PharmaCoNets of Desipramine (SPCN: 108.71 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Desipraminehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Desipraminehsa00040Pentose and glucuronate interconversions4.00E-021P15121AKR1B1More
Desipraminehsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Desipraminehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Desipraminehsa00620Pyruvate metabolism3.90E-022P07195, P11766LDHB, ADH5More
Desipraminehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Desipraminehsa00790Folate biosynthesis2.02E-021P15121AKR1B1More
Desipraminehsa00830Retinol metabolism3.15E-021P00325ADH1BMore
Desipraminehsa00980Metabolism of xenobiotics by cytochrome P4504.00E-021P09211GSTP1More
Desipraminehsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Desipraminehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Desipraminehsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Desipraminehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Desipraminehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Desipraminehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Desipraminehsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Desipraminehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Desipraminehsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Desipraminehsa03010Ribosome1.08E-0411P62753, P25398, P32969, P40429, P62829, Q07020, P18077, P36578, P27635, P05386, P62249RPS6, RPS12, RPL9, RPL13A, RPL23, RPL18, RPL35A, RPL4, RPL10, RPLP1, RPS16More
Desipraminehsa03020RNA polymerase1.15E-033P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Desipraminehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Desipraminehsa03050Proteasome1.21E-021P28074PSMB5More
Desipraminehsa03060Protein export4.46E-032Q15070, O76094OXA1L, SRP72More
Desipraminehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Desipraminehsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Desipraminehsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Desipraminehsa04015Rap1 signaling pathway2.99E-021P08069IGF1RMore
Desipraminehsa04064NF-kappa B signaling pathway1.60E-028P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Desipraminehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Desipraminehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Desipraminehsa04071Sphingolipid signaling pathway1.17E-036P21453, Q9H228, P01375, Q13362, Q9BX95, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Desipraminehsa04080Neuroactive ligand-receptor interaction2.16E-039P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2More
Desipraminehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Desipraminehsa04114Oocyte meiosis2.99E-021P08069IGF1RMore
Desipraminehsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Desipraminehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Desipraminehsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Desipraminehsa04141Protein processing in endoplasmic reticulum3.07E-037P18848, P07384, O95487, O60337, P11142, P07900, O95816ATF4, CAPN1, SEC24B, MARH6, HSPA8, HSP90AA1, BAG2More
Desipraminehsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Desipraminehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Desipraminehsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Desipraminehsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Desipraminehsa04213Longevity regulating pathway - multiple species2.83E-033P08069, Q9Y4H2, Q13547IGF1R, IRS2, HDAC1More
Desipraminehsa04217Necroptosis6.67E-0718P01375, P01568, P48023, Q13489, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q13557, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CAMK2D, CHMP2A, PPIDMore
Desipraminehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Desipraminehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Desipraminehsa04360Axon guidance1.50E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Desipraminehsa04510Focal adhesion3.48E-021P08069IGF1RMore
Desipraminehsa04520Adherens junction8.29E-031P08069IGF1RMore
Desipraminehsa04530Tight junction2.08E-023P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Desipraminehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Desipraminehsa04610Complement and coagulation cascades5.18E-061P0C0L4C4AMore
Desipraminehsa04612Antigen processing and presentation4.24E-059P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Desipraminehsa04613Neutrophil extracellular trap formation3.76E-0410P11215, Q13547, P04908, Q93077, P58876, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Desipraminehsa04621NOD-like receptor signaling pathway2.27E-029Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Desipraminehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Desipraminehsa04640Hematopoietic cell lineage3.69E-024P21926, P07766, P01730, P09564CD9, CD3E, CD4, CD7More
Desipraminehsa04650Natural killer cell mediated cytotoxicity4.40E-059P01375, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Desipraminehsa04657IL-17 signaling pathway2.51E-036P07900, P19875, P14780, P80188, P01375, P01584HSP90AA1, CXCL2, MMP9, LCN2, TNF, IL1BMore
Desipraminehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Desipraminehsa04714Thermogenesis1.73E-047Q16539, P15336, P63261, P33121, Q9Y478, Q16718, O14521MAPK14, ATF2, ACTG1, ACSL1, PRKAB1, NDUFA5, SDHDMore
Desipraminehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Desipraminehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Desipraminehsa04725Cholinergic synapse4.83E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Desipraminehsa04730Long-term depression1.16E-021P08069IGF1RMore
Desipraminehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Desipraminehsa04742Taste transduction1.01E-021P30939HTR1FMore
Desipraminehsa04913Ovarian steroidogenesis7.72E-033P42330, P22694, P08069AKR1C3, PRKACB, IGF1RMore
Desipraminehsa04914Progesterone-mediated oocyte maturation2.16E-021P08069IGF1RMore
Desipraminehsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Desipraminehsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Desipraminehsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Desipraminehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Desipraminehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Desipraminehsa04927Cortisol synthesis and secretion4.44E-043Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Desipraminehsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Desipraminehsa04932Non-alcoholic fatty liver disease6.73E-059P01375, P49841, P18848, P48023, P01584, P13073, O15239, Q16718, O14521TNF, GSK3B, ATF4, FASLG, IL1B, COX4I1, NDUFA1, NDUFA5, SDHDMore
Desipraminehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Desipraminehsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Desipraminehsa04966Collecting duct acid secretion1.29E-032P02730, P00918SLC4A1, CA2More
Desipraminehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Desipraminehsa04972Pancreatic secretion1.31E-022Q08828, P62491ADCY1, RAB11AMore
Desipraminehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Desipraminehsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Desipraminehsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Desipraminehsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Desipraminehsa05020Prion disease3.73E-0411P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14More
Desipraminehsa05022Pathways of neurodegeneration - multiple diseases1.47E-0312P49841, O15239, Q16718, O14521, P13073, P18848, Q13561, P05141, Q16539, P01584, Q08752, Q13557GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, DCTN2, SLC25A5, MAPK14, IL1B, PPID, CAMK2DMore
Desipraminehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Desipraminehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Desipraminehsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Desipraminehsa05133Pertussis3.60E-031P0C0L4C4AMore
Desipraminehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Desipraminehsa05140Leishmaniasis1.56E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Desipraminehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Desipraminehsa05144Malaria1.72E-034P60033, P01375, P35443, P26718CD81, TNF, THBS4, KLRK1More
Desipraminehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Desipraminehsa05150Staphylococcus aureus infection1.48E-049P0C0L4, P21730, P21462, O75015, P13646, P59665, P59666, P12838, P49913C4A, C5AR1, FPR1, FCGR3B, KRT13, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Desipraminehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Desipraminehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Desipraminehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Desipraminehsa05171Coronavirus disease - COVID-196.98E-0512P01584, P62753, P25398, P62249, P40429, P36578, P32969, P27635, Q07020, P18077, P05386, P62829IL1B, RPS6, RPS12, RPS16, RPL13A, RPL4, RPL9, RPL10, RPL18, RPL35A, RPLP1, RPL23More
Desipraminehsa05202Transcriptional misregulation in cancer1.33E-0416Q15532, Q13315, P14780, P27930, Q15744, Q16548, P11215, O15550, P08069, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522SS18, ATM, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, UTX, IGF1R, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Desipraminehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Desipraminehsa05204Chemical carcinogenesis4.00E-021P09211GSTP1More
Desipraminehsa05205Proteoglycans in cancer1.09E-026P14780, P01375, P08069, P23588, Q13635, P22694MMP9, TNF, IGF1R, EIF4B, PTCH1, PRKACBMore
Desipraminehsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Desipraminehsa05214Glioma9.95E-031P08069IGF1RMore
Desipraminehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Desipraminehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Desipraminehsa05218Melanoma9.63E-044P08069, P09619, Q9GZP0, Q02750IGF1R, PDGFRB, PDGFD, MAP2K1More
Desipraminehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Desipraminehsa05224Breast cancer1.49E-021P08069IGF1RMore
Desipraminehsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Desipraminehsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Desipraminehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-024P07766, P06239, Q9HC35, P01730CD3E, LCK, EML4, CD4More
Desipraminehsa05321Inflammatory bowel disease1.19E-036P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Desipraminehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Desipraminehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Desipraminehsa05332Graft-versus-host disease1.91E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Desipraminehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Desipraminehsa05412Arrhythmogenic right ventricular cardiomyopathy4.71E-033Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Desipraminehsa05414Dilated cardiomyopathy2.58E-034Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Desipraminehsa05415Diabetic cardiomyopathy5.78E-0512P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557, P04406PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2D, GAPDHMore

Community members of Desipramine (SDC: 6.69)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P09211GSTP1Glutathione SNonetransferase PPredicted00.32040.35230.45661.3213
P04156PRNPMajor prion proteinPredicted00.59090.173700.6429
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P37840SNCAAlphaNonesynucleinPredicted10.08530.13240.33210.6395
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
SLC6A4P31645IC5064
SLC6A4P31645IC50108
SLC6A4P31645IC50560
SLC6A4P31645Ki17.6
SLC6A4P31645Ki19.1
SLC6A4P31645Ki20
DRD2P14416Ki1561
DRD2P14416Ki3500