PharmaCoNets

PharmaCoNets of Dexamethasone (S_PCN: 52.80 )

Dexamethasone regulated-network (S_DN: 11.55)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Dexamethasone-acetate

hsa00030

Pentose phosphate pathway

8.97E-03

P11413

G6PD

Dexamethasone-acetate

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Dexamethasone-acetate

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Dexamethasone-acetate

hsa00480

Glutathione metabolism

1.35E-02

P11413

G6PD

Dexamethasone-acetate

hsa00500

Starch and sucrose metabolism

2.00E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Dexamethasone-acetate

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Dexamethasone-acetate

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Dexamethasone-acetate

hsa00730

Thiamine metabolism

5.29E-03

P05186, P24666

ALPL, ACP1

Dexamethasone-acetate

hsa00970

Aminoacyl-tRNA biosynthesis

1.21E-02

P14868

DARS

Dexamethasone-acetate

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Dexamethasone-acetate

hsa01200

Carbon metabolism

2.91E-02

P11413

G6PD

Dexamethasone-acetate

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Dexamethasone-acetate

hsa03013

RNA transport

9.39E-05

Q15287, Q9UBU9, P35658, P63279, P68104, P55884, O15371, P20042, Q14232

RNPS1, NXF1, NUP214, UBE2I, EEF1A1, EIF3B, EIF3D, EIF2S2, EIF2B1

Dexamethasone-acetate

hsa03040

Spliceosome

3.98E-02

Q15427, P38159, P61978, P11142

SF3B4, RBMX, HNRPK, HSPA8

Dexamethasone-acetate

hsa03060

Protein export

9.07E-04

P37108, Q15005

SRP14, SPCS2

Dexamethasone-acetate

hsa04012

ErbB signaling pathway

3.74E-02

P21860, Q13557, O14944

ERBB3, CAMK2D, EREG

Dexamethasone-acetate

hsa04020

Calcium signaling pathway

2.19E-05

Q96DU7, Q08828, P45880, Q13557, P21860, P61073, P0DP24, P05141, P51828, P23634

ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, CXCR4, CALM2, SLC25A5, ADCY7, ATP2B4

Dexamethasone-acetate

hsa04022

cGMP-PKG signaling pathway

2.45E-03

Q99941, P18848, P23634, Q08828, P51828, P05141, P45880, P0DP24

CREBL1, ATF4, ATP2B4, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2

Dexamethasone-acetate

hsa04061

Viral protein interaction with cytokine and cytokine receptor

9.15E-04

Q8NHW4, P09341, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P01375

CCL4L2, CXCL1, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, TNF

Dexamethasone-acetate

hsa04064

NF-kappa B signaling pathway

9.08E-04

Q13489, Q13546, P01584, Q9UDY8, P63279, Q8NHW4, Q9UNE0, Q9NQC7

BIRC3, RIPK1, IL1B, MALT1, UBE2I, CCL4L2, EDAR, CYLD

Dexamethasone-acetate

hsa04071

Sphingolipid signaling pathway

1.94E-02

Q9H228, P01375, Q9UQC2

EDG8, TNF, GAB2

Dexamethasone-acetate

hsa04114

Oocyte meiosis

4.36E-02

Q13557, P0DP24, Q08828, P51828, P27348

CAMK2D, CALM2, ADCY1, ADCY7, YWHAQ

Dexamethasone-acetate

hsa04140

Autophagy - animal

3.61E-02

Q9NQL2, P22694, Q14643, Q9H1Y0, Q04759

RRAGD, PRKACB, ITPR1, ATG5, PRKCQ

Dexamethasone-acetate

hsa04141

Protein processing in endoplasmic reticulum

5.75E-03

Q99941, O75460, P17861, P11142, Q9H3Z4, P07900, Q9NR31

CREBL1, ERN1, XBP1, HSPA8, DNAJC5, HSP90AA1, SAR1A

Dexamethasone-acetate

hsa04210

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Dexamethasone-acetate

hsa04211

Longevity regulating pathway

3.41E-03

Q12778, Q08828, P51828, Q99941, P18848, Q9UEF7, Q96KQ7

FOXO1, ADCY1, ADCY7, CREBL1, ATF4, KL, EHMT2

Dexamethasone-acetate

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Dexamethasone-acetate

hsa04217

Necroptosis

6.23E-04

P01568, P23458, Q13489, Q9NQC7, Q13546, P05141, P01584, P0C0S5, Q13557, Q9H444

IFNA21, JAK1, BIRC3, CYLD, RIPK1, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4B

Dexamethasone-acetate

hsa04261

Adrenergic signaling in cardiomyocytes

1.60E-03

Q08828, P51828, Q99941, P18848, P0DP24, Q13557, P23634

ADCY1, ADCY7, CREBL1, ATF4, CALM2, CAMK2D, ATP2B4

Dexamethasone-acetate

hsa04330

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Dexamethasone-acetate

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Dexamethasone-acetate

hsa04380

Osteoclast differentiation

4.98E-02

Q9NQC7, Q9UQC2, P23458, P01584

CYLD, GAB2, JAK1, IL1B

Dexamethasone-acetate

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Dexamethasone-acetate

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Dexamethasone-acetate

hsa04612

Antigen processing and presentation

2.73E-02

P13765, P48382, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Dexamethasone-acetate

hsa04613

Neutrophil extracellular trap formation

1.96E-02

O60603, P05164, P08246, Q9UM07, Q13547, Q16778, P20160, P08311, O75015, P21730, O43315, Q16539

TLR2, MPO, ELA2, PADI4, HDAC1, HIST2H2BE, AZU1, CTSG, FCGR3B, C5AR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805

Dexamethasone-acetate

hsa04620

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Dexamethasone-acetate

hsa04621

NOD-like receptor signaling pathway

3.95E-03

Q16539, Q14643, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, Q13546, P29728, P01375, P09341, P12838

MAPK14, ITPR1, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, RIPK1, OAS2, TNF, CXCL1, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899

Dexamethasone-acetate

hsa04622

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Dexamethasone-acetate

hsa04623

Cytosolic DNA-sensing pathway

5.86E-05

P01584, P01568, Q13546, Q8NHW4

IL1B, IFNA21, RIPK1, CCL4L2

Dexamethasone-acetate

hsa04640

Hematopoietic cell lineage

1.10E-02

P13612, P14778, P27930, P15144, P25063, P09693, P01732, P13765, P01375

ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNF

Dexamethasone-acetate

hsa04650

Natural killer cell mediated cytotoxicity

8.02E-03

P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715

TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83

Dexamethasone-acetate

hsa04657

IL-17 signaling pathway

1.80E-03

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Dexamethasone-acetate

hsa04658

Th1 and Th2 cell differentiation

5.94E-04

Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765

PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOB

Dexamethasone-acetate

hsa04659

Th17 cell differentiation

5.58E-04

P25963, Q04759, Q16539, P06239, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P09693, P20963

NFKBIA, PRKCQ, MAPK14, LCK, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877

Dexamethasone-acetate

hsa04660

T cell receptor signaling pathway

6.95E-04

P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Dexamethasone-acetate

hsa04668

TNF signaling pathway

4.74E-02

Q99941, P01584, O95429

CREBL1, IL1B, BAG4

Dexamethasone-acetate

hsa04710

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Dexamethasone-acetate

hsa04713

Circadian entrainment

1.91E-02

P0DP24, Q13557, Q08828, P51828

CALM2, CAMK2D, ADCY1, ADCY7

Dexamethasone-acetate

hsa04720

Long-term potentiation

1.91E-02

Q13557, P0DP24, P18848, Q08828

CAMK2D, CALM2, ATF4, ADCY1

Dexamethasone-acetate

hsa04725

Cholinergic synapse

3.77E-02

Q08828, P51828, P18848, Q13557

ADCY1, ADCY7, ATF4, CAMK2D

Dexamethasone-acetate

hsa04728

Dopaminergic synapse

2.67E-02

Q99941, P18848, Q13557, P0DP24, O15516

CREBL1, ATF4, CAMK2D, CALM2, CLOCK

Dexamethasone-acetate

hsa04750

Inflammatory mediator regulation of TRP channels

7.58E-05

P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, Q14643, Q04759, P0DP24

IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, ITPR1, PRKCQ, CALM2

Dexamethasone-acetate

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Dexamethasone-acetate

hsa04911

Insulin secretion

2.95E-05

Q08828, P51828, Q99941, P18848, Q13557

ADCY1, ADCY7, CREBL1, ATF4, CAMK2D

Dexamethasone-acetate

hsa04912

GnRH signaling pathway

6.99E-03

Q08828, P51828, P18848, Q13557, P0DP24

ADCY1, ADCY7, ATF4, CAMK2D, CALM2

Dexamethasone-acetate

hsa04915

Estrogen signaling pathway

4.72E-02

Q99941, P51828, P07900, P11142

CREBL1, ADCY7, HSP90AA1, HSPA8

Dexamethasone-acetate

hsa04916

Melanogenesis

7.61E-03

Q13557, P0DP24, Q08828, P51828

CAMK2D, CALM2, ADCY1, ADCY7

Dexamethasone-acetate

hsa04918

Thyroid hormone synthesis

4.47E-03

Q08828, P51828, Q99941, P18848, P02768

ADCY1, ADCY7, CREBL1, ATF4, ALB

Dexamethasone-acetate

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Dexamethasone-acetate

hsa04920

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Dexamethasone-acetate

hsa04925

Aldosterone synthesis and secretion

8.00E-06

Q99941, P18848, Q08828, P51828, P0DP24, Q13557, P23634

CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4

Dexamethasone-acetate

hsa04927

Cortisol synthesis and secretion

4.16E-03

Q99941, P18848, Q08828, P51828

CREBL1, ATF4, ADCY1, ADCY7

Dexamethasone-acetate

hsa04928

Parathyroid hormone synthesis, secretion and action

3.77E-02

Q08828, P51828, Q99941, P18848

ADCY1, ADCY7, CREBL1, ATF4

Dexamethasone-acetate

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Dexamethasone-acetate

hsa04932

Non-alcoholic fatty liver disease

3.45E-02

P18848, O75460, P01584, P12074, O15239

ATF4, ERN1, IL1B, COX6A1, NDUFA1

Dexamethasone-acetate

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.25E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Dexamethasone-acetate

hsa04934

Cushing syndrome

2.69E-06

Q99941, P18848, Q08828, P51828, O15169, Q13557

CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2D

Dexamethasone-acetate

hsa04935

Growth hormone synthesis, secretion and action

4.98E-02

Q08828, P51828, Q99941, P18848

ADCY1, ADCY7, CREBL1, ATF4

Dexamethasone-acetate

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Dexamethasone-acetate

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Dexamethasone-acetate

hsa04970

Salivary secretion

3.54E-02

Q08828, P51828, P0DP24

ADCY1, ADCY7, CALM2

Dexamethasone-acetate

hsa04971

Gastric acid secretion

2.95E-05

Q08828, P51828, P15311, P0DP24, Q13557

ADCY1, ADCY7, VIL2, CALM2, CAMK2D

Dexamethasone-acetate

hsa04975

Fat digestion and absorption

9.50E-04

O14494

PLPP1

Dexamethasone-acetate

hsa04976

Bile secretion

2.44E-02

P22694, P08183

PRKACB, ABCB1

Dexamethasone-acetate

hsa05010

Alzheimer disease

2.56E-05

Q92542, O15239, P05496, Q06055, P12074, Q00535, O75460, P0DP24, P01584, P18848, O15169, P05141, P45880, P17861, P28070, P43686, P62195

NCSTN, NDUFA1, ATP5G1, ATP5G2, COX6A1, CDK5, ERN1, CALM2, IL1B, ATF4, AXIN1, SLC25A5, VDAC2, XBP1, PSMB4, PSMC4, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814

Dexamethasone-acetate

hsa05012

Parkinson disease

5.28E-04

O15239, P12074, Q06055, P05141, O75460, P18848, P17861, P28070, P43686, P62195, P0DP24, Q13557

NDUFA1, COX6A1, ATP5G2, SLC25A5, ERN1, ATF4, XBP1, PSMB4, PSMC4, PSMC5, CALM2, CAMK2D

Dexamethasone-acetate

hsa05014

Amyotrophic lateral sclerosis

1.01E-02

Q06055, P17861, P62195

ATP5G2, XBP1, PSMC5

Dexamethasone-acetate

hsa05016

Huntington disease

3.54E-02

O15239, P12074, P24928, P62487, P05141, O75460, P28070, P43686

NDUFA1, COX6A1, POLR2A, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4

Dexamethasone-acetate

hsa05017

Spinocerebellar ataxia

1.42E-02

P17861, P62195

XBP1, PSMC5

Dexamethasone-acetate

hsa05020

Prion disease

1.76E-03

P01584, P46531, P11142, O15239, P05496, P12074, P18848, P05141, P45880, P28070, P43686, Q99941

IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX6A1, ATF4, SLC25A5, VDAC2, PSMB4, PSMC4, CREBL1

Dexamethasone-acetate

hsa05022

Pathways of neurodegeneration - multiple diseases

2.12E-04

O15239, P12074, Q06055, Q8TEV9, O75460, P18848, P17861, P05141, Q00535, O15169, P01584, P0DP24, Q13557, P28070, P43686, P62195

NDUFA1, COX6A1, ATP5G2, SMCR8, ERN1, ATF4, XBP1, SLC25A5, CDK5, AXIN1, IL1B, CALM2, CAMK2D, PSMB4, PSMC4, PSMC5

Dexamethasone-acetate

hsa05030

Cocaine addiction

3.54E-02

Q00535, Q99941, P18848

CDK5, CREBL1, ATF4

Dexamethasone-acetate

hsa05031

Amphetamine addiction

7.61E-03

P0DP24, Q13557, Q99941, P18848

CALM2, CAMK2D, CREBL1, ATF4

Dexamethasone-acetate

hsa05132

Salmonella infection

5.76E-04

P25963, Q13546, Q13489, P10415, Q9BQS8, O60282, P68371

NFKBIA, RIPK1, BIRC3, BCL2, FYCO1, KIF5C, TUBB2C

Dexamethasone-acetate

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Dexamethasone-acetate

hsa05134

Legionellosis

5.53E-03

Q9NR31, P68104

SAR1A, EEF1A1

Dexamethasone-acetate

hsa05135

Yersinia infection

3.72E-02

P13612, P06239, Q16539, P01375, P49841, P01732

ITGA4, LCK, MAPK14, TNF, GSK3B, CD8A

Dexamethasone-acetate

hsa05140

Leishmaniasis

2.69E-02

P13612, O75015, P13765, O60603, P01375, Q16539

ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14

Dexamethasone-acetate

hsa05143

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Dexamethasone-acetate

hsa05144

Malaria

1.12E-03

P60033, P69905, P68871, O60603, P01375, P35443, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Dexamethasone-acetate

hsa05145

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Dexamethasone-acetate

hsa05146

Amoebiasis

5.94E-04

P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311

CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG

Dexamethasone-acetate

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Dexamethasone-acetate

hsa05163

Human cytomegalovirus infection

6.52E-05

P01375, Q14643, P0DP24, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, Q99941, P18848, O00463

TNF, ITPR1, CALM2, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896

Dexamethasone-acetate

hsa05202

Transcriptional misregulation in cancer

3.51E-02

P14780, P27930, Q15744, Q16548, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522

MMP9, IL1R2, CEBPE, BCL2A1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45A

Dexamethasone-acetate

hsa05206

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Dexamethasone-acetate

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Dexamethasone-acetate

hsa05212

Pancreatic cancer

3.52E-02

P84022, Q13485

SMAD3, SMAD4

Dexamethasone-acetate

hsa05220

Chronic myeloid leukemia

1.25E-02

Q13485, P25963, P84022

SMAD4, NFKBIA, SMAD3

Dexamethasone-acetate

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Dexamethasone-acetate

hsa05226

Gastric cancer

2.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Dexamethasone-acetate

hsa05230

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Dexamethasone-acetate

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.42E-02

O95267, P20963, P09693, P06239, O60603, Q04759, Q16539

RASGRP1, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14

Dexamethasone-acetate

hsa05310

Asthma

1.62E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Dexamethasone-acetate

hsa05321

Inflammatory bowel disease

1.09E-03

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Dexamethasone-acetate

hsa05332

Graft-versus-host disease

1.76E-02

P13765, P01375, P26715, Q13241

HLA-DOB, TNF, KLRC1, KLRD1

Dexamethasone-acetate

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Dexamethasone-acetate

hsa05415

Diabetic cardiomyopathy

3.59E-02

P11413

G6PD

Dexamethasone

hsa00030

Pentose phosphate pathway

8.97E-03

P11413

G6PD

Dexamethasone

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Dexamethasone

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Dexamethasone

hsa00480

Glutathione metabolism

1.35E-02

P11413

G6PD

Dexamethasone

hsa00500

Starch and sucrose metabolism

2.00E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Dexamethasone

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Dexamethasone

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Dexamethasone

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Dexamethasone

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Dexamethasone

hsa00730

Thiamine metabolism

5.29E-03

P05186, P24666

ALPL, ACP1

Dexamethasone

hsa00970

Aminoacyl-tRNA biosynthesis

1.21E-02

P14868

DARS

Dexamethasone

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Dexamethasone

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Dexamethasone

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Dexamethasone

hsa01200

Carbon metabolism

2.91E-02

P11413

G6PD

Dexamethasone

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Dexamethasone

hsa03013

RNA transport

3.11E-02

P68104, Q14232

EEF1A1, EIF2B1

Dexamethasone

hsa04061

Viral protein interaction with cytokine and cytokine receptor

2.00E-02

P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P01375

CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, TNF

Dexamethasone

hsa04064

NF-kappa B signaling pathway

4.58E-03

Q13489, Q13546, Q9UDY8, Q9UNE0

BIRC3, RIPK1, MALT1, EDAR

Dexamethasone

hsa04071

Sphingolipid signaling pathway

1.94E-02

Q9H228, P01375, Q9UQC2

EDG8, TNF, GAB2

Dexamethasone

hsa04140

Autophagy - animal

3.61E-02

Q9NQL2, P22694, Q14643, Q9H1Y0, Q04759

RRAGD, PRKACB, ITPR1, ATG5, PRKCQ

Dexamethasone

hsa04141

Protein processing in endoplasmic reticulum

3.89E-02

P17861, Q9NR31

XBP1, SAR1A

Dexamethasone

hsa04210

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Dexamethasone

hsa04211

Longevity regulating pathway

1.18E-02

Q12778, Q9UEF7, Q96KQ7

FOXO1, KL, EHMT2

Dexamethasone

hsa04213

Longevity regulating pathway - multiple species

2.85E-02

Q9Y4H2, Q13547

IRS2, HDAC1

Dexamethasone

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Dexamethasone

hsa04217

Necroptosis

2.93E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Dexamethasone

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Dexamethasone

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Dexamethasone

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Dexamethasone

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Dexamethasone

hsa04612

Antigen processing and presentation

3.60E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Dexamethasone

hsa04613

Neutrophil extracellular trap formation

4.90E-05

P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431, P20160, P08311, O75015, P21730, O43315, Q16539

ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AZU1, CTSG, FCGR3B, C5AR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805

Dexamethasone

hsa04620

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Dexamethasone

hsa04621

NOD-like receptor signaling pathway

3.13E-04

Q16539, Q14643, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, Q13546, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838

MAPK14, ITPR1, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899

Dexamethasone

hsa04622

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Dexamethasone

hsa04623

Cytosolic DNA-sensing pathway

2.20E-03

P01568, Q13546

IFNA21, RIPK1

Dexamethasone

hsa04640

Hematopoietic cell lineage

1.10E-02

P13612, P14778, P27930, P15144, P25063, P09693, P01732, P13765, P01375

ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNF

Dexamethasone

hsa04650

Natural killer cell mediated cytotoxicity

3.11E-04

P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715

TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83

Dexamethasone

hsa04657

IL-17 signaling pathway

1.80E-03

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Dexamethasone

hsa04658

Th1 and Th2 cell differentiation

5.94E-04

Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765

PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOB

Dexamethasone

hsa04659

Th17 cell differentiation

5.58E-04

P25963, Q04759, Q16539, P06239, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P09693, P20963

NFKBIA, PRKCQ, MAPK14, LCK, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877

Dexamethasone

hsa04660

T cell receptor signaling pathway

6.95E-04

P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Dexamethasone

hsa04710

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Dexamethasone

hsa04750

Inflammatory mediator regulation of TRP channels

3.61E-02

P14778, P22694, Q16539, Q14643, Q04759

IL1R1, PRKACB, MAPK14, ITPR1, PRKCQ

Dexamethasone

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Dexamethasone

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Dexamethasone

hsa04920

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Dexamethasone

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Dexamethasone

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.25E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Dexamethasone

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Dexamethasone

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Dexamethasone

hsa04975

Fat digestion and absorption

9.50E-04

O14494

PLPP1

Dexamethasone

hsa04976

Bile secretion

2.44E-02

P22694, P08183

PRKACB, ABCB1

Dexamethasone

hsa05010

Alzheimer disease

1.01E-02

Q06055, P17861, P62195

ATP5G2, XBP1, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814

Dexamethasone

hsa05012

Parkinson disease

5.41E-03

Q06055, P17861, P62195

ATP5G2, XBP1, PSMC5

Dexamethasone

hsa05014

Amyotrophic lateral sclerosis

1.01E-02

Q06055, P17861, P62195

ATP5G2, XBP1, PSMC5

Dexamethasone

hsa05017

Spinocerebellar ataxia

1.42E-02

P17861, P62195

XBP1, PSMC5

Dexamethasone

hsa05022

Pathways of neurodegeneration - multiple diseases

1.66E-02

Q06055, P17861, P62195

ATP5G2, XBP1, PSMC5

Dexamethasone

hsa05034

Alcoholism

2.05E-05

Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431

HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Dexamethasone

hsa05132

Salmonella infection

5.76E-04

P25963, Q13546, Q13489, P10415, Q9BQS8, O60282, P68371

NFKBIA, RIPK1, BIRC3, BCL2, FYCO1, KIF5C, TUBB2C

Dexamethasone

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Dexamethasone

hsa05134

Legionellosis

5.53E-03

Q9NR31, P68104

SAR1A, EEF1A1

Dexamethasone

hsa05135

Yersinia infection

3.72E-02

P13612, P06239, Q16539, P01375, P49841, P01732

ITGA4, LCK, MAPK14, TNF, GSK3B, CD8A

Dexamethasone

hsa05140

Leishmaniasis

2.69E-02

P13612, O75015, P13765, O60603, P01375, Q16539

ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14

Dexamethasone

hsa05143

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Dexamethasone

hsa05144

Malaria

9.96E-05

P60033, P69905, P68871, O60603, P01375, P35443, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Dexamethasone

hsa05145

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Dexamethasone

hsa05146

Amoebiasis

5.94E-04

P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311

CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG

Dexamethasone

hsa05150

Staphylococcus aureus infection

1.02E-03

P21730, P21462, O75015, P59665, P59666, P12838, P49913

C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Dexamethasone

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Dexamethasone

hsa05163

Human cytomegalovirus infection

2.51E-02

P01375, Q14643, P22694, P49841, P14778, Q13651, P25025, Q16539, O00463

TNF, ITPR1, PRKACB, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896

Dexamethasone

hsa05202

Transcriptional misregulation in cancer

4.29E-03

P14780, P27930, Q15744, Q16548, P11215, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522

MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45A

Dexamethasone

hsa05203

Viral carcinogenesis

1.22E-03

Q13547, Q15283, P58876, P62807, Q16778, O60814

HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Dexamethasone

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Dexamethasone

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Dexamethasone

hsa05212

Pancreatic cancer

3.52E-02

P84022, Q13485

SMAD3, SMAD4

Dexamethasone

hsa05220

Chronic myeloid leukemia

1.25E-02

Q13485, P25963, P84022

SMAD4, NFKBIA, SMAD3

Dexamethasone

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Dexamethasone

hsa05226

Gastric cancer

2.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Dexamethasone

hsa05230

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Dexamethasone

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.42E-02

O95267, P20963, P09693, P06239, O60603, Q04759, Q16539

RASGRP1, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14

Dexamethasone

hsa05310

Asthma

1.62E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Dexamethasone

hsa05321

Inflammatory bowel disease

1.09E-03

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Dexamethasone

hsa05322

Systemic lupus erythematosus

4.80E-06

P09871, Q93077, P58876, P62807, Q16778, O60814, P68431

C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Dexamethasone

hsa05332

Graft-versus-host disease

1.76E-02

P13765, P01375, P26715, Q13241

HLA-DOB, TNF, KLRC1, KLRD1

Dexamethasone

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Dexamethasone

hsa05415

Diabetic cardiomyopathy

3.59E-02

P11413

G6PD

Community members of Dexamethasone (S_DC: 4.57)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

NR1I2

Nuclear receptor subfamily 1 group I member 2

Reported

0.0315

0.9493

1.9143

P08235

NR3C2

Mineralocorticoid receptor

Predicted

0.1855

0.0137

2.1064

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P01375

TNF

Tumor necrosis factor

Predicted

0.1865

0.551

2.1953

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P11413

G6PD

GlucoseNone6Nonephosphate 1Nonedehydrogenase

Predicted

0.4435

0.6369

0.2929

1.7884

O15245

SLC22A1

Solute carrier family 22 member 1

Predicted

0.0149

0.0219

2.0294

P12429

ANXA3

Annexin A3

Predicted

0.4492

0.063

0.3507

P08758

ANXA5

Annexin A5

Predicted

0.2128

0.0543

0.215

P10826

RARB

Retinoic acid receptor beta

Predicted

0.0094

0.3466

0.3005

0.9983

P01375

TNF

Tumor necrosis factor

Predicted

0.1865

0.551

2.1953

PharmaCoNets of Dexamethasone (SPCN: 52.80 )

Dexamethasone regulated-network (SDN: 11.55)

Community members of Dexamethasone (SDC: 4.57)

PharmaCoNets of Dexamethasone (S_PCN: 52.80 )

Dexamethasone regulated-network (S_DN: 11.55)

Community members of Dexamethasone (S_DC: 4.57)