PharmaCoNets of Dextrothyroxine (SPCN: 10.59 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dextrothyroxinehsa00040Pentose and glucuronate interconversions9.59E-032P15121, P14550AKR1B1, AKR1A1More
Dextrothyroxinehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Dextrothyroxinehsa00561Glycerolipid metabolism7.94E-033P15121, P14550, Q86XP1AKR1B1, AKR1A1, DGKHMore
Dextrothyroxinehsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Dextrothyroxinehsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Dextrothyroxinehsa03010Ribosome1.60E-029P30050, P40429, P62906, P62917, Q9H0U6, P36578, P05386, P62249, P23396RPL12, RPL13A, RPL10A, RPL8, MRPL18, RPL4, RPLP1, RPS16, RPS3More
Dextrothyroxinehsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Dextrothyroxinehsa03030DNA replication1.48E-023P49005, P33993, P15927POLD2, MCM7, RPA2More
Dextrothyroxinehsa04020Calcium signaling pathway5.81E-047Q96DU7, Q13557, P21860, P05141, P12236, P26678, P63092ITPKC, CAMK2D, ERBB3, SLC25A5, SLC25A6, PLN, GNASMore
Dextrothyroxinehsa04022cGMP-PKG signaling pathway9.36E-036P61586, P26678, Q99941, P18848, P05141, P12236RHOA, PLN, CREBL1, ATF4, SLC25A5, SLC25A6More
Dextrothyroxinehsa04064NF-kappa B signaling pathway1.60E-028P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Dextrothyroxinehsa04071Sphingolipid signaling pathway2.96E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Dextrothyroxinehsa04080Neuroactive ligand-receptor interaction3.22E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1More
Dextrothyroxinehsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Dextrothyroxinehsa04151PI3K-Akt signaling pathway1.36E-029P21860, P27348, O14944, P07900, Q15831, P22105, Q99941, P18848, O95988ERBB3, YWHAQ, EREG, HSP90AA1, STK11, TNXB, CREBL1, ATF4, TCL1BMore
Dextrothyroxinehsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Dextrothyroxinehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Dextrothyroxinehsa04261Adrenergic signaling in cardiomyocytes3.12E-025P63092, Q99941, P18848, P26678, Q13557GNAS, CREBL1, ATF4, PLN, CAMK2DMore
Dextrothyroxinehsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Dextrothyroxinehsa04612Antigen processing and presentation3.21E-026P13765, P48382, P26715, P26717, Q13241, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8AMore
Dextrothyroxinehsa04659Th17 cell differentiation3.17E-023P25963, P84022, Q13485NFKBIA, SMAD3, SMAD4More
Dextrothyroxinehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Dextrothyroxinehsa04725Cholinergic synapse4.83E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Dextrothyroxinehsa04911Insulin secretion4.47E-034P63092, Q99941, P18848, Q13557GNAS, CREBL1, ATF4, CAMK2DMore
Dextrothyroxinehsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Dextrothyroxinehsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Dextrothyroxinehsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Dextrothyroxinehsa04925Aldosterone synthesis and secretion1.68E-024Q99941, P18848, P63092, Q13557CREBL1, ATF4, GNAS, CAMK2DMore
Dextrothyroxinehsa04927Cortisol synthesis and secretion6.98E-045Q14643, Q99941, P18848, P63092, P22694ITPR1, CREBL1, ATF4, GNAS, PRKACBMore
Dextrothyroxinehsa04928Parathyroid hormone synthesis, secretion and action1.39E-038Q14643, P63092, P22694, P23771, P61586, Q99941, P18848, P10415ITPR1, GNAS, PRKACB, GATA3, RHOA, CREBL1, ATF4, BCL2More
Dextrothyroxinehsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Dextrothyroxinehsa04934Cushing syndrome1.37E-035Q99941, P18848, P63092, O15169, Q13557CREBL1, ATF4, GNAS, AXIN1, CAMK2DMore
Dextrothyroxinehsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Dextrothyroxinehsa05010Alzheimer disease1.36E-029Q92542, O15239, P05496, P18848, O15169, P05141, P12236, P43686, P62195NCSTN, NDUFA1, ATP5G1, ATF4, AXIN1, SLC25A5, SLC25A6, PSMC4, PSMC5More
Dextrothyroxinehsa05012Parkinson disease2.88E-039O15239, P05496, P05141, P12236, P63092, P18848, P43686, P62195, Q13557NDUFA1, ATP5G1, SLC25A5, SLC25A6, GNAS, ATF4, PSMC4, PSMC5, CAMK2DMore
Dextrothyroxinehsa05014Amyotrophic lateral sclerosis3.92E-028P20333, O15239, P05496, P18848, P43686, P62195, P51991, P35658TNFRSF1B, NDUFA1, ATP5G1, ATF4, PSMC4, PSMC5, HNRPA3, NUP214More
Dextrothyroxinehsa05020Prion disease1.15E-029P46531, O15239, P05496, P18848, P05141, P12236, P43686, P62195, Q99941NOTCH1, NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, PSMC4, PSMC5, CREBL1More
Dextrothyroxinehsa05022Pathways of neurodegeneration - multiple diseases1.57E-0210O15239, P05496, P18848, P05141, P12236, P20333, O15169, Q13557, P43686, P62195NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, TNFRSF1B, AXIN1, CAMK2D, PSMC4, PSMC5More
Dextrothyroxinehsa05030Cocaine addiction2.40E-023P63092, Q99941, P18848GNAS, CREBL1, ATF4More
Dextrothyroxinehsa05031Amphetamine addiction4.47E-034Q13557, P63092, Q99941, P18848CAMK2D, GNAS, CREBL1, ATF4More
Dextrothyroxinehsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Dextrothyroxinehsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Dextrothyroxinehsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Dextrothyroxinehsa05202Transcriptional misregulation in cancer1.77E-0211Q15532, Q13315, P14780, Q15744, Q16548, O15550, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, MMP9, CEBPE, BCL2A1, UTX, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Dextrothyroxinehsa05203Viral carcinogenesis7.09E-036Q99941, P18848, P27348, Q15283, P61586, P61978CREBL1, ATF4, YWHAQ, RASA2, RHOA, HNRPKMore
Dextrothyroxinehsa05206MicroRNAs in cancer1.54E-026P21860, P61978, P46531, P63279, P22105, P61586ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RHOAMore
Dextrothyroxinehsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Dextrothyroxinehsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Dextrothyroxinehsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Dextrothyroxinehsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Dextrothyroxinehsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Dextrothyroxinehsa05321Inflammatory bowel disease2.29E-024P13765, Q14765, P23771, Q9HBE5HLA-DOB, STAT4, GATA3, IL21RMore
Dextrothyroxinehsa05332Graft-versus-host disease7.89E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Dextrothyroxinehsa05415Diabetic cardiomyopathy1.92E-026P05141, P12236, O15239, P05496, Q13557, P26678SLC25A5, SLC25A6, NDUFA1, ATP5G1, CAMK2D, PLNMore

Community members of Dextrothyroxine (SDC: 1.62)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P40926MDH2Malate dehydrogenase, mitochondrialPredicted00.47210.16110.24740.8055
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)