PharmaCoNets of Deutetrabenazine (SPCN: 22.75 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Deutetrabenazinehsa00120Primary bile acid biosynthesis3.72E-022P22680, P22307CYP7A1, SCP2More
Deutetrabenazinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Deutetrabenazinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Deutetrabenazinehsa00591Linoleic acid metabolism1.34E-031P11712CYP2C9More
Deutetrabenazinehsa00630Glyoxylate and dicarboxylate metabolism6.94E-032P40925, P15104MDH1, GLULMore
Deutetrabenazinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Deutetrabenazinehsa00980Metabolism of xenobiotics by cytochrome P4501.04E-042P78417, P11712GSTO1, CYP2C9More
Deutetrabenazinehsa00982Drug metabolism - cytochrome P4501.04E-042P11712, P78417CYP2C9, GSTO1More
Deutetrabenazinehsa01524Platinum drug resistance4.67E-024Q13489, P98170, P78417, P43246BIRC3, BIRC4, GSTO1, MSH2More
Deutetrabenazinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Deutetrabenazinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Deutetrabenazinehsa03040Spliceosome4.87E-037O43143, P08579, P26368, Q13595, Q07955, P84103, Q13243DHX15, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS3, SFRS5More
Deutetrabenazinehsa03050Proteasome1.63E-031P55036PSMD4More
Deutetrabenazinehsa04062Chemokine signaling pathway3.81E-026P07948, P62873, P63218, P50151, P43250, Q13009LYN, GNB1, GNG5, GNG10, GRK6, TIAM1More
Deutetrabenazinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Deutetrabenazinehsa04217Necroptosis9.70E-0410P01375, P01568, P48023, Q13489, P98170, Q14765, P08238, P15104, Q99878, P21796TNF, IFNA21, FASLG, BIRC3, BIRC4, STAT4, HSP90AB1, GLUL, H2AC14, VDAC1More
Deutetrabenazinehsa04371Apelin signaling pathway3.23E-047P62873, P63218, P50151, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, SMAD4, SMAD3, CAMK4, CALM1More
Deutetrabenazinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Deutetrabenazinehsa04613Neutrophil extracellular trap formation2.18E-037P04908, Q93077, P62807, O60814, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Deutetrabenazinehsa04713Circadian entrainment1.78E-035O15399, P0DP23, P62873, P63218, P50151GRIN2D, CALM1, GNB1, GNG5, GNG10More
Deutetrabenazinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Deutetrabenazinehsa04720Long-term potentiation2.33E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Deutetrabenazinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Deutetrabenazinehsa04724Glutamatergic synapse1.11E-035O15399, P62873, P63218, P50151, P15104GRIN2D, GNB1, GNG5, GNG10, GLULMore
Deutetrabenazinehsa04725Cholinergic synapse9.51E-034P62873, P63218, P50151, Q16566GNB1, GNG5, GNG10, CAMK4More
Deutetrabenazinehsa04726Serotonergic synapse2.38E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Deutetrabenazinehsa04727GABAergic synapse2.45E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Deutetrabenazinehsa04744Phototransduction6.94E-032P62873, P0DP23GNB1, CALM1More
Deutetrabenazinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Deutetrabenazinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Deutetrabenazinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Deutetrabenazinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Deutetrabenazinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Deutetrabenazinehsa05032Morphine addiction1.34E-024P62873, P63218, P50151, P43250GNB1, GNG5, GNG10, GRK6More
Deutetrabenazinehsa05034Alcoholism4.45E-0511O15399, Q16566, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431GRIN2D, CAMK4, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Deutetrabenazinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Deutetrabenazinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Deutetrabenazinehsa05163Human cytomegalovirus infection2.00E-026P62873, P63218, P50151, P0DP23, P30101, P01568GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21More
Deutetrabenazinehsa05167Kaposi sarcoma-associated herpesvirus infection2.00E-026P01568, P62873, P63218, P50151, P07948, P0DP23IFNA21, GNB1, GNG5, GNG10, LYN, CALM1More
Deutetrabenazinehsa05168Herpes simplex virus 1 infection4.43E-028P01568, Q07955, P84103, Q13243, Q13489, P30101, Q13398, Q9NZL3IFNA21, SFRS1, SFRS3, SFRS5, BIRC3, PDIA3, ZNF211, ZNF224More
Deutetrabenazinehsa05170Human immunodeficiency virus 1 infection1.83E-027P62873, P63218, P50151, P0DP23, P30101, P01568, P23528GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, CFL1More
Deutetrabenazinehsa05200Pathways in cancer3.99E-0415Q13751, P08238, P43246, P84022, Q13485, Q13489, P98170, P62873, P63218, P50151, P78417, O75293, P0DP23, P01568, P01042LAMB3, HSP90AB1, MSH2, SMAD3, SMAD4, BIRC3, BIRC4, GNB1, GNG5, GNG10, GSTO1, GADD45B, CALM1, IFNA21, KNG1More
Deutetrabenazinehsa05203Viral carcinogenesis3.28E-033Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Deutetrabenazinehsa05204Chemical carcinogenesis2.96E-042P78417, P11712GSTO1, CYP2C9More
Deutetrabenazinehsa05210Colorectal cancer4.67E-024P84022, Q13485, P43246, O75293SMAD3, SMAD4, MSH2, GADD45BMore
Deutetrabenazinehsa05212Pancreatic cancer3.28E-023P84022, Q13485, O75293SMAD3, SMAD4, GADD45BMore
Deutetrabenazinehsa05214Glioma3.28E-023P0DP23, Q16566, O75293CALM1, CAMK4, GADD45BMore
Deutetrabenazinehsa05222Small cell lung cancer3.80E-024Q13751, Q13489, P98170, O75293LAMB3, BIRC3, BIRC4, GADD45BMore
Deutetrabenazinehsa05225Hepatocellular carcinoma4.54E-023Q92922, P78417, Q9NPI1SMARCC1, GSTO1, BRD7More
Deutetrabenazinehsa05322Systemic lupus erythematosus1.73E-055P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Deutetrabenazinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Deutetrabenazinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Deutetrabenazinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Deutetrabenazine (SDC: 3.36)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q9NPI1BRD7BromodomainNonecontaining protein 7Predicted00.03190.02750.12130.1923
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q96KQ7EHMT2HistoneNonelysine NNonemethyltransferase EHMT2Predicted00.07280.21650.29090.7603
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)