| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Dextromethorphan | hsa00020 | Citrate cycle (TCA cycle) | 1.55E-02 | 3 | Q9P2R7, P40925, O14521 | SUCLA2, MDH1, SDHD | More | | | Dextromethorphan | hsa00030 | Pentose phosphate pathway | 2.50E-05 | 4 | P06744, P60891, P51854, P37837 | GPI, PRPS1, TKTL1, TALDO1 | More | | | Dextromethorphan | hsa00071 | Fatty acid degradation | 4.66E-02 | 3 | O75521, P11766, P33121 | ECI2, ADH5, ACSL1 | More | | | Dextromethorphan | hsa00190 | Oxidative phosphorylation | 1.14E-06 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Dextromethorphan | hsa00220 | Arginine biosynthesis | 8.55E-05 | 2 | P05089, P49448 | ARG1, GLUD2 | More | | | Dextromethorphan | hsa00240 | Pyrimidine metabolism | 4.78E-02 | 1 | P21589 | NT5E | More | | | Dextromethorphan | hsa00430 | Taurine and hypotaurine metabolism | 2.38E-02 | 2 | Q6ZQY3, Q14032 | GADL1, BAAT | More | | | Dextromethorphan | hsa00500 | Starch and sucrose metabolism | 3.03E-05 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Dextromethorphan | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Dextromethorphan | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Dextromethorphan | hsa00600 | Sphingolipid metabolism | 3.76E-02 | 1 | P15289 | ARSA | More | | | Dextromethorphan | hsa00604 | Glycosphingolipid biosynthesis - ganglio series | 2.87E-03 | 3 | P06865, O15466, Q9H4F1 | HEXA, ST8SIA5, ST6GALNAC4 | More | | | Dextromethorphan | hsa00730 | Thiamine metabolism | 3.03E-03 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Dextromethorphan | hsa00760 | Nicotinate and nicotinamide metabolism | 2.42E-02 | 1 | P21589 | NT5E | More | | | Dextromethorphan | hsa00770 | Pantothenate and CoA biosynthesis | 2.26E-04 | 3 | O95498, O95497, Q9NRN7 | VNN2, VNN1, AASDHPPT | More | | | Dextromethorphan | hsa00970 | Aminoacyl-tRNA biosynthesis | 2.64E-08 | 4 | O95363, P54136, P14868, Q15046 | FARS2, RARS1, DARS, KARS | More | | | Dextromethorphan | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Dextromethorphan | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | | Dextromethorphan | hsa01100 | Metabolic pathways | 4.43E-02 | 23 | Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737 | MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL | More | | | Dextromethorphan | hsa01200 | Carbon metabolism | 8.05E-04 | 10 | P51854, P04406, P06744, P37837, P40925, P40926, O14521, Q9P2R7, P60891, Q02252 | TKTL1, GAPDH, GPI, TALDO1, MDH1, MDH2, SDHD, SUCLA2, PRPS1, ALDH6A1 | More | | | Dextromethorphan | hsa01230 | Biosynthesis of amino acids | 2.60E-02 | 3 | P51854, P60891, P37837 | TKTL1, PRPS1, TALDO1 | More | | | Dextromethorphan | hsa01240 | Biosynthesis of cofactors | 2.52E-02 | 2 | Q9BQB6, P14550 | VKORC1, AKR1A1 | More | | | Dextromethorphan | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 2.93E-03 | 4 | P49841, P42338, P08069, Q9NRA1 | GSK3B, PIK3CB, IGF1R, PDGFC | More | | | Dextromethorphan | hsa01522 | Endocrine resistance | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Dextromethorphan | hsa01523 | Antifolate resistance | 2.54E-03 | 4 | P41440, Q92820, P04818, P01375 | SLC19A1, GGH, TYMS, TNF | More | | | Dextromethorphan | hsa01524 | Platinum drug resistance | 8.85E-04 | 6 | Q13315, P10415, Q13489, P78417, P23025, P43246 | ATM, BCL2, BIRC3, GSTO1, XPA, MSH2 | More | | | Dextromethorphan | hsa02010 | ABC transporters | 9.60E-05 | 3 | P45844, P08183, Q8IZY2 | ABCG1, ABCB1, ABCA7 | More | | | Dextromethorphan | hsa03008 | Ribosome biogenesis in eukaryotes | 2.60E-03 | 5 | Q9NYH9, P78345, Q9BVP2, O15381, Q9GZY0 | UTP6, RPP38, GNL3, NVL, NXF2; NXF2B | More | | | Dextromethorphan | hsa03010 | Ribosome | 1.03E-02 | 2 | P46777, P50914 | RPL5, RPL14 | More | | | Dextromethorphan | hsa03013 | RNA transport | 2.29E-04 | 13 | O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114 | XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1 | More | | | Dextromethorphan | hsa03020 | RNA polymerase | 4.36E-03 | 2 | P24928, P62487 | POLR2A, POLR2G | More | | | Dextromethorphan | hsa03022 | Basal transcription factors | 3.32E-02 | 2 | O00268, Q15544 | TAF4, TAF11 | More | | | Dextromethorphan | hsa03040 | Spliceosome | 5.70E-04 | 13 | Q14562, O43143, O60508, Q99633, O14776, O75940, P52298, O75494, Q13595, Q07955, Q01130, Q13243, Q9UMS4 | DHX8, DHX15, CDC40, PRPF18, TCERG1, SMNDC1, NCBP2, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS5, PRPF19 | More | | | Dextromethorphan | hsa03050 | Proteasome | 1.21E-02 | 1 | P28074 | PSMB5 | More | | | Dextromethorphan | hsa03060 | Protein export | 5.88E-04 | 2 | P37108, Q15005 | SRP14, SPCS2 | More | | | Dextromethorphan | hsa03410 | Base excision repair | 2.52E-02 | 2 | P49005, P29372 | POLD2, MPG | More | | | Dextromethorphan | hsa03430 | Mismatch repair | 4.38E-02 | 1 | P20585 | MSH3 | More | | | Dextromethorphan | hsa03440 | Homologous recombination | 1.81E-02 | 1 | Q13315 | ATM | More | | | Dextromethorphan | hsa03450 | Non-homologous end-joining | 4.21E-02 | 1 | P13010 | XRCC5 | More | | | Dextromethorphan | hsa04010 | MAPK signaling pathway | 1.23E-03 | 3 | P08069, Q9H2K8, Q12933 | IGF1R, TAOK3, TRAF2 | More | | | Dextromethorphan | hsa04014 | Ras signaling pathway | 1.03E-04 | 10 | P42338, Q9NRA1, P08069, Q13009, P11233, Q15283, P61586, P62873, P63218, P50151 | PIK3CB, PDGFC, IGF1R, TIAM1, RALA, RASA2, RHOA, GNB1, GNG5, GNG10 | More | | | Dextromethorphan | hsa04015 | Rap1 signaling pathway | 3.90E-05 | 11 | P20827, P49767, P08069, P06213, P63261, P11233, P25116, Q13009, O00522, P0DP23, P17252 | EFNA1, VEGFC, IGF1R, INSR, ACTG1, RALA, F2R, TIAM1, KRIT1, CALM1, PRKCA | More | | | Dextromethorphan | hsa04020 | Calcium signaling pathway | 1.16E-03 | 7 | Q16566, P17252, O15399, P25116, P0DP23, P23634, P49767 | CAMK4, PRKCA, GRIN2D, F2R, CALM1, ATP2B4, VEGFC | More | | | Dextromethorphan | hsa04022 | cGMP-PKG signaling pathway | 2.55E-02 | 4 | P18848, Q8WYR1, P05141, P0DP24 | ATF4, PIK3R5, SLC25A5, CALM2 | More | | | Dextromethorphan | hsa04024 | cAMP signaling pathway | 2.84E-02 | 5 | P0DP23, P23634, Q16566, O15399, P25116 | CALM1, ATP2B4, CAMK4, GRIN2D, F2R | More | | | Dextromethorphan | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 5.55E-04 | 8 | P09341, P19875, P25024, P25025, Q13651, P14784, P09603, P01375 | CXCL1, CXCL2, CXCR1, CXCR2, IL10RA, IL2RB, CSF1, TNF | More | | | Dextromethorphan | hsa04062 | Chemokine signaling pathway | 8.09E-07 | 16 | P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, P22694, P49841 | CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, PRKACB, GSK3B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q13547 | HDAC1 | Histone deacetylase 1 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.803 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | 1 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.732 | | Q13547 | HDAC1 | Histone deacetylase 1 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | -0.719 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.929 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.788 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.814 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P47992 | XCL1 | Lymphotactin | -0.706 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | Q9UBD3 | XCL2 | Cytokine SCM-1 beta | -0.706 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.707 | | Q15669 | RHOH | Rho-related GTP-binding protein RhoH | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.723 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.732 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | Q15669 | RHOH | Rho-related GTP-binding protein RhoH | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.867 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | Q13547 | HDAC1 | Histone deacetylase 1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.864 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.727 | | Q15669 | RHOH | Rho-related GTP-binding protein RhoH | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.726 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.856 | | Q13547 | HDAC1 | Histone deacetylase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.716 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.743 | | Q15669 | RHOH | Rho-related GTP-binding protein RhoH | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.762 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.757 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P43250 | GRK6 | G protein-coupled receptor kinase 6 | -0.792 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P49407 | ARRB1 | Beta-arrestin-1 | -0.721 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.736 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.78 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | 0.721 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.823 | | Q15669 | RHOH | Rho-related GTP-binding protein RhoH | P49841 | GSK3B | Glycogen synthase kinase-3 beta | -0.796 |
| | Dextromethorphan | hsa04064 | NF-kappa B signaling pathway | 5.51E-06 | 19 | P10415, Q13489, P51617, O00463, Q13546, P14778, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643 | BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB | More | | | Dextromethorphan | hsa04066 | HIF-1 signaling pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Dextromethorphan | hsa04068 | FoxO signaling pathway | 1.12E-03 | 2 | P08069, Q13315 | IGF1R, ATM | More | | | Dextromethorphan | hsa04070 | Phosphatidylinositol signaling system | 3.54E-03 | 5 | P0DP23, Q14643, P23743, O14732, P17252 | CALM1, ITPR1, DGKA, IMPA2, PRKCA | More | | | Dextromethorphan | hsa04071 | Sphingolipid signaling pathway | 2.48E-06 | 11 | P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415, Q12933, Q02156 | PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2, TRAF2, PRKCE | More | | | Dextromethorphan | hsa04072 | Phospholipase D signaling pathway | 4.48E-02 | 5 | P42338, P43657, P25024, P25025, P19174 | PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1 | More | | | Dextromethorphan | hsa04080 | Neuroactive ligand-receptor interaction | 1.97E-02 | 5 | P28472, P21453, Q9H228, P21730, P07550 | GABRB3, S1PR1, EDG8, C5AR1, ADRB2 | More | | | Dextromethorphan | hsa04110 | Cell cycle | 2.43E-04 | 7 | P06493, Q13315, O75293, P30304, P33981, P42773, P01106 | CDK1, ATM, GADD45B, CDC25A, TTK, CDKN2C, MYC | More | | | Dextromethorphan | hsa04114 | Oocyte meiosis | 7.67E-05 | 11 | P51812, Q02750, Q13557, P0DP24, P16298, Q17RY0, Q08828, P51828, P27348, Q13362, P08069 | RPS6KA3, MAP2K1, CAMK2D, CALM2, PPP3CB, CPEB4, ADCY1, ADCY7, YWHAQ, PPP2R5C, IGF1R | More | | | Dextromethorphan | hsa04115 | p53 signaling pathway | 1.51E-02 | 1 | Q13315 | ATM | More | | | Dextromethorphan | hsa04120 | Ubiquitin mediated proteolysis | 3.44E-02 | 4 | Q14145, Q13042, P62837, Q15751 | KEAP1, CDC16, UBE2D2, HERC1 | More | | | Dextromethorphan | hsa04140 | Autophagy - animal | 2.82E-02 | 1 | P08069 | IGF1R | More | | | Dextromethorphan | hsa04142 | Lysosome | 3.31E-02 | 3 | P43234, Q9UBR2, P34059 | CTSO, CTSZ, GALNS | More | | | Dextromethorphan | hsa04145 | Phagosome | 8.85E-07 | 12 | O75015, P63261, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P27824, P13765 | FCGR3B, ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, CANX, HLA-DOB | More | | | Dextromethorphan | hsa04150 | mTOR signaling pathway | 7.74E-03 | 4 | P08069, Q02750, Q9NQL2, P51812 | IGF1R, MAP2K1, RRAGD, RPS6KA3 | More | | | Dextromethorphan | hsa04151 | PI3K-Akt signaling pathway | 2.20E-04 | 22 | P62753, P42338, P25116, P49841, O43521, P27348, Q9NRA1, P49767, Q13362, Q8WYR1, P62873, P63218, P50151, P16144, O60603, P14784, P01568, P18848, P10415, P17252, O00141, Q6ZUJ8 | RPS6, PIK3CB, F2R, GSK3B, BCL2L11, YWHAQ, PDGFC, VEGFC, PPP2R5C, PIK3R5, GNB1, GNG5, GNG10, ITGB4, TLR2, IL2RB, IFNA21, ATF4, BCL2, PRKCA, SGK, PIK3AP1 | More | | | Dextromethorphan | hsa04152 | AMPK signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Dextromethorphan | hsa04210 | Apoptosis | 7.34E-03 | 4 | Q13315, O75460, O43521, P18848 | ATM, ERN1, BCL2L11, ATF4 | More | | | Dextromethorphan | hsa04211 | Longevity regulating pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Dextromethorphan | hsa04213 | Longevity regulating pathway - multiple species | 1.14E-03 | 5 | P42338, P08069, Q9Y4H2, P11142, Q13547 | PIK3CB, IGF1R, IRS2, HSPA8, HDAC1 | More | | | Dextromethorphan | hsa04217 | Necroptosis | 8.98E-09 | 22 | P01375, P01568, P23458, P48023, Q13489, Q9NQC7, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, P10415, Q13557, Q9H444, O43633, Q08752 | TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CAMK2D, CHMP4B, CHMP2A, PPID | More | | | Dextromethorphan | hsa04218 | Cellular senescence | 4.79E-02 | 4 | P01106, O75293, P30304, P06493 | MYC, GADD45B, CDC25A, CDK1 | More | | | Dextromethorphan | hsa04261 | Adrenergic signaling in cardiomyocytes | 2.13E-05 | 14 | P09493, P07550, Q08828, P51828, P22694, P18848, Q13362, Q16537, P0DP23, P0DP24, Q13557, P17252, P10415, P20020 | TPM1, ADRB2, ADCY1, ADCY7, PRKACB, ATF4, PPP2R5C, PPP2R5E, CALM1, CALM2, CAMK2D, PRKCA, BCL2, ATP2B1 | More | | | Dextromethorphan | hsa04270 | Vascular smooth muscle contraction | 3.27E-05 | 6 | Q05655, P0DP24, Q08828, P51828, P35579, P35318 | PRKCD, CALM2, ADCY1, ADCY7, MYH9, ADM | More | | | Dextromethorphan | hsa04350 | TGF-beta signaling pathway | 4.88E-02 | 1 | P37173 | TGFBR2 | More | | | Dextromethorphan | hsa04370 | VEGF signaling pathway | 2.68E-03 | 3 | P16298, Q05397, Q02750 | PPP3CB, PTK2, MAP2K1 | More | | | Dextromethorphan | hsa04380 | Osteoclast differentiation | 2.67E-02 | 4 | Q9NQC7, Q9UQC2, P23458, P01584 | CYLD, GAB2, JAK1, IL1B | More | | | Dextromethorphan | hsa04390 | Hippo signaling pathway | 1.47E-02 | 5 | P63261, Q13485, Q9UJU2, O43623, Q13489 | ACTG1, SMAD4, LEF1, SNAI2, BIRC3 | More | | | Dextromethorphan | hsa04510 | Focal adhesion | 9.88E-03 | 7 | Q15942, P17252, Q13489, P10415, P08069, P49767, P63261 | ZYX, PRKCA, BIRC3, BCL2, IGF1R, VEGFC, ACTG1 | More | | | Dextromethorphan | hsa04520 | Adherens junction | 2.26E-03 | 5 | Q13485, Q9UJU2, O43623, P08069, P63261 | SMAD4, LEF1, SNAI2, IGF1R, ACTG1 | More | | | Dextromethorphan | hsa04530 | Tight junction | 3.29E-02 | 3 | P16989, P56750, Q14247 | CSDA, CLDN17, CTTN | More | | | Dextromethorphan | hsa04540 | Gap junction | 2.02E-04 | 5 | P17252, P22694, Q13509, P68371, Q14643 | PRKCA, PRKACB, TUBB3, TUBB2C, ITPR1 | More | | | Dextromethorphan | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Dextromethorphan | hsa04610 | Complement and coagulation cascades | 3.00E-06 | 4 | P00734, P0C0L4, P12259, P20023 | F2, C4A, F5, CR2 | More | | | Dextromethorphan | hsa04612 | Antigen processing and presentation | 3.98E-09 | 12 | P13765, P48382, P01730, Q14953, P26715, P26717, Q07444, Q13241, O43908, P01732, P30101, P01375 | HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, PDIA3, TNF | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P61225 | RAP2B | Ras-related protein Rap-2b | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.788 | | P10114 | RAP2A | Ras-related protein Rap-2a | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.788 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.7 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P48382 | RFX5 | DNA-binding protein RFX5 | -0.743 | | P61225 | RAP2B | Ras-related protein Rap-2b | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.784 | | P10114 | RAP2A | Ras-related protein Rap-2a | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.784 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q14953 | KIR2DS5 | Killer cell immunoglobulin-like receptor 2DS5 | 0.815 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.72 | | P61225 | RAP2B | Ras-related protein Rap-2b | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.737 | | P10114 | RAP2A | Ras-related protein Rap-2a | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.737 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.804 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.714 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.72 | | P61225 | RAP2B | Ras-related protein Rap-2b | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.737 | | P10114 | RAP2A | Ras-related protein Rap-2a | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.737 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.804 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.714 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | Q07444 | KLRC3 | NKG2-E type II integral membrane protein | 0.872 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.838 | | P61225 | RAP2B | Ras-related protein Rap-2b | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.721 | | P10114 | RAP2A | Ras-related protein Rap-2a | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.721 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.865 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.715 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | O43908 | KLRC4 | NKG2-F type II integral membrane protein | -0.721 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.812 | | P61225 | RAP2B | Ras-related protein Rap-2b | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.726 | | P10114 | RAP2A | Ras-related protein Rap-2a | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.726 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.796 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.722 | | P61225 | RAP2B | Ras-related protein Rap-2b | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.743 | | P10114 | RAP2A | Ras-related protein Rap-2a | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.743 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.732 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P01375 | TNF | Tumor necrosis factor | -0.755 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P01375 | TNF | Tumor necrosis factor | -0.722 |
| | Dextromethorphan | hsa04613 | Neutrophil extracellular trap formation | 5.01E-07 | 20 | P17252, P11215, O60603, P08246, Q13547, Q92769, P04908, Q6FI13, Q93077, P58876, P62807, P33778, Q16778, O60814, P68431, P14598, Q15080, P21462, O43315, Q16539 | PRKCA, ITGAM, TLR2, ELA2, HDAC1, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, H2BC3, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14 | More | | | Dextromethorphan | hsa04614 | Renin-angiotensin system | 1.52E-02 | 1 | P50052 | AGTR2 | More | | | Dextromethorphan | hsa04622 | RIG-I-like receptor signaling pathway | 2.47E-02 | 1 | Q12933 | TRAF2 | More | | | Dextromethorphan | hsa04623 | Cytosolic DNA-sensing pathway | 3.15E-02 | 2 | P01568, P25963 | IFNA21, NFKBIA | More | | | Dextromethorphan | hsa04630 | JAK-STAT signaling pathway | 1.44E-02 | 4 | P01106, Q09472, P48551, P16871 | MYC, EP300, IFNAR2, IL7R | More | | | Dextromethorphan | hsa04640 | Hematopoietic cell lineage | 5.08E-13 | 17 | P13612, P21926, P14778, P27930, P11215, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P16871, P13765, P01375, P09603 | ITGA4, CD9, IL1R1, IL1R2, ITGAM, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, IL7R, HLA-DOB, TNF, CSF1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P61225 | RAP2B | Ras-related protein Rap-2b | P13612 | ITGA4 | Integrin alpha-4 | 0.869 | | P10114 | RAP2A | Ras-related protein Rap-2a | P13612 | ITGA4 | Integrin alpha-4 | 0.869 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P13612 | ITGA4 | Integrin alpha-4 | 0.807 | | P52732 | KIF11 | Kinesin-like protein KIF11 | P21926 | CD9 | CD9 antigen | -0.787 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | Q13547 | HDAC1 | Histone deacetylase 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.837 | | Q13547 | HDAC1 | Histone deacetylase 1 | P11215 | ITGAM | Integrin alpha-M | -0.751 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P11215 | ITGAM | Integrin alpha-M | -0.713 | | P07101 | TH | Tyrosine 3-monooxygenase | P20023 | CR2 | Complement receptor type 2 | 0.827 | | P61225 | RAP2B | Ras-related protein Rap-2b | P20023 | CR2 | Complement receptor type 2 | 0.811 | | P10114 | RAP2A | Ras-related protein Rap-2a | P20023 | CR2 | Complement receptor type 2 | 0.811 | | P07101 | TH | Tyrosine 3-monooxygenase | P11836 | MS4A1 | B-lymphocyte antigen CD20 | 0.759 | | P61225 | RAP2B | Ras-related protein Rap-2b | P11836 | MS4A1 | B-lymphocyte antigen CD20 | 0.744 | | P10114 | RAP2A | Ras-related protein Rap-2a | P11836 | MS4A1 | B-lymphocyte antigen CD20 | 0.744 | | Q13547 | HDAC1 | Histone deacetylase 1 | P25063 | CD24 | Signal transducer CD24 | -0.706 | | P61225 | RAP2B | Ras-related protein Rap-2b | P25063 | CD24 | Signal transducer CD24 | -0.707 | | P10114 | RAP2A | Ras-related protein Rap-2a | P25063 | CD24 | Signal transducer CD24 | -0.707 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P25063 | CD24 | Signal transducer CD24 | -0.908 | | P52732 | KIF11 | Kinesin-like protein KIF11 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.724 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P61225 | RAP2B | Ras-related protein Rap-2b | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.902 | | P10114 | RAP2A | Ras-related protein Rap-2a | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.902 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.789 | | P07101 | TH | Tyrosine 3-monooxygenase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.738 | | P61225 | RAP2B | Ras-related protein Rap-2b | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.827 | | P10114 | RAP2A | Ras-related protein Rap-2a | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.827 | | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | | P61225 | RAP2B | Ras-related protein Rap-2b | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.726 | | P10114 | RAP2A | Ras-related protein Rap-2a | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.726 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.796 | | P52732 | KIF11 | Kinesin-like protein KIF11 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.719 | | P61225 | RAP2B | Ras-related protein Rap-2b | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.784 | | P10114 | RAP2A | Ras-related protein Rap-2a | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.784 | | P52732 | KIF11 | Kinesin-like protein KIF11 | P09564 | CD7 | T-cell antigen CD7 | -0.886 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09564 | CD7 | T-cell antigen CD7 | 0.738 | | P61225 | RAP2B | Ras-related protein Rap-2b | P09564 | CD7 | T-cell antigen CD7 | 0.751 | | P10114 | RAP2A | Ras-related protein Rap-2a | P09564 | CD7 | T-cell antigen CD7 | 0.751 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P09564 | CD7 | T-cell antigen CD7 | 0.731 | | P07101 | TH | Tyrosine 3-monooxygenase | P16871 | IL7R | Interleukin-7 receptor subunit alpha | 0.921 | | P61225 | RAP2B | Ras-related protein Rap-2b | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.788 | | P10114 | RAP2A | Ras-related protein Rap-2a | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.788 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P01375 | TNF | Tumor necrosis factor | -0.722 | | P61225 | RAP2B | Ras-related protein Rap-2b | P09603 | CSF1 | Macrophage colony-stimulating factor 1 | -0.807 | | P10114 | RAP2A | Ras-related protein Rap-2a | P09603 | CSF1 | Macrophage colony-stimulating factor 1 | -0.807 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P09603 | CSF1 | Macrophage colony-stimulating factor 1 | -0.702 |
| | Dextromethorphan | hsa04650 | Natural killer cell mediated cytotoxicity | 8.43E-19 | 21 | P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, Q29983, P10321, P01889, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, Q07444, Q14953, P26715 | PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, MICA, HLA-C, HLA-B, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P11511 | CYP19A1 | Aromatase | P16298 | PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | 0.706 | | P11511 | CYP19A1 | Aromatase | P50591 | TNFSF10 | Tumor necrosis factor ligand superfamily member 10 | 0.701 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P01375 | TNF | Tumor necrosis factor | 0.718 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P01375 | TNF | Tumor necrosis factor | -0.755 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P01375 | TNF | Tumor necrosis factor | -0.722 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.748 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.779 | | P61225 | RAP2B | Ras-related protein Rap-2b | P06239 | LCK | Tyrosine-protein kinase Lck | 0.9 | | P10114 | RAP2A | Ras-related protein Rap-2a | P06239 | LCK | Tyrosine-protein kinase Lck | 0.9 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.856 | | Q13547 | HDAC1 | Histone deacetylase 1 | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.786 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.788 | | P61225 | RAP2B | Ras-related protein Rap-2b | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.794 | | P10114 | RAP2A | Ras-related protein Rap-2a | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.794 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.811 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.751 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.771 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.727 | | P61225 | RAP2B | Ras-related protein Rap-2b | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.835 | | P10114 | RAP2A | Ras-related protein Rap-2a | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.835 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.937 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.722 | | P84095 | RHOG | Rho-related GTP-binding protein RhoG | Q29983 | MICA | MHC class I polypeptide-related sequence A | 0.797 | | P84095 | RHOG | Rho-related GTP-binding protein RhoG | P10321 | HLA-C | HLA class I histocompatibility antigen, C alpha chain | 0.797 | | P84095 | RHOG | Rho-related GTP-binding protein RhoG | P01889 | HLA-B | HLA class I histocompatibility antigen, B alpha chain | 0.797 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P11511 | CYP19A1 | Aromatase | Q02750 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | 0.783 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.807 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.701 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.838 | | P61225 | RAP2B | Ras-related protein Rap-2b | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.721 | | P10114 | RAP2A | Ras-related protein Rap-2a | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.721 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.865 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.715 | | Q13547 | HDAC1 | Histone deacetylase 1 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.772 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.81 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.701 | | P61225 | RAP2B | Ras-related protein Rap-2b | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.851 | | P10114 | RAP2A | Ras-related protein Rap-2a | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.851 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.847 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.842 | | Q13547 | HDAC1 | Histone deacetylase 1 | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.735 | | P61225 | RAP2B | Ras-related protein Rap-2b | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.73 | | P10114 | RAP2A | Ras-related protein Rap-2a | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.73 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.852 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.896 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.913 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.721 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.72 | | P61225 | RAP2B | Ras-related protein Rap-2b | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.737 | | P10114 | RAP2A | Ras-related protein Rap-2a | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.737 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.804 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.714 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | Q07444 | KLRC3 | NKG2-E type II integral membrane protein | 0.872 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q14953 | KIR2DS5 | Killer cell immunoglobulin-like receptor 2DS5 | 0.815 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.721 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.72 | | P61225 | RAP2B | Ras-related protein Rap-2b | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.737 | | P10114 | RAP2A | Ras-related protein Rap-2a | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.737 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.804 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.714 |
| | Dextromethorphan | hsa04657 | IL-17 signaling pathway | 3.33E-03 | 8 | O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375 | TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF | More | | | Dextromethorphan | hsa04658 | Th1 and Th2 cell differentiation | 7.18E-15 | 13 | Q04759, P07766, P20963, P09693, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761 | PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P61225 | RAP2B | Ras-related protein Rap-2b | Q04759 | PRKCQ | Protein kinase C theta type | 0.755 | | P10114 | RAP2A | Ras-related protein Rap-2a | Q04759 | PRKCQ | Protein kinase C theta type | 0.755 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.774 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P61225 | RAP2B | Ras-related protein Rap-2b | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.902 | | P10114 | RAP2A | Ras-related protein Rap-2a | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.902 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.789 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P61225 | RAP2B | Ras-related protein Rap-2b | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.835 | | P10114 | RAP2A | Ras-related protein Rap-2a | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.835 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.937 | | P61225 | RAP2B | Ras-related protein Rap-2b | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.827 | | P10114 | RAP2A | Ras-related protein Rap-2a | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.827 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P61225 | RAP2B | Ras-related protein Rap-2b | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.784 | | P10114 | RAP2A | Ras-related protein Rap-2a | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.784 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P61225 | RAP2B | Ras-related protein Rap-2b | P06239 | LCK | Tyrosine-protein kinase Lck | 0.9 | | P10114 | RAP2A | Ras-related protein Rap-2a | P06239 | LCK | Tyrosine-protein kinase Lck | 0.9 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.856 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.775 | | P61225 | RAP2B | Ras-related protein Rap-2b | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.762 | | P10114 | RAP2A | Ras-related protein Rap-2a | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.762 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | P61225 | RAP2B | Ras-related protein Rap-2b | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.833 | | P10114 | RAP2A | Ras-related protein Rap-2a | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.833 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.897 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.753 | | P61225 | RAP2B | Ras-related protein Rap-2b | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.788 | | P10114 | RAP2A | Ras-related protein Rap-2a | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.788 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.884 | | P61225 | RAP2B | Ras-related protein Rap-2b | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.766 | | P10114 | RAP2A | Ras-related protein Rap-2a | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.766 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.955 |
| | Dextromethorphan | hsa04659 | Th17 cell differentiation | 3.44E-09 | 12 | Q04759, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963 | PRKCQ, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P61225 | RAP2B | Ras-related protein Rap-2b | Q04759 | PRKCQ | Protein kinase C theta type | 0.755 | | P10114 | RAP2A | Ras-related protein Rap-2a | Q04759 | PRKCQ | Protein kinase C theta type | 0.755 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.774 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P61225 | RAP2B | Ras-related protein Rap-2b | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.784 | | P10114 | RAP2A | Ras-related protein Rap-2a | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.784 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P61225 | RAP2B | Ras-related protein Rap-2b | P06239 | LCK | Tyrosine-protein kinase Lck | 0.9 | | P10114 | RAP2A | Ras-related protein Rap-2a | P06239 | LCK | Tyrosine-protein kinase Lck | 0.9 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.856 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.753 | | P61225 | RAP2B | Ras-related protein Rap-2b | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.788 | | P10114 | RAP2A | Ras-related protein Rap-2a | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.788 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | P61225 | RAP2B | Ras-related protein Rap-2b | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.833 | | P10114 | RAP2A | Ras-related protein Rap-2a | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.833 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.897 | | P61225 | RAP2B | Ras-related protein Rap-2b | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.762 | | P10114 | RAP2A | Ras-related protein Rap-2a | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.762 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P61225 | RAP2B | Ras-related protein Rap-2b | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.902 | | P10114 | RAP2A | Ras-related protein Rap-2a | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.902 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.789 | | P61225 | RAP2B | Ras-related protein Rap-2b | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.827 | | P10114 | RAP2A | Ras-related protein Rap-2a | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.827 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P61225 | RAP2B | Ras-related protein Rap-2b | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.835 | | P10114 | RAP2A | Ras-related protein Rap-2a | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.835 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.937 |
| | Dextromethorphan | hsa04660 | T cell receptor signaling pathway | 1.80E-11 | 15 | P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841 | TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P01375 | TNF | Tumor necrosis factor | 0.718 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P01375 | TNF | Tumor necrosis factor | -0.722 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P61225 | RAP2B | Ras-related protein Rap-2b | Q04759 | PRKCQ | Protein kinase C theta type | 0.755 | | P10114 | RAP2A | Ras-related protein Rap-2a | Q04759 | PRKCQ | Protein kinase C theta type | 0.755 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.774 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P61225 | RAP2B | Ras-related protein Rap-2b | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.788 | | P10114 | RAP2A | Ras-related protein Rap-2a | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.788 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.716 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.736 | | P61225 | RAP2B | Ras-related protein Rap-2b | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.766 | | P10114 | RAP2A | Ras-related protein Rap-2a | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.766 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.78 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.746 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P61225 | RAP2B | Ras-related protein Rap-2b | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.902 | | P10114 | RAP2A | Ras-related protein Rap-2a | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.902 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.789 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.771 | | P61225 | RAP2B | Ras-related protein Rap-2b | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.835 | | P10114 | RAP2A | Ras-related protein Rap-2a | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.835 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.937 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.722 | | P61225 | RAP2B | Ras-related protein Rap-2b | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.827 | | P10114 | RAP2A | Ras-related protein Rap-2a | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.827 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.77 | | P61225 | RAP2B | Ras-related protein Rap-2b | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.784 | | P10114 | RAP2A | Ras-related protein Rap-2a | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.784 | | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | | P61225 | RAP2B | Ras-related protein Rap-2b | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.726 | | P10114 | RAP2A | Ras-related protein Rap-2a | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.726 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.796 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.722 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.806 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.734 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.907 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.719 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.779 | | P61225 | RAP2B | Ras-related protein Rap-2b | P06239 | LCK | Tyrosine-protein kinase Lck | 0.9 | | P10114 | RAP2A | Ras-related protein Rap-2a | P06239 | LCK | Tyrosine-protein kinase Lck | 0.9 | | O14966 | RAB29 | Ras-related protein Rab-7L1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.856 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.795 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.889 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.823 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.861 |
| | Dextromethorphan | hsa04662 | B cell receptor signaling pathway | 3.86E-03 | 4 | P49841, P42338, P07948, Q8N149 | GSK3B, PIK3CB, LYN, LILRA2 | More | | | Dextromethorphan | hsa04664 | Fc epsilon RI signaling pathway | 1.01E-02 | 3 | P42338, P07948, P09917 | PIK3CB, LYN, ALOX5 | More | | | Dextromethorphan | hsa04666 | Fc gamma R-mediated phagocytosis | 2.22E-02 | 4 | P49006, P06396, P14598, P17252 | MARCKSL1, GSN, NCF1, PRKCA | More | | | Dextromethorphan | hsa04668 | TNF signaling pathway | 2.67E-03 | 6 | P01375, P18848, P19875, P01584, P14780, P20333 | TNF, ATF4, CXCL2, IL1B, MMP9, TNFRSF1B | More | | | Dextromethorphan | hsa04670 | Leukocyte transendothelial migration | 1.08E-03 | 2 | Q96FS4, P19878 | SIPA1, NCF2 | More | | | Dextromethorphan | hsa04672 | Intestinal immune network for IgA production | 3.76E-03 | 3 | P29965, P10747, P13765 | CD40LG, CD28, HLA-DOB | More | | | Dextromethorphan | hsa04710 | Circadian rhythm | 2.43E-02 | 1 | O15516 | CLOCK | More | | | Dextromethorphan | hsa04713 | Circadian entrainment | 6.25E-05 | 11 | O15399, P0DP23, P0DP24, Q13557, P17252, P62873, P63218, P50151, Q14643, Q08828, P51828 | GRIN2D, CALM1, CALM2, CAMK2D, PRKCA, GNB1, GNG5, GNG10, ITPR1, ADCY1, ADCY7 | More | | | Dextromethorphan | hsa04714 | Thermogenesis | 5.21E-03 | 4 | Q16539, P33121, Q16718, O14521 | MAPK14, ACSL1, NDUFA5, SDHD | More | | | Dextromethorphan | hsa04720 | Long-term potentiation | 2.69E-06 | 8 | P17252, Q16566, P16298, P0DP23, P51812, O15399, Q02750, Q14643 | PRKCA, CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, MAP2K1, ITPR1 | More | | | Dextromethorphan | hsa04721 | Synaptic vesicle cycle | 3.15E-02 | 2 | Q13488, P31645 | TCIRG1, SLC6A4 | More | | | Dextromethorphan | hsa04722 | Neurotrophin signaling pathway | 5.35E-04 | 6 | Q05655, Q15418, P49841, O43524, P48023, P52566 | PRKCD, RPS6KA1, GSK3B, FOXO3, FASLG, ARHGDIB | More | | | Dextromethorphan | hsa04723 | Retrograde endocannabinoid signaling | 3.04E-04 | 9 | Q14643, P17252, P48169, P28472, P62873, P63218, P50151, P22694, Q16718 | ITPR1, PRKCA, GABRA4, GABRB3, GNB1, GNG5, GNG10, PRKACB, NDUFA5 | More | | | Dextromethorphan | hsa04724 | Glutamatergic synapse | 1.93E-03 | 4 | O15399, P63218, P50151, P15104 | GRIN2D, GNG5, GNG10, GLUL | More | | | Dextromethorphan | hsa04725 | Cholinergic synapse | 9.51E-04 | 7 | Q14643, P17252, P62873, P63218, P50151, P42338, P10415 | ITPR1, PRKCA, GNB1, GNG5, GNG10, PIK3CB, BCL2 | More | | | Dextromethorphan | hsa04726 | Serotonergic synapse | 2.25E-03 | 5 | P22694, P63218, P50151, P09917, P28472 | PRKACB, GNG5, GNG10, ALOX5, GABRB3 | More | | | Dextromethorphan | hsa04727 | GABAergic synapse | 9.87E-05 | 7 | P62873, P63218, P50151, P48169, P28472, P15104, P22694 | GNB1, GNG5, GNG10, GABRA4, GABRB3, GLUL, PRKACB | More | | | Dextromethorphan | hsa04728 | Dopaminergic synapse | 2.76E-03 | 11 | Q14643, P17252, P14416, P62873, P63218, P50151, P49841, Q16539, P49407, Q13362, P0DP23 | ITPR1, PRKCA, DRD2, GNB1, GNG5, GNG10, GSK3B, MAPK14, ARRB1, PPP2R5C, CALM1 | More | | | Dextromethorphan | hsa04730 | Long-term depression | 1.16E-02 | 1 | P08069 | IGF1R | More | | | Dextromethorphan | hsa04742 | Taste transduction | 4.80E-02 | 1 | P48169 | GABRA4 | More | | | Dextromethorphan | hsa04744 | Phototransduction | 1.48E-05 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Dextromethorphan | hsa04750 | Inflammatory mediator regulation of TRP channels | 3.72E-05 | 10 | P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP24 | IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM2 | More | | | Dextromethorphan | hsa04911 | Insulin secretion | 3.98E-02 | 3 | Q08828, P51828, Q13557 | ADCY1, ADCY7, CAMK2D | More | | | Dextromethorphan | hsa04912 | GnRH signaling pathway | 1.17E-05 | 9 | P17252, Q08828, P51828, Q13557, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694 | PRKCA, ADCY1, ADCY7, CAMK2D, MAP3K4, ITPR1, CALM1, CALM2, PRKACB | More | | | Dextromethorphan | hsa04913 | Ovarian steroidogenesis | 5.67E-04 | 4 | P42330, P22694, P06213, P08069 | AKR1C3, PRKACB, INSR, IGF1R | More | | | Dextromethorphan | hsa04914 | Progesterone-mediated oocyte maturation | 5.89E-03 | 4 | P08069, Q17RY0, P51812, Q02750 | IGF1R, CPEB4, RPS6KA3, MAP2K1 | More | | | Dextromethorphan | hsa04916 | Melanogenesis | 4.68E-04 | 7 | Q13557, P0DP24, P0DP23, Q9UJU2, Q08828, P51828, P17252 | CAMK2D, CALM2, CALM1, LEF1, ADCY1, ADCY7, PRKCA | More | | | Dextromethorphan | hsa04919 | Thyroid hormone signaling pathway | 4.44E-02 | 3 | P60709, Q09472, P01106 | ACTB, EP300, MYC | More | | | Dextromethorphan | hsa04921 | Oxytocin signaling pathway | 1.09E-03 | 9 | P0DP24, P0DP23, Q08828, P51828, P17252, Q16566, Q13557, P63261, Q96RR4 | CALM2, CALM1, ADCY1, ADCY7, PRKCA, CAMK4, CAMK2D, ACTG1, CAMKK2 | More | | | Dextromethorphan | hsa04922 | Glucagon signaling pathway | 3.35E-03 | 6 | P22694, P06737, Q12778, Q13370, P0DP23, Q14643 | PRKACB, PYGL, FOXO1, PDE3B, CALM1, ITPR1 | More | | | Dextromethorphan | hsa04923 | Regulation of lipolysis in adipocytes | 4.24E-03 | 4 | P07550, P06213, P42338, Q9Y4H2 | ADRB2, INSR, PIK3CB, IRS2 | More | | | Dextromethorphan | hsa04924 | Renin secretion | 1.71E-05 | 5 | P22694, P07550, Q14643, Q13370, P0DP23 | PRKACB, ADRB2, ITPR1, PDE3B, CALM1 | More | | | Dextromethorphan | hsa04925 | Aldosterone synthesis and secretion | 3.35E-06 | 11 | Q14643, Q08828, P51828, P0DP23, P0DP24, P17252, Q16566, Q13557, P22694, P20020, P23634 | ITPR1, ADCY1, ADCY7, CALM1, CALM2, PRKCA, CAMK4, CAMK2D, PRKACB, ATP2B1, ATP2B4 | More | | | Dextromethorphan | hsa04926 | Relaxin signaling pathway | 2.41E-02 | 4 | P18848, P22694, P14780, P30679 | ATF4, PRKACB, MMP9, GNA15 | More | | | Dextromethorphan | hsa04927 | Cortisol synthesis and secretion | 2.54E-02 | 2 | P18848, P22694 | ATF4, PRKACB | More | | | Dextromethorphan | hsa04930 | Type II diabetes mellitus | 1.28E-03 | 2 | P06213, Q02156 | INSR, PRKCE | More | | | Dextromethorphan | hsa04931 | Insulin resistance | 1.59E-02 | 2 | Q05655, Q15418 | PRKCD, RPS6KA1 | More | | | Dextromethorphan | hsa04932 | Non-alcoholic fatty liver disease | 9.41E-07 | 12 | P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O14521 | TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, SDHD | More | | | Dextromethorphan | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.15E-03 | 6 | Q13485, P42224, P10415, Q12778, P49767, P17252 | SMAD4, STAT1, BCL2, FOXO1, VEGFC, PRKCA | More | | | Dextromethorphan | hsa04940 | Type I diabetes mellitus | 1.06E-03 | 4 | P48023, P01889, P10321, P01375 | FASLG, HLA-B, HLA-C, TNF | More | | | Dextromethorphan | hsa04960 | Aldosterone-regulated sodium reabsorption | 3.14E-02 | 1 | P06213 | INSR | More | | | Dextromethorphan | hsa04961 | Endocrine and other factor-regulated calcium reabsorption | 3.42E-02 | 3 | P20020, Q9UEF7, P17252 | ATP2B1, KL, PRKCA | More | | | Dextromethorphan | hsa04964 | Proximal tubule bicarbonate reclamation | 4.48E-02 | 1 | P00918 | CA2 | More | | | Dextromethorphan | hsa04966 | Collecting duct acid secretion | 4.05E-06 | 4 | Q13488, P02730, P00918, Q9Y666 | TCIRG1, SLC4A1, CA2, SLC12A7 | More | | | Dextromethorphan | hsa04970 | Salivary secretion | 3.28E-07 | 11 | P07550, Q08828, P51828, P22694, Q14643, P20020, P23634, P17252, P0DP23, P0DP24, P49913 | ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1, CALM2, CAMP | More | | | Dextromethorphan | hsa04971 | Gastric acid secretion | 4.68E-04 | 7 | Q08828, P51828, P17252, P63261, P0DP24, P0DP23, Q13557 | ADCY1, ADCY7, PRKCA, ACTG1, CALM2, CALM1, CAMK2D | More | | | Dextromethorphan | hsa04972 | Pancreatic secretion | 1.44E-03 | 5 | Q14643, P20020, P17252, Q08828, P62491 | ITPR1, ATP2B1, PRKCA, ADCY1, RAB11A | More | | | Dextromethorphan | hsa04973 | Carbohydrate digestion and absorption | 1.29E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | | Dextromethorphan | hsa04974 | Protein digestion and absorption | 2.47E-02 | 1 | Q7Z2H8 | SLC36A1 | More | | | Dextromethorphan | hsa04976 | Bile secretion | 1.01E-03 | 5 | O43315, Q08828, P51828, P08183, Q14032 | AQP9, ADCY1, ADCY7, ABCB1, BAAT | More | | | Dextromethorphan | hsa04978 | Mineral absorption | 3.94E-02 | 2 | P23634, Q9BXS9 | ATP2B4, SLC26A6 | More | | | Dextromethorphan | hsa05010 | Alzheimer disease | 5.01E-03 | 13 | Q16718, O14521, P13073, Q14643, O75460, P0DP23, P0DP24, P01584, P18848, Q13509, P68371, P05141, Q08752 | NDUFA5, SDHD, COX4I1, ITPR1, ERN1, CALM1, CALM2, IL1B, ATF4, TUBB3, TUBB2C, SLC25A5, PPID | More | | | Dextromethorphan | hsa05012 | Parkinson disease | 4.51E-03 | 11 | Q16718, O14521, P13073, P05141, O75460, P18848, Q14643, P0DP23, P0DP24, Q13509, P68371 | NDUFA5, SDHD, COX4I1, SLC25A5, ERN1, ATF4, ITPR1, CALM1, CALM2, TUBB3, TUBB2C | More | | | Dextromethorphan | hsa05014 | Amyotrophic lateral sclerosis | 4.31E-02 | 7 | O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0 | GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2B | More | | | Dextromethorphan | hsa05016 | Huntington disease | 4.87E-02 | 5 | P13073, P24928, P62487, P05141, O75460 | COX4I1, POLR2A, POLR2G, SLC25A5, ERN1 | More | | | Dextromethorphan | hsa05017 | Spinocerebellar ataxia | 2.43E-02 | 1 | P28074 | PSMB5 | More | | | Dextromethorphan | hsa05020 | Prion disease | 1.31E-03 | 9 | Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539 | NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14 | More | | | Dextromethorphan | hsa05022 | Pathways of neurodegeneration - multiple diseases | 2.05E-05 | 19 | Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P17252, P20333, Q16539, P01584, Q08752, P0DP23, P0DP24 | ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, TNFRSF1B, MAPK14, IL1B, PPID, CALM1, CALM2 | More | | | Dextromethorphan | hsa05031 | Amphetamine addiction | 1.61E-03 | 7 | O15399, P0DP23, Q16566, P22694, P18848, P17252, Q13547 | GRIN2D, CALM1, CAMK4, PRKACB, ATF4, PRKCA, HDAC1 | More | | | Dextromethorphan | hsa05032 | Morphine addiction | 5.16E-04 | 7 | P22694, P62873, P63218, P50151, P48169, P28472, P43250 | PRKACB, GNB1, GNG5, GNG10, GABRA4, GABRB3, GRK6 | More | | | Dextromethorphan | hsa05033 | Nicotine addiction | 2.43E-02 | 1 | P48169 | GABRA4 | More | | | Dextromethorphan | hsa05034 | Alcoholism | 2.41E-06 | 11 | O15399, P22694, Q13547, P63218, P50151, Q93077, P58876, P62807, Q16778, O60814, P68431 | GRIN2D, PRKACB, HDAC1, GNG5, GNG10, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Dextromethorphan | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 1.43E-06 | 7 | Q16539, P09341, P19875, P19174, P25024, P25025, P07948 | MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN | More | | | Dextromethorphan | hsa05131 | Shigellosis | 3.33E-03 | 10 | Q12933, P68431, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752 | TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID | More | | | Dextromethorphan | hsa05132 | Salmonella infection | 1.18E-07 | 17 | P51617, P25963, P08238, Q9UJU2, P63261, Q13546, Q13489, P10415, P04406, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371, P49754 | IRAK1, NFKBIA, HSP90AB1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, GAPDH, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2C, VPS41 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P51684 | CCR6 | C-C chemokine receptor type 6 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.722 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.864 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.785 | | P17252 | PRKCA | Protein kinase C alpha type | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.881 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.736 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.835 | | P46091 | GPR1 | Chemerin-like receptor 2 | P63261 | ACTG1 | Actin, cytoplasmic 2 | 0.776 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.868 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.816 | | P17252 | PRKCA | Protein kinase C alpha type | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.849 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.759 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.844 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | P46091 | GPR1 | Chemerin-like receptor 2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.808 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.84 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P04406 | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | 0.762 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | O75369 | FLNB | Filamin-B | 0.878 | | P51684 | CCR6 | C-C chemokine receptor type 6 | O75369 | FLNB | Filamin-B | -0.717 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | O60603 | TLR2 | Toll-like receptor 2 | 0.763 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | P51684 | CCR6 | C-C chemokine receptor type 6 | O60603 | TLR2 | Toll-like receptor 2 | -0.767 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | -0.726 | | P17252 | PRKCA | Protein kinase C alpha type | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | 0.701 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | 0.721 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P51808 | DYNLT3 | Dynein light chain Tctex-type 3 | 0.731 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | Q13561 | DCTN2 | Dynactin subunit 2 | 0.809 | | P17252 | PRKCA | Protein kinase C alpha type | Q13561 | DCTN2 | Dynactin subunit 2 | -0.844 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q13561 | DCTN2 | Dynactin subunit 2 | -0.781 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | Q13509 | TUBB3 | Tubulin beta-3 chain | 0.908 | | P17252 | PRKCA | Protein kinase C alpha type | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.756 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.748 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.835 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P68371 | TUBB2C | Tubulin beta-4B chain | 0.774 | | P17252 | PRKCA | Protein kinase C alpha type | P68371 | TUBB2C | Tubulin beta-4B chain | -0.842 | | P46091 | GPR1 | Chemerin-like receptor 2 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.751 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P49754 | VPS41 | Vacuolar protein sorting-associated protein 41 homolog | 0.824 |
| | Dextromethorphan | hsa05133 | Pertussis | 7.22E-05 | 6 | P0DP23, P10145, P23528, P09871, P0C0L4, Q02556 | CALM1, IL8, CFL1, C1S, C4A, IRF8 | More | | | Dextromethorphan | hsa05134 | Legionellosis | 5.43E-04 | 5 | P11215, P11142, P01375, P09341, P19875 | ITGAM, HSPA8, TNF, CXCL1, CXCL2 | More | | | Dextromethorphan | hsa05135 | Yersinia infection | 4.65E-02 | 5 | P13612, P06239, Q16539, P01375, P49841 | ITGA4, LCK, MAPK14, TNF, GSK3B | More | | | Dextromethorphan | hsa05140 | Leishmaniasis | 5.22E-08 | 11 | O75015, P14598, P42224, P13765, O60603, P25963, P29350, P49006, Q16539, P51617, Q15080 | FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.814 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P14598 | NCF1 | Neutrophil cytosol factor 1 | 1 | | P17252 | PRKCA | Protein kinase C alpha type | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.821 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.798 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.713 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.801 | | P17252 | PRKCA | Protein kinase C alpha type | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.706 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.787 | | P17252 | PRKCA | Protein kinase C alpha type | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.709 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.754 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | O60603 | TLR2 | Toll-like receptor 2 | 0.763 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | | P51684 | CCR6 | C-C chemokine receptor type 6 | O60603 | TLR2 | Toll-like receptor 2 | -0.767 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.864 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.768 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P29350 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | 0.818 | | P17252 | PRKCA | Protein kinase C alpha type | P29350 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | -0.754 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P29350 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | 0.808 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49006 | MARCKSL1 | MARCKS-related protein | -0.852 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P49006 | MARCKSL1 | MARCKS-related protein | 0.727 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.722 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.846 | | P17252 | PRKCA | Protein kinase C alpha type | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.836 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.758 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.803 |
| | Dextromethorphan | hsa05143 | African trypanosomiasis | 2.72E-02 | 2 | P01375, P48023 | TNF, FASLG | More | | | Dextromethorphan | hsa05144 | Malaria | 5.13E-06 | 5 | P60033, O60603, P01375, P35443, P26718 | CD81, TLR2, TNF, THBS4, KLRK1 | More | | | Dextromethorphan | hsa05145 | Toxoplasmosis | 1.11E-02 | 6 | P10415, Q13489, P42224, P13765, O60603, P29965 | BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG | More | | | Dextromethorphan | hsa05146 | Amoebiasis | 1.62E-09 | 13 | P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311 | CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSG | More | | | Dextromethorphan | hsa05150 | Staphylococcus aureus infection | 1.31E-02 | 2 | P0C0L4, P13646 | C4A, KRT13 | More | | | Dextromethorphan | hsa05152 | Tuberculosis | 8.00E-06 | 11 | Q13488, P0DP23, O75015, P42224, P48382, P25208, O60603, P10415, P13765, P01568, Q9UDY8 | TCIRG1, CALM1, FCGR3B, STAT1, RFX5, NFYB, TLR2, BCL2, HLA-DOB, IFNA21, MALT1 | More | | | Dextromethorphan | hsa05160 | Hepatitis C | 1.53E-03 | 5 | P60033, P49841, P01375, P20591, P48023 | CD81, GSK3B, TNF, MX1, FASLG | More | | | Dextromethorphan | hsa05162 | Measles | 4.50E-02 | 1 | P20591 | MX1 | More | | | Dextromethorphan | hsa05163 | Human cytomegalovirus infection | 1.13E-04 | 11 | P42338, P01375, P63218, P50151, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463 | PIK3CB, TNF, GNG5, GNG10, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5 | More | | | Dextromethorphan | hsa05164 | Influenza A | 8.62E-03 | 4 | Q09472, P48551, P29728, P60709 | EP300, IFNAR2, OAS2, ACTB | More | | | Dextromethorphan | hsa05165 | Human papillomavirus infection | 8.49E-04 | 12 | P16144, Q05086, P01568, P42224, P20591, P01889, P10321, Q13488, P30153, Q13362, Q12778, Q13315 | ITGB4, UBE3A, IFNA21, STAT1, MX1, HLA-B, HLA-C, TCIRG1, PPP2R1A, PPP2R5C, FOXO1, ATM | More | | | Dextromethorphan | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 7.21E-06 | 18 | P01568, P42224, P42338, P01889, P10321, P49841, P62873, P62879, P63218, P50151, P16298, Q14643, Q02750, P07948, Q29983, P0DP23, P0CG47, Q9UJU2 | IFNA21, STAT1, PIK3CB, HLA-B, HLA-C, GSK3B, GNB1, GNB2, GNG5, GNG10, PPP3CB, ITPR1, MAP2K1, LYN, MICA, CALM1, UBB, LEF1 | More | | | Dextromethorphan | hsa05168 | Herpes simplex virus 1 infection | 3.41E-06 | 21 | Q9UKJ0, O60603, P25963, P01568, Q05823, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13489, Q13398, P51522, Q9NR11, Q9HCX3, P17097, Q03923, P52738, O75820, Q9UDV6, P10415 | PILRB, TLR2, NFKBIA, IFNA21, RNASEL, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, ZNF211, ZNF83, ZNF302, ZNF304, ZNF7, ZNF85, ZNF140, ZNF189, ZNF212, BCL2 | More | | | Dextromethorphan | hsa05169 | Epstein-Barr virus infection | 8.82E-08 | 19 | P20023, P13765, P01106, Q92769, P04637, Q13546, O00463, P10415, O00232, P30101, Q13761, P24522, P48551, O60603, P29728, P51617, P07766, P09693, P20963 | CR2, HLA-DOB, MYC, HDAC2, TP53, RIPK1, TRAF5, BCL2, PSMD12, PDIA3, RUNX3, GADD45A, IFNAR2, TLR2, OAS2, IRAK1, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P07101 | TH | Tyrosine 3-monooxygenase | P20023 | CR2 | Complement receptor type 2 | 0.827 | | P61225 | RAP2B | Ras-related protein Rap-2b | P20023 | CR2 | Complement receptor type 2 | 0.811 | | P10114 | RAP2A | Ras-related protein Rap-2a | P20023 | CR2 | Complement receptor type 2 | 0.811 | | P61225 | RAP2B | Ras-related protein Rap-2b | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.788 | | P10114 | RAP2A | Ras-related protein Rap-2a | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.788 | | P07101 | TH | Tyrosine 3-monooxygenase | P01106 | MYC | Myc proto-oncogene protein | 0.872 | | P61225 | RAP2B | Ras-related protein Rap-2b | P01106 | MYC | Myc proto-oncogene protein | 0.783 | | P10114 | RAP2A | Ras-related protein Rap-2a | P01106 | MYC | Myc proto-oncogene protein | 0.783 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q92769 | HDAC2 | Histone deacetylase 2 | 0.702 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P04637 | TP53 | Cellular tumor antigen p53 | 0.728 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.868 | | P61225 | RAP2B | Ras-related protein Rap-2b | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.733 | | P10114 | RAP2A | Ras-related protein Rap-2a | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.733 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.84 | | P61225 | RAP2B | Ras-related protein Rap-2b | O00232 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | -0.731 | | P61225 | RAP2B | Ras-related protein Rap-2b | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.743 | | P10114 | RAP2A | Ras-related protein Rap-2a | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.743 | | P61225 | RAP2B | Ras-related protein Rap-2b | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.766 | | P10114 | RAP2A | Ras-related protein Rap-2a | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.766 | | P61225 | RAP2B | Ras-related protein Rap-2b | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.76 | | P10114 | RAP2A | Ras-related protein Rap-2a | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.76 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.712 | | P07101 | TH | Tyrosine 3-monooxygenase | P48551 | IFNAR2 | Interferon alpha/beta receptor 2 | 0.814 | | P51684 | CCR6 | C-C chemokine receptor type 6 | O60603 | TLR2 | Toll-like receptor 2 | -0.767 | | P07101 | TH | Tyrosine 3-monooxygenase | P29728 | OAS2 | 2'-5'-oligoadenylate synthase 2 | 0.754 | | P61225 | RAP2B | Ras-related protein Rap-2b | P29728 | OAS2 | 2'-5'-oligoadenylate synthase 2 | 0.786 | | P10114 | RAP2A | Ras-related protein Rap-2a | P29728 | OAS2 | 2'-5'-oligoadenylate synthase 2 | 0.786 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.722 | | P61225 | RAP2B | Ras-related protein Rap-2b | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.902 | | P10114 | RAP2A | Ras-related protein Rap-2a | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.902 | | P07101 | TH | Tyrosine 3-monooxygenase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.738 | | P61225 | RAP2B | Ras-related protein Rap-2b | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.827 | | P10114 | RAP2A | Ras-related protein Rap-2a | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.827 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.753 | | P61225 | RAP2B | Ras-related protein Rap-2b | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.835 | | P10114 | RAP2A | Ras-related protein Rap-2a | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.835 |
| | Dextromethorphan | hsa05170 | Human immunodeficiency virus 1 infection | 5.94E-07 | 20 | Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q13546, Q14643, P01568, P51617, P25963, O60603, Q13315, P23528, P09693, P10415, Q13619, Q9Y6Q5, P20333 | MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, RIPK1, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CFL1, CD3G, BCL2, CUL4A, AP1M2, TNFRSF1B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P11511 | CYP19A1 | Aromatase | Q02750 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | 0.783 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.877 | | P17252 | PRKCA | Protein kinase C alpha type | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.852 | | P11511 | CYP19A1 | Aromatase | P62879 | GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | 0.704 | | P11511 | CYP19A1 | Aromatase | P16298 | PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | 0.706 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P0DP23 | CALM1 | Calmodulin-1 | 0.854 | | P17252 | PRKCA | Protein kinase C alpha type | P0DP23 | CALM1 | Calmodulin-1 | -0.776 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P0DP23 | CALM1 | Calmodulin-1 | -0.734 | | P11511 | CYP19A1 | Aromatase | Q05397 | PTK2 | Focal adhesion kinase 1 | 0.75 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P17252 | PRKCA | Protein kinase C alpha type | -0.821 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P17252 | PRKCA | Protein kinase C alpha type | 0.738 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.868 | | P17252 | PRKCA | Protein kinase C alpha type | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.786 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.81 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P01568 | IFNA21 | Interferon alpha-21 | -0.854 | | P17252 | PRKCA | Protein kinase C alpha type | P01568 | IFNA21 | Interferon alpha-21 | 0.733 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.722 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.864 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | O60603 | TLR2 | Toll-like receptor 2 | 0.763 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | P51684 | CCR6 | C-C chemokine receptor type 6 | O60603 | TLR2 | Toll-like receptor 2 | -0.767 | | P17252 | PRKCA | Protein kinase C alpha type | Q13315 | ATM | Serine-protein kinase ATM | 0.739 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P23528 | CFL1 | Cofilin-1 | -0.782 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.753 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.844 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | P51684 | CCR6 | C-C chemokine receptor type 6 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.84 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | Q13619 | CUL4A | Cullin-4A | -0.7 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | 0.891 | | P17252 | PRKCA | Protein kinase C alpha type | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.829 | | P51684 | CCR6 | C-C chemokine receptor type 6 | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.86 | | P11511 | CYP19A1 | Aromatase | P20333 | TNFRSF1B | Tumor necrosis factor receptor superfamily member 1B | -0.75 |
| | Dextromethorphan | hsa05171 | Coronavirus disease - COVID-19 | 1.93E-02 | 4 | P48551, P29728, P46777, P50914 | IFNAR2, OAS2, RPL5, RPL14 | More | | | Dextromethorphan | hsa05200 | Pathways in cancer | 4.06E-04 | 23 | P04628, P08238, P42224, P25963, Q9UJU2, P17252, P43246, Q13485, P10826, P14923, P10415, Q13489, P49767, P14921, Q12778, P25116, P62873, Q9UM47, P78417, O75293, P0DP23, P01568, P40189 | WNT1, HSP90AB1, STAT1, NFKBIA, LEF1, PRKCA, MSH2, SMAD4, RARB, JUP, BCL2, BIRC3, VEGFC, ETS1, FOXO1, F2R, GNB1, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL6ST | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P14598 | NCF1 | Neutrophil cytosol factor 1 | P04628 | WNT1 | Proto-oncogene Wnt-1 | -0.755 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.785 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.801 | | P17252 | PRKCA | Protein kinase C alpha type | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.706 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.864 | | P17252 | PRKCA | Protein kinase C alpha type | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.881 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.736 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P17252 | PRKCA | Protein kinase C alpha type | -0.821 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | P46091 | GPR1 | Chemerin-like receptor 2 | P17252 | PRKCA | Protein kinase C alpha type | 0.741 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.811 | | P46091 | GPR1 | Chemerin-like receptor 2 | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.838 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.809 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P10826 | RARB | Retinoic acid receptor beta | 0.785 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P14923 | JUP | Junction plakoglobin | -0.801 | | P17252 | PRKCA | Protein kinase C alpha type | P14923 | JUP | Junction plakoglobin | 0.761 | | P46091 | GPR1 | Chemerin-like receptor 2 | P14923 | JUP | Junction plakoglobin | 0.883 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.844 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | P46091 | GPR1 | Chemerin-like receptor 2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.808 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.816 | | P17252 | PRKCA | Protein kinase C alpha type | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.849 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.759 | | P17252 | PRKCA | Protein kinase C alpha type | P49767 | VEGFC | Vascular endothelial growth factor C | 0.719 | | P46091 | GPR1 | Chemerin-like receptor 2 | P49767 | VEGFC | Vascular endothelial growth factor C | 0.718 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P14921 | ETS1 | Protein C-ets-1 | 0.773 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | Q12778 | FOXO1 | Forkhead box protein O1 | -0.797 | | P17252 | PRKCA | Protein kinase C alpha type | Q12778 | FOXO1 | Forkhead box protein O1 | 0.863 | | P17252 | PRKCA | Protein kinase C alpha type | P25116 | F2R | Proteinase-activated receptor 1 | 0.857 | | P46091 | GPR1 | Chemerin-like receptor 2 | P25116 | F2R | Proteinase-activated receptor 1 | 0.76 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.877 | | P17252 | PRKCA | Protein kinase C alpha type | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.852 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | Q9UM47 | NOTCH3 | Neurogenic locus notch homolog protein 3 | 0.711 | | P46091 | GPR1 | Chemerin-like receptor 2 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | 0.738 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.87 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P0DP23 | CALM1 | Calmodulin-1 | 0.854 | | P17252 | PRKCA | Protein kinase C alpha type | P0DP23 | CALM1 | Calmodulin-1 | -0.776 | | P46091 | GPR1 | Chemerin-like receptor 2 | P0DP23 | CALM1 | Calmodulin-1 | -0.846 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P01568 | IFNA21 | Interferon alpha-21 | -0.854 | | P17252 | PRKCA | Protein kinase C alpha type | P01568 | IFNA21 | Interferon alpha-21 | 0.733 | | P46091 | GPR1 | Chemerin-like receptor 2 | P01568 | IFNA21 | Interferon alpha-21 | 0.724 | | P14598 | NCF1 | Neutrophil cytosol factor 1 | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.703 |
| | Dextromethorphan | hsa05202 | Transcriptional misregulation in cancer | 8.55E-04 | 5 | P27930, P11215, P08069, Q13547, P12980 | IL1R2, ITGAM, IGF1R, HDAC1, LYL1 | More | | | Dextromethorphan | hsa05203 | Viral carcinogenesis | 1.22E-03 | 6 | Q13547, Q15283, P58876, P62807, Q16778, O60814 | HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12 | More | | | Dextromethorphan | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Dextromethorphan | hsa05205 | Proteoglycans in cancer | 1.09E-02 | 6 | P14780, P01375, P08069, P23588, Q13635, P22694 | MMP9, TNF, IGF1R, EIF4B, PTCH1, PRKACB | More | | | Dextromethorphan | hsa05211 | Renal cell carcinoma | 1.67E-02 | 2 | Q09472, Q99814 | EP300, EPAS1 | More | | | Dextromethorphan | hsa05212 | Pancreatic cancer | 3.40E-02 | 1 | P37173 | TGFBR2 | More | | | Dextromethorphan | hsa05213 | Endometrial cancer | 3.79E-02 | 2 | O15169, Q02750 | AXIN1, MAP2K1 | More | | | Dextromethorphan | hsa05214 | Glioma | 1.39E-04 | 6 | P08069, P0DP23, Q16566, P17252, P04637, P24522 | IGF1R, CALM1, CAMK4, PRKCA, TP53, GADD45A | More | | | Dextromethorphan | hsa05215 | Prostate cancer | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Dextromethorphan | hsa05216 | Thyroid cancer | 1.58E-03 | 5 | P01106, Q9UJU2, P04637, P24522, O75293 | MYC, LEF1, TP53, GADD45A, GADD45B | More | | | Dextromethorphan | hsa05217 | Basal cell carcinoma | 4.42E-02 | 3 | Q9UJU2, P04637, P24522 | LEF1, TP53, GADD45A | More | | | Dextromethorphan | hsa05218 | Melanoma | 8.86E-05 | 6 | P08069, P09619, Q9NRA1, Q9GZP0, P42338, Q02750 | IGF1R, PDGFRB, PDGFC, PDGFD, PIK3CB, MAP2K1 | More | | | Dextromethorphan | hsa05219 | Bladder cancer | 4.07E-02 | 2 | P14780, P04637 | MMP9, TP53 | More | | | Dextromethorphan | hsa05223 | Non-small cell lung cancer | 1.39E-02 | 3 | P10826, Q9HC35, O75293 | RARB, EML4, GADD45B | More | | | Dextromethorphan | hsa05224 | Breast cancer | 1.24E-02 | 5 | P08069, P49841, Q92837, P04637, P24522 | IGF1R, GSK3B, FRAT1, TP53, GADD45A | More | | | Dextromethorphan | hsa05225 | Hepatocellular carcinoma | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Dextromethorphan | hsa05226 | Gastric cancer | 3.79E-02 | 2 | Q02750, O15169 | MAP2K1, AXIN1 | More | | | Dextromethorphan | hsa05231 | Choline metabolism in cancer | 9.39E-03 | 4 | Q02750, P09619, Q9GZP0, O15245 | MAP2K1, PDGFRB, PDGFD, SLC22A1 | More | | | Dextromethorphan | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 1.04E-08 | 12 | P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, Q9HC35, P01730 | PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, EML4, CD4 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.716 | | P61225 | RAP2B | Ras-related protein Rap-2b | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.788 | | P10114 | RAP2A | Ras-related protein Rap-2a | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.788 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P52732 | KIF11 | Kinesin-like protein KIF11 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.724 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P61225 | RAP2B | Ras-related protein Rap-2b | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.902 | | P10114 | RAP2A | Ras-related protein Rap-2a | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.902 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P61225 | RAP2B | Ras-related protein Rap-2b | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.835 | | P10114 | RAP2A | Ras-related protein Rap-2a | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.835 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.744 | | P61225 | RAP2B | Ras-related protein Rap-2b | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.827 | | P10114 | RAP2A | Ras-related protein Rap-2a | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.827 | | P52732 | KIF11 | Kinesin-like protein KIF11 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.721 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P61225 | RAP2B | Ras-related protein Rap-2b | P06239 | LCK | Tyrosine-protein kinase Lck | 0.9 | | P10114 | RAP2A | Ras-related protein Rap-2a | P06239 | LCK | Tyrosine-protein kinase Lck | 0.9 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P61225 | RAP2B | Ras-related protein Rap-2b | Q04759 | PRKCQ | Protein kinase C theta type | 0.755 | | P10114 | RAP2A | Ras-related protein Rap-2a | Q04759 | PRKCQ | Protein kinase C theta type | 0.755 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | | P52732 | KIF11 | Kinesin-like protein KIF11 | Q9HC35 | EML4 | Echinoderm microtubule-associated protein-like 4 | 0.794 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.707 | | P52732 | KIF11 | Kinesin-like protein KIF11 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.719 | | P61225 | RAP2B | Ras-related protein Rap-2b | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.784 | | P10114 | RAP2A | Ras-related protein Rap-2a | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.784 |
| | Dextromethorphan | hsa05320 | Autoimmune thyroid disease | 1.35E-04 | 6 | P13765, P29965, P01889, P10321, P01568, P10747 | HLA-DOB, CD40LG, HLA-B, HLA-C, IFNA21, CD28 | More | | | Dextromethorphan | hsa05321 | Inflammatory bowel disease | 1.91E-02 | 3 | P01375, Q14765, Q9UL17 | TNF, STAT4, TBX21 | More | | | Dextromethorphan | hsa05322 | Systemic lupus erythematosus | 1.26E-07 | 15 | P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P12814 | ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1 | More | | | Dextromethorphan | hsa05323 | Rheumatoid arthritis | 4.22E-05 | 9 | P01375, Q06643, P09603, P13765, Q13488, P10747, P09341, P19875, O60603 | TNF, LTB, CSF1, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2 | More | | | Dextromethorphan | hsa05330 | Allograft rejection | 8.32E-05 | 7 | P01889, P10321, P13765, P29965, P48023, P10747, P01375 | HLA-B, HLA-C, HLA-DOB, CD40LG, FASLG, CD28, TNF | More | | | Dextromethorphan | hsa05332 | Graft-versus-host disease | 1.50E-06 | 7 | P13765, P48023, P01889, P10321, P01375, P26715, Q13241 | HLA-DOB, FASLG, HLA-B, HLA-C, TNF, KLRC1, KLRD1 | More | | | Dextromethorphan | hsa05340 | Primary immunodeficiency | 6.82E-06 | 5 | P01730, P01732, P11912, P07766, P06239 | CD4, CD8A, CD79A, CD3E, LCK | More | | | Dextromethorphan | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.71E-03 | 3 | Q8IZS8, P54284, P13612 | CACNA2D3, CACNB3, ITGA4 | More | | | Dextromethorphan | hsa05414 | Dilated cardiomyopathy | 2.21E-04 | 5 | Q8IZS8, P54284, P13612, P09493, P26678 | CACNA2D3, CACNB3, ITGA4, TPM1, PLN | More | | | Dextromethorphan | hsa05415 | Diabetic cardiomyopathy | 5.60E-05 | 8 | P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406 | PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH | More | | | Dextromethorphan | hsa05416 | Viral myocarditis | 3.62E-03 | 5 | P13765, P29965, P01889, P10321, P10747 | HLA-DOB, CD40LG, HLA-B, HLA-C, CD28 | More | | | Dextromethorphan | hsa05418 | Fluid shear stress and atherosclerosis | 2.06E-04 | 12 | Q16539, P78417, P10599, P14780, P01375, P63261, P04637, P10415, P14778, P27930, P0DP23, Q92974 | MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, TP53, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2 | More | |
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