PharmaCoNets of Dextroamphetamine (SPCN: 33.24 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dextroamphetaminehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Dextroamphetaminehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Dextroamphetaminehsa00531Glycosaminoglycan degradation8.18E-042P15586, P34059GNS, GALNSMore
Dextroamphetaminehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate2.92E-021Q9Y2C2USTMore
Dextroamphetaminehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Dextroamphetaminehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Dextroamphetaminehsa00830Retinol metabolism4.25E-021P00325ADH1BMore
Dextroamphetaminehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Dextroamphetaminehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Dextroamphetaminehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Dextroamphetaminehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Dextroamphetaminehsa03008Ribosome biogenesis in eukaryotes2.06E-022Q9NYH9, Q9BVP2UTP6, GNL3More
Dextroamphetaminehsa03015mRNA surveillance pathway1.37E-036Q13362, Q14738, O94913, Q9UBU9, Q9H307, Q13148PPP2R5C, PPP2R5D, PCF11, NXF1, PNN, TARDBPMore
Dextroamphetaminehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Dextroamphetaminehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Dextroamphetaminehsa04020Calcium signaling pathway1.39E-024P30679, O15399, P07550, P23634GNA15, GRIN2D, ADRB2, ATP2B4More
Dextroamphetaminehsa04071Sphingolipid signaling pathway8.46E-047P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Dextroamphetaminehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Dextroamphetaminehsa04114Oocyte meiosis1.25E-037P51812, Q02750, P0DP23, P16298, Q17RY0, Q13362, Q14738RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, PPP2R5C, PPP2R5DMore
Dextroamphetaminehsa04120Ubiquitin mediated proteolysis3.42E-036Q14145, Q13042, P30260, Q13191, P62837, Q15751KEAP1, CDC16, CDC27, CBLB, UBE2D2, HERC1More
Dextroamphetaminehsa04142Lysosome1.14E-023P43234, P15586, P34059CTSO, GNS, GALNSMore
Dextroamphetaminehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Dextroamphetaminehsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Dextroamphetaminehsa04210Apoptosis9.18E-034P04637, P24522, P43234, P63261TP53, GADD45A, CTSO, ACTG1More
Dextroamphetaminehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Dextroamphetaminehsa04261Adrenergic signaling in cardiomyocytes3.75E-036P07550, P22694, P18848, Q13362, Q14738, P0DP23ADRB2, PRKACB, ATF4, PPP2R5C, PPP2R5D, CALM1More
Dextroamphetaminehsa04340Hedgehog signaling pathway1.80E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Dextroamphetaminehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Dextroamphetaminehsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Dextroamphetaminehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Dextroamphetaminehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Dextroamphetaminehsa04650Natural killer cell mediated cytotoxicity3.52E-0510P16298, P50591, P01375, P20963, Q02750, Q13241, P26718, P26717, Q14953, P26715PPP3CB, TNFSF10, TNF, CD247, MAP2K1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Dextroamphetaminehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Dextroamphetaminehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Dextroamphetaminehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Dextroamphetaminehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Dextroamphetaminehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Dextroamphetaminehsa04728Dopaminergic synapse2.66E-023Q13362, Q14738, P0DP23PPP2R5C, PPP2R5D, CALM1More
Dextroamphetaminehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Dextroamphetaminehsa04742Taste transduction1.01E-021P30939HTR1FMore
Dextroamphetaminehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Dextroamphetaminehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Dextroamphetaminehsa04921Oxytocin signaling pathway3.13E-023P0DP23, Q96RR4, Q13469CALM1, CAMKK2, NFATC2More
Dextroamphetaminehsa04924Renin secretion3.43E-033P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Dextroamphetaminehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Dextroamphetaminehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Dextroamphetaminehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Dextroamphetaminehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Dextroamphetaminehsa04966Collecting duct acid secretion1.68E-022P02730, P00918SLC4A1, CA2More
Dextroamphetaminehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Dextroamphetaminehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Dextroamphetaminehsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Dextroamphetaminehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Dextroamphetaminehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Dextroamphetaminehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Dextroamphetaminehsa05033Nicotine addiction1.22E-022P28472, O15399GABRB3, GRIN2DMore
Dextroamphetaminehsa05133Pertussis4.94E-021P0C0L4C4AMore
Dextroamphetaminehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Dextroamphetaminehsa05144Malaria3.02E-034O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Dextroamphetaminehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Dextroamphetaminehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Dextroamphetaminehsa05167Kaposi sarcoma-associated herpesvirus infection2.39E-037P23458, P62879, Q13469, P16298, Q02750, P0DP23, P0CG47JAK1, GNB2, NFATC2, PPP3CB, MAP2K1, CALM1, UBBMore
Dextroamphetaminehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Dextroamphetaminehsa05205Proteoglycans in cancer4.79E-038P63261, P04637, P14780, P01375, P23588, Q06124, Q13635, P22694ACTG1, TP53, MMP9, TNF, EIF4B, PTPN11, PTCH1, PRKACBMore
Dextroamphetaminehsa05211Renal cell carcinoma7.75E-032Q06124, Q99814PTPN11, EPAS1More
Dextroamphetaminehsa05212Pancreatic cancer2.33E-034Q15311, P23458, P04637, P24522RALBP1, JAK1, TP53, GADD45AMore
Dextroamphetaminehsa05213Endometrial cancer2.44E-034O15169, Q02750, P04637, P24522AXIN1, MAP2K1, TP53, GADD45AMore
Dextroamphetaminehsa05214Glioma2.60E-022P04637, P24522TP53, GADD45AMore
Dextroamphetaminehsa05216Thyroid cancer1.14E-022P04637, P24522TP53, GADD45AMore
Dextroamphetaminehsa05217Basal cell carcinoma2.06E-022P04637, P24522TP53, GADD45AMore
Dextroamphetaminehsa05218Melanoma3.41E-045P09619, Q9GZP0, P04637, Q02750, P24522PDGFRB, PDGFD, TP53, MAP2K1, GADD45AMore
Dextroamphetaminehsa05220Chronic myeloid leukemia7.90E-033Q06124, P04637, P24522PTPN11, TP53, GADD45AMore
Dextroamphetaminehsa05223Non-small cell lung cancer3.19E-022P04637, P24522TP53, GADD45AMore
Dextroamphetaminehsa05224Breast cancer4.51E-022P04637, P24522TP53, GADD45AMore
Dextroamphetaminehsa05225Hepatocellular carcinoma3.30E-023P04637, P24522, P63261TP53, GADD45A, ACTG1More
Dextroamphetaminehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Dextroamphetaminehsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Dextroamphetaminehsa05321Inflammatory bowel disease3.02E-034O60603, P01375, Q14765, Q9UL17TLR2, TNF, STAT4, TBX21More
Dextroamphetaminehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Dextroamphetaminehsa05332Graft-versus-host disease5.46E-055P48023, P10747, P01375, P26715, Q13241FASLG, CD28, TNF, KLRC1, KLRD1More
Dextroamphetaminehsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Dextroamphetaminehsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Dextroamphetaminehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Dextroamphetamine (SDC: 3.39)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q9Y4K0LOXL2Lysyl oxidase homolog 2Predicted00.02690.119800.253
P30679GNA15Guanine nucleotideNonebinding protein subunit alphaNone15Predicted00.03730.11460.28910.5369
P15144ANPEPAminopeptidase NPredicted10.18750.23650.29340.8601
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)