PharmaCoNets of Dexlansoprazole (SPCN: 146.48 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dexlansoprazolehsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Dexlansoprazolehsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Dexlansoprazolehsa00220Arginine biosynthesis1.21E-021P15104GLULMore
Dexlansoprazolehsa00230Purine metabolism1.56E-023Q7LG56, P51828, Q9Y227RRM2B, ADCY7, ENTPD4More
Dexlansoprazolehsa00240Pyrimidine metabolism1.51E-034Q7LG56, Q9Y227, P21589, P04183RRM2B, ENTPD4, NT5E, TK1More
Dexlansoprazolehsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Dexlansoprazolehsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Dexlansoprazolehsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Dexlansoprazolehsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Dexlansoprazolehsa00500Starch and sucrose metabolism2.33E-083O43451, P46976, P06737MGAM, GYG1, PYGLMore
Dexlansoprazolehsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Dexlansoprazolehsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Dexlansoprazolehsa00564Glycerophospholipid metabolism5.68E-033Q6P1A2, P23743, Q8TCT1MBOAT5, DGKA, PHOSPHO1More
Dexlansoprazolehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Dexlansoprazolehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Dexlansoprazolehsa00630Glyoxylate and dicarboxylate metabolism4.19E-052P40925, P15104MDH1, GLULMore
Dexlansoprazolehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Dexlansoprazolehsa00730Thiamine metabolism1.87E-062P05186, P24666ALPL, ACP1More
Dexlansoprazolehsa00790Folate biosynthesis1.04E-023Q92820, P05186, P42330GGH, ALPL, AKR1C3More
Dexlansoprazolehsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Dexlansoprazolehsa00970Aminoacyl-tRNA biosynthesis1.17E-023O95363, P14868, Q15046FARS2, DARS, KARSMore
Dexlansoprazolehsa00980Metabolism of xenobiotics by cytochrome P4508.28E-064Q16772, P78417, P09211, P11712GSTA3, GSTO1, GSTP1, CYP2C9More
Dexlansoprazolehsa00982Drug metabolism - cytochrome P4501.58E-054P11712, Q16772, P09211, P78417CYP2C9, GSTA3, GSTP1, GSTO1More
Dexlansoprazolehsa00983Drug metabolism - other enzymes1.66E-045P04183, P32320, P05164, Q16772, P09211TK1, CDA, MPO, GSTA3, GSTP1More
Dexlansoprazolehsa01100Metabolic pathways3.55E-0334Q9NR34, P35790, P05089, Q16772, P09211, Q9UJ14, P30041, P32320, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, Q7KZN9, P05186, P24666, P15121, Q9HCC0, P33121, Q9UHK6, Q86VZ5, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q9BQB6MAN1C1, CHKA, ARG1, GSTA3, GSTP1, GGTL3, PRDX6, CDA, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, COX15, ALPL, ACP1, AKR1B1, MCCC2, ACSL1, AMACR, SGMS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, VKORC1More
Dexlansoprazolehsa01230Biosynthesis of amino acids5.53E-032P15104, P37837GLUL, TALDO1More
Dexlansoprazolehsa01523Antifolate resistance2.54E-034P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Dexlansoprazolehsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Dexlansoprazolehsa03013RNA transport4.49E-025P62826, Q9UBU9, P63279, P68104, Q14232RAN, NXF1, UBE2I, EEF1A1, EIF2B1More
Dexlansoprazolehsa03020RNA polymerase6.21E-044P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Dexlansoprazolehsa03040Spliceosome9.99E-0610Q14562, O43143, O60508, P08579, Q13595, Q07955, Q01130, P84103, Q13243, P11142DHX8, DHX15, CDC40, SNRPB2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8More
Dexlansoprazolehsa03050Proteasome4.83E-021P55036PSMD4More
Dexlansoprazolehsa04012ErbB signaling pathway3.15E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Dexlansoprazolehsa04014Ras signaling pathway1.07E-0310P20827, Q9NRA1, P49767, Q13009, Q14644, P0DP23, P62873, P63218, P50151, P19174EFNA1, PDGFC, VEGFC, TIAM1, RASA3, CALM1, GNB1, GNG5, GNG10, PLCG1More
Dexlansoprazolehsa04015Rap1 signaling pathway3.07E-024P25116, Q8TEU7, P08514, P17252F2R, RAPGEF6, ITGA2B, PRKCAMore
Dexlansoprazolehsa04020Calcium signaling pathway6.68E-0510Q08828, Q16566, P30679, O15399, P0DP24, P0DP23, P05141, P51828, P23634, P49767ADCY1, CAMK4, GNA15, GRIN2D, CALM2, CALM1, SLC25A5, ADCY7, ATP2B4, VEGFCMore
Dexlansoprazolehsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Dexlansoprazolehsa04024cAMP signaling pathway5.14E-049Q08828, P51828, P42338, P31751, P0DP24, P0DP23, P23634, Q13370, Q13009ADCY1, ADCY7, PIK3CB, AKT2, CALM2, CALM1, ATP2B4, PDE3B, TIAM1More
Dexlansoprazolehsa04061Viral protein interaction with cytokine and cytokine receptor3.16E-038Q8NHW4, P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P01375CCL4L2, CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, TNFMore
Dexlansoprazolehsa04062Chemokine signaling pathway1.59E-039P07948, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963LYN, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIAMore
Dexlansoprazolehsa04064NF-kappa B signaling pathway4.85E-0411O00463, P14778, P01584, Q13077, Q16548, Q8WV28, P63279, P24522, Q8NHW4, P09341, Q9NQC7TRAF5, IL1R1, IL1B, TRAF1, BCL2A1, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, CYLDMore
Dexlansoprazolehsa04070Phosphatidylinositol signaling system1.13E-048P19174, P0DP23, P42338, O14986, P23743, Q16760, P48426, P27987PLCG1, CALM1, PIK3CB, PIP5K1B, DGKA, DGKD, PIP4K2A, ITPKBMore
Dexlansoprazolehsa04071Sphingolipid signaling pathway9.99E-045Q9H228, P01375, Q13510, Q13362, Q9UQC2EDG8, TNF, ASAH1, PPP2R5C, GAB2More
Dexlansoprazolehsa04072Phospholipase D signaling pathway2.40E-036P31751, O14986, Q15438, Q08828, P51828, Q16760AKT2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Dexlansoprazolehsa04080Neuroactive ligand-receptor interaction1.40E-028P08311, Q15722, P21453, Q9H228, P43657, P21730, P07550, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY5, C5AR1, ADRB2, ADMMore
Dexlansoprazolehsa04110Cell cycle7.05E-058P06493, O60566, O75293, P30304, P33981, P42773, P01106, Q13547CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Dexlansoprazolehsa04114Oocyte meiosis3.70E-047P0DP24, P0DP23, Q08828, P51828, P27348, Q13362, Q14738CALM2, CALM1, ADCY1, ADCY7, YWHAQ, PPP2R5C, PPP2R5DMore
Dexlansoprazolehsa04120Ubiquitin mediated proteolysis4.82E-032Q9UBT2, Q14669SAE2, TRIP12More
Dexlansoprazolehsa04140Autophagy - animal1.71E-025P31751, Q7L523, O75460, Q96GC9, Q8TEV9AKT2, RRAGA, ERN1, TMEM49, SMCR8More
Dexlansoprazolehsa04141Protein processing in endoplasmic reticulum8.60E-036P30101, P60604, P11142, P08238, Q9H173, Q9UNL2PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3More
Dexlansoprazolehsa04142Lysosome2.08E-036Q99437, P25774, P22304, Q13510, Q04900, Q9Y227ATP6V0B, CTSS, IDS, ASAH1, CD164, ENTPD4More
Dexlansoprazolehsa04144Endocytosis2.25E-025O75351, P42566, Q15438, Q14161, Q9UNH7VPS4B, EPS15, PSCD1, GIT2, SNX6More
Dexlansoprazolehsa04145Phagosome2.53E-038P11215, P14598, Q71U36, Q13509, P68371, Q13488, Q99437, P25774ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, ATP6V0B, CTSSMore
Dexlansoprazolehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Dexlansoprazolehsa04211Longevity regulating pathway1.88E-024P31751, Q08828, P51828, P18848AKT2, ADCY1, ADCY7, ATF4More
Dexlansoprazolehsa04213Longevity regulating pathway - multiple species4.07E-035P31751, Q9Y4H2, Q08828, P51828, Q13547AKT2, IRS2, ADCY1, ADCY7, HDAC1More
Dexlansoprazolehsa04261Adrenergic signaling in cardiomyocytes1.71E-059Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP24, P0DP23, P23634ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM2, CALM1, ATP2B4More
Dexlansoprazolehsa04270Vascular smooth muscle contraction3.82E-025P24723, Q04759, Q14643, P22694, P35318PRKCH, PRKCQ, ITPR1, PRKACB, ADMMore
Dexlansoprazolehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Dexlansoprazolehsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Dexlansoprazolehsa04371Apelin signaling pathway1.56E-0512P62873, P63218, P50151, P31751, Q08828, P51828, Q13370, Q14344, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, AKT2, ADCY1, ADCY7, PDE3B, GNA13, SMAD4, SMAD3, CAMK4, CALM1More
Dexlansoprazolehsa04380Osteoclast differentiation5.27E-0410Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Dexlansoprazolehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Dexlansoprazolehsa04540Gap junction1.08E-024Q13509, P68371, Q71U36, Q9NRA1TUBB3, TUBB2C, TUBA1A, PDGFCMore
Dexlansoprazolehsa04610Complement and coagulation cascades4.48E-023P01042, P09871, P11215KNG1, C1S, ITGAMMore
Dexlansoprazolehsa04611Platelet activation3.39E-023P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Dexlansoprazolehsa04612Antigen processing and presentation5.27E-049P13765, P48382, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNFMore
Dexlansoprazolehsa04613Neutrophil extracellular trap formation1.02E-048P11215, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431ITGAM, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Dexlansoprazolehsa04620Toll-like receptor signaling pathway2.54E-033P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Dexlansoprazolehsa04623Cytosolic DNA-sensing pathway1.25E-055P01584, P01568, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, NFKBIA, POLR3H, CCL4L2More
Dexlansoprazolehsa04625C-type lectin receptor signaling pathway1.14E-038Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Dexlansoprazolehsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Dexlansoprazolehsa04640Hematopoietic cell lineage2.50E-0311P13612, P27930, P15144, P25063, P09693, P01732, P01730, P06127, P09564, P13765, P01375ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNFMore
Dexlansoprazolehsa04650Natural killer cell mediated cytotoxicity5.68E-0611P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, Q07444, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC3, KLRC1More
Dexlansoprazolehsa04657IL-17 signaling pathway2.18E-046O00463, Q16539, P49841, P09341, P14780, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNFMore
Dexlansoprazolehsa04658Th1 and Th2 cell differentiation6.56E-0915Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Dexlansoprazolehsa04659Th17 cell differentiation6.61E-0818P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P84022, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, HSP90AB1, CD3E, CD3G, CD247More
Dexlansoprazolehsa04660T cell receptor signaling pathway1.08E-0415P01375, Q04759, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Dexlansoprazolehsa04664Fc epsilon RI signaling pathway7.09E-047P01375, P04141, Q16539, Q9UQC2, P07948, P19174, P09917TNF, CSF2, MAPK14, GAB2, LYN, PLCG1, ALOX5More
Dexlansoprazolehsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Dexlansoprazolehsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Dexlansoprazolehsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Dexlansoprazolehsa04713Circadian entrainment2.39E-036P0DP23, P62873, P63218, P50151, Q08828, P51828CALM1, GNB1, GNG5, GNG10, ADCY1, ADCY7More
Dexlansoprazolehsa04720Long-term potentiation1.95E-035Q16566, P0DP23, P18848, O15399, Q08828CAMK4, CALM1, ATF4, GRIN2D, ADCY1More
Dexlansoprazolehsa04724Glutamatergic synapse1.74E-036O15399, P62873, P63218, P50151, P15104, Q9NSB8GRIN2D, GNB1, GNG5, GNG10, GLUL, HOMER2More
Dexlansoprazolehsa04725Cholinergic synapse1.39E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Dexlansoprazolehsa04726Serotonergic synapse3.80E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Dexlansoprazolehsa04727GABAergic synapse4.18E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Dexlansoprazolehsa04728Dopaminergic synapse7.83E-035P31751, P18848, Q13362, Q14738, P0DP23AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Dexlansoprazolehsa04730Long-term depression4.86E-022Q14344, P07948GNA13, LYNMore
Dexlansoprazolehsa04744Phototransduction9.21E-032P62873, P0DP23GNB1, CALM1More
Dexlansoprazolehsa04750Inflammatory mediator regulation of TRP channels9.86E-034P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Dexlansoprazolehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Dexlansoprazolehsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Dexlansoprazolehsa04912GnRH signaling pathway7.29E-046Q08828, P51828, P18848, P0DP24, P0DP23, P45985ADCY1, ADCY7, ATF4, CALM2, CALM1, MAP2K4More
Dexlansoprazolehsa04914Progesterone-mediated oocyte maturation3.92E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Dexlansoprazolehsa04915Estrogen signaling pathway2.13E-025P18848, Q08828, P51828, P31751, P0DP23ATF4, ADCY1, ADCY7, AKT2, CALM1More
Dexlansoprazolehsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Dexlansoprazolehsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Dexlansoprazolehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Dexlansoprazolehsa04923Regulation of lipolysis in adipocytes5.15E-033Q08828, P51828, P31751ADCY1, ADCY7, AKT2More
Dexlansoprazolehsa04924Renin secretion1.94E-035P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Dexlansoprazolehsa04925Aldosterone synthesis and secretion3.67E-057P18848, Q08828, P51828, P0DP24, P0DP23, Q16566, P23634ATF4, ADCY1, ADCY7, CALM2, CALM1, CAMK4, ATP2B4More
Dexlansoprazolehsa04926Relaxin signaling pathway2.46E-024P31751, P18848, Q08828, P51828AKT2, ATF4, ADCY1, ADCY7More
Dexlansoprazolehsa04927Cortisol synthesis and secretion1.59E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Dexlansoprazolehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Dexlansoprazolehsa04932Non-alcoholic fatty liver disease1.04E-025P31751, P18848, O75460, P01584, O95298AKT2, ATF4, ERN1, IL1B, NDUFC2More
Dexlansoprazolehsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Dexlansoprazolehsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Dexlansoprazolehsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Dexlansoprazolehsa04970Salivary secretion1.73E-055Q08828, P51828, P23634, P0DP24, P0DP23ADCY1, ADCY7, ATP2B4, CALM2, CALM1More
Dexlansoprazolehsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Dexlansoprazolehsa04972Pancreatic secretion4.94E-033P23634, P51828, P62491ATP2B4, ADCY7, RAB11AMore
Dexlansoprazolehsa04976Bile secretion7.23E-045Q08828, P51828, P22694, P08183, Q14032ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Dexlansoprazolehsa05010Alzheimer disease4.94E-039O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4More
Dexlansoprazolehsa05012Parkinson disease1.77E-026P60604, P19174, P0DP23, Q71U36, Q13509, P68371UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2CMore
Dexlansoprazolehsa05016Huntington disease2.24E-027O95298, P24928, P30876, P62487, P05141, O75460, P28070NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Dexlansoprazolehsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Dexlansoprazolehsa05022Pathways of neurodegeneration - multiple diseases1.67E-029O95298, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, P28070NDUFC2, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, PSMB4More
Dexlansoprazolehsa05032Morphine addiction2.18E-024P62873, P63218, P50151, Q13370GNB1, GNG5, GNG10, PDE3BMore
Dexlansoprazolehsa05034Alcoholism1.53E-0611O15399, Q16566, Q13547, P0DP23, P63218, Q93077, P58876, P62807, Q16778, O60814, P68431GRIN2D, CAMK4, HDAC1, CALM1, GNG5, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Dexlansoprazolehsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Dexlansoprazolehsa05120Epithelial cell signaling in Helicobacter pylori infection6.88E-048Q16539, P25963, Q13488, P09341, P19174, P25024, P25025, P07948MAPK14, NFKBIA, TCIRG1, CXCL1, PLCG1, CXCR1, CXCR2, LYNMore
Dexlansoprazolehsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Dexlansoprazolehsa05132Salmonella infection2.75E-027P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41More
Dexlansoprazolehsa05133Pertussis1.70E-034P11215, P0DP23, P23528, P09871ITGAM, CALM1, CFL1, C1SMore
Dexlansoprazolehsa05134Legionellosis4.75E-023P25963, P11215, P11142NFKBIA, ITGAM, HSPA8More
Dexlansoprazolehsa05140Leishmaniasis3.37E-039O75015, P14598, P11215, P42224, P13765, O60603, P25963, P49006, Q16539FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, MARCKSL1, MAPK14More
Dexlansoprazolehsa05144Malaria1.20E-034P60033, O60603, P35443, P26718CD81, TLR2, THBS4, KLRK1More
Dexlansoprazolehsa05146Amoebiasis8.26E-049P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSGMore
Dexlansoprazolehsa05150Staphylococcus aureus infection1.91E-024Q14532, P59665, P59666, P49913KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Dexlansoprazolehsa05152Tuberculosis4.16E-022Q99437, P25774ATP6V0B, CTSSMore
Dexlansoprazolehsa05163Human cytomegalovirus infection4.22E-0824P31751, P01375, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101, P01568AKT2, TNF, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3, IFNA21More
Dexlansoprazolehsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Dexlansoprazolehsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Dexlansoprazolehsa05167Kaposi sarcoma-associated herpesvirus infection8.62E-0510P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1More
Dexlansoprazolehsa05168Herpes simplex virus 1 infection2.66E-0416P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212More
Dexlansoprazolehsa05169Epstein-Barr virus infection4.41E-028P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247More
Dexlansoprazolehsa05170Human immunodeficiency virus 1 infection1.19E-028P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1More
Dexlansoprazolehsa05200Pathways in cancer2.98E-0418P42338, P08238, P42224, P25963, P19174, P43246, P84022, P20585, P14923, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784, P40189PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, JUP, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Dexlansoprazolehsa05202Transcriptional misregulation in cancer2.87E-0312P14780, P27930, Q15744, Q16548, P11215, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Dexlansoprazolehsa05203Viral carcinogenesis2.10E-048Q12933, P42229, Q13547, Q15283, P58876, P62807, Q16778, O60814TRAF2, STAT5A, HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Dexlansoprazolehsa05204Chemical carcinogenesis2.81E-054Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Dexlansoprazolehsa05205Proteoglycans in cancer4.46E-024Q12955, Q14247, P17252, P08962ANK3, CTTN, PRKCA, CD63More
Dexlansoprazolehsa05212Pancreatic cancer1.31E-047P42338, P31751, Q15311, P23458, P42224, P84022, O75293PIK3CB, AKT2, RALBP1, JAK1, STAT1, SMAD3, GADD45BMore
Dexlansoprazolehsa05214Glioma2.11E-034P0DP23, P42338, P19174, O75293CALM1, PIK3CB, PLCG1, GADD45BMore
Dexlansoprazolehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Dexlansoprazolehsa05223Non-small cell lung cancer4.24E-023P19174, Q9HC35, O75293PLCG1, EML4, GADD45BMore
Dexlansoprazolehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Dexlansoprazolehsa05231Choline metabolism in cancer3.32E-036P31751, Q9Y259, P19174, P49619, Q16760, O14986AKT2, CHKB, PLCG1, DGKG, DGKD, PIP5K1BMore
Dexlansoprazolehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.47E-0511O95267, P19174, P07766, P20963, P09693, P06239, P42224, O60603, Q16539, Q9HC35, P01730RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, MAPK14, EML4, CD4More
Dexlansoprazolehsa05310Asthma3.47E-044P13765, P29965, P12724, P01375HLA-DOB, CD40LG, RNASE3, TNFMore
Dexlansoprazolehsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Dexlansoprazolehsa05321Inflammatory bowel disease4.38E-035P01375, P13765, Q14765, Q9UL17, P23771TNF, HLA-DOB, STAT4, TBX21, GATA3More
Dexlansoprazolehsa05322Systemic lupus erythematosus5.29E-0613O75015, P08246, P08311, P09871, P01375, P13765, Q93077, P58876, P62807, Q16778, O60814, P68431, P12814FCGR3B, ELA2, CTSG, C1S, TNF, HLA-DOB, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1More
Dexlansoprazolehsa05330Allograft rejection3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Dexlansoprazolehsa05332Graft-versus-host disease9.99E-034P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Dexlansoprazolehsa05340Primary immunodeficiency4.24E-023P01730, P07766, P06239CD4, CD3E, LCKMore
Dexlansoprazolehsa05412Arrhythmogenic right ventricular cardiomyopathy1.82E-023P14923, P08514, Q9UJU2JUP, ITGA2B, LEF1More
Dexlansoprazolehsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore
Dexlansoprazolehsa05418Fluid shear stress and atherosclerosis1.56E-0512Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Dexlansoprazole (SDC: 6.52)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q8TCT1PHOSPHO1Phosphoethanolamine/phosphocholine phosphatasePredicted00.35580.04750.15910.432
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P08575PTPRCReceptorNonetype tyrosineNoneprotein phosphatase CPredicted10.27330.13580.41320.8216
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P78417GSTO1Glutathione SNonetransferase omegaNone1Predicted00.41090.13990.4250.9103
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P30304CDC25AMNonephase inducer phosphatase 1Predicted00.17950.23470.42740.9865
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)