PharmaCoNets of Desflurane (SPCN: 12.59 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Desfluranehsa00061Fatty acid biosynthesis4.83E-021P33121ACSL1More
Desfluranehsa00190Oxidative phosphorylation3.50E-022Q16718, Q13488NDUFA5, TCIRG1More
Desfluranehsa00230Purine metabolism3.71E-024Q13370, P36959, Q13956, P27707PDE3B, GMPR, PDE6H, DCKMore
Desfluranehsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Desfluranehsa00500Starch and sucrose metabolism2.86E-022O43451, P46976MGAM, GYG1More
Desfluranehsa00600Sphingolipid metabolism3.01E-022Q9BX95, P06280SGPP1, GLAMore
Desfluranehsa00620Pyruvate metabolism4.20E-022P40926, P14550MDH2, AKR1A1More
Desfluranehsa00730Thiamine metabolism1.75E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Desfluranehsa00770Pantothenate and CoA biosynthesis1.78E-022O95498, O95497VNN2, VNN1More
Desfluranehsa01100Metabolic pathways4.56E-0211P15144, P32320, P06280, P24666, P33121, P42330, Q13093, Q9NY28, Q9BX95, P09960, Q16718ANPEP, CDA, GLA, ACP1, ACSL1, AKR1C3, PLA2G7, GALNT8, SGPP1, LTA4H, NDUFA5More
Desfluranehsa01240Biosynthesis of cofactors3.34E-023P05186, Q9Y6K8, O75911ALPL, AK5, DHRS3More
Desfluranehsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Desfluranehsa03010Ribosome3.56E-0614P62753, P42677, P32969, P40429, P62917, P46776, Q9H0U6, Q07020, P62910, Q02878, P36578, P05386, P62249, P23396RPS6, RPS27, RPL9, RPL13A, RPL8, RPL27A, MRPL18, RPL18, RPL32, RPL6, RPL4, RPLP1, RPS16, RPS3More
Desfluranehsa03013RNA transport1.13E-028P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, TACC3More
Desfluranehsa03020RNA polymerase9.86E-072Q9GZM3, P52435POLR2J2, POLR2JMore
Desfluranehsa03022Basal transcription factors2.17E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Desfluranehsa03050Proteasome1.40E-021P55036PSMD4More
Desfluranehsa03430Mismatch repair3.21E-022P43246, P15927MSH2, RPA2More
Desfluranehsa04020Calcium signaling pathway4.50E-035P30679, O15399, P0DP23, P23634, P49767GNA15, GRIN2D, CALM1, ATP2B4, VEGFCMore
Desfluranehsa04024cAMP signaling pathway1.27E-037P49019, P63092, P22694, P26678, P20020, P61586, P48058HCAR3, GNAS, PRKACB, PLN, ATP2B1, RHOA, GRIA4More
Desfluranehsa04070Phosphatidylinositol signaling system2.82E-023P0DP23, Q16760, Q96PE3CALM1, DGKD, INPP4AMore
Desfluranehsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Desfluranehsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Desfluranehsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Desfluranehsa04145Phagosome2.75E-024Q15080, P14598, P68371, Q13488NCF4, NCF1, TUBB2C, TCIRG1More
Desfluranehsa04217Necroptosis1.70E-025P01568, Q13489, P08238, O43633, Q08752IFNA21, BIRC3, HSP90AB1, CHMP2A, PPIDMore
Desfluranehsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Desfluranehsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Desfluranehsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Desfluranehsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Desfluranehsa04640Hematopoietic cell lineage4.27E-024P08514, P14778, P01730, P13765ITGA2B, IL1R1, CD4, HLA-DOBMore
Desfluranehsa04650Natural killer cell mediated cytotoxicity2.11E-024P17252, O60880, P26717, P26715PRKCA, SH2D1A, KLRC2, KLRC1More
Desfluranehsa04659Th17 cell differentiation2.73E-024Q16539, P01730, P13765, P14778MAPK14, CD4, HLA-DOB, IL1R1More
Desfluranehsa04713Circadian entrainment1.84E-035P17252, P62873, P48058, P22694, P63092PRKCA, GNB1, GRIA4, PRKACB, GNASMore
Desfluranehsa04714Thermogenesis3.16E-023P22694, P33121, Q16718PRKACB, ACSL1, NDUFA5More
Desfluranehsa04721Synaptic vesicle cycle1.14E-022Q13488, P31645TCIRG1, SLC6A4More
Desfluranehsa04723Retrograde endocannabinoid signaling1.47E-046P17252, P48169, P62873, P48058, P22694, Q16718PRKCA, GABRA4, GNB1, GRIA4, PRKACB, NDUFA5More
Desfluranehsa04724Glutamatergic synapse1.06E-035P48058, P63092, P22694, P17252, P62873GRIA4, GNAS, PRKACB, PRKCA, GNB1More
Desfluranehsa04726Serotonergic synapse1.84E-035P63092, P22694, P17252, P31645, P62873GNAS, PRKACB, PRKCA, SLC6A4, GNB1More
Desfluranehsa04911Insulin secretion3.01E-022P22694, P17252PRKACB, PRKCAMore
Desfluranehsa04913Ovarian steroidogenesis1.28E-022P42330, P22694AKR1C3, PRKACBMore
Desfluranehsa04918Thyroid hormone synthesis3.01E-022P22694, P17252PRKACB, PRKCAMore
Desfluranehsa04925Aldosterone synthesis and secretion9.86E-033P17252, P22694, P20020PRKCA, PRKACB, ATP2B1More
Desfluranehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Desfluranehsa04961Endocrine and other factor-regulated calcium reabsorption9.85E-053P20020, P17252, P22694ATP2B1, PRKCA, PRKACBMore
Desfluranehsa04962Vasopressin-regulated water reabsorption6.61E-032P22694, Q13561PRKACB, DCTN2More
Desfluranehsa04970Salivary secretion7.14E-033P22694, P20020, P17252PRKACB, ATP2B1, PRKCAMore
Desfluranehsa04972Pancreatic secretion1.29E-044P20020, P17252, P63092, P61586ATP2B1, PRKCA, GNAS, RHOAMore
Desfluranehsa04976Bile secretion3.01E-022P22694, P08183PRKACB, ABCB1More
Desfluranehsa05010Alzheimer disease7.11E-039O15239, P13073, P18848, O15169, P67870, P05141, P12236, P28070, P43686NDUFA1, COX4I1, ATF4, AXIN1, CSNK2B, SLC25A5, SLC25A6, PSMB4, PSMC4More
Desfluranehsa05012Parkinson disease2.14E-027O15239, P13073, P05141, P12236, P18848, P28070, P43686NDUFA1, COX4I1, SLC25A5, SLC25A6, ATF4, PSMB4, PSMC4More
Desfluranehsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Desfluranehsa05017Spinocerebellar ataxia4.66E-024P28070, P43686, P05141, P12236PSMB4, PSMC4, SLC25A5, SLC25A6More
Desfluranehsa05020Prion disease1.55E-0310P46531, O15239, P13073, P18848, P05141, P12236, P28070, P43686, P67870, P51636NOTCH1, NDUFA1, COX4I1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, CSNK2B, CAV2More
Desfluranehsa05022Pathways of neurodegeneration - multiple diseases5.20E-0415P67870, O15239, Q16718, P13073, P18848, Q13561, P48058, P05141, P12236, P17252, P20333, O15169, Q08752, P28070, P43686CSNK2B, NDUFA1, NDUFA5, COX4I1, ATF4, DCTN2, GRIA4, SLC25A5, SLC25A6, PRKCA, TNFRSF1B, AXIN1, PPID, PSMB4, PSMC4More
Desfluranehsa05031Amphetamine addiction1.69E-023P48058, P22694, P17252GRIA4, PRKACB, PRKCAMore
Desfluranehsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Desfluranehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Desfluranehsa05110Vibrio cholerae infection3.01E-022P17252, P22694PRKCA, PRKACBMore
Desfluranehsa05140Leishmaniasis1.98E-025O75015, P14598, O60603, P29350, Q15080FCGR3B, NCF1, TLR2, PTPN6, NCF4More
Desfluranehsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Desfluranehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Desfluranehsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Desfluranehsa05163Human cytomegalovirus infection2.09E-024P62873, P61586, P63092, P61769GNB1, RHOA, GNAS, B2MMore
Desfluranehsa05171Coronavirus disease - COVID-196.74E-0715P23396, P62753, P62249, P42677, P40429, Q9UHA3, P36578, Q02878, P62917, P32969, Q07020, P46776, P62910, P05386, O14786RPS3, RPS6, RPS16, RPS27, RPL13A, RSL24D1, RPL4, RPL6, RPL8, RPL9, RPL18, RPL27A, RPL32, RPLP1, NRP1More
Desfluranehsa05224Breast cancer3.88E-023P46531, Q9UM47, O15169NOTCH1, NOTCH3, AXIN1More
Desfluranehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Desfluranehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Desfluranehsa05340Primary immunodeficiency1.58E-023P01730, P11912, Q8WV28CD4, CD79A, BLNKMore
Desfluranehsa05415Diabetic cardiomyopathy2.75E-024P17252, P14598, Q15080, Q16718PRKCA, NCF1, NCF4, NDUFA5More

Community members of Desflurane (SDC: 1.73)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
P20020ATP2B1Plasma membrane calciumNonetransporting ATPase 1Reported00.1480.01330.25720.3578
P23634ATP2B4Plasma membrane calciumNonetransporting ATPase 4Reported00.52210.01330.25720.5449
P16389KCNA2Potassium voltageNonegated channel subfamily A member 2Predicted00.01310.083500.1736
P17658KCNA6Potassium voltageNonegated channel subfamily A member 6Predicted00.28270.078500.2984
P48058GRIA4Glutamate receptor 4Predicted00.40370.12090.37480.8184
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
Q9ULS6KCNS2Potassium voltageNonegated channel subfamily S member 2Predicted00.19550.041200.1801
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)