PharmaCoNets of Debrisoquine (SPCN: 8.57 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Debrisoquinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Debrisoquinehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Debrisoquinehsa00670One carbon pool by folate3.62E-021P00374DHFRMore
Debrisoquinehsa00790Folate biosynthesis3.62E-021P00374DHFRMore
Debrisoquinehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Debrisoquinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Debrisoquinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Debrisoquinehsa03050Proteasome4.83E-021P55036PSMD4More
Debrisoquinehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Debrisoquinehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Debrisoquinehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Debrisoquinehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Debrisoquinehsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Debrisoquinehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Debrisoquinehsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Debrisoquinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Debrisoquinehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Debrisoquinehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Debrisoquinehsa04932Non-alcoholic fatty liver disease3.62E-023P49841, Q16718, O14521GSK3B, NDUFA5, SDHDMore
Debrisoquinehsa04966Collecting duct acid secretion1.68E-022P02730, P00918SLC4A1, CA2More
Debrisoquinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Debrisoquinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Debrisoquinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Debrisoquinehsa05034Alcoholism2.79E-022P62879, Q9BTM1GNB2, H2AFJMore
Debrisoquinehsa05133Pertussis4.94E-021P0C0L4C4AMore
Debrisoquinehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Debrisoquinehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Debrisoquinehsa05200Pathways in cancer4.70E-023P17301, P20585, P62879ITGA2, MSH3, GNB2More
Debrisoquinehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Debrisoquinehsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Debrisoquinehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Debrisoquinehsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Debrisoquinehsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Debrisoquinehsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Debrisoquinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Debrisoquine (SDC: 2.55)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P00374DHFRDihydrofolate reductasePredicted00.3380.18680.22630.7688
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)