PharmaCoNets of Diacerein (SPCN: 46.22 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Diacereinhsa00230Purine metabolism1.56E-023Q7LG56, P51828, Q9Y227RRM2B, ADCY7, ENTPD4More
Diacereinhsa00240Pyrimidine metabolism1.45E-022Q7LG56, Q9Y227RRM2B, ENTPD4More
Diacereinhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Diacereinhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Diacereinhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Diacereinhsa00600Sphingolipid metabolism4.50E-021P15289ARSAMore
Diacereinhsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Diacereinhsa00920Sulfur metabolism3.18E-021Q16762TSTMore
Diacereinhsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Diacereinhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Diacereinhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Diacereinhsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Diacereinhsa03013RNA transport4.09E-029P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Diacereinhsa03015mRNA surveillance pathway4.42E-024O60942, O43148, P52298, Q53GS7RNGTT, RNMT, NCBP2, GLE1More
Diacereinhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Diacereinhsa03040Spliceosome5.67E-0716O43143, O60508, P17844, P08579, P26368, P51991, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, DDX5, SNRPB2, U2AF2, HNRPA3, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Diacereinhsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Diacereinhsa04015Rap1 signaling pathway2.69E-0311P20827, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P08514, P19174EFNA1, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, ITGA2B, PLCG1More
Diacereinhsa04062Chemokine signaling pathway9.23E-0310P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Diacereinhsa04064NF-kappa B signaling pathway1.91E-0412P10415, Q13489, P25963, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45AMore
Diacereinhsa04071Sphingolipid signaling pathway9.39E-037P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Diacereinhsa04080Neuroactive ligand-receptor interaction1.18E-027P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1More
Diacereinhsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Diacereinhsa04120Ubiquitin mediated proteolysis1.68E-022O00762, Q14139UBE2C, UBE4AMore
Diacereinhsa04122Sulfur relay system3.18E-021Q16762TSTMore
Diacereinhsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Diacereinhsa04142Lysosome2.23E-024P22304, Q13510, Q04900, Q9Y227IDS, ASAH1, CD164, ENTPD4More
Diacereinhsa04144Endocytosis2.25E-025O75351, P42566, Q15438, Q14161, Q9UNH7VPS4B, EPS15, PSCD1, GIT2, SNX6More
Diacereinhsa04145Phagosome1.61E-0310P63261, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Diacereinhsa04151PI3K-Akt signaling pathway1.19E-0319P62753, P42338, P43657, P27348, P20827, P49767, P07900, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P22105, P14784, Q99941, P18848, O00141, P30281RPS6, PIK3CB, P2RY5, YWHAQ, EFNA1, VEGFC, HSP90AA1, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, TNXB, IL2RB, CREBL1, ATF4, SGK, CCND3More
Diacereinhsa04210Apoptosis1.52E-029Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1More
Diacereinhsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Diacereinhsa04217Necroptosis5.89E-037P01568, Q13489, Q13546, P07384, Q6FI13, P10415, O43633IFNA21, BIRC3, RIPK1, CAPN1, H2AC18; H2AC19, BCL2, CHMP2AMore
Diacereinhsa04261Adrenergic signaling in cardiomyocytes1.46E-024P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Diacereinhsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Diacereinhsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Diacereinhsa04510Focal adhesion4.64E-026O75369, Q15942, Q13489, P10415, P49767, P63261FLNB, ZYX, BIRC3, BCL2, VEGFC, ACTG1More
Diacereinhsa04512ECM-receptor interaction3.73E-022P07359, P08514GP1BA, ITGA2BMore
Diacereinhsa04514Cell adhesion molecules8.19E-033P16109, P56750, O00501SELP, CLDN17, CLDN5More
Diacereinhsa04530Tight junction2.47E-055Q8TEU7, P16989, P56750, O00501, Q14247RAPGEF6, CSDA, CLDN17, CLDN5, CTTNMore
Diacereinhsa04610Complement and coagulation cascades4.47E-022P25116, P09871F2R, C1SMore
Diacereinhsa04611Platelet activation5.18E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Diacereinhsa04613Neutrophil extracellular trap formation2.36E-0520P17252, P16109, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, P21730, P08514, P21462, P07359PRKCA, SELP, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, ITGA2B, FPR1, GP1BAMore
Diacereinhsa04621NOD-like receptor signaling pathway3.10E-0311Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4More
Diacereinhsa04623Cytosolic DNA-sensing pathway2.46E-022P01568, Q13546IFNA21, RIPK1More
Diacereinhsa04659Th17 cell differentiation1.70E-027P19174, P14784, P14778, P84022, Q13485, P08238, P07766PLCG1, IL2RB, IL1R1, SMAD3, SMAD4, HSP90AB1, CD3EMore
Diacereinhsa04660T cell receptor signaling pathway4.20E-027P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITKMore
Diacereinhsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Diacereinhsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Diacereinhsa04668TNF signaling pathway2.59E-027P01375, O00463, Q13489, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9More
Diacereinhsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Diacereinhsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Diacereinhsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Diacereinhsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Diacereinhsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Diacereinhsa04810Regulation of actin cytoskeleton2.58E-023Q15746, P08514, P25116MYLK, ITGA2B, F2RMore
Diacereinhsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Diacereinhsa04912GnRH signaling pathway1.05E-035P51828, P18848, Q13557, P0DP24, P45985ADCY7, ATF4, CAMK2D, CALM2, MAP2K4More
Diacereinhsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Diacereinhsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Diacereinhsa04920Adipocytokine signaling pathway5.84E-036P25963, P33121, Q9Y478, Q04759, Q96RR4, P01375NFKBIA, ACSL1, PRKAB1, PRKCQ, CAMKK2, TNFMore
Diacereinhsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Diacereinhsa04926Relaxin signaling pathway3.34E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Diacereinhsa04927Cortisol synthesis and secretion4.16E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Diacereinhsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Diacereinhsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Diacereinhsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Diacereinhsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Diacereinhsa04970Salivary secretion6.20E-036P51828, P22694, Q14643, P17252, P0DP24, P49913ADCY7, PRKACB, ITPR1, PRKCA, CALM2, CAMPMore
Diacereinhsa04976Bile secretion4.50E-021Q9BY07SLC4A5More
Diacereinhsa05022Pathways of neurodegeneration - multiple diseases2.69E-028O15399, Q13509, P68371, P10415, Q13561, P07384, P04628, P0DP23GRIN2D, TUBB3, TUBB2C, BCL2, DCTN2, CAPN1, WNT1, CALM1More
Diacereinhsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Diacereinhsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Diacereinhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Diacereinhsa05130Pathogenic Escherichia coli infection7.39E-034Q14247, P56750, O00501, P25116CTTN, CLDN17, CLDN5, F2RMore
Diacereinhsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Diacereinhsa05132Salmonella infection9.55E-0415P51617, P25963, P01375, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, NFKBIA, TNF, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Diacereinhsa05133Pertussis2.41E-022P09871, Q02556C1S, IRF8More
Diacereinhsa05140Leishmaniasis1.18E-027P14598, P13765, O60603, P25963, P01375, P51617, Q15080NCF1, HLA-DOB, TLR2, NFKBIA, TNF, IRAK1, NCF4More
Diacereinhsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Diacereinhsa05152Tuberculosis2.07E-029Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Diacereinhsa05161Hepatitis B2.41E-0311P17252, P14780, Q99941, P18848, P25963, P01375, P10415, P27348, P51617, O60603, Q14765PRKCA, MMP9, CREBL1, ATF4, NFKBIA, TNF, BCL2, YWHAQ, IRAK1, TLR2, STAT4More
Diacereinhsa05168Herpes simplex virus 1 infection1.17E-0210Q9UKJ0, Q06124, P01568, Q01130, Q13489, Q13398, Q9NR11, Q03923, Q9UDV6, P10415PILRB, PTPN11, IFNA21, SFRS2, BIRC3, ZNF211, ZNF302, ZNF85, ZNF212, BCL2More
Diacereinhsa05170Human immunodeficiency virus 1 infection1.06E-0313P01375, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5TNF, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2More
Diacereinhsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Diacereinhsa05202Transcriptional misregulation in cancer1.51E-0414Q12778, Q15532, Q13315, P14780, P14923, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, MMP9, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Diacereinhsa05203Viral carcinogenesis2.63E-037Q99941, P18848, P27348, Q15283, P61978, P62807, O60814CREBL1, ATF4, YWHAQ, RASA2, HNRPK, HIST1H2BC, H2BC12More
Diacereinhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Diacereinhsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Diacereinhsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Diacereinhsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Diacereinhsa05310Asthma3.88E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Diacereinhsa05321Inflammatory bowel disease1.28E-025O60603, P01375, P13765, Q14765, P23771TLR2, TNF, HLA-DOB, STAT4, GATA3More
Diacereinhsa05322Systemic lupus erythematosus2.09E-0412P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Diacereinhsa05332Graft-versus-host disease9.30E-035P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More

Community members of Diacerein (SDC: 3.49)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q13133NR1H3Oxysterols receptor LXRNonealphaReported00.01620.4390.20861.0947
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenaseReported00.382210.27012.4612
P11712CYP2C9Cytochrome P450 2C9Reported10.010610.15242.1577
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P08575PTPRCReceptorNonetype tyrosineNoneprotein phosphatase CPredicted10.27330.13580.41320.8216
P18054ALOX12Polyunsaturated fatty acid lipoxygenase ALOX12Predicted00.00750.37030.24160.986
P33260CYP2C18Cytochrome P450 2C18Predicted10.02390.07560.15280.316
O75342ALOX12BArachidonate 12Nonelipoxygenase, 12RNonetypePredicted00.0750.03990.15890.2762
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)