PharmaCoNets of Deflazacort (SPCN: 23.85 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Deflazacorthsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Deflazacorthsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Deflazacorthsa01200Carbon metabolism2.91E-021P11413G6PDMore
Deflazacorthsa03013RNA transport8.19E-047Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2More
Deflazacorthsa03040Spliceosome3.98E-024Q15427, P38159, P61978, P11142SF3B4, RBMX, HNRPK, HSPA8More
Deflazacorthsa03060Protein export9.07E-042P37108, Q15005SRP14, SPCS2More
Deflazacorthsa04012ErbB signaling pathway3.74E-023P21860, Q13557, O14944ERBB3, CAMK2D, EREGMore
Deflazacorthsa04020Calcium signaling pathway2.19E-0510Q96DU7, Q08828, P45880, Q13557, P21860, P61073, P0DP24, P05141, P51828, P23634ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, CXCR4, CALM2, SLC25A5, ADCY7, ATP2B4More
Deflazacorthsa04022cGMP-PKG signaling pathway2.45E-038Q99941, P18848, P23634, Q08828, P51828, P05141, P45880, P0DP24CREBL1, ATF4, ATP2B4, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2More
Deflazacorthsa04061Viral protein interaction with cytokine and cytokine receptor1.91E-023Q8NHW4, P61073, Q13651CCL4L2, CXCR4, IL10RAMore
Deflazacorthsa04064NF-kappa B signaling pathway9.08E-048Q13489, Q13546, P01584, Q9UDY8, P63279, Q8NHW4, Q9UNE0, Q9NQC7BIRC3, RIPK1, IL1B, MALT1, UBE2I, CCL4L2, EDAR, CYLDMore
Deflazacorthsa04114Oocyte meiosis4.36E-025Q13557, P0DP24, Q08828, P51828, P27348CAMK2D, CALM2, ADCY1, ADCY7, YWHAQMore
Deflazacorthsa04141Protein processing in endoplasmic reticulum3.64E-025Q99941, O75460, P11142, Q9H3Z4, P07900CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Deflazacorthsa04211Longevity regulating pathway3.41E-037Q12778, Q08828, P51828, Q99941, P18848, Q9UEF7, Q96KQ7FOXO1, ADCY1, ADCY7, CREBL1, ATF4, KL, EHMT2More
Deflazacorthsa04217Necroptosis6.23E-0410P01568, P23458, Q13489, Q9NQC7, Q13546, P05141, P01584, P0C0S5, Q13557, Q9H444IFNA21, JAK1, BIRC3, CYLD, RIPK1, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4BMore
Deflazacorthsa04261Adrenergic signaling in cardiomyocytes1.60E-037Q08828, P51828, Q99941, P18848, P0DP24, Q13557, P23634ADCY1, ADCY7, CREBL1, ATF4, CALM2, CAMK2D, ATP2B4More
Deflazacorthsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Deflazacorthsa04380Osteoclast differentiation4.98E-024Q9NQC7, Q9UQC2, P23458, P01584CYLD, GAB2, JAK1, IL1BMore
Deflazacorthsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Deflazacorthsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Deflazacorthsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Deflazacorthsa04623Cytosolic DNA-sensing pathway5.86E-054P01584, P01568, Q13546, Q8NHW4IL1B, IFNA21, RIPK1, CCL4L2More
Deflazacorthsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Deflazacorthsa04713Circadian entrainment1.91E-024P0DP24, Q13557, Q08828, P51828CALM2, CAMK2D, ADCY1, ADCY7More
Deflazacorthsa04720Long-term potentiation1.91E-024Q13557, P0DP24, P18848, Q08828CAMK2D, CALM2, ATF4, ADCY1More
Deflazacorthsa04725Cholinergic synapse3.77E-024Q08828, P51828, P18848, Q13557ADCY1, ADCY7, ATF4, CAMK2DMore
Deflazacorthsa04728Dopaminergic synapse2.67E-025Q99941, P18848, Q13557, P0DP24, O15516CREBL1, ATF4, CAMK2D, CALM2, CLOCKMore
Deflazacorthsa04750Inflammatory mediator regulation of TRP channels4.53E-045P01584, Q08828, P51828, Q13557, P0DP24IL1B, ADCY1, ADCY7, CAMK2D, CALM2More
Deflazacorthsa04911Insulin secretion2.95E-055Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Deflazacorthsa04912GnRH signaling pathway6.99E-035Q08828, P51828, P18848, Q13557, P0DP24ADCY1, ADCY7, ATF4, CAMK2D, CALM2More
Deflazacorthsa04915Estrogen signaling pathway4.72E-024Q99941, P51828, P07900, P11142CREBL1, ADCY7, HSP90AA1, HSPA8More
Deflazacorthsa04916Melanogenesis7.61E-034Q13557, P0DP24, Q08828, P51828CAMK2D, CALM2, ADCY1, ADCY7More
Deflazacorthsa04918Thyroid hormone synthesis4.47E-035Q08828, P51828, Q99941, P18848, P02768ADCY1, ADCY7, CREBL1, ATF4, ALBMore
Deflazacorthsa04925Aldosterone synthesis and secretion8.00E-067Q99941, P18848, Q08828, P51828, P0DP24, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4More
Deflazacorthsa04927Cortisol synthesis and secretion4.16E-034Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Deflazacorthsa04928Parathyroid hormone synthesis, secretion and action3.77E-024Q08828, P51828, Q99941, P18848ADCY1, ADCY7, CREBL1, ATF4More
Deflazacorthsa04932Non-alcoholic fatty liver disease3.45E-025P18848, O75460, P01584, P12074, O15239ATF4, ERN1, IL1B, COX6A1, NDUFA1More
Deflazacorthsa04934Cushing syndrome2.69E-066Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Deflazacorthsa04935Growth hormone synthesis, secretion and action4.98E-024Q08828, P51828, Q99941, P18848ADCY1, ADCY7, CREBL1, ATF4More
Deflazacorthsa04970Salivary secretion3.54E-023Q08828, P51828, P0DP24ADCY1, ADCY7, CALM2More
Deflazacorthsa04971Gastric acid secretion2.95E-055Q08828, P51828, P15311, P0DP24, Q13557ADCY1, ADCY7, VIL2, CALM2, CAMK2DMore
Deflazacorthsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Deflazacorthsa05010Alzheimer disease2.62E-0414Q92542, O15239, P05496, P12074, Q00535, O75460, P0DP24, P01584, P18848, O15169, P05141, P45880, P28070, P43686NCSTN, NDUFA1, ATP5G1, COX6A1, CDK5, ERN1, CALM2, IL1B, ATF4, AXIN1, SLC25A5, VDAC2, PSMB4, PSMC4More
Deflazacorthsa05012Parkinson disease7.90E-039O15239, P12074, P05141, O75460, P18848, P28070, P43686, P0DP24, Q13557NDUFA1, COX6A1, SLC25A5, ERN1, ATF4, PSMB4, PSMC4, CALM2, CAMK2DMore
Deflazacorthsa05016Huntington disease3.54E-028O15239, P12074, P24928, P62487, P05141, O75460, P28070, P43686NDUFA1, COX6A1, POLR2A, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4More
Deflazacorthsa05020Prion disease1.76E-0312P01584, P46531, P11142, O15239, P05496, P12074, P18848, P05141, P45880, P28070, P43686, Q99941IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX6A1, ATF4, SLC25A5, VDAC2, PSMB4, PSMC4, CREBL1More
Deflazacorthsa05022Pathways of neurodegeneration - multiple diseases1.74E-0313O15239, P12074, Q8TEV9, O75460, P18848, P05141, Q00535, O15169, P01584, P0DP24, Q13557, P28070, P43686NDUFA1, COX6A1, SMCR8, ERN1, ATF4, SLC25A5, CDK5, AXIN1, IL1B, CALM2, CAMK2D, PSMB4, PSMC4More
Deflazacorthsa05030Cocaine addiction3.54E-023Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Deflazacorthsa05031Amphetamine addiction7.61E-034P0DP24, Q13557, Q99941, P18848CALM2, CAMK2D, CREBL1, ATF4More
Deflazacorthsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Deflazacorthsa05163Human cytomegalovirus infection2.62E-0410P0DP24, Q8NHW4, Q08828, P51828, P23458, P01584, P61073, Q13651, Q99941, P18848CALM2, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, CXCR4, IL10RA, CREBL1, ATF4More
Deflazacorthsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Deflazacorthsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Deflazacorthsa05415Diabetic cardiomyopathy3.59E-021P11413G6PDMore

Community members of Deflazacort (SDC: 3.04)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P01584IL1BInterleukinNone1 betaPredicted10.2060.137611.3782
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)