PharmaCoNets of Daunorubicin (SPCN: 37.13 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Daunorubicinhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Daunorubicinhsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Daunorubicinhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Daunorubicinhsa00500Starch and sucrose metabolism6.40E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Daunorubicinhsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Daunorubicinhsa00564Glycerophospholipid metabolism1.18E-034Q6P1A2, Q9Y259, P23743, P49619MBOAT5, CHKB, DGKA, DGKGMore
Daunorubicinhsa00630Glyoxylate and dicarboxylate metabolism3.73E-043P40925, P40926, P15104MDH1, MDH2, GLULMore
Daunorubicinhsa00730Thiamine metabolism5.86E-042P05186, P24666ALPL, ACP1More
Daunorubicinhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Daunorubicinhsa01100Metabolic pathways6.99E-0330Q9NR34, Q9Y259, P05089, P32320, Q13956, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, P49619, O95954, Q9HCC0, P33121, Q02318, P57054, Q9UBX8, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737MAN1C1, CHKB, ARG1, CDA, PDE6H, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, DGKG, FTCD, MCCC2, ACSL1, CYP27A1, PIGP, B4GALT6, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGLMore
Daunorubicinhsa03013RNA transport7.27E-0312O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, EIF4A2, TACC3, FXR1More
Daunorubicinhsa03040Spliceosome2.51E-0410Q14562, O43143, O60508, P17844, P51991, P61978, Q07955, Q01130, Q13243, P11142DHX8, DHX15, CDC40, DDX5, HNRPA3, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8More
Daunorubicinhsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Daunorubicinhsa04015Rap1 signaling pathway3.07E-024P25116, Q8TEU7, P08514, P17252F2R, RAPGEF6, ITGA2B, PRKCAMore
Daunorubicinhsa04024cAMP signaling pathway4.38E-024P42338, P0DP23, Q13370, Q13009PIK3CB, CALM1, PDE3B, TIAM1More
Daunorubicinhsa04064NF-kappa B signaling pathway2.99E-027O00463, P14778, Q13077, Q16548, Q8WV28, P24522, P09341TRAF5, IL1R1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1More
Daunorubicinhsa04070Phosphatidylinositol signaling system4.86E-023P0DP23, P42338, P27987CALM1, PIK3CB, ITPKBMore
Daunorubicinhsa04071Sphingolipid signaling pathway4.77E-037P17252, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2PRKCA, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Daunorubicinhsa04110Cell cycle3.57E-023Q9UBD5, P06493, P33981ORC3, CDK1, TTKMore
Daunorubicinhsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Daunorubicinhsa04151PI3K-Akt signaling pathway3.91E-037P62753, P27348, P07900, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGKMore
Daunorubicinhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Daunorubicinhsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Daunorubicinhsa04261Adrenergic signaling in cardiomyocytes1.46E-024P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Daunorubicinhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Daunorubicinhsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Daunorubicinhsa04611Platelet activation3.39E-023P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Daunorubicinhsa04657IL-17 signaling pathway5.03E-036O00463, Q16539, P49841, P09341, P14780, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNFMore
Daunorubicinhsa04659Th17 cell differentiation4.38E-024P42224, P14784, P40189, P08238STAT1, IL2RB, IL6ST, HSP90AB1More
Daunorubicinhsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Daunorubicinhsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Daunorubicinhsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Daunorubicinhsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Daunorubicinhsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Daunorubicinhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Daunorubicinhsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Daunorubicinhsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Daunorubicinhsa04914Progesterone-mediated oocyte maturation3.92E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Daunorubicinhsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Daunorubicinhsa04918Thyroid hormone synthesis1.16E-046P51828, P17252, Q99941, P18848, P27824, P02768ADCY7, PRKCA, CREBL1, ATF4, CANX, ALBMore
Daunorubicinhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Daunorubicinhsa04924Renin secretion3.77E-022Q13370, P0DP23PDE3B, CALM1More
Daunorubicinhsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Daunorubicinhsa04926Relaxin signaling pathway3.34E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Daunorubicinhsa04927Cortisol synthesis and secretion4.16E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Daunorubicinhsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Daunorubicinhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Daunorubicinhsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Daunorubicinhsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Daunorubicinhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Daunorubicinhsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Daunorubicinhsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Daunorubicinhsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Daunorubicinhsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Daunorubicinhsa05146Amoebiasis4.55E-025P09341, P14778, P27930, O60603, P05089CXCL1, IL1R1, IL1R2, TLR2, ARG1More
Daunorubicinhsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Daunorubicinhsa05163Human cytomegalovirus infection3.64E-027Q14643, P49841, P14778, P25025, Q16539, P04637, O00463ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Daunorubicinhsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Daunorubicinhsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Daunorubicinhsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Daunorubicinhsa05205Proteoglycans in cancer4.46E-024Q12955, Q14247, P17252, P08962ANK3, CTTN, PRKCA, CD63More
Daunorubicinhsa05212Pancreatic cancer1.72E-023P42338, P42224, O75293PIK3CB, STAT1, GADD45BMore
Daunorubicinhsa05214Glioma1.72E-023P0DP23, P42338, O75293CALM1, PIK3CB, GADD45BMore
Daunorubicinhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Daunorubicinhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Daunorubicinhsa05231Choline metabolism in cancer2.00E-022Q9Y259, P49619CHKB, DGKGMore
Daunorubicinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.55E-025O95267, P09693, O60603, Q16539, P01730RASGRP1, CD3G, TLR2, MAPK14, CD4More
Daunorubicinhsa05310Asthma1.35E-022P13765, P29965HLA-DOB, CD40LGMore
Daunorubicinhsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Daunorubicinhsa05330Allograft rejection3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Daunorubicinhsa05412Arrhythmogenic right ventricular cardiomyopathy1.82E-023P14923, P08514, Q9UJU2JUP, ITGA2B, LEF1More
Daunorubicinhsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore
Daunorubicinhsa05418Fluid shear stress and atherosclerosis2.84E-0310Q16539, P42338, P14598, P10599, P14780, P04637, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, NCF1, TXN, MMP9, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Daunorubicin (SDC: 4.10)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11388TOP2ADNA topoisomerase 2NonealphaReported00.19920.46590.19271.2242
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)