PharmaCoNets

PharmaCoNets of Diamorphine (S_PCN: 26.20 )

Diamorphine regulated-network (S_DN: 12.30)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Diamorphine

hsa00071

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Diamorphine

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Diamorphine

hsa00500

Starch and sucrose metabolism

9.22E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Diamorphine

hsa00730

Thiamine metabolism

4.66E-02

P05186, P24666

ALPL, ACP1

Diamorphine

hsa00770

Pantothenate and CoA biosynthesis

7.90E-03

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Diamorphine

hsa00830

Retinol metabolism

3.49E-02

P00325

ADH1B

Diamorphine

hsa00970

Aminoacyl-tRNA biosynthesis

1.58E-04

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Diamorphine

hsa01524

Platinum drug resistance

1.13E-02

P10415, Q13489, P78417, P23025, P43246

BCL2, BIRC3, GSTO1, XPA, MSH2

Diamorphine

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Diamorphine

hsa03008

Ribosome biogenesis in eukaryotes

2.60E-03

Q9NYH9, P78345, Q9BVP2, O15381, Q9GZY0

UTP6, RPP38, GNL3, NVL, NXF2; NXF2B

Diamorphine

hsa03013

RNA transport

2.29E-04

O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1

Diamorphine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Diamorphine

hsa03040

Spliceosome

5.79E-03

Q14562, O43143, O60508, Q99633, Q13595, Q01130, Q9UMS4

DHX8, DHX15, CDC40, PRPF18, TRA2A, SFRS2, PRPF19

Diamorphine

hsa04014

Ras signaling pathway

4.65E-02

Q15311, P0DP23, P17612

RALBP1, CALM1, PRKACA

Diamorphine

hsa04015

Rap1 signaling pathway

1.58E-02

P20827, P49767, P63261, P25116, P0DP23, P17252

EFNA1, VEGFC, ACTG1, F2R, CALM1, PRKCA

Diamorphine

hsa04020

Calcium signaling pathway

1.16E-03

Q16566, P17252, O15399, P25116, P0DP23, P23634, P49767

CAMK4, PRKCA, GRIN2D, F2R, CALM1, ATP2B4, VEGFC

Diamorphine

hsa04024

cAMP signaling pathway

2.84E-02

P0DP23, P23634, Q16566, O15399, P25116

CALM1, ATP2B4, CAMK4, GRIN2D, F2R

Diamorphine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Diamorphine

hsa04062

Chemokine signaling pathway

2.43E-04

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P49407, Q08881, P49841

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, ARRB1, ITK, GSK3B

Diamorphine

hsa04064

NF-kappa B signaling pathway

3.08E-03

P10415, P51617, Q13546, P14778, P19174, Q04759, Q9UDY8, Q13077, P06239, P24522, P09341, P19875, Q06643

BCL2, IRAK1, RIPK1, IL1R1, PLCG1, PRKCQ, MALT1, TRAF1, LCK, GADD45A, CXCL1, CXCL2, LTB

Diamorphine

hsa04070

Phosphatidylinositol signaling system

4.07E-02

P0DP23, Q14643, O14732, P17252

CALM1, ITPR1, IMPA2, PRKCA

Diamorphine

hsa04071

Sphingolipid signaling pathway

1.90E-03

P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415

PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2

Diamorphine

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Diamorphine

hsa04114

Oocyte meiosis

2.15E-02

P0DP23, P17612, Q13362

CALM1, PRKACA, PPP2R5C

Diamorphine

hsa04144

Endocytosis

4.07E-03

Q9H444, O75351, P42566, Q15438, Q14161

CHMP4B, VPS4B, EPS15, PSCD1, GIT2

Diamorphine

hsa04145

Phagosome

1.86E-02

P63261, Q15080, Q13509, P68371, P27824

ACTG1, NCF4, TUBB3, TUBB2C, CANX

Diamorphine

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Diamorphine

hsa04217

Necroptosis

4.56E-03

P23458, Q9NQC7, Q9H444, O75351

JAK1, CYLD, CHMP4B, VPS4B

Diamorphine

hsa04261

Adrenergic signaling in cardiomyocytes

4.37E-03

P17612, Q13362, Q16537, P0DP23, P17252, P10415, P20020

PRKACA, PPP2R5C, PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1

Diamorphine

hsa04350

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Diamorphine

hsa04390

Hippo signaling pathway

1.47E-02

P63261, Q13485, Q9UJU2, O43623, Q13489

ACTG1, SMAD4, LEF1, SNAI2, BIRC3

Diamorphine

hsa04510

Focal adhesion

3.21E-02

Q15942, P17252, Q13489, P10415, P49767, P63261

ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1

Diamorphine

hsa04520

Adherens junction

3.36E-02

Q13485, Q9UJU2, O43623, P63261

SMAD4, LEF1, SNAI2, ACTG1

Diamorphine

hsa04540

Gap junction

4.76E-02

P17252, Q13509, P68371

PRKCA, TUBB3, TUBB2C

Diamorphine

hsa04612

Antigen processing and presentation

1.51E-02

P13765, P48382, P26715, P26717, Q13241, O43908, P01732

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A

Diamorphine

hsa04613

Neutrophil extracellular trap formation

2.23E-03

P17252, O60603, P08246, Q92769, P04908, Q6FI13, Q93077, P33778, P68431, P14598, Q15080, P21462, O43315, Q16539

PRKCA, TLR2, ELA2, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC3, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14

Diamorphine

hsa04614

Renin-angiotensin system

1.52E-02

P50052

AGTR2

Diamorphine

hsa04640

Hematopoietic cell lineage

1.37E-02

P14778, P27930, P11215, P25063, P07766, P01732, P09564

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7

Diamorphine

hsa04650

Natural killer cell mediated cytotoxicity

6.78E-07

P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715

PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721

Diamorphine

hsa04658

Th1 and Th2 cell differentiation

2.21E-04

Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761

PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3

Diamorphine

hsa04659

Th17 cell differentiation

1.25E-03

Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963

PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247

Diamorphine

hsa04660

T cell receptor signaling pathway

2.21E-05

P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Diamorphine

hsa04666

Fc gamma R-mediated phagocytosis

2.22E-02

P49006, P06396, P14598, P17252

MARCKSL1, GSN, NCF1, PRKCA

Diamorphine

hsa04713

Circadian entrainment

4.42E-02

P0DP23, P17612

CALM1, PRKACA

Diamorphine

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Diamorphine

hsa04720

Long-term potentiation

8.84E-05

P17252, Q16566, P0DP23, O15399, P17612, Q14643

PRKCA, CAMK4, CALM1, GRIN2D, PRKACA, ITPR1

Diamorphine

hsa04728

Dopaminergic synapse

2.18E-03

P17612, P14416, P63218, P50151, P49841, Q16539, P49407, Q13362, P0DP23

PRKACA, DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1, PPP2R5C, CALM1

Diamorphine

hsa04740

Olfactory transduction

6.71E-03

P0DP23, P17612

CALM1, PRKACA

Diamorphine

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Diamorphine

hsa04910

Insulin signaling pathway

3.62E-02

P0DP23, P17612

CALM1, PRKACA

Diamorphine

hsa04912

GnRH signaling pathway

4.42E-02

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Diamorphine

hsa04916

Melanogenesis

2.99E-03

P17612, P0DP23, Q9UJU2, P17252

PRKACA, CALM1, LEF1, PRKCA

Diamorphine

hsa04921

Oxytocin signaling pathway

3.44E-03

P0DP23, P17612, P17252, Q16566, P63261, Q96RR4

CALM1, PRKACA, PRKCA, CAMK4, ACTG1, CAMKK2

Diamorphine

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Diamorphine

hsa04924

Renin secretion

1.09E-02

P17612, P0DP23

PRKACA, CALM1

Diamorphine

hsa04925

Aldosterone synthesis and secretion

2.90E-04

Q14643, P0DP23, P17252, Q16566, P20020, P23634

ITPR1, CALM1, PRKCA, CAMK4, ATP2B1, ATP2B4

Diamorphine

hsa04932

Non-alcoholic fatty liver disease

3.62E-02

P49841, Q16718, O14521

GSK3B, NDUFA5, SDHD

Diamorphine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.36E-02

Q13485, P10415, P49767, P17252

SMAD4, BCL2, VEGFC, PRKCA

Diamorphine

hsa04966

Collecting duct acid secretion

3.15E-02

P02730, Q9Y666

SLC4A1, SLC12A7

Diamorphine

hsa04970

Salivary secretion

6.19E-05

P17612, Q14643, P20020, P23634, P17252, P0DP23

PRKACA, ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1

Diamorphine

hsa04971

Gastric acid secretion

3.94E-03

P17612, P17252, P63261, P0DP23

PRKACA, PRKCA, ACTG1, CALM1

Diamorphine

hsa04972

Pancreatic secretion

1.00E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Diamorphine

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Diamorphine

hsa04976

Bile secretion

1.74E-03

O43315, P17612, P08183, Q14032

AQP9, PRKACA, ABCB1, BAAT

Diamorphine

hsa04978

Mineral absorption

3.94E-02

P23634, Q9BXS9

ATP2B4, SLC26A6

Diamorphine

hsa05014

Amyotrophic lateral sclerosis

4.31E-02

O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0

GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2B

Diamorphine

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Diamorphine

hsa05022

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Diamorphine

hsa05031

Amphetamine addiction

9.97E-04

O15399, P0DP23, Q16566, P17612, P17252

GRIN2D, CALM1, CAMK4, PRKACA, PRKCA

Diamorphine

hsa05034

Alcoholism

1.29E-02

P17612, P0DP23, Q96RR4

PRKACA, CALM1, CAMKK2

Diamorphine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.62E-04

Q16539, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Diamorphine

hsa05132

Salmonella infection

2.12E-04

P51617, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371

IRAK1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2C

Diamorphine

hsa05133

Pertussis

2.52E-02

P0DP23, P23528, P09871

CALM1, CFL1, C1S

Diamorphine

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Diamorphine

hsa05135

Yersinia infection

4.65E-02

P13612, P06239, Q16539, P01375, P49841

ITGA4, LCK, MAPK14, TNF, GSK3B

Diamorphine

hsa05140

Leishmaniasis

1.56E-02

P14598, O60603, P49006, P51617, Q15080

NCF1, TLR2, MARCKSL1, IRAK1, NCF4

Diamorphine

hsa05144

Malaria

1.64E-03

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Diamorphine

hsa05146

Amoebiasis

2.21E-04

P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814

CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1

Diamorphine

hsa05163

Human cytomegalovirus infection

1.72E-02

P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463

TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5

Diamorphine

hsa05168

Herpes simplex virus 1 infection

1.94E-02

Q9UKJ0, P01568, Q9GZY0, Q01130, Q13489, Q13398, Q03923, Q9UDV6, P10415

PILRB, IFNA21, NXF2; NXF2B, SFRS2, BIRC3, ZNF211, ZNF85, ZNF212, BCL2

Diamorphine

hsa05169

Epstein-Barr virus infection

2.54E-02

Q92769, P04637, Q13546, P10415, P24522, O60603, P51617, P09693

HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, IRAK1, CD3G

Diamorphine

hsa05170

Human immunodeficiency virus 1 infection

6.54E-03

P0DP23, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5

CALM1, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2

Diamorphine

hsa05200

Pathways in cancer

1.51E-02

Q9UJU2, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P25116, P78417, P0DP23, P01568

LEF1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, F2R, GSTO1, CALM1, IFNA21

Diamorphine

hsa05212

Pancreatic cancer

2.97E-03

Q15311, P23458, P37173

RALBP1, JAK1, TGFBR2

Diamorphine

hsa05214

Glioma

8.71E-04

P0DP23, Q16566, P17252, P04637, P24522

CALM1, CAMK4, PRKCA, TP53, GADD45A

Diamorphine

hsa05216

Thyroid cancer

1.85E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Diamorphine

hsa05217

Basal cell carcinoma

4.42E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Diamorphine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

8.27E-03

P42338, P19174, P07766, P20963, P06239, Q04759

PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQ

Diamorphine

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Diamorphine

hsa05418

Fluid shear stress and atherosclerosis

2.49E-03

Q16539, P78417, P10599, P14780, P01375, P63261, P10415, P14778, P27930, P0DP23, Q92974

MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2

Community members of Diamorphine (S_DC: 2.13)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

Q8NFZ4

NLGN2

NeuroliginNone2

Predicted

0.566

0.0692

0.1627

0.5841

P50052

AGTR2

TypeNone2 angiotensin II receptor

Predicted

0.0604

0.4365

0.1541

1.0572

P21462

FPR1

fMetNoneLeuNonePhe receptor

Predicted

0.1205

0.3492

0.4378

1.1964

P25025

CXCR2

CNoneXNoneC chemokine receptor type 2

Predicted

0.0278

0.5189

0.4494

1.5011

P25024

CXCR1

CNoneXNoneC chemokine receptor type 1

Predicted

0.1656

0.4232

0.4009

1.33

P51684

CCR6

CNoneC chemokine receptor type 6

Predicted

0.085

0.1741

0.3304

0.7212

P46091

GPR1

ChemerinNonelike receptor 2

Predicted

0.2476

0.1372

0.3982

PharmaCoNets of Diamorphine (SPCN: 26.20 )

Diamorphine regulated-network (SDN: 12.30)

Community members of Diamorphine (SDC: 2.13)

PharmaCoNets of Diamorphine (S_PCN: 26.20 )

Diamorphine regulated-network (S_DN: 12.30)

Community members of Diamorphine (S_DC: 2.13)