PharmaCoNets

PharmaCoNets of Dexibuprofen (S_PCN: 73.21 )

Dexibuprofen regulated-network (S_DN: 15.38)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Dexibuprofen

hsa00030

Pentose phosphate pathway

5.07E-03

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Dexibuprofen

hsa00071

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Dexibuprofen

hsa00190

Oxidative phosphorylation

1.39E-03

Q16718, Q13488, P36542, O14521

NDUFA5, TCIRG1, ATP5C1, SDHD

Dexibuprofen

hsa00220

Arginine biosynthesis

1.54E-02

P05089, P49448

ARG1, GLUD2

Dexibuprofen

hsa00230

Purine metabolism

1.81E-02

P20839, Q02153

IMPDH1, GUCY1B3

Dexibuprofen

hsa00260

Glycine, serine and threonine metabolism

1.99E-02

P22557

ALAS2

Dexibuprofen

hsa00500

Starch and sucrose metabolism

1.97E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Dexibuprofen

hsa00510

N-Glycan biosynthesis

1.00E-02

O94777, Q9BVK2

DPM2, ALG8

Dexibuprofen

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Dexibuprofen

hsa00561

Glycerolipid metabolism

3.09E-02

P14550, Q86XP1

AKR1A1, DGKH

Dexibuprofen

hsa00563

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

3.47E-03

O94777, Q14442

DPM2, PIGH

Dexibuprofen

hsa00565

Ether lipid metabolism

2.31E-04

Q9Y6K0, Q8N661

CEPT1, TMEM86B

Dexibuprofen

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Dexibuprofen

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Dexibuprofen

hsa00600

Sphingolipid metabolism

4.63E-04

Q9BX95, Q96G23, O14494, Q06136, P06280, Q86VZ5

SGPP1, LASS2, PLPP1, FVT1, GLA, SGMS1

Dexibuprofen

hsa00630

Glyoxylate and dicarboxylate metabolism

1.29E-02

P40925, P15104

MDH1, GLUL

Dexibuprofen

hsa00785

Lipoic acid metabolism

4.32E-02

Q9Y234

LIPT1

Dexibuprofen

hsa00910

Nitrogen metabolism

2.93E-02

P22748, P49448

CA4, GLUD2

Dexibuprofen

hsa00970

Aminoacyl-tRNA biosynthesis

6.79E-06

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Dexibuprofen

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Dexibuprofen

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Dexibuprofen

hsa00983

Drug metabolism - other enzymes

2.58E-04

P04183, P32320, P05164

TK1, CDA, MPO

Dexibuprofen

hsa01100

Metabolic pathways

6.91E-04

Q9Y234, Q6ZQY3, P20839, O94777, Q9Y6K0, Q86XP1, P14550, Q9UHK6, Q86VZ5, Q96G23, Q9BVK2, Q14442, Q06055, Q99437, Q9NVH6

LIPT1, GADL1, IMPDH1, DPM2, CEPT1, DGKH, AKR1A1, AMACR, SGMS1, LASS2, ALG8, PIGH, ATP5G2, ATP6V0B, TMLHE

Dexibuprofen

hsa03010

Ribosome

1.88E-02

P62753, P25398, P32969, P62829, P18077, P36578

RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4

Dexibuprofen

hsa03013

RNA transport

3.81E-06

O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, P47813, Q14152, O75822, P78345, Q14240, Q9BZI7, Q9Y6A5, Q06787, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, RPP38, EIF4A2, UPF3B, TACC3, FMR1, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14980	XPO1	Exportin-1	0.799
P10415	BCL2	Apoptosis regulator Bcl-2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.888
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.956
P10415	BCL2	Apoptosis regulator Bcl-2	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.742
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.771
P10415	BCL2	Apoptosis regulator Bcl-2	O14893	GEMIN2	Gem-associated protein 2	0.853
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14893	GEMIN2	Gem-associated protein 2	0.72
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O14893	GEMIN2	Gem-associated protein 2	0.925
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P61326	MAGOH	Protein mago nashi homolog	0.761
P10415	BCL2	Apoptosis regulator Bcl-2	Q7Z3B4	NUP54	Nucleoporin p54	0.774
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q7Z3B4	NUP54	Nucleoporin p54	0.883
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q7Z3B4	NUP54	Nucleoporin p54	0.854
P10415	BCL2	Apoptosis regulator Bcl-2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.751
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.708
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.79
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.844
P10415	BCL2	Apoptosis regulator Bcl-2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.734
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.869
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.715
P10415	BCL2	Apoptosis regulator Bcl-2	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.837
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.77
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.793
P10415	BCL2	Apoptosis regulator Bcl-2	P78345	RPP38	Ribonuclease P protein subunit p38	0.852
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P78345	RPP38	Ribonuclease P protein subunit p38	0.819
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.849
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.764
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.812
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.891
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q06787	FMR1	Synaptic functional regulator FMR1	0.863
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.798

Dexibuprofen

hsa03020

RNA polymerase

3.59E-02

P30876, P62487

POLR2B, POLR2G

Dexibuprofen

hsa03022

Basal transcription factors

3.50E-02

P20226, O00268, Q15544

TBP, TAF4, TAF11

Dexibuprofen

hsa03040

Spliceosome

1.28E-05

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Dexibuprofen

hsa03060

Protein export

4.22E-02

P37108, Q15005

SRP14, SPCS2

Dexibuprofen

hsa03450

Non-homologous end-joining

4.32E-02

Q9NP87

POLM

Dexibuprofen

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Dexibuprofen

hsa04015

Rap1 signaling pathway

1.66E-03

P20827, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P08514, P19174

EFNA1, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, ITGA2B, PLCG1

Dexibuprofen

hsa04020

Calcium signaling pathway

1.39E-02

Q16566, Q15746, P25116, P49767

CAMK4, MYLK, F2R, VEGFC

Dexibuprofen

hsa04060

Cytokine-cytokine receptor interaction

1.74E-04

P14784, P27930, P14778, P08476, P26842, Q06643, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, P01375, P09341, P19875, P18510, P01730, Q93038

IL2RB, IL1R2, IL1R1, INHBA, CD27, LTB, IL10RA, IL21R, CXCR1, XCL2, XCL1, TNF, CXCL1, CXCL2, IL1RN, CD4, TNFRSF25

Dexibuprofen

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.97E-06

Q8NHW4, P09341, P19875, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P14784, P01375

CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, IL2RB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P51124	GZMM	Granzyme M	P09341	CXCL1	Growth-regulated alpha protein	-0.733
P49863	GZMK	Granzyme K	P09341	CXCL1	Growth-regulated alpha protein	-0.846
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P51124	GZMM	Granzyme M	P19875	CXCL2	C-X-C motif chemokine 2	-0.739
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P51124	GZMM	Granzyme M	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.737
P49863	GZMK	Granzyme K	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.793
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P49863	GZMK	Granzyme K	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.798
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P61073	CXCR4	C-X-C chemokine receptor type 4	0.774
P49863	GZMK	Granzyme K	P47992	XCL1	Lymphotactin	0.788
P08311	CTSG	Cathepsin G	P47992	XCL1	Lymphotactin	-0.823
P49863	GZMK	Granzyme K	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.788
P08311	CTSG	Cathepsin G	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.823
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.769
P51124	GZMM	Granzyme M	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.778
P49863	GZMK	Granzyme K	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.74
P08311	CTSG	Cathepsin G	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.736
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P51124	GZMM	Granzyme M	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.887
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733

Dexibuprofen

hsa04062

Chemokine signaling pathway

1.25E-05

P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
P51124	GZMM	Granzyme M	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.737
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P51124	GZMM	Granzyme M	P09341	CXCL1	Growth-regulated alpha protein	-0.733
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P51124	GZMM	Granzyme M	P19875	CXCL2	C-X-C motif chemokine 2	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P51124	GZMM	Granzyme M	P07948	LYN	Tyrosine-protein kinase Lyn	-0.76
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P51124	GZMM	Granzyme M	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.845
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P51124	GZMM	Granzyme M	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P51124	GZMM	Granzyme M	P43250	GRK6	G protein-coupled receptor kinase 6	-0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Dexibuprofen

hsa04064

NF-kappa B signaling pathway

1.35E-10

P10415, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, P67870, Q16548, P07948, P06239, Q13315, P63279, P24522, O75293, Q8NHW4, P09341, P19875, Q06643, Q9NQC7

BCL2, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, CSNK2B, BCL2A1, LYN, LCK, ATM, UBE2I, GADD45A, GADD45B, CCL4L2, CXCL1, CXCL2, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P24158	PRTN3	Myeloblastin	P10415	BCL2	Apoptosis regulator Bcl-2	-0.787
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P24158	PRTN3	Myeloblastin	O00463	TRAF5	TNF receptor-associated factor 5	-0.8
P08311	CTSG	Cathepsin G	O00463	TRAF5	TNF receptor-associated factor 5	-0.853
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P51124	GZMM	Granzyme M	P14778	IL1R1	Interleukin-1 receptor type 1	-0.886
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P01584	IL1B	Interleukin-1 beta	0.762
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P24158	PRTN3	Myeloblastin	Q04759	PRKCQ	Protein kinase C theta type	-0.845
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P24158	PRTN3	Myeloblastin	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.733
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P67870	CSNK2B	Casein kinase II subunit beta	0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P24158	PRTN3	Myeloblastin	Q16548	BCL2A1	Bcl-2-related protein A1	0.802
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
P51124	GZMM	Granzyme M	P07948	LYN	Tyrosine-protein kinase Lyn	-0.76
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P24158	PRTN3	Myeloblastin	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.772
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P51124	GZMM	Granzyme M	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.78
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.727
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P24158	PRTN3	Myeloblastin	P09341	CXCL1	Growth-regulated alpha protein	0.751
P51124	GZMM	Granzyme M	P09341	CXCL1	Growth-regulated alpha protein	-0.733
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P51124	GZMM	Granzyme M	P19875	CXCL2	C-X-C motif chemokine 2	-0.739
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P51124	GZMM	Granzyme M	Q06643	LTB	Lymphotoxin-beta	0.811
P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.763

Dexibuprofen

hsa04071

Sphingolipid signaling pathway

1.14E-04

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2

Dexibuprofen

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Dexibuprofen

hsa04080

Neuroactive ligand-receptor interaction

1.96E-04

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2

Dexibuprofen

hsa04120

Ubiquitin mediated proteolysis

2.89E-02

O95071, P0CG47

UBR5, UBB

Dexibuprofen

hsa04137

Mitophagy - animal

9.52E-03

Q07817, P0CG47

BCL2L1, UBB

Dexibuprofen

hsa04140

Autophagy - animal

3.19E-02

P22694, Q14643, P10415, Q04759

PRKACB, ITPR1, BCL2, PRKCQ

Dexibuprofen

hsa04141

Protein processing in endoplasmic reticulum

4.88E-02

P18848, O60337, P11142, P07900

ATF4, MARH6, HSPA8, HSP90AA1

Dexibuprofen

hsa04145

Phagosome

3.04E-07

Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10415	BCL2	Apoptosis regulator Bcl-2	Q15080	NCF4	Neutrophil cytosol factor 4	-0.951
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q15080	NCF4	Neutrophil cytosol factor 4	-0.919
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P24158	PRTN3	Myeloblastin	Q15080	NCF4	Neutrophil cytosol factor 4	0.815
P10415	BCL2	Apoptosis regulator Bcl-2	P14598	NCF1	Neutrophil cytosol factor 1	-0.844
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14598	NCF1	Neutrophil cytosol factor 1	-0.857
P10415	BCL2	Apoptosis regulator Bcl-2	Q13509	TUBB3	Tubulin beta-3 chain	-0.809
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13509	TUBB3	Tubulin beta-3 chain	-0.846
P10415	BCL2	Apoptosis regulator Bcl-2	P68371	TUBB2C	Tubulin beta-4B chain	-0.766
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P68371	TUBB2C	Tubulin beta-4B chain	-0.783
P10415	BCL2	Apoptosis regulator Bcl-2	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.718
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.716
P10415	BCL2	Apoptosis regulator Bcl-2	P05164	MPO	Myeloperoxidase	-0.81
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P05164	MPO	Myeloperoxidase	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P24158	PRTN3	Myeloblastin	P05164	MPO	Myeloperoxidase	0.979
P24158	PRTN3	Myeloblastin	P78380	OLR1	Oxidized low-density lipoprotein receptor 1	0.736
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
P10415	BCL2	Apoptosis regulator Bcl-2	P35443	THBS4	Thrombospondin-4	-0.765
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35443	THBS4	Thrombospondin-4	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P24158	PRTN3	Myeloblastin	P35443	THBS4	Thrombospondin-4	0.935
P10415	BCL2	Apoptosis regulator Bcl-2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P24158	PRTN3	Myeloblastin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.796

Dexibuprofen

hsa04146

Peroxisome

4.83E-02

O96011, P56589, Q9UKG9, O75521

PEX11B, PEX3, CROT, ECI2

Dexibuprofen

hsa04151

PI3K-Akt signaling pathway

3.70E-02

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Dexibuprofen

hsa04210

Apoptosis

2.63E-03

Q13315, P10415, O76075, P01375, P24522, Q16548, P43234, P18848, Q14643

ATM, BCL2, DFFB, TNF, GADD45A, BCL2A1, CTSO, ATF4, ITPR1

Dexibuprofen

hsa04213

Longevity regulating pathway - multiple species

3.66E-03

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Dexibuprofen

hsa04217

Necroptosis

3.28E-05

P01568, Q13489, Q13546, P07900, P15104, P05141, P01584, P0C0S5, Q6FI13, Q13557

IFNA21, BIRC3, RIPK1, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, CAMK2D

Dexibuprofen

hsa04260

Cardiac muscle contraction

4.49E-02

P67936, P13073, P12074

TPM4, COX4I1, COX6A1

Dexibuprofen

hsa04330

Notch signaling pathway

3.09E-02

P49768, P78504

PSEN1, JAG1

Dexibuprofen

hsa04340

Hedgehog signaling pathway

3.16E-03

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Dexibuprofen

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Dexibuprofen

hsa04371

Apelin signaling pathway

1.39E-03

P63218, P50151, Q8WYR1, Q15746, Q14814, Q14344, Q13485, P84022, Q16566

GNG5, GNG10, PIK3R5, MYLK, MEF2D, GNA13, SMAD4, SMAD3, CAMK4

Dexibuprofen

hsa04390

Hippo signaling pathway

5.79E-03

P04628, Q9UJU2, O43623, Q13489

WNT1, LEF1, SNAI2, BIRC3

Dexibuprofen

hsa04514

Cell adhesion molecules

2.43E-02

P16109, P29965, O00501

SELP, CD40LG, CLDN5

Dexibuprofen

hsa04530

Tight junction

6.92E-04

Q8TEU7, P16989, P56750, O00501, Q92974, Q14247

RAPGEF6, CSDA, CLDN17, CLDN5, ARHGEF2, CTTN

Dexibuprofen

hsa04611

Platelet activation

3.72E-04

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Dexibuprofen

hsa04612

Antigen processing and presentation

6.76E-08

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P24158	PRTN3	Myeloblastin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.796
P49863	GZMK	Granzyme K	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.882
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P24158	PRTN3	Myeloblastin	P48382	RFX5	DNA-binding protein RFX5	-0.87
P49863	GZMK	Granzyme K	P48382	RFX5	DNA-binding protein RFX5	0.796
P08311	CTSG	Cathepsin G	P48382	RFX5	DNA-binding protein RFX5	-0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P24158	PRTN3	Myeloblastin	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
P49863	GZMK	Granzyme K	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.891
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P24158	PRTN3	Myeloblastin	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.77
P49863	GZMK	Granzyme K	P26717	KLRC2	NKG2-C type II integral membrane protein	0.891
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P24158	PRTN3	Myeloblastin	Q13241	KLRD1	Natural killer cells antigen CD94	-0.732
P49863	GZMK	Granzyme K	Q13241	KLRD1	Natural killer cells antigen CD94	0.809
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P49863	GZMK	Granzyme K	O43908	KLRC4	NKG2-F type II integral membrane protein	0.702
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P24158	PRTN3	Myeloblastin	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.767
P49863	GZMK	Granzyme K	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.784
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733

Dexibuprofen

hsa04613

Neutrophil extracellular trap formation

2.89E-05

P16109, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, P21730, P08514, P21462, P07359

SELP, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, C5AR1, ITGA2B, FPR1, GP1BA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07359	GP1BA	Platelet glycoprotein Ib alpha chain	P16109	SELP	P-selectin	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P24158	PRTN3	Myeloblastin	P05164	MPO	Myeloperoxidase	0.979
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P24158	PRTN3	Myeloblastin	P08246	ELA2	Neutrophil elastase	0.894
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P24158	PRTN3	Myeloblastin	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.873
P24158	PRTN3	Myeloblastin	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.713
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P07359	GP1BA	Platelet glycoprotein Ib alpha chain	O60814	H2BC12	Histone H2B type 1-K	0.757
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P07359	GP1BA	Platelet glycoprotein Ib alpha chain	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.79
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P24158	PRTN3	Myeloblastin	Q15080	NCF4	Neutrophil cytosol factor 4	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P24158	PRTN3	Myeloblastin	P20160	AZU1	Azurocidin	0.942
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P24158	PRTN3	Myeloblastin	P08311	CTSG	Cathepsin G	0.914
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P24158	PRTN3	Myeloblastin	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.738
P07359	GP1BA	Platelet glycoprotein Ib alpha chain	P08514	ITGA2B	Integrin alpha-IIb	0.826
P24158	PRTN3	Myeloblastin	P21462	FPR1	fMet-Leu-Phe receptor	0.73
P07359	GP1BA	Platelet glycoprotein Ib alpha chain	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	1

Dexibuprofen

hsa04623

Cytosolic DNA-sensing pathway

1.41E-04

P01584, P01568, Q13546, Q8NHW4

IL1B, IFNA21, RIPK1, CCL4L2

Dexibuprofen

hsa04640

Hematopoietic cell lineage

1.39E-05

P13612, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49863	GZMK	Granzyme K	P13612	ITGA4	Integrin alpha-4	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P51124	GZMM	Granzyme M	P14778	IL1R1	Interleukin-1 receptor type 1	-0.886
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P51124	GZMM	Granzyme M	P27930	IL1R2	Interleukin-1 receptor type 2	-0.739
P49863	GZMK	Granzyme K	P27930	IL1R2	Interleukin-1 receptor type 2	-0.797
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P51124	GZMM	Granzyme M	P11215	ITGAM	Integrin alpha-M	-0.804
P49863	GZMK	Granzyme K	P15144	ANPEP	Aminopeptidase N	-0.752
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
P49863	GZMK	Granzyme K	P25063	CD24	Signal transducer CD24	-0.839
P08311	CTSG	Cathepsin G	P25063	CD24	Signal transducer CD24	0.902
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P49863	GZMK	Granzyme K	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.784
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P51124	GZMM	Granzyme M	P09564	CD7	T-cell antigen CD7	0.903
P49863	GZMK	Granzyme K	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.882
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733

Dexibuprofen

hsa04650

Natural killer cell mediated cytotoxicity

5.22E-11

P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715

PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P24158	PRTN3	Myeloblastin	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.816
P51124	GZMM	Granzyme M	O60880	SH2D1A	SH2 domain-containing protein 1A	0.743
P49863	GZMK	Granzyme K	O60880	SH2D1A	SH2 domain-containing protein 1A	0.899
P08311	CTSG	Cathepsin G	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.92
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P24158	PRTN3	Myeloblastin	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.729
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P24158	PRTN3	Myeloblastin	Q13241	KLRD1	Natural killer cells antigen CD94	-0.732
P49863	GZMK	Granzyme K	Q13241	KLRD1	Natural killer cells antigen CD94	0.809
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P24158	PRTN3	Myeloblastin	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.76
P51124	GZMM	Granzyme M	P26718	KLRK1	NKG2-D type II integral membrane protein	0.713
P49863	GZMK	Granzyme K	P26718	KLRK1	NKG2-D type II integral membrane protein	0.96
P08311	CTSG	Cathepsin G	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.875
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P49863	GZMK	Granzyme K	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.775
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P24158	PRTN3	Myeloblastin	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.77
P49863	GZMK	Granzyme K	P26717	KLRC2	NKG2-C type II integral membrane protein	0.891
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P24158	PRTN3	Myeloblastin	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
P49863	GZMK	Granzyme K	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.891
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867

Dexibuprofen

hsa04657

IL-17 signaling pathway

8.16E-05

P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Dexibuprofen

hsa04658

Th1 and Th2 cell differentiation

6.96E-16

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P49863	GZMK	Granzyme K	Q04759	PRKCQ	Protein kinase C theta type	0.874
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P49863	GZMK	Granzyme K	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.756
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P49863	GZMK	Granzyme K	Q14765	STAT4	Signal transducer and activator of transcription 4	0.848
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P49863	GZMK	Granzyme K	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.768
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P51124	GZMM	Granzyme M	Q9UL17	TBX21	T-box transcription factor TBX21	0.755
P49863	GZMK	Granzyme K	Q9UL17	TBX21	T-box transcription factor TBX21	0.918
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P51124	GZMM	Granzyme M	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.887
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P49863	GZMK	Granzyme K	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.882
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P51124	GZMM	Granzyme M	Q13761	RUNX3	Runt-related transcription factor 3	0.849
P49863	GZMK	Granzyme K	Q13761	RUNX3	Runt-related transcription factor 3	0.704

Dexibuprofen

hsa04659

Th17 cell differentiation

3.10E-12

Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P49863	GZMK	Granzyme K	Q04759	PRKCQ	Protein kinase C theta type	0.874
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P49863	GZMK	Granzyme K	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.756
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P51124	GZMM	Granzyme M	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.887
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P49863	GZMK	Granzyme K	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.882
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P51124	GZMM	Granzyme M	P14778	IL1R1	Interleukin-1 receptor type 1	-0.886
P49863	GZMK	Granzyme K	Q9HBE5	IL21R	Interleukin-21 receptor	0.722
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P51124	GZMM	Granzyme M	Q9UL17	TBX21	T-box transcription factor TBX21	0.755
P49863	GZMK	Granzyme K	Q9UL17	TBX21	T-box transcription factor TBX21	0.918
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P49863	GZMK	Granzyme K	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.768
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888

Dexibuprofen

hsa04660

T cell receptor signaling pathway

1.60E-11

P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P49863	GZMK	Granzyme K	Q04759	PRKCQ	Protein kinase C theta type	0.874
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P49863	GZMK	Granzyme K	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.872
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P49863	GZMK	Granzyme K	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.952
P08311	CTSG	Cathepsin G	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P49863	GZMK	Granzyme K	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.784
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P49863	GZMK	Granzyme K	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.793
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P49863	GZMK	Granzyme K	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.756
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P49863	GZMK	Granzyme K	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.716

Dexibuprofen

hsa04662

B cell receptor signaling pathway

5.04E-04

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Dexibuprofen

hsa04664

Fc epsilon RI signaling pathway

8.44E-04

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Dexibuprofen

hsa04666

Fc gamma R-mediated phagocytosis

2.42E-02

P23528, P06396, O14494, P14598, P17252

CFL1, GSN, PLPP1, NCF1, PRKCA

Dexibuprofen

hsa04668

TNF signaling pathway

3.19E-02

P01375, O00463, Q16539, P09341, P20749, Q13077, P14780

TNF, TRAF5, MAPK14, CXCL1, BCL3, TRAF1, MMP9

Dexibuprofen

hsa04672

Intestinal immune network for IgA production

1.62E-02

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Dexibuprofen

hsa04710

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Dexibuprofen

hsa04721

Synaptic vesicle cycle

3.09E-02

Q99437, P43005

ATP6V0B, SLC1A1

Dexibuprofen

hsa04724

Glutamatergic synapse

2.81E-02

P43003, P63218, P50151, P15104

SLC1A3, GNG5, GNG10, GLUL

Dexibuprofen

hsa04725

Cholinergic synapse

3.86E-02

P22694, Q14643, P18848, P10415

PRKACB, ITPR1, ATF4, BCL2

Dexibuprofen

hsa04744

Phototransduction

2.80E-02

P62873, P0DP23

GNB1, CALM1

Dexibuprofen

hsa04750

Inflammatory mediator regulation of TRP channels

1.05E-04

P14778, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759

IL1R1, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ

Dexibuprofen

hsa04915

Estrogen signaling pathway

2.25E-02

P14780, P22694, P18848, Q14643, P10415

MMP9, PRKACB, ATF4, ITPR1, BCL2

Dexibuprofen

hsa04916

Melanogenesis

4.80E-02

P0DP23, Q9UJU2, P17252, P04628

CALM1, LEF1, PRKCA, WNT1

Dexibuprofen

hsa04918

Thyroid hormone synthesis

2.91E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Dexibuprofen

hsa04920

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Dexibuprofen

hsa04921

Oxytocin signaling pathway

3.51E-02

Q15746, Q16566, Q8WYR1

MYLK, CAMK4, PIK3R5

Dexibuprofen

hsa04922

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Dexibuprofen

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Dexibuprofen

hsa04924

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Dexibuprofen

hsa04927

Cortisol synthesis and secretion

7.04E-03

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Dexibuprofen

hsa04928

Parathyroid hormone synthesis, secretion and action

1.78E-03

Q14643, P22694, P23771, P18848, P10415

ITPR1, PRKACB, GATA3, ATF4, BCL2

Dexibuprofen

hsa04932

Non-alcoholic fatty liver disease

4.35E-04

O43521, P18848, O75460, P01584, P13073, P12074, O15239

BCL2L11, ATF4, ERN1, IL1B, COX4I1, COX6A1, NDUFA1

Dexibuprofen

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Dexibuprofen

hsa04934

Cushing syndrome

4.06E-02

Q14643, P22694, P49841, Q9UJU2, O00170

ITPR1, PRKACB, GSK3B, LEF1, AIP

Dexibuprofen

hsa04961

Endocrine and other factor-regulated calcium reabsorption

2.68E-02

P20020, Q9UEF7, P17252

ATP2B1, KL, PRKCA

Dexibuprofen

hsa04964

Proximal tubule bicarbonate reclamation

2.93E-02

P22748, P49448

CA4, GLUD2

Dexibuprofen

hsa04972

Pancreatic secretion

2.68E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Dexibuprofen

hsa04973

Carbohydrate digestion and absorption

1.66E-04

O43451, P42338

MGAM, PIK3CB

Dexibuprofen

hsa05010

Alzheimer disease

2.21E-02

O15239, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P67870, P28070

NDUFA1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, CSNK2B, PSMB4

Dexibuprofen

hsa05012

Parkinson disease

2.53E-02

O15239, P13073, P05141, P18848, Q13557

NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D

Dexibuprofen

hsa05014

Amyotrophic lateral sclerosis

2.72E-02

P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629

TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7

Dexibuprofen

hsa05016

Huntington disease

3.21E-02

O15239, P13073, P30876, P62487, P05141

NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5

Dexibuprofen

hsa05020

Prion disease

3.37E-03

P13591, P01584, P11142, O15239, P13073, P18848, P05141

NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5

Dexibuprofen

hsa05022

Pathways of neurodegeneration - multiple diseases

3.80E-02

O15239, P13073, P18848, P05141, P01584, Q13557

NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2D

Dexibuprofen

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Dexibuprofen

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.86E-06

Q99437, P09341, P19875, P10145, P19174, P25024, P25025, P07948

ATP6V0B, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2, LYN

Dexibuprofen

hsa05130

Pathogenic Escherichia coli infection

2.94E-02

Q14247, O00501, Q92974, P25116

CTTN, CLDN5, ARHGEF2, F2R

Dexibuprofen

hsa05132

Salmonella infection

1.10E-05

P51617, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371

IRAK1, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
P10415	BCL2	Apoptosis regulator Bcl-2	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.908
Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.72
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.825
Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.769
P10415	BCL2	Apoptosis regulator Bcl-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.848
Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.788
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.794
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P10415	BCL2	Apoptosis regulator Bcl-2	O75369	FLNB	Filamin-B	-0.762
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O75369	FLNB	Filamin-B	-0.746
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P10415	BCL2	Apoptosis regulator Bcl-2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.929
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.924
P10415	BCL2	Apoptosis regulator Bcl-2	Q13561	DCTN2	Dynactin subunit 2	-0.843
Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q13561	DCTN2	Dynactin subunit 2	0.754
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13561	DCTN2	Dynactin subunit 2	-0.809
P10415	BCL2	Apoptosis regulator Bcl-2	Q13509	TUBB3	Tubulin beta-3 chain	-0.809
Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q13509	TUBB3	Tubulin beta-3 chain	0.735
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13509	TUBB3	Tubulin beta-3 chain	-0.846
P10415	BCL2	Apoptosis regulator Bcl-2	P68371	TUBB2C	Tubulin beta-4B chain	-0.766
Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	P68371	TUBB2C	Tubulin beta-4B chain	0.748
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P68371	TUBB2C	Tubulin beta-4B chain	-0.783

Dexibuprofen

hsa05134

Legionellosis

2.52E-05

P01584, P11215, P68104, P11142, P09341, P19875

IL1B, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2

Dexibuprofen

hsa05135

Yersinia infection

4.26E-02

P13612, P06239, Q16539, P01375, P49841, P01732

ITGA4, LCK, MAPK14, TNF, GSK3B, CD8A

Dexibuprofen

hsa05144

Malaria

1.45E-03

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Dexibuprofen

hsa05146

Amoebiasis

1.43E-11

Q13751, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

LAMB3, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51124	GZMM	Granzyme M	Q13751	LAMB3	Laminin subunit beta-3	-0.702
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P24158	PRTN3	Myeloblastin	P09341	CXCL1	Growth-regulated alpha protein	0.751
P51124	GZMM	Granzyme M	P09341	CXCL1	Growth-regulated alpha protein	-0.733
P49863	GZMK	Granzyme K	P09341	CXCL1	Growth-regulated alpha protein	-0.846
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P51124	GZMM	Granzyme M	P19875	CXCL2	C-X-C motif chemokine 2	-0.739
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P51124	GZMM	Granzyme M	P14778	IL1R1	Interleukin-1 receptor type 1	-0.886
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P24158	PRTN3	Myeloblastin	P27930	IL1R2	Interleukin-1 receptor type 2	0.735
P51124	GZMM	Granzyme M	P27930	IL1R2	Interleukin-1 receptor type 2	-0.739
P49863	GZMK	Granzyme K	P27930	IL1R2	Interleukin-1 receptor type 2	-0.797
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P51124	GZMM	Granzyme M	P11215	ITGAM	Integrin alpha-M	-0.804
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P24158	PRTN3	Myeloblastin	P05089	ARG1	Arginase-1	0.834
P49863	GZMK	Granzyme K	P05089	ARG1	Arginase-1	-0.92
P08311	CTSG	Cathepsin G	P05089	ARG1	Arginase-1	0.931
P24158	PRTN3	Myeloblastin	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.792
P49863	GZMK	Granzyme K	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.829
P08311	CTSG	Cathepsin G	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.847
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P51124	GZMM	Granzyme M	P12814	ACTN1	Alpha-actinin-1	-0.916
P49863	GZMK	Granzyme K	P12814	ACTN1	Alpha-actinin-1	-0.707
P08311	CTSG	Cathepsin G	P12814	ACTN1	Alpha-actinin-1	0.708
P24158	PRTN3	Myeloblastin	P08311	CTSG	Cathepsin G	0.914
P49863	GZMK	Granzyme K	P08311	CTSG	Cathepsin G	-0.892
P08311	CTSG	Cathepsin G	P08311	CTSG	Cathepsin G	1

Dexibuprofen

hsa05150

Staphylococcus aureus infection

4.02E-03

P21462, O75015, Q14532, P59665, P59666, P12838

FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4

Dexibuprofen

hsa05152

Tuberculosis

3.22E-05

Q13488, P0DP23, P48382, P25208, O60603, P01375, P10415, P13765, P01568, Q9UDY8, P51617

TCIRG1, CALM1, RFX5, NFYB, TLR2, TNF, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10415	BCL2	Apoptosis regulator Bcl-2	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.718
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.716
P10415	BCL2	Apoptosis regulator Bcl-2	P0DP23	CALM1	Calmodulin-1	-0.772
P10415	BCL2	Apoptosis regulator Bcl-2	P48382	RFX5	DNA-binding protein RFX5	0.856
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P48382	RFX5	DNA-binding protein RFX5	0.797
P24158	PRTN3	Myeloblastin	P48382	RFX5	DNA-binding protein RFX5	-0.87
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P25208	NFYB	Nuclear transcription factor Y subunit beta	0.742
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P24158	PRTN3	Myeloblastin	P10415	BCL2	Apoptosis regulator Bcl-2	-0.787
P10415	BCL2	Apoptosis regulator Bcl-2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.754
P24158	PRTN3	Myeloblastin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.796
P10415	BCL2	Apoptosis regulator Bcl-2	P01568	IFNA21	Interferon alpha-21	0.721
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P01568	IFNA21	Interferon alpha-21	0.716
P10415	BCL2	Apoptosis regulator Bcl-2	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.94
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	1
P24158	PRTN3	Myeloblastin	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.733
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741

Dexibuprofen

hsa05162

Measles

4.02E-02

P11142, P01584, Q9NP90

HSPA8, IL1B, RAB9B

Dexibuprofen

hsa05163

Human cytomegalovirus infection

2.14E-03

P42338, P63218, P50151, P0DP23, Q8NHW4, Q08828, P23458, P01106, P14778, P01584, P61073, Q13651, P30101

PIK3CB, GNG5, GNG10, CALM1, CCL4L2, ADCY1, JAK1, MYC, IL1R1, IL1B, CXCR4, IL10RA, PDIA3

Dexibuprofen

hsa05167

Kaposi sarcoma-associated herpesvirus infection

7.60E-03

P42338, P63218, P50151, P09341, P19875, P19174, P07948, P01106

PIK3CB, GNG5, GNG10, CXCL1, CXCL2, PLCG1, LYN, MYC

Dexibuprofen

hsa05169

Epstein-Barr virus infection

1.27E-02

P01106, Q13547, P42338, P07948, P30101, Q13761, O75293, P07766, P20963

MYC, HDAC1, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, CD3E, CD247

Dexibuprofen

hsa05170

Human immunodeficiency virus 1 infection

5.17E-05

P42338, P62873, P63218, P50151, P0DP23, P17252, Q13546, O00463, P30101, Q14643, P01568, P01730, P51617, O60603, Q13315, P19174, P23528, P07766, P20963, P10415, Q93034, Q9Y6Q5

PIK3CB, GNB1, GNG5, GNG10, CALM1, PRKCA, RIPK1, TRAF5, PDIA3, ITPR1, IFNA21, CD4, IRAK1, TLR2, ATM, PLCG1, CFL1, CD3E, CD247, BCL2, CUL5, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
P10415	BCL2	Apoptosis regulator Bcl-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.777
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.701
P51124	GZMM	Granzyme M	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.845
P51124	GZMM	Granzyme M	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P10415	BCL2	Apoptosis regulator Bcl-2	P0DP23	CALM1	Calmodulin-1	-0.772
P10415	BCL2	Apoptosis regulator Bcl-2	P17252	PRKCA	Protein kinase C alpha type	0.844
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P17252	PRKCA	Protein kinase C alpha type	0.769
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.769
P10415	BCL2	Apoptosis regulator Bcl-2	O00463	TRAF5	TNF receptor-associated factor 5	0.773
P51124	GZMM	Granzyme M	P30101	PDIA3	Protein disulfide-isomerase A3	0.846
P10415	BCL2	Apoptosis regulator Bcl-2	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.858
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.823
P10415	BCL2	Apoptosis regulator Bcl-2	P01568	IFNA21	Interferon alpha-21	0.721
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P01568	IFNA21	Interferon alpha-21	0.716
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13315	ATM	Serine-protein kinase ATM	0.758
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P10415	BCL2	Apoptosis regulator Bcl-2	P23528	CFL1	Cofilin-1	0.741
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P10415	BCL2	Apoptosis regulator Bcl-2	Q93034	CUL5	Cullin-5	0.704
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.901
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.946

Dexibuprofen

hsa05171

Coronavirus disease - COVID-19

9.72E-03

P01584, P62753, P25398, P36578, P32969, P18077, P62829

IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23

Dexibuprofen

hsa05200

Pathways in cancer

9.46E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Dexibuprofen

hsa05202

Transcriptional misregulation in cancer

3.12E-07

Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522

FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10415	BCL2	Apoptosis regulator Bcl-2	Q12778	FOXO1	Forkhead box protein O1	0.794
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q12778	FOXO1	Forkhead box protein O1	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P10415	BCL2	Apoptosis regulator Bcl-2	Q15532	SS18	Protein SSXT	0.877
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q15532	SS18	Protein SSXT	0.763
P24158	PRTN3	Myeloblastin	Q15532	SS18	Protein SSXT	-0.732
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13315	ATM	Serine-protein kinase ATM	0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P10415	BCL2	Apoptosis regulator Bcl-2	P14780	MMP9	Matrix metalloproteinase-9	-0.765
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14780	MMP9	Matrix metalloproteinase-9	-0.767
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P24158	PRTN3	Myeloblastin	P14780	MMP9	Matrix metalloproteinase-9	0.837
P08311	CTSG	Cathepsin G	P14780	MMP9	Matrix metalloproteinase-9	0.79
P24158	PRTN3	Myeloblastin	P27930	IL1R2	Interleukin-1 receptor type 2	0.735
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P10415	BCL2	Apoptosis regulator Bcl-2	P14923	JUP	Junction plakoglobin	0.861
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14923	JUP	Junction plakoglobin	0.845
P24158	PRTN3	Myeloblastin	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.741
P08311	CTSG	Cathepsin G	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.909
P10415	BCL2	Apoptosis regulator Bcl-2	Q16548	BCL2A1	Bcl-2-related protein A1	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P24158	PRTN3	Myeloblastin	Q16548	BCL2A1	Bcl-2-related protein A1	0.802
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
P10415	BCL2	Apoptosis regulator Bcl-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.848
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.794
P10415	BCL2	Apoptosis regulator Bcl-2	Q13077	TRAF1	TNF receptor-associated factor 1	0.816
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13077	TRAF1	TNF receptor-associated factor 1	0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P24158	PRTN3	Myeloblastin	O15550	UTX	Lysine-specific demethylase 6A	0.776
P10415	BCL2	Apoptosis regulator Bcl-2	P35226	BMI1	Polycomb complex protein BMI-1	0.78
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
P10415	BCL2	Apoptosis regulator Bcl-2	P35226	BMI1	Polycomb complex protein BMI-1	0.78
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
P10415	BCL2	Apoptosis regulator Bcl-2	P05164	MPO	Myeloperoxidase	-0.81
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P05164	MPO	Myeloperoxidase	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P24158	PRTN3	Myeloblastin	P05164	MPO	Myeloperoxidase	0.979
P08311	CTSG	Cathepsin G	P05164	MPO	Myeloperoxidase	0.956
P08311	CTSG	Cathepsin G	P12838	DEFA4	Neutrophil defensin 4	0.817
P10415	BCL2	Apoptosis regulator Bcl-2	P08246	ELA2	Neutrophil elastase	-0.942
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P08246	ELA2	Neutrophil elastase	-0.896
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P24158	PRTN3	Myeloblastin	P08246	ELA2	Neutrophil elastase	0.894
P08311	CTSG	Cathepsin G	P08246	ELA2	Neutrophil elastase	0.792
P10415	BCL2	Apoptosis regulator Bcl-2	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.766
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.787
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P24158	PRTN3	Myeloblastin	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.777
P08311	CTSG	Cathepsin G	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P24158	PRTN3	Myeloblastin	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.772
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799

Dexibuprofen

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Dexibuprofen

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Dexibuprofen

hsa05205

Proteoglycans in cancer

5.78E-04

Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P04628, Q13635, P08962

TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63

Dexibuprofen

hsa05212

Pancreatic cancer

3.94E-02

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Dexibuprofen

hsa05217

Basal cell carcinoma

4.62E-03

Q13635, P04628, P49841, Q9UJU2, P24522

PTCH1, WNT1, GSK3B, LEF1, GADD45A

Dexibuprofen

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Dexibuprofen

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.84E-07

P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
P49863	GZMK	Granzyme K	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.872
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P49863	GZMK	Granzyme K	Q04759	PRKCQ	Protein kinase C theta type	0.874
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P49863	GZMK	Granzyme K	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.756
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746

Dexibuprofen

hsa05310

Asthma

5.72E-05

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Dexibuprofen

hsa05320

Autoimmune thyroid disease

8.64E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Dexibuprofen

hsa05321

Inflammatory bowel disease

3.03E-10

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P24158	PRTN3	Myeloblastin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.796
P49863	GZMK	Granzyme K	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.882
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P24158	PRTN3	Myeloblastin	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.753
P49863	GZMK	Granzyme K	Q14765	STAT4	Signal transducer and activator of transcription 4	0.848
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P49863	GZMK	Granzyme K	Q9UL17	TBX21	T-box transcription factor TBX21	0.918
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P24158	PRTN3	Myeloblastin	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.81
P49863	GZMK	Granzyme K	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.768
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P49863	GZMK	Granzyme K	Q9HBE5	IL21R	Interleukin-21 receptor	0.722
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763