PharmaCoNets of Dequalinium (SPCN: 23.07 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dequaliniumhsa00190Oxidative phosphorylation8.71E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Dequaliniumhsa00670One carbon pool by folate3.62E-021P00374DHFRMore
Dequaliniumhsa00790Folate biosynthesis3.62E-021P00374DHFRMore
Dequaliniumhsa03020RNA polymerase9.80E-052Q9GZM3, P52435POLR2J2, POLR2JMore
Dequaliniumhsa03050Proteasome3.05E-021P55036PSMD4More
Dequaliniumhsa04064NF-kappa B signaling pathway3.99E-026P10415, Q13489, P29965, Q9UDY8, Q8WV28, Q13315BCL2, BIRC3, CD40LG, MALT1, BLNK, ATMMore
Dequaliniumhsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Dequaliniumhsa04071Sphingolipid signaling pathway4.49E-024P17252, Q13362, Q9BX95, P10415PRKCA, PPP2R5C, SGPP1, BCL2More
Dequaliniumhsa04145Phagosome1.59E-037Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOBMore
Dequaliniumhsa04151PI3K-Akt signaling pathway4.50E-029P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCAMore
Dequaliniumhsa04217Necroptosis9.14E-037P01568, Q13489, P42224, Q6FI13, P10415, O43633, Q08752IFNA21, BIRC3, STAT1, H2AC18; H2AC19, BCL2, CHMP2A, PPIDMore
Dequaliniumhsa04261Adrenergic signaling in cardiomyocytes2.84E-025P09493, Q13362, P0DP23, P17252, P10415TPM1, PPP2R5C, CALM1, PRKCA, BCL2More
Dequaliniumhsa04540Gap junction1.29E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Dequaliniumhsa04612Antigen processing and presentation1.64E-028P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Dequaliniumhsa04613Neutrophil extracellular trap formation2.64E-0317P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, Q6FI13, P68431, P14598, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Dequaliniumhsa04625C-type lectin receptor signaling pathway4.80E-026Q9ULY5, P20749, Q14643, P01375, Q13191, Q16539CLEC4E, BCL3, ITPR1, TNF, CBLB, MAPK14More
Dequaliniumhsa04640Hematopoietic cell lineage2.52E-029P13612, P14778, P27930, P15144, P11836, P09693, P01732, P13765, P01375ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD3G, CD8A, HLA-DOB, TNFMore
Dequaliniumhsa04650Natural killer cell mediated cytotoxicity1.88E-029P01375, P78314, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Dequaliniumhsa04657IL-17 signaling pathway2.81E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Dequaliniumhsa04658Th1 and Th2 cell differentiation7.47E-038Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Dequaliniumhsa04659Th17 cell differentiation3.13E-028Q04759, Q16539, P13765, P14778, Q9UL17, P23771, P09693, P20963PRKCQ, MAPK14, HLA-DOB, IL1R1, TBX21, GATA3, CD3G, CD247More
Dequaliniumhsa04660T cell receptor signaling pathway8.00E-0310P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Dequaliniumhsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Dequaliniumhsa04713Circadian entrainment2.60E-024P0DP23, P17252, P62873, Q14643CALM1, PRKCA, GNB1, ITPR1More
Dequaliniumhsa04720Long-term potentiation3.89E-023P17252, P0DP23, Q14643PRKCA, CALM1, ITPR1More
Dequaliniumhsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Dequaliniumhsa04725Cholinergic synapse1.88E-024Q14643, P17252, P62873, P10415ITPR1, PRKCA, GNB1, BCL2More
Dequaliniumhsa04728Dopaminergic synapse3.55E-025Q14643, P17252, P62873, Q13362, P0DP23ITPR1, PRKCA, GNB1, PPP2R5C, CALM1More
Dequaliniumhsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Dequaliniumhsa04912GnRH signaling pathway4.59E-036P17252, Q16539, Q9Y6R4, Q14643, P0DP23, P22694PRKCA, MAPK14, MAP3K4, ITPR1, CALM1, PRKACBMore
Dequaliniumhsa04920Adipocytokine signaling pathway4.72E-024P33121, Q04759, Q9Y4H2, P01375ACSL1, PRKCQ, IRS2, TNFMore
Dequaliniumhsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Dequaliniumhsa04924Renin secretion8.71E-033Q14643, Q13370, P0DP23ITPR1, PDE3B, CALM1More
Dequaliniumhsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Dequaliniumhsa04966Collecting duct acid secretion2.86E-022Q13488, Q9Y666TCIRG1, SLC12A7More
Dequaliniumhsa05010Alzheimer disease3.55E-027Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPIDMore
Dequaliniumhsa05012Parkinson disease2.25E-026Q16718, O14521, Q14643, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2CMore
Dequaliniumhsa05016Huntington disease1.07E-023Q9GZM3, P52435, P55036POLR2J2, POLR2J, PSMD4More
Dequaliniumhsa05020Prion disease1.15E-027Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4More
Dequaliniumhsa05022Pathways of neurodegeneration - multiple diseases4.48E-0310Q14643, Q13509, P68371, P10415, Q16718, O14521, Q13561, P17252, Q08752, P0DP23ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, PPID, CALM1More
Dequaliniumhsa05034Alcoholism2.79E-022P62879, Q9BTM1GNB2, H2AFJMore
Dequaliniumhsa05131Shigellosis2.27E-028P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Dequaliniumhsa05132Salmonella infection1.11E-028Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Dequaliniumhsa05140Leishmaniasis1.18E-0410P13612, O75015, P14598, P42224, P13765, O60603, P01375, P29350, Q16539, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, TNF, PTPN6, MAPK14, NCF4More
Dequaliniumhsa05144Malaria1.54E-025P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Dequaliniumhsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Dequaliniumhsa05146Amoebiasis7.47E-038P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Dequaliniumhsa05152Tuberculosis7.93E-048Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1More
Dequaliniumhsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Dequaliniumhsa05167Kaposi sarcoma-associated herpesvirus infection4.73E-026P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1More
Dequaliniumhsa05170Human immunodeficiency virus 1 infection4.67E-039P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2More
Dequaliniumhsa05200Pathways in cancer8.04E-0315P17301, P42224, Q9UJU2, P17252, P20585, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P62879, P0DP23, P01568ITGA2, STAT1, LEF1, PRKCA, MSH3, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, GNB2, CALM1, IFNA21More
Dequaliniumhsa05202Transcriptional misregulation in cancer2.41E-0315P41732, P14780, P27930, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522TSPAN7, MMP9, IL1R2, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Dequaliniumhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Dequaliniumhsa05321Inflammatory bowel disease2.22E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Dequaliniumhsa05322Systemic lupus erythematosus4.18E-037P08246, P09871, P10747, P13765, P29965, Q6FI13, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Dequaliniumhsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Dequaliniumhsa05330Allograft rejection1.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Dequaliniumhsa05332Graft-versus-host disease2.76E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Dequaliniumhsa05415Diabetic cardiomyopathy3.55E-025P17252, P14598, Q15080, Q16718, O14521PRKCA, NCF1, NCF4, NDUFA5, SDHDMore
Dequaliniumhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More

Community members of Dequalinium (SDC: 2.40)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P98170BIRC4E3 ubiquitinNoneprotein ligase XIAPReported00.29740.22980.791.3984
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P21730C5AR1C5a anaphylatoxin chemotactic receptor 1Predicted10.02580.21670.53960.986
P00374DHFRDihydrofolate reductasePredicted00.3380.18680.22630.7688
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)