiation2.42E-0812Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Diazepamhsa04660T cell receptor signaling pathway4.88E-0713Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Diazepamhsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Diazepamhsa04666Fc gamma R-mediated phagocytosis9.96E-035P23528, P49006, P06396, P14598, P17252CFL1, MARCKSL1, GSN, NCF1, PRKCAMore
Diazepamhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Diazepamhsa04713Circadian entrainment5.44E-035P0DP23, P62873, Q08828, P51828, P63092CALM1, GNB1, ADCY1, ADCY7, GNASMore
Diazepamhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Diazepamhsa04720Long-term potentiation1.71E-036P16298, P0DP23, P51812, P18848, Q08828, Q02750PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1More
Diazepamhsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Diazepamhsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Diazepamhsa04725Cholinergic synapse1.39E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Diazepamhsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Diazepamhsa04728Dopaminergic synapse7.83E-035P31751, P18848, Q13362, Q14738, P0DP23AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Diazepamhsa04750Inflammatory mediator regulation of TRP channels2.03E-049P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Diazepamhsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Diazepamhsa04912GnRH signaling pathway1.39E-024Q08828, P51828, P18848, P0DP23ADCY1, ADCY7, ATF4, CALM1More
Diazepamhsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Diazepamhsa04915Estrogen signaling pathway2.13E-025P18848, Q08828, P51828, P31751, P0DP23ATF4, ADCY1, ADCY7, AKT2, CALM1More
Diazepamhsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Diazepamhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Diazepamhsa04923Regulation of lipolysis in adipocytes2.89E-046Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Diazepamhsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Diazepamhsa04925Aldosterone synthesis and secretion9.86E-034P18848, Q08828, P51828, P0DP23ATF4, ADCY1, ADCY7, CALM1More
Diazepamhsa04926Relaxin signaling pathway2.46E-024P31751, P18848, Q08828, P51828AKT2, ATF4, ADCY1, ADCY7More
Diazepamhsa04927Cortisol synthesis and secretion1.59E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Diazepamhsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Diazepamhsa04932Non-alcoholic fatty liver disease2.59E-0510P31751, P49841, P18848, O75460, P01584, P13073, O15239, Q16718, O95298, O14521AKT2, GSK3B, ATF4, ERN1, IL1B, COX4I1, NDUFA1, NDUFA5, NDUFC2, SDHDMore
Diazepamhsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Diazepamhsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Diazepamhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Diazepamhsa04970Salivary secretion1.59E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Diazepamhsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Diazepamhsa04972Pancreatic secretion3.42E-035Q14643, P20020, P17252, P63092, P61586ITPR1, ATP2B1, PRKCA, GNAS, RHOAMore
Diazepamhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Diazepamhsa04976Bile secretion9.77E-045O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Diazepamhsa05010Alzheimer disease4.94E-039O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4More
Diazepamhsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Diazepamhsa05016Huntington disease2.14E-039O15239, O95298, P13073, P24928, P30876, P62487, P05141, O75460, P28070NDUFA1, NDUFC2, COX4I1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Diazepamhsa05017Spinocerebellar ataxia1.04E-025O75460, P31751, P28070, P28074, P05141ERN1, AKT2, PSMB4, PSMB5, SLC25A5More
Diazepamhsa05020Prion disease3.73E-0411P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14More
Diazepamhsa05022Pathways of neurodegeneration - multiple diseases6.87E-0518P49841, O15239, Q16718, O95298, O14521, P13073, Q8TEV9, O75460, P18848, Q13561, P05141, Q16539, Q00535, P01584, Q08752, P0DP23, Q13557, P28070GSK3B, NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, MAPK14, CDK5, IL1B, PPID, CALM1, CAMK2D, PSMB4More
Diazepamhsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Diazepamhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Diazepamhsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Diazepamhsa05132Salmonella infection2.10E-029Q9UJU2, P63261, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371LEF1, ACTG1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Diazepamhsa05134Legionellosis6.38E-046P01584, P11215, P68104, P11142, P09341, P19875IL1B, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2More
Diazepamhsa05140Leishmaniasis2.95E-037O75015, P14598, P13765, O60603, P49006, Q16539, Q15080FCGR3B, NCF1, HLA-DOB, TLR2, MARCKSL1, MAPK14, NCF4More
Diazepamhsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Diazepamhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Diazepamhsa05144Malaria1.44E-024P60033, O60603, P35443, P26718CD81, TLR2, THBS4, KLRK1More
Diazepamhsa05146Amoebiasis5.28E-0610P09341, P19875, P14778, P27930, O60603, P42338, P11215, P05089, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TLR2, PIK3CB, ITGAM, ARG1, ACTN1, CTSGMore
Diazepamhsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Diazepamhsa05152Tuberculosis3.52E-022Q15075, Q13651EEA1, IL10RAMore
Diazepamhsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Diazepamhsa05163Human cytomegalovirus infection4.44E-0721P31751, P01375, P62873, Q14643, P0DP23, P61586, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P63092, P04637, O00463, P61769AKT2, TNF, GNB1, ITPR1, CALM1, RHOA, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, GNAS, TP53, TRAF5, B2MMore
Diazepamhsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Diazepamhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Diazepamhsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Diazepamhsa05169Epstein-Barr virus infection4.41E-028P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247More
Diazepamhsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Diazepamhsa05171Coronavirus disease - COVID-193.15E-049P01584, P62753, P25398, Q9UHA3, P36578, P32969, P18077, P62829, O14786IL1B, RPS6, RPS12, RSL24D1, RPL4, RPL9, RPL35A, RPL23, NRP1More
Diazepamhsa05202Transcriptional misregulation in cancer6.67E-0414Q12778, Q15532, Q13315, P41732, P14780, P14923, Q16548, Q13489, O15550, P04637, P05164, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, JUP, BCL2A1, BIRC3, UTX, TP53, MPO, ELA2, BCL11B, GADD45AMore
Diazepamhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Diazepamhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Diazepamhsa05205Proteoglycans in cancer2.66E-028Q14643, P63261, P04637, P14780, P17252, O60603, Q13635, P08962ITPR1, ACTG1, TP53, MMP9, PRKCA, TLR2, PTCH1, CD63More
Diazepamhsa05212Pancreatic cancer2.40E-023P31751, Q15311, P23458AKT2, RALBP1, JAK1More
Diazepamhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Diazepamhsa05216Thyroid cancer3.35E-035P01106, Q9UJU2, P04637, P24522, O75293MYC, LEF1, TP53, GADD45A, GADD45BMore
Diazepamhsa05217Basal cell carcinoma1.46E-024Q13635, Q9UJU2, P04637, P24522PTCH1, LEF1, TP53, GADD45AMore
Diazepamhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Diazepamhsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Diazepamhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Diazepamhsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Diazepamhsa05231Choline metabolism in cancer3.38E-023P31751, Q16760, O14986AKT2, DGKD, PIP5K1BMore
Diazepamhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.60E-0813P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Diazepamhsa05321Inflammatory bowel disease1.17E-035O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Diazepamhsa05322Systemic lupus erythematosus1.49E-058P08311, P09871, Q93077, P62807, Q16778, O60814, P68431, P12814CTSG, C1S, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1More
Diazepamhsa05323Rheumatoid arthritis1.45E-034P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Diazepamhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Diazepamhsa05332Graft-versus-host disease3.49E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Diazepamhsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Diazepamhsa05415Diabetic cardiomyopathy1.02E-038P05141, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557SLC25A5, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2DMore
Diazepamhsa05418Fluid shear stress and atherosclerosis2.22E-0512Q16539, Q14145, P14598, P10599, P14780, P01375, P63261, P04637, P10415, P14778, P27930, Q92974MAPK14, KEAP1, NCF1, TXN, MMP9, TNF, ACTG1, TP53, BCL2, IL1R1, IL1R2, ARHGEF2More

Community members of Diazepam (SDC: 7.38)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
Q13093PLA2G7PlateletNoneactivating factor acetylhydrolasePredicted00.05050.20960.15580.6001
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
Q06609RAD51DNA repair protein RAD51 homolog 1Predicted00.10220.09540.27250.5144
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P11766ADH5Alcohol dehydrogenase classNone3Predicted00.2650.13970.21460.6265
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)