PharmaCoNets
.
Dantrolene
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PharmaCoNets of Dantrolene (S
PCN
: 0.27 )
Dantrolene regulated-network (S
DN
: 0.16)
Drug Name
Pathway ID
Pathway name
P-value
No. of gene members
UniProt AC
Gene name
Detail of Coexpression
Dantrolene
hsa00340
Histidine metabolism
3.28E-02
1
O95954
FTCD
More
Genes in community(ComG)
Gene name of ComG
Protein name of ComG
Co-expressed genes in pathway (PathG)
Gene name of PathG
Protein name of PathG
Coexpression
Q92736
RYR2
Ryanodine receptor 2
O95954
FTCD
Formimidoyltransferase-cyclodeaminase
0.78
Dantrolene
hsa00670
One carbon pool by folate
4.88E-02
1
O95954
FTCD
More
Genes in community(ComG)
Gene name of ComG
Protein name of ComG
Co-expressed genes in pathway (PathG)
Gene name of PathG
Protein name of PathG
Coexpression
Q92736
RYR2
Ryanodine receptor 2
O95954
FTCD
Formimidoyltransferase-cyclodeaminase
0.78
Dantrolene
hsa03050
Proteasome
4.83E-02
1
P55036
PSMD4
More
Genes in community(ComG)
Gene name of ComG
Protein name of ComG
Co-expressed genes in pathway (PathG)
Gene name of PathG
Protein name of PathG
Coexpression
Q07343
PDE4B
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
P55036
PSMD4
26S proteasome non-ATPase regulatory subunit 4
0.855
Dantrolene
hsa04360
Axon guidance
2.65E-02
2
P20936, P34925
RASA1, RYK
More
Genes in community(ComG)
Gene name of ComG
Protein name of ComG
Co-expressed genes in pathway (PathG)
Gene name of PathG
Protein name of PathG
Coexpression
Q92736
RYR2
Ryanodine receptor 2
P20936
RASA1
Ras GTPase-activating protein 1
-0.73
Q92736
RYR2
Ryanodine receptor 2
P34925
RYK
Tyrosine-protein kinase RYK
-0.7
Community members of Dantrolene (S
DC
: 1.64)
UniProtAC
Gene Name
Protein Name
Reported/
Predicted
DisGeNET
S
PV
S
drugability
S
HiSBiN
S
DisG
Q07343
PDE4B
cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B
Predicted
0
0.0253
0.9946
0.22
2.2219
BDBM ID
C.S.
Homologus UniProt ID
Gene Name
I.S.
Text mining Similar drug DB ID
C.S.
BDBM50185748
0.811
None
None
None
None
None
Q92736
RYR2
Ryanodine receptor 2
Predicted
0
0.3011
0.0221
0.4706
0.6655
BDBM ID
C.S.
Homologus UniProt ID
Gene Name
I.S.
Text mining Similar drug DB ID
C.S.
None
None
Q92736
RYR2
0.661
None
None
This pair is Reported in Drugbank.
Gene name
UniProt_ID
Bioactivity
Value (nM)
