PharmaCoNets of Decitabine (SPCN: 30.12 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Decitabinehsa00120Primary bile acid biosynthesis3.72E-022P22680, P22307CYP7A1, SCP2More
Decitabinehsa00190Oxidative phosphorylation3.20E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Decitabinehsa00240Pyrimidine metabolism8.44E-044P31350, P21589, P32320, P04183RRM2, NT5E, CDA, TK1More
Decitabinehsa00280Valine, leucine and isoleucine degradation3.41E-034P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Decitabinehsa00531Glycosaminoglycan degradation4.51E-022P22304, P06865IDS, HEXAMore
Decitabinehsa00630Glyoxylate and dicarboxylate metabolism6.94E-032P40925, P15104MDH1, GLULMore
Decitabinehsa00983Drug metabolism - other enzymes3.83E-044P04183, P32320, P31350, P05164TK1, CDA, RRM2, MPOMore
Decitabinehsa01524Platinum drug resistance4.67E-024Q13489, P98170, P78417, P43246BIRC3, BIRC4, GSTO1, MSH2More
Decitabinehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Decitabinehsa03013RNA transport4.13E-026Q09161, P35658, P47813, Q14152, O75822, P51114NCBP1, NUP214, EIF1AX, EIF3A, EIF3J, FXR1More
Decitabinehsa03020RNA polymerase3.22E-033P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Decitabinehsa03040Spliceosome3.15E-0515Q14562, O43143, O14776, P08579, P26368, O75940, P52298, P09651, O75494, Q13595, Q07955, P84103, Q13243, O95777, P61326DHX8, DHX15, TCERG1, SNRPB2, U2AF2, SMNDC1, NCBP2, HNRNPA1, FUSIP1, TRA2A, SFRS1, SFRS3, SFRS5, LSM8, MAGOHMore
Decitabinehsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Decitabinehsa04061Viral protein interaction with cytokine and cytokine receptor4.28E-027P51684, P09341, P25024, P25025, P47992, Q9UBD3, P01375CCR6, CXCL1, CXCR1, CXCR2, XCL1, XCL2, TNFMore
Decitabinehsa04062Chemokine signaling pathway3.81E-026P07948, P62873, P63218, P50151, P43250, Q13009LYN, GNB1, GNG5, GNG10, GRK6, TIAM1More
Decitabinehsa04064NF-kappa B signaling pathway2.37E-0411P10415, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522, P09341BCL2, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45A, CXCL1More
Decitabinehsa04071Sphingolipid signaling pathway9.29E-037P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Decitabinehsa04072Phospholipase D signaling pathway3.55E-024Q9UQC2, Q8WYR1, Q15438, P51828GAB2, PIK3R5, PSCD1, ADCY7More
Decitabinehsa04115p53 signaling pathway3.35E-035P24522, Q13315, P31350, O95067, P10415GADD45A, ATM, RRM2, CCNB2, BCL2More
Decitabinehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Decitabinehsa04142Lysosome3.32E-036P06865, P22304, Q13510, P07602, P61916, Q04900HEXA, IDS, ASAH1, PSAP, NPC2, CD164More
Decitabinehsa04145Phagosome1.73E-036Q15080, P68371, P05164, P78380, P35443, P13765NCF4, TUBB2C, MPO, OLR1, THBS4, HLA-DOBMore
Decitabinehsa04151PI3K-Akt signaling pathway7.39E-037P62753, O43521, P27348, Q8WYR1, P18848, O00141, Q6ZUJ8RPS6, BCL2L11, YWHAQ, PIK3R5, ATF4, SGK, PIK3AP1More
Decitabinehsa04210Apoptosis3.63E-023O75460, O43521, P18848ERN1, BCL2L11, ATF4More
Decitabinehsa04213Longevity regulating pathway - multiple species3.03E-022P51828, P0DMV8ADCY7, HSPA1AMore
Decitabinehsa04217Necroptosis7.15E-0712P01568, Q13489, P98170, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q13557, Q9H444, P21796IFNA21, BIRC3, BIRC4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4B, VDAC1More
Decitabinehsa04261Adrenergic signaling in cardiomyocytes8.89E-035P67936, P51828, Q8WYR1, Q13362, P0DP24TPM4, ADCY7, PIK3R5, PPP2R5C, CALM2More
Decitabinehsa04270Vascular smooth muscle contraction1.86E-024P0DP24, P51828, P35579, P35749CALM2, ADCY7, MYH9, MYH11More
Decitabinehsa04371Apelin signaling pathway3.23E-047P62873, P63218, P50151, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, SMAD4, SMAD3, CAMK4, CALM1More
Decitabinehsa04612Antigen processing and presentation4.72E-024P13765, P48382, P26715, P26717HLA-DOB, RFX5, KLRC1, KLRC2More
Decitabinehsa04613Neutrophil extracellular trap formation1.02E-0214O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Decitabinehsa04621NOD-like receptor signaling pathway4.83E-0210Q16539, Q14643, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P49913, P12838MAPK14, ITPR1, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, CAMP, DEFA4More
Decitabinehsa04657IL-17 signaling pathway4.87E-022P07900, P01584HSP90AA1, IL1BMore
Decitabinehsa04658Th1 and Th2 cell differentiation8.47E-038Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Decitabinehsa04660T cell receptor signaling pathway2.57E-0311P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14More
Decitabinehsa04668TNF signaling pathway2.91E-023P18848, P01584, P20333ATF4, IL1B, TNFRSF1BMore
Decitabinehsa04713Circadian entrainment1.78E-035O15399, P0DP23, P62873, P63218, P50151GRIN2D, CALM1, GNB1, GNG5, GNG10More
Decitabinehsa04720Long-term potentiation2.33E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Decitabinehsa04724Glutamatergic synapse1.11E-035O15399, P62873, P63218, P50151, P15104GRIN2D, GNB1, GNG5, GNG10, GLULMore
Decitabinehsa04725Cholinergic synapse9.51E-034P62873, P63218, P50151, Q16566GNB1, GNG5, GNG10, CAMK4More
Decitabinehsa04726Serotonergic synapse2.38E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Decitabinehsa04727GABAergic synapse2.45E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Decitabinehsa04744Phototransduction2.20E-042P62873, P0DP23GNB1, CALM1More
Decitabinehsa04915Estrogen signaling pathway1.12E-024P51828, P0DMV8, P0DP24, Q15788ADCY7, HSPA1A, CALM2, NCOA1More
Decitabinehsa04921Oxytocin signaling pathway2.92E-024P0DP24, P51828, Q96RR4, Q8WYR1CALM2, ADCY7, CAMKK2, PIK3R5More
Decitabinehsa04932Non-alcoholic fatty liver disease5.73E-056O43521, P18848, O75460, P01584, P13073, O15239BCL2L11, ATF4, ERN1, IL1B, COX4I1, NDUFA1More
Decitabinehsa05010Alzheimer disease2.78E-026P13073, O75460, P0DP24, P01584, P18848, P05141COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5More
Decitabinehsa05012Parkinson disease2.77E-037O15239, P13073, P05141, O75460, P18848, P0DP24, Q13557NDUFA1, COX4I1, SLC25A5, ERN1, ATF4, CALM2, CAMK2DMore
Decitabinehsa05016Huntington disease4.33E-037O15239, P13073, P24928, P30876, P62487, P05141, O75460NDUFA1, COX4I1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1More
Decitabinehsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Decitabinehsa05022Pathways of neurodegeneration - multiple diseases2.20E-039O15239, P13073, O75460, P18848, P05141, P20333, P01584, P0DP24, Q13557NDUFA1, COX4I1, ERN1, ATF4, SLC25A5, TNFRSF1B, IL1B, CALM2, CAMK2DMore
Decitabinehsa05032Morphine addiction1.34E-024P62873, P63218, P50151, P43250GNB1, GNG5, GNG10, GRK6More
Decitabinehsa05034Alcoholism3.87E-037O15399, Q16566, P0DP23, P62873, P63218, P50151, Q93079GRIN2D, CAMK4, CALM1, GNB1, GNG5, GNG10, H2BC9More
Decitabinehsa05132Salmonella infection2.35E-0312P25963, P08238, Q13489, P10415, P04406, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P49754NFKBIA, HSP90AB1, BIRC3, BCL2, GAPDH, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, VPS41More
Decitabinehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Decitabinehsa05140Leishmaniasis2.25E-026P14598, P42224, O60603, P25963, P29350, Q15080NCF1, STAT1, TLR2, NFKBIA, PTPN6, NCF4More
Decitabinehsa05145Toxoplasmosis3.55E-023P23458, Q8WYR1, P0DMV8JAK1, PIK3R5, HSPA1AMore
Decitabinehsa05146Amoebiasis3.11E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Decitabinehsa05150Staphylococcus aureus infection1.90E-039P21730, P21462, O75015, P13765, Q14532, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Decitabinehsa05152Tuberculosis1.88E-0516Q13488, Q15075, P0DP23, O75015, P42224, P48382, P25208, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, Q16539, P51617TCIRG1, EEA1, CALM1, FCGR3B, STAT1, RFX5, NFYB, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, MAPK14, IRAK1More
Decitabinehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Decitabinehsa05163Human cytomegalovirus infection2.00E-026P62873, P63218, P50151, P0DP23, P30101, P01568GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21More
Decitabinehsa05167Kaposi sarcoma-associated herpesvirus infection2.00E-026P01568, P62873, P63218, P50151, P07948, P0DP23IFNA21, GNB1, GNG5, GNG10, LYN, CALM1More
Decitabinehsa05168Herpes simplex virus 1 infection1.51E-0420O60603, P25963, P01568, Q05823, P42224, Q07955, P84103, Q13243, Q13489, P30101, Q13398, P51522, Q9NR11, Q9HCX3, P17097, Q03923, P52738, O75820, Q9NZL3, P10415TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS3, SFRS5, BIRC3, PDIA3, ZNF211, ZNF83, ZNF302, ZNF304, ZNF7, ZNF85, ZNF140, ZNF189, ZNF224, BCL2More
Decitabinehsa05170Human immunodeficiency virus 1 infection3.76E-0318P62873, P63218, P50151, P0DP23, P01375, O00463, P30101, Q14643, P01568, Q16539, O60603, Q13315, P23528, P09693, P20963, P10415, Q93034, Q9Y6Q5GNB1, GNG5, GNG10, CALM1, TNF, TRAF5, PDIA3, ITPR1, IFNA21, MAPK14, TLR2, ATM, CFL1, CD3G, CD247, BCL2, CUL5, AP1M2More
Decitabinehsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Decitabinehsa05200Pathways in cancer3.99E-0415Q13751, P08238, P43246, P84022, Q13485, Q13489, P98170, P62873, P63218, P50151, P78417, O75293, P0DP23, P01568, P01042LAMB3, HSP90AB1, MSH2, SMAD3, SMAD4, BIRC3, BIRC4, GNB1, GNG5, GNG10, GSTO1, GADD45B, CALM1, IFNA21, KNG1More
Decitabinehsa05202Transcriptional misregulation in cancer1.01E-0315Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Decitabinehsa05210Colorectal cancer4.67E-024P84022, Q13485, P43246, O75293SMAD3, SMAD4, MSH2, GADD45BMore
Decitabinehsa05212Pancreatic cancer3.28E-023P84022, Q13485, O75293SMAD3, SMAD4, GADD45BMore
Decitabinehsa05214Glioma3.28E-023P0DP23, Q16566, O75293CALM1, CAMK4, GADD45BMore
Decitabinehsa05221Acute myeloid leukemia3.29E-023P14923, Q15744, P05164JUP, CEBPE, MPOMore
Decitabinehsa05222Small cell lung cancer3.80E-024Q13751, Q13489, P98170, O75293LAMB3, BIRC3, BIRC4, GADD45BMore
Decitabinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.11E-027O95267, P20963, P09693, O60603, P10747, Q04759, Q16539RASGRP1, CD247, CD3G, TLR2, CD28, PRKCQ, MAPK14More
Decitabinehsa05310Asthma1.68E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Decitabinehsa05321Inflammatory bowel disease2.47E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Decitabinehsa05322Systemic lupus erythematosus4.61E-028O75015, P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Decitabinehsa05323Rheumatoid arthritis2.84E-025P01375, P13765, P10747, P09341, O60603TNF, HLA-DOB, CD28, CXCL1, TLR2More
Decitabinehsa05332Graft-versus-host disease3.93E-035P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Decitabinehsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore

Community members of Decitabine (SDC: 2.21)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P26358DNMT1DNAReported00.34040.28090.26590.998
P32320CDACytidine deaminasePredicted00.05160.05690.16530.3049
P27707DCKDeoxycytidine kinasePredicted00.05740.06140.16530.3169
Q96KQ7EHMT2HistoneNonelysine NNonemethyltransferase EHMT2Predicted00.07280.21650.29090.7603
P04183TK1Thymidine kinase, cytosolicPredicted00.27170.16370.16530.6286
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
Q15788NCOA1Nuclear receptor coactivator 1Predicted00.43680.08280.31140.6954
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DNMT1P26358IC5030