PharmaCoNets of Dexmedetomidine (SPCN: 141.58 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dexmedetomidinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Dexmedetomidinehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Dexmedetomidinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Dexmedetomidinehsa00220Arginine biosynthesis1.26E-033P15104, P05089, P49448GLUL, ARG1, GLUD2More
Dexmedetomidinehsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Dexmedetomidinehsa00500Starch and sucrose metabolism8.96E-063O43451, P46976, P06737MGAM, GYG1, PYGLMore
Dexmedetomidinehsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Dexmedetomidinehsa00531Glycosaminoglycan degradation8.18E-042P15586, P34059GNS, GALNSMore
Dexmedetomidinehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate2.92E-021Q9Y2C2USTMore
Dexmedetomidinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Dexmedetomidinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Dexmedetomidinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Dexmedetomidinehsa00730Thiamine metabolism1.44E-032P05186, P24666ALPL, ACP1More
Dexmedetomidinehsa00750Vitamin B6 metabolism3.56E-021O00764PDXKMore
Dexmedetomidinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Dexmedetomidinehsa00830Retinol metabolism2.51E-034P00325, P00352, Q9BPW9, O75911ADH1B, ALDH1A1, DHRS9, DHRS3More
Dexmedetomidinehsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Dexmedetomidinehsa00970Aminoacyl-tRNA biosynthesis2.41E-043O95363, P54136, P14868FARS2, RARS1, DARSMore
Dexmedetomidinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Dexmedetomidinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Dexmedetomidinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Dexmedetomidinehsa012102-Oxocarboxylic acid metabolism3.56E-021P50213IDH3AMore
Dexmedetomidinehsa01230Biosynthesis of amino acids1.16E-034P51854, P60891, P15104, P37837TKTL1, PRPS1, GLUL, TALDO1More
Dexmedetomidinehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Dexmedetomidinehsa01524Platinum drug resistance4.78E-021P31751AKT2More
Dexmedetomidinehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Dexmedetomidinehsa03008Ribosome biogenesis in eukaryotes1.34E-033Q9NYH9, P78345, Q9BVP2UTP6, RPP38, GNL3More
Dexmedetomidinehsa03013RNA transport4.92E-0310P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Dexmedetomidinehsa03015mRNA surveillance pathway1.83E-023Q13362, Q14738, Q9UBU9PPP2R5C, PPP2R5D, NXF1More
Dexmedetomidinehsa03020RNA polymerase9.80E-052Q9GZM3, P52435POLR2J2, POLR2JMore
Dexmedetomidinehsa03050Proteasome9.60E-032P55036, P28074PSMD4, PSMB5More
Dexmedetomidinehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Dexmedetomidinehsa04014Ras signaling pathway7.30E-032P31751, P0DP23AKT2, CALM1More
Dexmedetomidinehsa04015Rap1 signaling pathway6.14E-032P31751, P0DP23AKT2, CALM1More
Dexmedetomidinehsa04022cGMP-PKG signaling pathway5.07E-032P31751, P0DP23AKT2, CALM1More
Dexmedetomidinehsa04024cAMP signaling pathway3.23E-032P31751, P0DP23AKT2, CALM1More
Dexmedetomidinehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Dexmedetomidinehsa04061Viral protein interaction with cytokine and cytokine receptor1.13E-038P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Dexmedetomidinehsa04062Chemokine signaling pathway6.73E-039P25024, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881CXCR1, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITKMore
Dexmedetomidinehsa04064NF-kappa B signaling pathway4.91E-0617P10415, Q13489, P25963, P51617, O00463, P14778, P01375, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q13315, P24522, P09341, Q06643BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, ATM, GADD45A, CXCL1, LTBMore
Dexmedetomidinehsa04071Sphingolipid signaling pathway5.48E-068P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Dexmedetomidinehsa04080Neuroactive ligand-receptor interaction3.10E-0512P08311, P28472, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, P14416, P07550, P35318CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, DRD2, ADRB2, ADMMore
Dexmedetomidinehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Dexmedetomidinehsa04114Oocyte meiosis1.25E-037P51812, Q02750, P0DP23, P16298, Q17RY0, Q13362, Q14738RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, PPP2R5C, PPP2R5DMore
Dexmedetomidinehsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Dexmedetomidinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Dexmedetomidinehsa04142Lysosome1.12E-035Q99437, P43234, P25774, P15586, P34059ATP6V0B, CTSO, CTSS, GNS, GALNSMore
Dexmedetomidinehsa04145Phagosome7.50E-0310Q15080, P14598, Q13509, Q13488, Q99437, P05164, O60603, P35443, P13765, P25774NCF4, NCF1, TUBB3, TCIRG1, ATP6V0B, MPO, TLR2, THBS4, HLA-DOB, CTSSMore
Dexmedetomidinehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Dexmedetomidinehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Dexmedetomidinehsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Dexmedetomidinehsa04210Apoptosis1.42E-0312Q13315, P04637, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, P43234, Q14643, P63261ATM, TP53, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ITPR1, ACTG1More
Dexmedetomidinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Dexmedetomidinehsa04218Cellular senescence2.09E-036P01106, P31751, O75293, P30304, P06493, P0DP23MYC, AKT2, GADD45B, CDC25A, CDK1, CALM1More
Dexmedetomidinehsa04261Adrenergic signaling in cardiomyocytes3.26E-047P07550, P22694, P31751, P18848, Q13362, Q14738, P0DP23ADRB2, PRKACB, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Dexmedetomidinehsa04340Hedgehog signaling pathway3.46E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Dexmedetomidinehsa04360Axon guidance1.66E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Dexmedetomidinehsa04370VEGF signaling pathway3.03E-044P16298, P31751, Q05397, Q02750PPP3CB, AKT2, PTK2, MAP2K1More
Dexmedetomidinehsa04371Apelin signaling pathway3.23E-032P31751, P0DP23AKT2, CALM1More
Dexmedetomidinehsa04380Osteoclast differentiation2.72E-048Q9NQC7, Q9UQC2, Q16539, P31751, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, AKT2, IL1R1, FCGR3B, TNF, LILRA2More
Dexmedetomidinehsa04390Hippo signaling pathway2.30E-023P63261, P04628, O43623ACTG1, WNT1, SNAI2More
Dexmedetomidinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Dexmedetomidinehsa04550Signaling pathways regulating pluripotency of stem cells1.96E-023P04628, P40189, P14653WNT1, IL6ST, HOXB1More
Dexmedetomidinehsa04610Complement and coagulation cascades1.29E-052P00734, P0C0L4F2, C4AMore
Dexmedetomidinehsa04612Antigen processing and presentation4.86E-0710P13765, P48382, P01730, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Dexmedetomidinehsa04613Neutrophil extracellular trap formation3.26E-0821P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Dexmedetomidinehsa04620Toll-like receptor signaling pathway4.78E-021P31751AKT2More
Dexmedetomidinehsa04621NOD-like receptor signaling pathway2.68E-0414Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4More
Dexmedetomidinehsa04622RIG-I-like receptor signaling pathway1.81E-021Q9NQC7CYLDMore
Dexmedetomidinehsa04625C-type lectin receptor signaling pathway2.27E-047Q9ULY5, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Dexmedetomidinehsa04630JAK-STAT signaling pathway4.43E-023P48551, P40189, Q06124IFNAR2, IL6ST, PTPN11More
Dexmedetomidinehsa04640Hematopoietic cell lineage2.49E-0511P13612, P21926, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P09564, P13765ITGA4, CD9, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOBMore
Dexmedetomidinehsa04650Natural killer cell mediated cytotoxicity3.97E-0915P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Dexmedetomidinehsa04657IL-17 signaling pathway2.36E-069O00463, Q16539, P49841, P09341, P19875, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, ANAPC5, LCN2, TNFMore
Dexmedetomidinehsa04658Th1 and Th2 cell differentiation4.07E-0913Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Dexmedetomidinehsa04659Th17 cell differentiation2.51E-0712Q04759, Q16539, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Dexmedetomidinehsa04660T cell receptor signaling pathway2.43E-0616P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Dexmedetomidinehsa04662B cell receptor signaling pathway4.78E-021P31751AKT2More
Dexmedetomidinehsa04664Fc epsilon RI signaling pathway9.49E-034P01375, P31751, Q16539, Q9UQC2TNF, AKT2, MAPK14, GAB2More
Dexmedetomidinehsa04668TNF signaling pathway2.13E-0410P01375, O00463, Q13489, Q16539, P25963, P18848, P19875, P20749, Q13077, P14780TNF, TRAF5, BIRC3, MAPK14, NFKBIA, ATF4, CXCL2, BCL3, TRAF1, MMP9More
Dexmedetomidinehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Dexmedetomidinehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Dexmedetomidinehsa04722Neurotrophin signaling pathway1.26E-035P31751, P49841, O43524, P48023, P0DP23AKT2, GSK3B, FOXO3, FASLG, CALM1More
Dexmedetomidinehsa04728Dopaminergic synapse7.72E-044P31751, Q13362, Q14738, P0DP23AKT2, PPP2R5C, PPP2R5D, CALM1More
Dexmedetomidinehsa04740Olfactory transduction9.46E-042Q9H255, P0DP23OR51E2, CALM1More
Dexmedetomidinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Dexmedetomidinehsa04744Phototransduction1.81E-021P0DP23CALM1More
Dexmedetomidinehsa04910Insulin signaling pathway9.82E-042P0DP23, P31751CALM1, AKT2More
Dexmedetomidinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Dexmedetomidinehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Dexmedetomidinehsa04915Estrogen signaling pathway5.07E-032P31751, P0DP23AKT2, CALM1More
Dexmedetomidinehsa04916Melanogenesis4.78E-021P0DP23CALM1More
Dexmedetomidinehsa04917Prolactin signaling pathway2.41E-021P31751AKT2More
Dexmedetomidinehsa04920Adipocytokine signaling pathway1.22E-025P25963, P33121, Q04759, P31751, P01375NFKBIA, ACSL1, PRKCQ, AKT2, TNFMore
Dexmedetomidinehsa04921Oxytocin signaling pathway3.13E-023P0DP23, Q96RR4, Q13469CALM1, CAMKK2, NFATC2More
Dexmedetomidinehsa04922Glucagon signaling pathway1.79E-032P31751, P0DP23AKT2, CALM1More
Dexmedetomidinehsa04923Regulation of lipolysis in adipocytes3.01E-021P31751AKT2More
Dexmedetomidinehsa04924Renin secretion6.02E-033P22694, P07550, P0DP23PRKACB, ADRB2, CALM1More
Dexmedetomidinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Dexmedetomidinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Dexmedetomidinehsa04929GnRH secretion1.81E-021P31751AKT2More
Dexmedetomidinehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Dexmedetomidinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Dexmedetomidinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Dexmedetomidinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Dexmedetomidinehsa04970Salivary secretion6.99E-046P07550, P22694, Q14643, P17252, P0DP23, P49913ADRB2, PRKACB, ITPR1, PRKCA, CALM1, CAMPMore
Dexmedetomidinehsa04971Gastric acid secretion4.78E-021P0DP23CALM1More
Dexmedetomidinehsa04973Carbohydrate digestion and absorption2.41E-021P31751AKT2More
Dexmedetomidinehsa04976Bile secretion3.87E-023O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Dexmedetomidinehsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Dexmedetomidinehsa05010Alzheimer disease8.59E-043Q00535, P0DP23, P31751CDK5, CALM1, AKT2More
Dexmedetomidinehsa05016Huntington disease1.07E-023Q9GZM3, P52435, P55036POLR2J2, POLR2J, PSMD4More
Dexmedetomidinehsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Dexmedetomidinehsa05022Pathways of neurodegeneration - multiple diseases2.95E-022Q00535, P0DP23CDK5, CALM1More
Dexmedetomidinehsa05030Cocaine addiction4.19E-021Q00535CDK5More
Dexmedetomidinehsa05031Amphetamine addiction6.98E-034P0DP23, P22694, P18848, Q13547CALM1, PRKACB, ATF4, HDAC1More
Dexmedetomidinehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Dexmedetomidinehsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Dexmedetomidinehsa05120Epithelial cell signaling in Helicobacter pylori infection3.87E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Dexmedetomidinehsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Dexmedetomidinehsa05132Salmonella infection2.98E-0211P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3More
Dexmedetomidinehsa05133Pertussis2.64E-032P0DP23, P0C0L4CALM1, C4AMore
Dexmedetomidinehsa05140Leishmaniasis1.10E-0410P13612, O75015, P14598, P13765, O60603, P25963, P01375, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, MAPK14, IRAK1, NCF4More
Dexmedetomidinehsa05143African trypanosomiasis1.11E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Dexmedetomidinehsa05144Malaria6.46E-067P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Dexmedetomidinehsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Dexmedetomidinehsa05146Amoebiasis6.20E-0711P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Dexmedetomidinehsa05152Tuberculosis2.24E-0313Q13488, Q99437, P0DP23, P48382, O60603, P01375, P31751, P10415, P13765, P25774, P49913, Q9UDY8, P51617TCIRG1, ATP6V0B, CALM1, RFX5, TLR2, TNF, AKT2, BCL2, HLA-DOB, CTSS, CAMP, MALT1, IRAK1More
Dexmedetomidinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Dexmedetomidinehsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Dexmedetomidinehsa05163Human cytomegalovirus infection8.39E-038P31751, P01375, P0DP23, P49841, P14778, P25025, Q16539, O00463AKT2, TNF, CALM1, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Dexmedetomidinehsa05167Kaposi sarcoma-associated herpesvirus infection1.44E-048P31751, P23458, P62879, Q13469, P16298, Q02750, P0DP23, P0CG47AKT2, JAK1, GNB2, NFATC2, PPP3CB, MAP2K1, CALM1, UBBMore
Dexmedetomidinehsa05169Epstein-Barr virus infection7.82E-0412P13765, P01106, Q13547, O00463, Q16539, P07948, Q13761, P24522, O60603, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, MAPK14, LYN, RUNX3, GADD45A, TLR2, CD3E, CD3G, CD247More
Dexmedetomidinehsa05170Human immunodeficiency virus 1 infection2.37E-0620P31751, Q02750, P62879, P16298, P0DP23, P01375, Q05397, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5, P20333AKT2, MAP2K1, GNB2, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Dexmedetomidinehsa05200Pathways in cancer3.07E-022P31751, P0DP23AKT2, CALM1More
Dexmedetomidinehsa05202Transcriptional misregulation in cancer1.07E-0620Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Dexmedetomidinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Dexmedetomidinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Dexmedetomidinehsa05205Proteoglycans in cancer4.79E-038P63261, P04637, P14780, P01375, P23588, Q06124, Q13635, P22694ACTG1, TP53, MMP9, TNF, EIF4B, PTPN11, PTCH1, PRKACBMore
Dexmedetomidinehsa05211Renal cell carcinoma1.47E-033Q06124, Q99814, P31751PTPN11, EPAS1, AKT2More
Dexmedetomidinehsa05212Pancreatic cancer3.61E-045P31751, Q15311, P23458, P04637, P24522AKT2, RALBP1, JAK1, TP53, GADD45AMore
Dexmedetomidinehsa05213Endometrial cancer2.88E-045O15169, P31751, Q02750, P04637, P24522AXIN1, AKT2, MAP2K1, TP53, GADD45AMore
Dexmedetomidinehsa05214Glioma1.51E-044P0DP23, P31751, P04637, P24522CALM1, AKT2, TP53, GADD45AMore
Dexmedetomidinehsa05216Thyroid cancer1.08E-034P01106, P04637, P24522, O75293MYC, TP53, GADD45A, GADD45BMore
Dexmedetomidinehsa05217Basal cell carcinoma2.06E-022P04637, P24522TP53, GADD45AMore
Dexmedetomidinehsa05218Melanoma8.68E-043P04637, P31751, P24522TP53, AKT2, GADD45AMore
Dexmedetomidinehsa05220Chronic myeloid leukemia5.62E-044Q06124, P04637, P31751, P24522PTPN11, TP53, AKT2, GADD45AMore
Dexmedetomidinehsa05221Acute myeloid leukemia4.19E-021P31751AKT2More
Dexmedetomidinehsa05222Small cell lung cancer5.10E-037P31751, Q13489, P10415, P25963, Q13077, O00463, P24522AKT2, BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Dexmedetomidinehsa05223Non-small cell lung cancer6.59E-056P31751, P10826, Q9HC35, P04637, P24522, O75293AKT2, RARB, EML4, TP53, GADD45A, GADD45BMore
Dexmedetomidinehsa05224Breast cancer4.51E-022P04637, P24522TP53, GADD45AMore
Dexmedetomidinehsa05225Hepatocellular carcinoma3.30E-023P04637, P24522, P63261TP53, GADD45A, ACTG1More
Dexmedetomidinehsa05226Gastric cancer4.72E-033Q02750, P31751, O15169MAP2K1, AKT2, AXIN1More
Dexmedetomidinehsa05230Central carbon metabolism in cancer4.78E-021P31751AKT2More
Dexmedetomidinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer5.29E-059P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, Q9HC35, P01730CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, EML4, CD4More
Dexmedetomidinehsa05310Asthma3.11E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Dexmedetomidinehsa05321Inflammatory bowel disease9.74E-066O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Dexmedetomidinehsa05322Systemic lupus erythematosus2.09E-0412P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Dexmedetomidinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Dexmedetomidinehsa05332Graft-versus-host disease4.57E-076P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Dexmedetomidinehsa05340Primary immunodeficiency1.31E-045P01730, P01732, P11912, P07766, P06239CD4, CD8A, CD79A, CD3E, LCKMore
Dexmedetomidinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Dexmedetomidinehsa05416Viral myocarditis2.30E-022P10747, P63261CD28, ACTG1More
Dexmedetomidinehsa05418Fluid shear stress and atherosclerosis3.33E-059Q16539, P31751, Q14145, P10599, P14780, P01375, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2, CALM1More

Community members of Dexmedetomidine (SDC: 7.18)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P98170BIRC4E3 ubiquitinNoneprotein ligase XIAPPredicted00.29740.22980.791.3984
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P07384CAPN1CalpainNone1 catalytic subunitPredicted00.0230.14890.60380.9131
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q9Y4K0LOXL2Lysyl oxidase homolog 2Predicted00.02690.119800.253
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
O15164TRIM24Transcription intermediary factor 1NonealphaPredicted00.28070.105500.3514
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)