PharmaCoNets of Degarelix (SPCN: 5.85 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Degarelixhsa00072Synthesis and degradation of ketone bodies2.78E-021Q01581HMGCS1More
Degarelixhsa00310Lysine degradation2.86E-022Q96KQ7, Q02809EHMT2, PLOD1More
Degarelixhsa00900Terpenoid backbone biosynthesis1.40E-021Q01581HMGCS1More
Degarelixhsa01521EGFR tyrosine kinase inhibitor resistance2.18E-022P49841, Q9NRA1GSK3B, PDGFCMore
Degarelixhsa03020RNA polymerase9.80E-052Q9GZM3, P52435POLR2J2, POLR2JMore
Degarelixhsa03040Spliceosome4.73E-026Q14562, O43143, P52298, Q13595, Q07955, Q13243DHX8, DHX15, NCBP2, TRA2A, SFRS1, SFRS5More
Degarelixhsa03050Proteasome3.05E-021P55036PSMD4More
Degarelixhsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Degarelixhsa04071Sphingolipid signaling pathway4.49E-024P17252, P21453, Q9BX95, P10415PRKCA, S1PR1, SGPP1, BCL2More
Degarelixhsa04080Neuroactive ligand-receptor interaction5.10E-038Q15722, P21453, O00398, P25116, Q01726, P41968, P21462, Q16581LTB4R, S1PR1, P2RY10, F2R, MC1R, MC3R, FPR1, C3AR1More
Degarelixhsa04145Phagosome8.42E-036Q15080, P14598, Q13509, P68371, Q13488, O60603NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2More
Degarelixhsa04217Necroptosis3.34E-026P01568, Q13489, Q13546, Q6FI13, P10415, O43633IFNA21, BIRC3, RIPK1, H2AC18; H2AC19, BCL2, CHMP2AMore
Degarelixhsa04540Gap junction1.29E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Degarelixhsa04613Neutrophil extracellular trap formation3.58E-028P17252, O60603, P08246, Q6FI13, P68431, P14598, Q15080, P21462PRKCA, TLR2, ELA2, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1More
Degarelixhsa04623Cytosolic DNA-sensing pathway2.86E-022P01568, Q13546IFNA21, RIPK1More
Degarelixhsa04666Fc gamma R-mediated phagocytosis1.88E-024P23528, O14494, P14598, P17252CFL1, PLPP1, NCF1, PRKCAMore
Degarelixhsa04713Circadian entrainment2.60E-024P0DP23, P17252, P62873, Q14643CALM1, PRKCA, GNB1, ITPR1More
Degarelixhsa04720Long-term potentiation5.06E-034P17252, Q16566, P0DP23, Q14643PRKCA, CAMK4, CALM1, ITPR1More
Degarelixhsa04725Cholinergic synapse2.72E-035Q14643, P17252, P62873, Q16566, P10415ITPR1, PRKCA, GNB1, CAMK4, BCL2More
Degarelixhsa04726Serotonergic synapse4.49E-024Q14643, P17252, P62873, P33260ITPR1, PRKCA, GNB1, CYP2C18More
Degarelixhsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Degarelixhsa04912GnRH signaling pathway3.89E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Degarelixhsa04916Melanogenesis2.18E-022P49841, Q01726GSK3B, MC1RMore
Degarelixhsa04925Aldosterone synthesis and secretion1.29E-024Q14643, P0DP23, P17252, Q16566ITPR1, CALM1, PRKCA, CAMK4More
Degarelixhsa04966Collecting duct acid secretion2.86E-022Q13488, Q9Y666TCIRG1, SLC12A7More
Degarelixhsa05016Huntington disease1.07E-023Q9GZM3, P52435, P55036POLR2J2, POLR2J, PSMD4More
Degarelixhsa05020Prion disease3.99E-026O14521, Q14643, Q13509, P68371, P14598, Q15080SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4More
Degarelixhsa05022Pathways of neurodegeneration - multiple diseases4.11E-028Q14643, Q13509, P68371, P10415, O14521, Q13561, P17252, P0DP23ITPR1, TUBB3, TUBB2C, BCL2, SDHD, DCTN2, PRKCA, CALM1More
Degarelixhsa05132Salmonella infection1.11E-028Q9UJU2, Q13546, Q13489, P10415, O60603, Q13561, Q13509, P68371LEF1, RIPK1, BIRC3, BCL2, TLR2, DCTN2, TUBB3, TUBB2CMore
Degarelixhsa05133Pertussis3.89E-023P0DP23, P23528, P09871CALM1, CFL1, C1SMore
Degarelixhsa05152Tuberculosis4.18E-037Q13488, P0DP23, P48382, O60603, P10415, P01568, Q9UDY8TCIRG1, CALM1, RFX5, TLR2, BCL2, IFNA21, MALT1More
Degarelixhsa05163Human cytomegalovirus infection4.73E-026P62873, Q14643, P0DP23, P17252, Q13546, P01568GNB1, ITPR1, CALM1, PRKCA, RIPK1, IFNA21More
Degarelixhsa05170Human immunodeficiency virus 1 infection1.16E-0310P62873, P0DP23, P17252, Q13546, Q14643, P01568, O60603, P23528, P10415, Q9Y6Q5GNB1, CALM1, PRKCA, RIPK1, ITPR1, IFNA21, TLR2, CFL1, BCL2, AP1M2More

Community members of Degarelix (SDC: 1.50)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P41968MC3RMelanocortin receptor 3Predicted10.22350.263700.6392
Q01726MC1RMelanocyteNonestimulating hormone receptorPredicted10.0470.23750.0110.5095
Q13489BIRC3Baculoviral IAP repeatNonecontaining protein 3Predicted00.33620.04930.84721.114
P98170BIRC4E3 ubiquitinNoneprotein ligase XIAPPredicted00.29740.22980.791.3984
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)