PharmaCoNets

PharmaCoNets of Darolutamide (S_PCN: 82.98 )

Darolutamide regulated-network (S_DN: 15.17)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Darolutamide

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Darolutamide

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Darolutamide

hsa00310

Lysine degradation

2.59E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Darolutamide

hsa00500

Starch and sucrose metabolism

7.50E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Darolutamide

hsa00510

N-Glycan biosynthesis

3.15E-02

P15907, Q9NR34

ST6GAL1, MAN1C1

Darolutamide

hsa00512

Mucin type O-glycan biosynthesis

3.19E-03

O95395, Q8N4A0, Q9NY28

GCNT3, GALNT4, GALNT8

Darolutamide

hsa00524

Neomycin, kanamycin and gentamicin biosynthesis

2.03E-02

P35557

GCK

Darolutamide

hsa00630

Glyoxylate and dicarboxylate metabolism

9.21E-03

P40925, P15104

MDH1, GLUL

Darolutamide

hsa00640

Propanoate metabolism

3.83E-02

Q02252, Q9P2R7

ALDH6A1, SUCLA2

Darolutamide

hsa00730

Thiamine metabolism

2.15E-05

Q9Y6K8, P05186, P24666

AK5, ALPL, ACP1

Darolutamide

hsa00740

Riboflavin metabolism

4.03E-02

P24666

ACP1

Darolutamide

hsa00790

Folate biosynthesis

1.04E-02

Q92820, P05186, P42330

GGH, ALPL, AKR1C3

Darolutamide

hsa00970

Aminoacyl-tRNA biosynthesis

3.78E-02

O95363, Q15046

FARS2, KARS

Darolutamide

hsa00983

Drug metabolism - other enzymes

4.16E-02

P04183, P32320, P05164

TK1, CDA, MPO

Darolutamide

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Darolutamide

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Darolutamide

hsa01523

Antifolate resistance

4.16E-02

P41440, Q92820, P01375

SLC19A1, GGH, TNF

Darolutamide

hsa03020

RNA polymerase

3.00E-02

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Darolutamide

hsa03040

Spliceosome

6.48E-07

Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.775
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.871
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O60508	CDC40	Pre-mRNA-processing factor 17	0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Darolutamide

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Darolutamide

hsa03060

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Darolutamide

hsa04014

Ras signaling pathway

7.47E-04

P42338, P20827, Q9NRA1, P49767, Q13009, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174

PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1

Darolutamide

hsa04015

Rap1 signaling pathway

1.79E-02

P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174

EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1

Darolutamide

hsa04061

Viral protein interaction with cytokine and cytokine receptor

3.29E-02

P09341, P25024, P25025, P47992, Q9UBD3, P01375

CXCL1, CXCR1, CXCR2, XCL1, XCL2, TNF

Darolutamide

hsa04062

Chemokine signaling pathway

6.84E-05

P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q7LDG7, Q13009, P14598, P42224, P25963, Q8WYR1

FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, NCF1, STAT1, NFKBIA, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Darolutamide

hsa04064

NF-kappa B signaling pathway

1.85E-06

P10415, Q13489, O00463, Q13546, P01584, P01375, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q9UNE0, Q9NQC7

BCL2, BIRC3, TRAF5, RIPK1, IL1B, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, EDAR, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P10415	BCL2	Apoptosis regulator Bcl-2	0.744
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O00463	TRAF5	TNF receptor-associated factor 5	0.945
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09341	CXCL1	Growth-regulated alpha protein	-0.802
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Darolutamide

hsa04070

Phosphatidylinositol signaling system

2.93E-02

P19174, P0DP23, P23743, P27987

PLCG1, CALM1, DGKA, ITPKB

Darolutamide

hsa04071

Sphingolipid signaling pathway

9.47E-04

P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2

S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2

Darolutamide

hsa04080

Neuroactive ligand-receptor interaction

9.66E-05

P08311, P28472, Q15722, P21453, Q9H228, P43657, P21462, P21730, Q16581, P07550, P35318

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY5, FPR1, C5AR1, C3AR1, ADRB2, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08311	CTSG	Cathepsin G	-0.898
P07550	ADRB2	Beta-2 adrenergic receptor	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	-0.77
P06737	PYGL	Glycogen phosphorylase, liver form	Q15722	LTB4R	Leukotriene B4 receptor 1	0.863
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.777
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.744
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.92
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.768
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.852
P07550	ADRB2	Beta-2 adrenergic receptor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.717
P06737	PYGL	Glycogen phosphorylase, liver form	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.808
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P07550	ADRB2	Beta-2 adrenergic receptor	0.737
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1
P06737	PYGL	Glycogen phosphorylase, liver form	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.727
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	-0.734

Darolutamide

hsa04120

Ubiquitin mediated proteolysis

4.82E-03

Q9UBT2, Q14669

SAE2, TRIP12

Darolutamide

hsa04140

Autophagy - animal

4.55E-02

P22694, Q14643, P10415, Q9H1Y0, Q04759

PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Darolutamide

hsa04141

Protein processing in endoplasmic reticulum

8.60E-03

P30101, P60604, P11142, P08238, Q9H173, Q9UNL2

PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3

Darolutamide

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Darolutamide

hsa04144

Endocytosis

1.67E-02

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12

Darolutamide

hsa04145

Phagosome

9.75E-04

O75015, P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765

FCGR3B, ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOB

Darolutamide

hsa04151

PI3K-Akt signaling pathway

3.70E-02

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Darolutamide

hsa04211

Longevity regulating pathway

1.18E-02

Q12778, Q9UEF7, Q96KQ7

FOXO1, KL, EHMT2

Darolutamide

hsa04213

Longevity regulating pathway - multiple species

2.82E-02

Q08828, P51828, P0DMV8

ADCY1, ADCY7, HSPA1A

Darolutamide

hsa04217

Necroptosis

2.93E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Darolutamide

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Darolutamide

hsa04270

Vascular smooth muscle contraction

8.40E-04

P24723, Q04759, Q14643, P0DP23, Q08828, P51828, P22694, P35579, P35749, P35318

PRKCH, PRKCQ, ITPR1, CALM1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADM

Darolutamide

hsa04340

Hedgehog signaling pathway

1.43E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Darolutamide

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Darolutamide

hsa04371

Apelin signaling pathway

3.84E-05

P62873, P63218, P50151, Q8WYR1, Q13370, Q14814, Q14344, Q13485, P84022, P0DP23

GNB1, GNG5, GNG10, PIK3R5, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CALM1

Darolutamide

hsa04380

Osteoclast differentiation

1.02E-02

Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2

Darolutamide

hsa04540

Gap junction

1.08E-02

Q13509, P68371, Q71U36, Q9NRA1

TUBB3, TUBB2C, TUBA1A, PDGFC

Darolutamide

hsa04612

Antigen processing and presentation

1.34E-05

P13765, P48382, Q14953, P26715, P26717, Q07444, Q13241, P01732, P01375

HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P48382	RFX5	DNA-binding protein RFX5	0.826
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.915
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.943
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26717	KLRC2	NKG2-C type II integral membrane protein	0.915
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.718
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13241	KLRD1	Natural killer cells antigen CD94	0.941
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.892
P07550	ADRB2	Beta-2 adrenergic receptor	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755

Darolutamide

hsa04613

Neutrophil extracellular trap formation

1.37E-02

O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Darolutamide

hsa04620

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Darolutamide

hsa04621

NOD-like receptor signaling pathway

7.00E-03

Q16539, Q14643, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, P01375, P09341, P12838

MAPK14, ITPR1, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, TNF, CXCL1, DEFA4

Darolutamide

hsa04622

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Darolutamide

hsa04623

Cytosolic DNA-sensing pathway

5.33E-06

P01584, P01568, Q13546, P25963, Q8NHW4

IL1B, IFNA21, RIPK1, NFKBIA, CCL4L2

Darolutamide

hsa04625

C-type lectin receptor signaling pathway

3.87E-02

Q9ULY5, P20749, P01375, Q16539

CLEC4E, BCL3, TNF, MAPK14

Darolutamide

hsa04640

Hematopoietic cell lineage

2.14E-03

P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375

ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNF

Darolutamide

hsa04650

Natural killer cell mediated cytotoxicity

1.22E-07

P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, Q07444, Q14953, P26715

TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60880	SH2D1A	SH2 domain-containing protein 1A	0.862
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O60880	SH2D1A	SH2 domain-containing protein 1A	0.922
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13241	KLRD1	Natural killer cells antigen CD94	0.941
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26718	KLRK1	NKG2-D type II integral membrane protein	0.922
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26718	KLRK1	NKG2-D type II integral membrane protein	0.858
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.716
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.943
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26717	KLRC2	NKG2-C type II integral membrane protein	0.915
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.718
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.915
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Darolutamide

hsa04657

IL-17 signaling pathway

5.58E-05

O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF

Darolutamide

hsa04658

Th1 and Th2 cell differentiation

5.62E-08

Q04759, P20963, P09693, Q16539, P06239, Q14765, P42226, P23771, Q9UL17, P13765, Q13761

PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, STAT6, GATA3, TBX21, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q04759	PRKCQ	Protein kinase C theta type	0.869
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.731
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q14765	STAT4	Signal transducer and activator of transcription 4	0.904
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q14765	STAT4	Signal transducer and activator of transcription 4	0.821
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.878
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9UL17	TBX21	T-box transcription factor TBX21	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13761	RUNX3	Runt-related transcription factor 3	0.702

Darolutamide

hsa04659

Th17 cell differentiation

4.72E-07

P25963, Q04759, Q16539, P19174, P06239, P42224, P42226, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, STAT1, STAT6, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q04759	PRKCQ	Protein kinase C theta type	0.869
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9HBE5	IL21R	Interleukin-21 receptor	0.713
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9UL17	TBX21	T-box transcription factor TBX21	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.878
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.731
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881

Darolutamide

hsa04660

T cell receptor signaling pathway

6.92E-06

P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q04759	PRKCQ	Protein kinase C theta type	0.869
P06737	PYGL	Glycogen phosphorylase, liver form	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P06737	PYGL	Glycogen phosphorylase, liver form	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.8
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	1
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.808
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.731
P06737	PYGL	Glycogen phosphorylase, liver form	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.72
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.892
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.811
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.795
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815

Darolutamide

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Darolutamide

hsa04664

Fc epsilon RI signaling pathway

5.49E-05

P01375, P04141, Q16539, P42338, Q9UQC2, P07948, P19174, P09917

TNF, CSF2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5

Darolutamide

hsa04668

TNF signaling pathway

2.12E-03

P01375, O00463, Q16539, P18848, P19875, P20749, P14780

TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9

Darolutamide

hsa04713

Circadian entrainment

2.18E-02

P0DP23, P62873, P63218, P50151

CALM1, GNB1, GNG5, GNG10

Darolutamide

hsa04724

Glutamatergic synapse

1.57E-02

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Darolutamide

hsa04726

Serotonergic synapse

3.80E-02

P62873, P63218, P50151, P09917

GNB1, GNG5, GNG10, ALOX5

Darolutamide

hsa04727

GABAergic synapse

4.18E-03

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Darolutamide

hsa04730

Long-term depression

4.86E-02

Q14344, P07948

GNA13, LYN

Darolutamide

hsa04744

Phototransduction

9.21E-03

P62873, P0DP23

GNB1, CALM1

Darolutamide

hsa04750

Inflammatory mediator regulation of TRP channels

4.01E-02

P01584, Q08828, P51828, P0DP23

IL1B, ADCY1, ADCY7, CALM1

Darolutamide

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Darolutamide

hsa04915

Estrogen signaling pathway

3.17E-02

Q08828, P51828, P0DMV8, P0DP23, Q15788

ADCY1, ADCY7, HSPA1A, CALM1, NCOA1

Darolutamide

hsa04924

Renin secretion

2.05E-03

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Darolutamide

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Darolutamide

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Darolutamide

hsa04932

Non-alcoholic fatty liver disease

1.39E-02

O43521, O75460, P01584, P13073, P12074, O95298

BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2

Darolutamide

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Darolutamide

hsa04950

Maturity onset diabetes of the young

2.03E-02

P35557

GCK

Darolutamide

hsa04970

Salivary secretion

2.43E-03

P07550, Q08828, P51828, P22694, P0DP23, P49913

ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CAMP

Darolutamide

hsa04975

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Darolutamide

hsa04976

Bile secretion

4.78E-02

Q08828, P51828, Q14032

ADCY1, ADCY7, BAAT

Darolutamide

hsa05012

Parkinson disease

1.77E-02

P60604, P19174, P0DP23, Q71U36, Q13509, P68371

UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C

Darolutamide

hsa05016

Huntington disease

2.46E-02

O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12

Darolutamide

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Darolutamide

hsa05032

Morphine addiction

2.18E-02

P62873, P63218, P50151, Q13370

GNB1, GNG5, GNG10, PDE3B

Darolutamide

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.08E-02

P25963, Q13488, P19174, P07948

NFKBIA, TCIRG1, PLCG1, LYN

Darolutamide

hsa05130

Pathogenic Escherichia coli infection

3.19E-02

Q71U36, P16333, Q13509, P68371, Q14344, P25963

TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA

Darolutamide

hsa05132

Salmonella infection

1.44E-03

P25963, P08238, Q13546, Q13489, O75369, O60282, Q71U36, Q13509, P68371, P49754

NFKBIA, HSP90AB1, RIPK1, BIRC3, FLNB, KIF5C, TUBA1A, TUBB3, TUBB2C, VPS41

Darolutamide

hsa05134

Legionellosis

2.84E-03

P01584, P25963, Q9NR31, P11215, P0DMV8, P11142

IL1B, NFKBIA, SAR1A, ITGAM, HSPA1A, HSPA8

Darolutamide

hsa05140

Leishmaniasis

4.71E-03

P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, Q15080

ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, NCF4

Darolutamide

hsa05144

Malaria

6.75E-04

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Darolutamide

hsa05146

Amoebiasis

3.36E-05

P09341, P19875, P27930, P01375, O60603, P05089, P30679, P22694, P12814, P08311

CXCL1, CXCL2, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, ACTN1, CTSG

Darolutamide

hsa05150

Staphylococcus aureus infection

2.92E-03

P21730, P21462, O75015, P13765, Q16581, Q14532, P59665, P59666, P12838, P49913

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Darolutamide

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Darolutamide

hsa05163

Human cytomegalovirus infection

2.58E-05

P01375, P25963, P62873, P63218, P50151, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, O00463, P30101, P01568

TNF, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TRAF5, PDIA3, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733

Darolutamide

hsa05167

Kaposi sarcoma-associated herpesvirus infection

8.62E-05

P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23

IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1

Darolutamide

hsa05168

Herpes simplex virus 1 infection

5.39E-03

P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q9Y2A4, Q13398, P51522, P17038, P52738, O75820

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF443, ZNF211, ZNF83, ZNF43, ZNF140, ZNF189

Darolutamide

hsa05169

Epstein-Barr virus infection

4.32E-02

P13765, O00463, P16070, P10415, Q16539, P24522, Q8WV28, P01375, O60603, P09693, P20963

HLA-DOB, TRAF5, CD44, BCL2, MAPK14, GADD45A, BLNK, TNF, TLR2, CD3G, CD247

Darolutamide

hsa05170

Human immunodeficiency virus 1 infection

1.19E-02

P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174

GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1

Darolutamide

hsa05200

Pathways in cancer

8.64E-05

Q13751, P42338, P08238, P42224, P25963, P19174, P43246, P84022, Q13485, P20585, Q13547, P30281, P49767, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784

LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, SMAD4, MSH3, HDAC1, CCND3, VEGFC, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P43246	MSH2	DNA mismatch repair protein Msh2	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P20585	MSH3	DNA mismatch repair protein Msh3	0.825
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Darolutamide

hsa05202

Transcriptional misregulation in cancer

6.62E-06

Q15532, Q13315, P14780, P27930, Q15744, Q16548, Q13077, Q15652, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522

SS18, ATM, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, JMJD1C, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q15532	SS18	Protein SSXT	-0.772
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P14780	MMP9	Matrix metalloproteinase-9	-0.855
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P14780	MMP9	Matrix metalloproteinase-9	-0.869
P06737	PYGL	Glycogen phosphorylase, liver form	P27930	IL1R2	Interleukin-1 receptor type 2	0.881
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P27930	IL1R2	Interleukin-1 receptor type 2	-0.813
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.833
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.844
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q16548	BCL2A1	Bcl-2-related protein A1	-0.762
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
P06737	PYGL	Glycogen phosphorylase, liver form	Q15652	JMJD1C	Probable JmjC domain-containing histone demethylation protein 2C	0.754
P06737	PYGL	Glycogen phosphorylase, liver form	O15550	UTX	Lysine-specific demethylase 6A	0.724
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05164	MPO	Myeloperoxidase	-0.811
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P05164	MPO	Myeloperoxidase	-0.867
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P12838	DEFA4	Neutrophil defensin 4	-0.86
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12838	DEFA4	Neutrophil defensin 4	-0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P08246	ELA2	Neutrophil elastase	-0.782
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08246	ELA2	Neutrophil elastase	-0.742
P06737	PYGL	Glycogen phosphorylase, liver form	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.742
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.9
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	P41182	BCL6	B-cell lymphoma 6 protein	0.847
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13547	HDAC1	Histone deacetylase 1	0.83
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12980	LYL1	Protein lyl-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.787

Darolutamide

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Darolutamide

hsa05212

Pancreatic cancer

4.73E-03

P42338, P42224, P84022, Q13485, O75293

PIK3CB, STAT1, SMAD3, SMAD4, GADD45B

Darolutamide

hsa05214

Glioma

4.75E-02

P0DP23, P19174, O75293

CALM1, PLCG1, GADD45B

Darolutamide

hsa05217

Basal cell carcinoma

1.43E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Darolutamide

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Darolutamide

hsa05310

Asthma

3.44E-04

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Darolutamide

hsa05321

Inflammatory bowel disease

4.23E-10

O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q14765	STAT4	Signal transducer and activator of transcription 4	0.904
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q14765	STAT4	Signal transducer and activator of transcription 4	0.821
P07550	ADRB2	Beta-2 adrenergic receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.826
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9UL17	TBX21	T-box transcription factor TBX21	0.858
P07550	ADRB2	Beta-2 adrenergic receptor	Q9UL17	TBX21	T-box transcription factor TBX21	0.758
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.878
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9HBE5	IL21R	Interleukin-21 receptor	0.713