PharmaCoNets

PharmaCoNets of Dapagliflozin (S_PCN: 8.66 )

Dapagliflozin regulated-network (S_DN: 4.89)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Dapagliflozin

hsa00030

Pentose phosphate pathway

6.81E-03

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Dapagliflozin

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Dapagliflozin

hsa00510

N-Glycan biosynthesis

3.61E-02

P15907, Q9NR34

ST6GAL1, MAN1C1

Dapagliflozin

hsa00524

Neomycin, kanamycin and gentamicin biosynthesis

2.03E-02

P35557

GCK

Dapagliflozin

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Dapagliflozin

hsa00730

Thiamine metabolism

1.15E-03

Q9Y6K8, P24666

AK5, ACP1

Dapagliflozin

hsa00740

Riboflavin metabolism

4.03E-02

P24666

ACP1

Dapagliflozin

hsa00920

Sulfur metabolism

2.29E-02

Q16762

TST

Dapagliflozin

hsa01100

Metabolic pathways

3.32E-02

Q9NR34, P05089, O14521, P15144, O14732, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, O60701, Q9HCC0, P33121, P42330, P51854, Q08477, Q96EB6, P15907, Q9UNP4, Q9BX95, P37837, P32321, P60891, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q16718

MAN1C1, ARG1, SDHD, ANPEP, IMPA2, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, UGDH, MCCC2, ACSL1, AKR1C3, TKTL1, CYP4F3, SIRT1, ST6GAL1, ST3GAL5, SGPP1, TALDO1, DCTD, PRPS1, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, NDUFA5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16548	BCL2A1	Bcl-2-related protein A1	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.723
Q16548	BCL2A1	Bcl-2-related protein A1	P05089	ARG1	Arginase-1	0.842
Q16548	BCL2A1	Bcl-2-related protein A1	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.709
Q16548	BCL2A1	Bcl-2-related protein A1	P15144	ANPEP	Aminopeptidase N	0.864
Q16548	BCL2A1	Bcl-2-related protein A1	O14732	IMPA2	Inositol monophosphatase 2	0.844
Q16548	BCL2A1	Bcl-2-related protein A1	P32320	CDA	Cytidine deaminase	0.852
Q16548	BCL2A1	Bcl-2-related protein A1	P22748	CA4	Carbonic anhydrase 4	0.833
Q16548	BCL2A1	Bcl-2-related protein A1	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.827
Q16548	BCL2A1	Bcl-2-related protein A1	P06280	GLA	Alpha-galactosidase A	0.903
Q16548	BCL2A1	Bcl-2-related protein A1	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.889
Q16548	BCL2A1	Bcl-2-related protein A1	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.78
Q16548	BCL2A1	Bcl-2-related protein A1	O43451	MGAM	Maltase-glucoamylase	0.845
Q16548	BCL2A1	Bcl-2-related protein A1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.889
Q16548	BCL2A1	Bcl-2-related protein A1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.863
Q16548	BCL2A1	Bcl-2-related protein A1	O60701	UGDH	UDP-glucose 6-dehydrogenase	-0.701
Q16548	BCL2A1	Bcl-2-related protein A1	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.922
Q16548	BCL2A1	Bcl-2-related protein A1	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.933
Q16548	BCL2A1	Bcl-2-related protein A1	P42330	AKR1C3	Aldo-keto reductase family 1 member C3	-0.701
Q16548	BCL2A1	Bcl-2-related protein A1	P51854	TKTL1	Transketolase-like protein 1	-0.7
Q16548	BCL2A1	Bcl-2-related protein A1	Q08477	CYP4F3	Cytochrome P450 4F3	0.729
Q16548	BCL2A1	Bcl-2-related protein A1	Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	-0.718
Q16548	BCL2A1	Bcl-2-related protein A1	P15907	ST6GAL1	Beta-galactoside alpha-2,6-sialyltransferase 1	-0.768
Q16548	BCL2A1	Bcl-2-related protein A1	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.789
Q16548	BCL2A1	Bcl-2-related protein A1	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.822
Q16548	BCL2A1	Bcl-2-related protein A1	P37837	TALDO1	Transaldolase	0.795
Q16548	BCL2A1	Bcl-2-related protein A1	P32321	DCTD	Deoxycytidylate deaminase	-0.718
Q16548	BCL2A1	Bcl-2-related protein A1	P60891	PRPS1	Ribose-phosphate pyrophosphokinase 1	-0.742
Q16548	BCL2A1	Bcl-2-related protein A1	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.773
Q16548	BCL2A1	Bcl-2-related protein A1	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.827
Q16548	BCL2A1	Bcl-2-related protein A1	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.867
Q16548	BCL2A1	Bcl-2-related protein A1	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.958
Q16548	BCL2A1	Bcl-2-related protein A1	P46976	GYG1	Glycogenin-1	0.756
Q16548	BCL2A1	Bcl-2-related protein A1	P06737	PYGL	Glycogen phosphorylase, liver form	0.967
Q16548	BCL2A1	Bcl-2-related protein A1	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.729

Dapagliflozin

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Dapagliflozin

hsa04064

NF-kappa B signaling pathway

4.25E-02

P10415, O00463, P01375, Q04759, Q13077, Q16548, Q8WV28, P24522, P09341

BCL2, TRAF5, TNF, PRKCQ, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1

Dapagliflozin

hsa04071

Sphingolipid signaling pathway

8.29E-03

Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2

EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2

Dapagliflozin

hsa04122

Sulfur relay system

2.29E-02

Q16762

TST

Dapagliflozin

hsa04340

Hedgehog signaling pathway

2.76E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Dapagliflozin

hsa04512

ECM-receptor interaction

2.00E-02

P07359, P08514

GP1BA, ITGA2B

Dapagliflozin

hsa04514

Cell adhesion molecules

3.82E-02

P16109, O00501

SELP, CLDN5

Dapagliflozin

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Dapagliflozin

hsa04611

Platelet activation

2.25E-04

P08514, Q15746, Q8WYR1, P07359

ITGA2B, MYLK, PIK3R5, GP1BA

Dapagliflozin

hsa04612

Antigen processing and presentation

1.64E-02

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Dapagliflozin

hsa04613

Neutrophil extracellular trap formation

9.55E-03

P16109, Q99878, P08514, P07359

SELP, H2AC14, ITGA2B, GP1BA

Dapagliflozin

hsa04621

NOD-like receptor signaling pathway

4.27E-02

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, DEFA4

Dapagliflozin

hsa04657

IL-17 signaling pathway

2.81E-02

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Dapagliflozin

hsa04658

Th1 and Th2 cell differentiation

7.47E-03

Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765

PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOB

Dapagliflozin

hsa04660

T cell receptor signaling pathway

2.52E-02

P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q16539, P49841

TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, MAPK14, GSK3B

Dapagliflozin

hsa04714

Thermogenesis

4.80E-02

P22694, Q16539, Q969G3, P33121, Q16718, O14521

PRKACB, MAPK14, SMARCE1, ACSL1, NDUFA5, SDHD

Dapagliflozin

hsa04912

GnRH signaling pathway

4.72E-02

Q16539, Q9Y6R4, Q14643, P22694

MAPK14, MAP3K4, ITPR1, PRKACB

Dapagliflozin

hsa04921

Oxytocin signaling pathway

4.91E-02

Q15746, Q8WYR1

MYLK, PIK3R5

Dapagliflozin

hsa04950

Maturity onset diabetes of the young

2.03E-02

P35557

GCK

Dapagliflozin

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Dapagliflozin

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Dapagliflozin

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Dapagliflozin

hsa05140

Leishmaniasis

4.80E-02

O75015, P13765, O60603, P01375, Q16539, Q15080

FCGR3B, HLA-DOB, TLR2, TNF, MAPK14, NCF4

Dapagliflozin

hsa05143

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Dapagliflozin

hsa05144

Malaria

2.19E-03

P60033, P69905, P68871, O60603, P01375, P35443, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Dapagliflozin

hsa05145

Toxoplasmosis

3.96E-02

P28068, Q16787

HLA-DMB, LAMA3

Dapagliflozin

hsa05146

Amoebiasis

2.81E-02

P09341, P27930, P01375, O60603, P05089, P22694, P08311

CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Dapagliflozin

hsa05150

Staphylococcus aureus infection

4.13E-03

P21730, P21462, O75015, P13765, Q16581, Q14532, P16109, P12838

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT32, SELP, DEFA4

Dapagliflozin

hsa05165

Human papillomavirus infection

2.01E-02

Q16787, Q02930, Q13315

LAMA3, CREB5, ATM

Dapagliflozin

hsa05166

Human T-cell leukemia virus 1 infection

2.91E-02

Q02930, P28068, Q13315

CREB5, HLA-DMB, ATM

Dapagliflozin

hsa05217

Basal cell carcinoma

4.72E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Dapagliflozin

hsa05310

Asthma

2.34E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Dapagliflozin

hsa05321

Inflammatory bowel disease

2.22E-03

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Dapagliflozin

hsa05332

Graft-versus-host disease

2.76E-02

P13765, P01375, P26715, Q13241

HLA-DOB, TNF, KLRC1, KLRD1

Dapagliflozin

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Community members of Dapagliflozin (S_DC: 1.77)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

SLC5A1

Sodium/glucose cotransporter 1

Predicted

0.3719

0.1105

0.105

0.512

Q16548

BCL2A1

BclNone2Nonerelated protein A1

Predicted

0.0306

0.0336

0.4687

0.5512

Q13822

ENPP2

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Predicted

0.113

0.305

0.0063

0.6729

P16109

SELP

PNoneselectin

Predicted

0.1523

0.0722

0.5733

0.7938

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P13866

SLC5A1

Sodium/glucose cotransporter 1

Predicted

0.3719

0.1105

0.105

0.512

PharmaCoNets of Dapagliflozin (SPCN: 8.66 )

Dapagliflozin regulated-network (SDN: 4.89)

Community members of Dapagliflozin (SDC: 1.77)

PharmaCoNets of Dapagliflozin (S_PCN: 8.66 )

Dapagliflozin regulated-network (S_DN: 4.89)

Community members of Dapagliflozin (S_DC: 1.77)