PharmaCoNets of Darifenacin (SPCN: 267.75 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Darifenacinhsa00030Pentose phosphate pathway3.74E-022P60891, P52209PRPS1, PGDMore
Darifenacinhsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Darifenacinhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Darifenacinhsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Darifenacinhsa00072Synthesis and degradation of ketone bodies2.78E-021Q01581HMGCS1More
Darifenacinhsa00130Ubiquinone and other terpenoid-quinone biosynthesis1.66E-021Q9BQB6VKORC1More
Darifenacinhsa00190Oxidative phosphorylation2.10E-077P13073, Q16718, O15239, P12074, Q13488, P05496, O14521COX4I1, NDUFA5, NDUFA1, COX6A1, TCIRG1, ATP5G1, SDHDMore
Darifenacinhsa00220Arginine biosynthesis9.09E-053P15104, P05089, P49448GLUL, ARG1, GLUD2More
Darifenacinhsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Darifenacinhsa00250Alanine, aspartate and glutamate metabolism4.92E-021P15104GLULMore
Darifenacinhsa00260Glycine, serine and threonine metabolism2.49E-021P22557ALAS2More
Darifenacinhsa00280Valine, leucine and isoleucine degradation1.67E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Darifenacinhsa00500Starch and sucrose metabolism9.19E-063O43451, P46976, P06737MGAM, GYG1, PYGLMore
Darifenacinhsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Darifenacinhsa00520Amino sugar and nucleotide sugar metabolism2.11E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Darifenacinhsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Darifenacinhsa00561Glycerolipid metabolism2.21E-023O14494, P06280, P23743PLPP1, GLA, DGKAMore
Darifenacinhsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Darifenacinhsa00565Ether lipid metabolism3.55E-031Q8N661TMEM86BMore
Darifenacinhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Darifenacinhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Darifenacinhsa00600Sphingolipid metabolism8.72E-034Q9BX95, O14494, P06280, P15289SGPP1, PLPP1, GLA, ARSAMore
Darifenacinhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Darifenacinhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Darifenacinhsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Darifenacinhsa00670One carbon pool by folate1.33E-022P04818, Q99707TYMS, MTRMore
Darifenacinhsa00730Thiamine metabolism1.75E-073Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Darifenacinhsa00740Riboflavin metabolism1.79E-032P30043, P24666BLVRB, ACP1More
Darifenacinhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Darifenacinhsa00830Retinol metabolism2.27E-035P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Darifenacinhsa00860Porphyrin and chlorophyll metabolism4.51E-021P30043BLVRBMore
Darifenacinhsa00900Terpenoid backbone biosynthesis1.40E-021Q01581HMGCS1More
Darifenacinhsa00910Nitrogen metabolism2.49E-021P15104GLULMore
Darifenacinhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Darifenacinhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Darifenacinhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Darifenacinhsa00983Drug metabolism - other enzymes8.82E-044P20839, P32320, P05164, Q16772IMPDH1, CDA, MPO, GSTA3More
Darifenacinhsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Darifenacinhsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Darifenacinhsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Darifenacinhsa01521EGFR tyrosine kinase inhibitor resistance3.30E-033P49841, P04049, Q9NRA1GSK3B, RAF1, PDGFCMore
Darifenacinhsa01522Endocrine resistance3.41E-026P14780, P22694, P04049, Q9UM47, P10415, Q13323MMP9, PRKACB, RAF1, NOTCH3, BCL2, BIKMore
Darifenacinhsa01524Platinum drug resistance4.78E-021P31751AKT2More
Darifenacinhsa02010ABC transporters1.66E-043P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Darifenacinhsa03010Ribosome4.43E-0516P62753, P39019, P42677, P62917, P62829, Q9H0U6, Q07020, P62888, P61927, P61513, Q02878, P63173, P36578, P27635, P05386, P23396RPS6, RPS19, RPS27, RPL8, RPL23, MRPL18, RPL18, RPL30, RPL37, RPL37A, RPL6, RPL38, RPL4, RPL10, RPLP1, RPS3More
Darifenacinhsa03013RNA transport2.99E-024P38919, P37198, P35658, P55884EIF4A3, NUP62, NUP214, EIF3BMore
Darifenacinhsa03020RNA polymerase1.44E-075P30876, P24928, P62487, Q9GZM3, P52435POLR2B, POLR2A, POLR2G, POLR2J2, POLR2JMore
Darifenacinhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Darifenacinhsa03040Spliceosome1.46E-024P17844, P51991, P61978, P11142DDX5, HNRPA3, HNRPK, HSPA8More
Darifenacinhsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Darifenacinhsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Darifenacinhsa03430Mismatch repair4.38E-021P20585MSH3More
Darifenacinhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Darifenacinhsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Darifenacinhsa04012ErbB signaling pathway6.63E-034P16333, P19174, P01106, P04049NCK1, PLCG1, MYC, RAF1More
Darifenacinhsa04014Ras signaling pathway4.31E-043P04049, P31751, P0DP23RAF1, AKT2, CALM1More
Darifenacinhsa04015Rap1 signaling pathway1.58E-059P04049, P06213, P25116, Q8TEU7, O00522, P31751, P0DP23, P08514, P17252RAF1, INSR, F2R, RAPGEF6, KRIT1, AKT2, CALM1, ITGA2B, PRKCAMore
Darifenacinhsa04020Calcium signaling pathway1.60E-025Q96DU7, Q08828, Q13557, P21860, P05141ITPKC, ADCY1, CAMK2D, ERBB3, SLC25A5More
Darifenacinhsa04022cGMP-PKG signaling pathway2.83E-047P04049, P18848, Q8WYR1, P31751, P05141, P0DP24, P0DP23RAF1, ATF4, PIK3R5, AKT2, SLC25A5, CALM2, CALM1More
Darifenacinhsa04024cAMP signaling pathway1.30E-043P31751, P0DP23, P04049AKT2, CALM1, RAF1More
Darifenacinhsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Darifenacinhsa04061Viral protein interaction with cytokine and cytokine receptor1.70E-038P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RBMore
Darifenacinhsa04062Chemokine signaling pathway1.90E-0414P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, P04049CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RAF1More
Darifenacinhsa04064NF-kappa B signaling pathway1.28E-1026Q07817, P10415, Q13489, P51617, O00463, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, P19784, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2L1, BCL2, BIRC3, IRAK1, TRAF5, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, CSNK2A2, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Darifenacinhsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Darifenacinhsa04070Phosphatidylinositol signaling system2.81E-037P19174, P0DP23, Q14643, P23743, P49619, P27987, P17252PLCG1, CALM1, ITPR1, DGKA, DGKG, ITPKB, PRKCAMore
Darifenacinhsa04071Sphingolipid signaling pathway8.70E-0610P04049, P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Darifenacinhsa04072Phospholipase D signaling pathway2.31E-026P04049, P42338, P43657, P25024, P25025, P19174RAF1, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Darifenacinhsa04080Neuroactive ligand-receptor interaction1.30E-0210P08311, Q15722, P21453, Q9H228, O00398, Q01726, P41968, P21462, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, MC1R, MC3R, FPR1, C5AR1, C3AR1More
Darifenacinhsa04110Cell cycle1.72E-037Q9UBD5, P06493, Q14683, P30304, P33981, P01106, Q13547ORC3, CDK1, SMC1A, CDC25A, TTK, MYC, HDAC1More
Darifenacinhsa04114Oocyte meiosis2.05E-025Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Darifenacinhsa04120Ubiquitin mediated proteolysis3.45E-036Q14145, Q13042, P62837, Q15751, O95071, P0CG47KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBBMore
Darifenacinhsa04136Autophagy - other3.03E-021O94817ATG12More
Darifenacinhsa04137Mitophagy - animal6.50E-043P19784, Q07817, P0CG47CSNK2A2, BCL2L1, UBBMore
Darifenacinhsa04140Autophagy - animal6.54E-026P04049, P22694, Q14643, P10415, Q9H1Y0, Q04759RAF1, PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Darifenacinhsa04141Protein processing in endoplasmic reticulum1.03E-049P18848, P07384, O95487, Q15437, Q99941, P11142, P07900, Q9NR31, O95816ATF4, CAPN1, SEC24B, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1A, BAG2More
Darifenacinhsa04142Lysosome7.47E-059P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2More
Darifenacinhsa04144Endocytosis3.32E-0714P40818, P0DMV8, Q9H444, O75351, P62491, Q96B97, P49407, Q15438, Q8WU79, Q14161, P01889, P10321, P49418, Q9UMY4USP8, HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, ARRB1, PSCD1, SMAP1L, GIT2, HLA-B, HLA-C, AMPH, SNX12More
Darifenacinhsa04145Phagosome5.09E-0614O75015, P60709, Q15075, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765, P01889, P10321FCGR3B, ACTB, EEA1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB, HLA-B, HLA-CMore
Darifenacinhsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Darifenacinhsa04151PI3K-Akt signaling pathway3.53E-0519P62753, P25116, O43521, P27348, P49767, Q13362, P07900, Q8WYR1, P62873, P16144, P22105, O60603, P01568, Q99941, P18848, P10415, P17252, O00141, Q6ZUJ8RPS6, F2R, BCL2L11, YWHAQ, VEGFC, PPP2R5C, HSP90AA1, PIK3R5, GNB1, ITGB4, TNXB, TLR2, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGK, PIK3AP1More
Darifenacinhsa04210Apoptosis6.94E-048O76075, P01375, Q9NR28, O75460, Q16548, O43521, P18848, P04049DFFB, TNF, DIABLO, ERN1, BCL2A1, BCL2L11, ATF4, RAF1More
Darifenacinhsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Darifenacinhsa04213Longevity regulating pathway - multiple species4.52E-047P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Darifenacinhsa04217Necroptosis1.74E-0920P01375, P01568, P48023, Q13489, Q9NQC7, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, P10415, Q9H444, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP4B, CHMP2A, PPIDMore
Darifenacinhsa04218Cellular senescence2.04E-055P31751, P04049, P0DP23, P01889, P10321AKT2, RAF1, CALM1, HLA-B, HLA-CMore
Darifenacinhsa04260Cardiac muscle contraction4.02E-022P09493, P14927TPM1, UQCRBMore
Darifenacinhsa04261Adrenergic signaling in cardiomyocytes2.02E-0410P09493, P51828, P31751, Q99941, P18848, Q13362, P0DP23, Q13557, P17252, P10415TPM1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2More
Darifenacinhsa04270Vascular smooth muscle contraction8.53E-057P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Darifenacinhsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Darifenacinhsa04340Hedgehog signaling pathway4.15E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Darifenacinhsa04360Axon guidance2.85E-034P20827, P23528, P04049, Q06124EFNA1, CFL1, RAF1, PTPN11More
Darifenacinhsa04370VEGF signaling pathway1.99E-045P16298, P31751, Q05397, Q02750, P04049PPP3CB, AKT2, PTK2, MAP2K1, RAF1More
Darifenacinhsa04371Apelin signaling pathway1.43E-043P31751, P04049, P0DP23AKT2, RAF1, CALM1More
Darifenacinhsa04380Osteoclast differentiation5.19E-0614Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Darifenacinhsa04510Focal adhesion3.48E-021P04049RAF1More
Darifenacinhsa04514Cell adhesion molecules3.29E-022P01889, P10321HLA-B, HLA-CMore
Darifenacinhsa04530Tight junction1.74E-036P63261, P16989, P56750, Q9Y478, Q92974, Q14247ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTNMore
Darifenacinhsa04540Gap junction2.79E-035P17252, Q13509, P68371, P04049, Q14643PRKCA, TUBB3, TUBB2C, RAF1, ITPR1More
Darifenacinhsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Darifenacinhsa04610Complement and coagulation cascades1.56E-091P0C0L4C4AMore
Darifenacinhsa04611Platelet activation3.39E-023P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Darifenacinhsa04612Antigen processing and presentation1.85E-0511P13765, P48382, P01730, P26715, P26717, Q13241, O43908, P01732, P01889, P10321, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, HLA-B, HLA-C, TNFMore
Darifenacinhsa04613Neutrophil extracellular trap formation2.27E-1028P19174, P17252, P04049, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PLCG1, PRKCA, RAF1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Darifenacinhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Darifenacinhsa04620Toll-like receptor signaling pathway4.78E-021P31751AKT2More
Darifenacinhsa04621NOD-like receptor signaling pathway1.38E-0313P01584, P07900, Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838IL1B, HSP90AA1, MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4More
Darifenacinhsa04622RIG-I-like receptor signaling pathway1.81E-021Q9NQC7CYLDMore
Darifenacinhsa04623Cytosolic DNA-sensing pathway8.36E-044P01584, P01568, P25963, Q8NHW4IL1B, IFNA21, NFKBIA, CCL4L2More
Darifenacinhsa04625C-type lectin receptor signaling pathway8.21E-0712Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Darifenacinhsa04630JAK-STAT signaling pathway2.69E-035P01106, P42224, P14784, Q13651, P04049MYC, STAT1, IL2RB, IL10RA, RAF1More
Darifenacinhsa04640Hematopoietic cell lineage5.78E-0715P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, IL1BMore
Darifenacinhsa04650Natural killer cell mediated cytotoxicity1.00E-0917P19174, P01375, P78314, P06239, O60880, P20963, Q29983, P10321, P01889, P42338, P04049, Q13241, P26718, O14931, O75015, P26717, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, MICA, HLA-C, HLA-B, PIK3CB, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Darifenacinhsa04657IL-17 signaling pathway2.01E-0912P25963, P07900, O00463, Q16539, P49841, P09341, P14780, P04141, P80188, P01375, P06702, P01584NFKBIA, HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, CSF2, LCN2, TNF, S100A9, IL1BMore
Darifenacinhsa04658Th1 and Th2 cell differentiation2.15E-1516Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Darifenacinhsa04659Th17 cell differentiation6.98E-1116Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1More
Darifenacinhsa04660T cell receptor signaling pathway3.05E-1117P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Darifenacinhsa04662B cell receptor signaling pathway1.12E-032P31751, P04049AKT2, RAF1More
Darifenacinhsa04664Fc epsilon RI signaling pathway1.50E-035P01375, P31751, Q16539, Q9UQC2, P04049TNF, AKT2, MAPK14, GAB2, RAF1More
Darifenacinhsa04666Fc gamma R-mediated phagocytosis7.33E-037O75015, P04049, P06396, O14494, P14598, P49418, P17252FCGR3B, RAF1, GSN, PLPP1, NCF1, AMPH, PRKCAMore
Darifenacinhsa04668TNF signaling pathway1.56E-038P01375, O00463, Q16539, P18848, P01584, P20749, P14780, P20333TNF, TRAF5, MAPK14, ATF4, IL1B, BCL3, MMP9, TNFRSF1BMore
Darifenacinhsa04672Intestinal immune network for IgA production1.06E-043P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Darifenacinhsa04710Circadian rhythm4.40E-021O15516CLOCKMore
Darifenacinhsa04713Circadian entrainment2.60E-024P0DP23, P17252, P62873, Q14643CALM1, PRKCA, GNB1, ITPR1More
Darifenacinhsa04714Thermogenesis8.70E-0714Q16539, P15336, Q08828, P51828, P63261, P62753, P33121, Q9Y478, P13073, P12074, O15239, Q16718, O14521, P05496MAPK14, ATF2, ADCY1, ADCY7, ACTG1, RPS6, ACSL1, PRKAB1, COX4I1, COX6A1, NDUFA1, NDUFA5, SDHD, ATP5G1More
Darifenacinhsa04720Long-term potentiation1.75E-024P17252, P0DP23, P04049, Q14643PRKCA, CALM1, RAF1, ITPR1More
Darifenacinhsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Darifenacinhsa04722Neurotrophin signaling pathway2.01E-046P31751, P04049, P49841, O43524, P48023, P0DP23AKT2, RAF1, GSK3B, FOXO3, FASLG, CALM1More
Darifenacinhsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Darifenacinhsa04725Cholinergic synapse1.41E-037P51828, Q14643, P17252, P62873, P18848, Q13557, P10415ADCY7, ITPR1, PRKCA, GNB1, ATF4, CAMK2D, BCL2More
Darifenacinhsa04726Serotonergic synapse1.33E-021P04049RAF1More
Darifenacinhsa04728Dopaminergic synapse4.05E-049Q14643, P17252, P62873, P31751, Q99941, P18848, Q13557, Q13362, P0DP23ITPR1, PRKCA, GNB1, AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, CALM1More
Darifenacinhsa04730Long-term depression1.16E-021P04049RAF1More
Darifenacinhsa04740Olfactory transduction9.46E-042Q9H255, P0DP23OR51E2, CALM1More
Darifenacinhsa04742Taste transduction1.01E-021P30939HTR1FMore
Darifenacinhsa04744Phototransduction1.74E-032P62873, P0DP23GNB1, CALM1More
Darifenacinhsa04750Inflammatory mediator regulation of TRP channels3.66E-0513P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Darifenacinhsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Darifenacinhsa04910Insulin signaling pathway2.43E-056P0DP23, P22694, P06737, P04049, P31751, P49841CALM1, PRKACB, PYGL, RAF1, AKT2, GSK3BMore
Darifenacinhsa04911Insulin secretion6.24E-055Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Darifenacinhsa04912GnRH signaling pathway9.54E-0713P17252, Q08828, P51828, P18848, Q13557, Q16539, Q99759, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694, P04049PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K3, MAP3K4, ITPR1, CALM1, CALM2, PRKACB, RAF1More
Darifenacinhsa04913Ovarian steroidogenesis2.52E-021P06213INSRMore
Darifenacinhsa04914Progesterone-mediated oocyte maturation7.70E-035Q17RY0, Q9Y6D9, P51812, Q02750, P04049CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Darifenacinhsa04915Estrogen signaling pathway2.49E-0711P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1More
Darifenacinhsa04916Melanogenesis2.15E-044P0DP23, P49841, Q01726, P04049CALM1, GSK3B, MC1R, RAF1More
Darifenacinhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Darifenacinhsa04918Thyroid hormone synthesis1.16E-046P51828, P17252, Q99941, P18848, P27824, P02768ADCY7, PRKCA, CREBL1, ATF4, CANX, ALBMore
Darifenacinhsa04919Thyroid hormone signaling pathway3.93E-059P49841, P19174, P04049, P42224, P22694, Q13547, O60244, Q9NVC6, P01106GSK3B, PLCG1, RAF1, STAT1, PRKACB, HDAC1, MED14, MED17, MYCMore
Darifenacinhsa04920Adipocytokine signaling pathway9.48E-0510P25963, Q06124, P33121, Q9Y478, Q04759, Q15831, P20333, P31751, Q9Y4H2, P01375NFKBIA, PTPN11, ACSL1, PRKAB1, PRKCQ, STK11, TNFRSF1B, AKT2, IRS2, TNFMore
Darifenacinhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Darifenacinhsa04922Glucagon signaling pathway2.33E-035Q12778, P31751, Q13370, P0DP23, Q14643FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Darifenacinhsa04923Regulation of lipolysis in adipocytes6.26E-045P07550, P06213, P42338, Q9Y4H2, P31751ADRB2, INSR, PIK3CB, IRS2, AKT2More
Darifenacinhsa04924Renin secretion2.05E-044P07550, Q14643, Q13370, P0DP23ADRB2, ITPR1, PDE3B, CALM1More
Darifenacinhsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Darifenacinhsa04926Relaxin signaling pathway4.90E-046Q99941, P18848, P02452, P51828, P04049, P49407CREBL1, ATF4, COL1A1, ADCY7, RAF1, ARRB1More
Darifenacinhsa04927Cortisol synthesis and secretion4.16E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Darifenacinhsa04928Parathyroid hormone synthesis, secretion and action3.95E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Darifenacinhsa04929GnRH secretion1.87E-042P31751, P04049AKT2, RAF1More
Darifenacinhsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Darifenacinhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Darifenacinhsa04932Non-alcoholic fatty liver disease4.51E-0913P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHDMore
Darifenacinhsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Darifenacinhsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Darifenacinhsa04935Growth hormone synthesis, secretion and action5.33E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Darifenacinhsa04940Type I diabetes mellitus2.76E-046P10747, P48023, P13765, P01889, P10321, P01375CD28, FASLG, HLA-DOB, HLA-B, HLA-C, TNFMore
Darifenacinhsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Darifenacinhsa04960Aldosterone-regulated sodium reabsorption7.59E-032O00141, P06213SGK, INSRMore
Darifenacinhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Darifenacinhsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Darifenacinhsa04966Collecting duct acid secretion1.26E-043Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Darifenacinhsa04970Salivary secretion4.76E-044P07550, Q08828, P51828, P0DP23ADRB2, ADCY1, ADCY7, CALM1More
Darifenacinhsa04971Gastric acid secretion4.78E-021P0DP23CALM1More
Darifenacinhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Darifenacinhsa04974Protein digestion and absorption3.03E-021P02452COL1A1More
Darifenacinhsa04976Bile secretion1.90E-046O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Darifenacinhsa05010Alzheimer disease2.06E-0520O15239, Q16718, O14521, P05496, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P0DP24, P01584, P18848, Q13509, P68371, P31751, P05141, Q08752, P28070, P43686NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, CALM2, IL1B, ATF4, TUBB3, TUBB2C, AKT2, SLC25A5, PPID, PSMB4, PSMC4More
Darifenacinhsa05012Parkinson disease3.50E-0517O15239, Q16718, O14521, P13073, P12074, P05496, P05141, O75460, P18848, P28070, P43686, Q14643, P0DP23, P0DP24, Q13557, Q13509, P68371NDUFA1, NDUFA5, SDHD, COX4I1, COX6A1, ATP5G1, SLC25A5, ERN1, ATF4, PSMB4, PSMC4, ITPR1, CALM1, CALM2, CAMK2D, TUBB3, TUBB2CMore
Darifenacinhsa05014Amyotrophic lateral sclerosis2.84E-0310P20333, O15239, P13073, P12074, P05496, P18848, P28070, P43686, P35658, Q9UBU9TNFRSF1B, NDUFA1, COX4I1, COX6A1, ATP5G1, ATF4, PSMB4, PSMC4, NUP214, NXF1More
Darifenacinhsa05016Huntington disease1.46E-0615O15239, O95298, P13073, P12074, P05496, Q9GZM3, P24928, P30876, P62487, P52435, P05141, O75460, P28070, P43686, O00232NDUFA1, NDUFC2, COX4I1, COX6A1, ATP5G1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, ERN1, PSMB4, PSMC4, PSMD12More
Darifenacinhsa05020Prion disease1.91E-0620P01584, P46531, O15239, Q16718, O14521, P05496, P13073, P12074, Q14643, P18848, P05141, P28070, P43686, Q13509, P68371, P49841, P51636, P14598, Q15080, Q16539IL1B, NOTCH1, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, ATF4, SLC25A5, PSMB4, PSMC4, TUBB3, TUBB2C, GSK3B, CAV2, NCF1, NCF4, MAPK14More
Darifenacinhsa05022Pathways of neurodegeneration - multiple diseases1.18E-0726Q14643, Q13509, P68371, P49841, P10415, O15239, Q16718, O14521, P13073, P12074, P05496, O75460, P18848, Q13561, P05141, P17252, P20333, Q16539, Q00535, P01584, Q08752, P0DP23, P0DP24, Q13557, P28070, P43686ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA1, NDUFA5, SDHD, COX4I1, COX6A1, ATP5G1, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, TNFRSF1B, MAPK14, CDK5, IL1B, PPID, CALM1, CALM2, CAMK2D, PSMB4, PSMC4More
Darifenacinhsa05030Cocaine addiction6.96E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Darifenacinhsa05031Amphetamine addiction9.24E-044P0DP23, Q13557, Q99941, P18848CALM1, CAMK2D, CREBL1, ATF4More
Darifenacinhsa05034Alcoholism7.35E-057Q13547, P04049, Q93077, P62807, Q16778, O60814, P68431HDAC1, RAF1, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Darifenacinhsa05110Vibrio cholerae infection4.50E-034Q13488, P17252, P19174, P60709TCIRG1, PRKCA, PLCG1, ACTBMore
Darifenacinhsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Darifenacinhsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Darifenacinhsa05131Shigellosis2.27E-028P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Darifenacinhsa05132Salmonella infection7.93E-039P04049, Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371RAF1, LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Darifenacinhsa05133Pertussis3.47E-041P0C0L4C4AMore
Darifenacinhsa05134Legionellosis8.80E-047P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Darifenacinhsa05140Leishmaniasis4.45E-1215P13612, O75015, P14598, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Darifenacinhsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Darifenacinhsa05144Malaria1.89E-048P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1More
Darifenacinhsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Darifenacinhsa05146Amoebiasis4.09E-0913P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Darifenacinhsa05150Staphylococcus aureus infection2.68E-038P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, P49913C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, CAMPMore
Darifenacinhsa05152Tuberculosis3.92E-0618P04049, Q13488, Q99437, P13473, P0DP23, O75015, P42224, P48382, P25208, O60603, P01375, P31751, P10415, P13765, P01568, P49913, Q9UDY8, P51617RAF1, TCIRG1, ATP6V0B, LAMP2, CALM1, FCGR3B, STAT1, RFX5, NFYB, TLR2, TNF, AKT2, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, IRAK1More
Darifenacinhsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Darifenacinhsa05161Hepatitis B5.33E-034P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Darifenacinhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Darifenacinhsa05163Human cytomegalovirus infection1.11E-0417P31751, P04049, P01375, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463AKT2, RAF1, TNF, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5More
Darifenacinhsa05164Influenza A3.65E-021P04049RAF1More
Darifenacinhsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Darifenacinhsa05167Kaposi sarcoma-associated herpesvirus infection3.36E-0511P01568, P31751, P42224, P01889, P10321, P62873, Q14643, P04049, Q29983, P0DP23, Q9UJU2IFNA21, AKT2, STAT1, HLA-B, HLA-C, GNB1, ITPR1, RAF1, MICA, CALM1, LEF1More
Darifenacinhsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Darifenacinhsa05169Epstein-Barr virus infection6.86E-0513P13765, P01106, Q13547, O00463, P07948, P01889, P10321, Q13761, P24522, P42224, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, HLA-B, HLA-C, RUNX3, GADD45A, STAT1, CD3E, CD3G, CD247More
Darifenacinhsa05170Human immunodeficiency virus 1 infection3.12E-0719P31751, P04049, P01889, P10321, P62873, P0DP23, P01375, P17252, Q14643, P01568, P51617, P25963, O60603, Q13315, Q9NQU5, P10415, Q93034, Q9Y6Q5, P20333AKT2, RAF1, HLA-B, HLA-C, GNB1, CALM1, TNF, PRKCA, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, PAK6, BCL2, CUL5, AP1M2, TNFRSF1BMore
Darifenacinhsa05171Coronavirus disease - COVID-197.88E-0621P01375, P01584, P51617, P25963, P42224, P23396, P62753, P39019, P42677, P36578, Q02878, P62917, P27635, Q07020, P62888, P61927, P61513, P63173, P05386, P62829, P04141TNF, IL1B, IRAK1, NFKBIA, STAT1, RPS3, RPS6, RPS19, RPS27, RPL4, RPL6, RPL8, RPL10, RPL18, RPL30, RPL37, RPL37A, RPL38, RPLP1, RPL23, CSF2More
Darifenacinhsa05200Pathways in cancer8.38E-0313P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P31751, P25116, P62873, P0DP23, P01568STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, AKT2, F2R, GNB1, CALM1, IFNA21More
Darifenacinhsa05202Transcriptional misregulation in cancer5.25E-0721Q12778, Q15532, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Darifenacinhsa05203Viral carcinogenesis1.56E-0614Q99941, P18848, P27348, Q13547, Q15283, P06396, P12814, P01889, P10321, P61978, P06493, P62807, Q16778, O60814CREBL1, ATF4, YWHAQ, HDAC1, RASA2, GSN, ACTN1, HLA-B, HLA-C, HNRPK, CDK1, HIST1H2BC, HIST2H2BE, H2BC12More
Darifenacinhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Darifenacinhsa05205Proteoglycans in cancer1.15E-025Q12955, P04049, Q14247, P17252, P08962ANK3, RAF1, CTTN, PRKCA, CD63More
Darifenacinhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Darifenacinhsa05210Colorectal cancer1.66E-021P04049RAF1More
Darifenacinhsa05211Renal cell carcinoma1.99E-044Q06124, Q99814, P31751, P04049PTPN11, EPAS1, AKT2, RAF1More
Darifenacinhsa05212Pancreatic cancer1.29E-032P31751, P04049AKT2, RAF1More
Darifenacinhsa05213Endometrial cancer8.16E-042P31751, P04049AKT2, RAF1More
Darifenacinhsa05214Glioma8.46E-063P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Darifenacinhsa05215Prostate cancer1.33E-021P04049RAF1More
Darifenacinhsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Darifenacinhsa05218Melanoma4.47E-042P31751, P04049AKT2, RAF1More
Darifenacinhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Darifenacinhsa05220Chronic myeloid leukemia9.63E-042P31751, P04049AKT2, RAF1More
Darifenacinhsa05221Acute myeloid leukemia8.16E-042P31751, P04049AKT2, RAF1More
Darifenacinhsa05222Small cell lung cancer4.78E-021P31751AKT2More
Darifenacinhsa05223Non-small cell lung cancer3.07E-046P17252, O43524, P31751, P19174, P04049, O75293PRKCA, FOXO3, AKT2, PLCG1, RAF1, GADD45BMore
Darifenacinhsa05224Breast cancer1.24E-025P04049, P49841, Q92837, P04637, P24522RAF1, GSK3B, FRAT1, TP53, GADD45AMore
Darifenacinhsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Darifenacinhsa05226Gastric cancer6.81E-042P04049, P31751RAF1, AKT2More
Darifenacinhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Darifenacinhsa05231Choline metabolism in cancer3.64E-057P04049, Q9Y259, P19174, P23743, P49619, O14494, P17252RAF1, CHKB, PLCG1, DGKA, DGKG, PLPP1, PRKCAMore
Darifenacinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.22E-0815P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, P42224, O60603, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, STAT1, TLR2, PRKCQ, MAPK14, EML4, CD4More
Darifenacinhsa05310Asthma4.89E-054P13765, P29965, P12724, P01375HLA-DOB, CD40LG, RNASE3, TNFMore
Darifenacinhsa05320Autoimmune thyroid disease3.25E-066P13765, P29965, P01889, P10321, P01568, P10747HLA-DOB, CD40LG, HLA-B, HLA-C, IFNA21, CD28More
Darifenacinhsa05321Inflammatory bowel disease5.16E-087O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Darifenacinhsa05322Systemic lupus erythematosus1.89E-0716O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSBMore
Darifenacinhsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Darifenacinhsa05330Allograft rejection2.63E-067P01889, P10321, P13765, P29965, P48023, P10747, P01375HLA-B, HLA-C, HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Darifenacinhsa05332Graft-versus-host disease2.62E-078P13765, P48023, P01889, P10321, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, HLA-B, HLA-C, CD28, TNF, KLRC1, KLRD1More
Darifenacinhsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Darifenacinhsa05410Hypertrophic cardiomyopathy1.73E-022P26012, P09493ITGB8, TPM1More
Darifenacinhsa05412Arrhythmogenic right ventricular cardiomyopathy8.80E-066P54284, P14923, P15924, P08514, P26012, Q9UJU2CACNB3, JUP, DSP, ITGA2B, ITGB8, LEF1More
Darifenacinhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Darifenacinhsa05415Diabetic cardiomyopathy8.05E-0816P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P05496, P13073, P12074, Q92736, Q16539, P49841, Q13557, P02452, P04406PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, COX6A1, RYR2, MAPK14, GSK3B, CAMK2D, COL1A1, GAPDHMore
Darifenacinhsa05416Viral myocarditis1.76E-045P13765, P29965, P01889, P10321, P10747HLA-DOB, CD40LG, HLA-B, HLA-C, CD28More
Darifenacinhsa05418Fluid shear stress and atherosclerosis1.27E-0510Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Darifenacin (SDC: 9.58)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
P21730C5AR1C5a anaphylatoxin chemotactic receptor 1Predicted10.02580.21670.53960.986
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P40818USP8Ubiquitin carboxylNoneterminal hydrolase 8Predicted00.22780.02220.20360.362
P29350PTPN6TyrosineNoneprotein phosphatase nonNonereceptor type 6Predicted10.28070.24590.56831.2004
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
Q9UM47NOTCH3Neurogenic locus notch homolog protein 3Predicted00.35290.02220.48680.7077
P46531NOTCH1Neurogenic locus notch homolog protein 1Predicted00.44070.02220.50470.7694
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P41968MC3RMelanocortin receptor 3Predicted10.22350.263700.6392
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
Q9H4A3WNK1Serine/threonineNoneprotein kinase WNK1Predicted00.17530.038600.1648
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q01726MC1RMelanocyteNonestimulating hormone receptorPredicted10.0470.23750.0110.5095
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
O75381PEX14Peroxisomal membrane protein PEX14Predicted00.19070.09950.10970.4039
Q96A54ADIPOR1Adiponectin receptor protein 1Predicted00.07390.01080.28410.3428
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)