PharmaCoNets of Danazol (SPCN: 24.47 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Danazolhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Danazolhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Danazolhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Danazolhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Danazolhsa03020RNA polymerase4.50E-021P30876POLR2BMore
Danazolhsa03450Non-homologous end-joining3.65E-021P13010XRCC5More
Danazolhsa04015Rap1 signaling pathway2.41E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Danazolhsa04020Calcium signaling pathway1.74E-023Q08828, P0DP23, P51828ADCY1, CALM1, ADCY7More
Danazolhsa04022cGMP-PKG signaling pathway2.80E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Danazolhsa04024cAMP signaling pathway1.45E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Danazolhsa04060Cytokine-cytokine receptor interaction2.29E-044P01584, Q13651, Q8NHW4, P13500IL1B, IL10RA, CCL4L2, CCL2More
Danazolhsa04061Viral protein interaction with cytokine and cytokine receptor3.99E-043P13500, Q8NHW4, Q13651CCL2, CCL4L2, IL10RAMore
Danazolhsa04062Chemokine signaling pathway1.59E-034Q8NHW4, P13500, Q08828, P51828CCL4L2, CCL2, ADCY1, ADCY7More
Danazolhsa04064NF-kappa B signaling pathway1.41E-046Q13489, Q13546, P01584, Q9UDY8, Q8NHW4, Q9UNE0BIRC3, RIPK1, IL1B, MALT1, CCL4L2, EDARMore
Danazolhsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Danazolhsa04114Oocyte meiosis2.41E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Danazolhsa04120Ubiquitin mediated proteolysis3.77E-022Q13620, Q14139CUL4B, UBE4AMore
Danazolhsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Danazolhsa04213Longevity regulating pathway - multiple species4.79E-022Q08828, P51828ADCY1, ADCY7More
Danazolhsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Danazolhsa04261Adrenergic signaling in cardiomyocytes2.41E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Danazolhsa04270Vascular smooth muscle contraction1.18E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Danazolhsa04371Apelin signaling pathway1.74E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Danazolhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Danazolhsa04540Gap junction3.12E-022Q08828, P51828ADCY1, ADCY7More
Danazolhsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Danazolhsa04620Toll-like receptor signaling pathway2.11E-044Q13546, P01568, P01584, Q8NHW4RIPK1, IFNA21, IL1B, CCL4L2More
Danazolhsa04621NOD-like receptor signaling pathway5.41E-034P01568, Q13489, Q13546, P13500IFNA21, BIRC3, RIPK1, CCL2More
Danazolhsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Danazolhsa04623Cytosolic DNA-sensing pathway1.32E-064P01584, P01568, Q13546, Q8NHW4IL1B, IFNA21, RIPK1, CCL4L2More
Danazolhsa04625C-type lectin receptor signaling pathway3.92E-022P01584, P0DP23IL1B, CALM1More
Danazolhsa04630JAK-STAT signaling pathway3.92E-022P23458, Q13651JAK1, IL10RAMore
Danazolhsa04657IL-17 signaling pathway1.16E-021P13500CCL2More
Danazolhsa04668TNF signaling pathway1.99E-021P13500CCL2More
Danazolhsa04713Circadian entrainment4.30E-033P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Danazolhsa04720Long-term potentiation4.79E-022P0DP23, Q08828CALM1, ADCY1More
Danazolhsa04723Retrograde endocannabinoid signaling4.79E-022Q08828, P51828ADCY1, ADCY7More
Danazolhsa04724Glutamatergic synapse4.79E-022Q08828, P51828ADCY1, ADCY7More
Danazolhsa04750Inflammatory mediator regulation of TRP channels2.43E-044P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Danazolhsa04911Insulin secretion3.12E-022Q08828, P51828ADCY1, ADCY7More
Danazolhsa04912GnRH signaling pathway5.77E-033Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Danazolhsa04913Ovarian steroidogenesis2.39E-022Q08828, P51828ADCY1, ADCY7More
Danazolhsa04915Estrogen signaling pathway2.41E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Danazolhsa04916Melanogenesis2.10E-033P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Danazolhsa04921Oxytocin signaling pathway1.18E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Danazolhsa04923Regulation of lipolysis in adipocytes1.19E-022Q08828, P51828ADCY1, ADCY7More
Danazolhsa04925Aldosterone synthesis and secretion5.77E-033Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Danazolhsa04927Cortisol synthesis and secretion2.39E-022Q08828, P51828ADCY1, ADCY7More
Danazolhsa04933AGE-RAGE signaling pathway in diabetic complications1.16E-021P13500CCL2More
Danazolhsa04934Cushing syndrome4.79E-022Q08828, P51828ADCY1, ADCY7More
Danazolhsa04970Salivary secretion1.35E-033Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Danazolhsa04971Gastric acid secretion1.35E-033Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Danazolhsa04972Pancreatic secretion1.75E-022Q08828, P51828ADCY1, ADCY7More
Danazolhsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Danazolhsa04976Bile secretion7.88E-043Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Danazolhsa04979Cholesterol metabolism1.19E-022P38571, P61916LIPA, NPC2More
Danazolhsa05032Morphine addiction2.39E-022Q08828, P51828ADCY1, ADCY7More
Danazolhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Danazolhsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Danazolhsa05133Pertussis2.39E-022P0DP23, P01584CALM1, IL1BMore
Danazolhsa05135Yersinia infection2.99E-021P13500CCL2More
Danazolhsa05142Chagas disease5.60E-033P01584, Q08828, P13500IL1B, ADCY1, CCL2More
Danazolhsa05144Malaria1.16E-021P13500CCL2More
Danazolhsa05152Tuberculosis8.75E-034P0DP23, P23458, Q13651, P01584CALM1, JAK1, IL10RA, IL1BMore
Danazolhsa05163Human cytomegalovirus infection4.84E-078P0DP23, P13500, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651CALM1, CCL2, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RAMore
Danazolhsa05164Influenza A8.23E-034P01584, P23458, Q9UBU9, P13500IL1B, JAK1, NXF1, CCL2More
Danazolhsa05168Herpes simplex virus 1 infection2.70E-024P01584, Q9UBU9, P23458, Q6P280IL1B, NXF1, JAK1, ZNF529More
Danazolhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Danazolhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Danazolhsa05225Hepatocellular carcinoma3.04E-022P37173, Q92922TGFBR2, SMARCC1More
Danazolhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Danazolhsa05323Rheumatoid arthritis1.82E-021P13500CCL2More
Danazolhsa05414Dilated cardiomyopathy3.92E-022Q08828, P51828ADCY1, ADCY7More
Danazolhsa05418Fluid shear stress and atherosclerosis2.49E-021P13500CCL2More

Community members of Danazol (SDC: 2.68)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P13500CCL2CNoneC motif chemokine 2Reported10.21210.01670.77340.9128
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P80075CCL8CNoneC motif chemokine 8Predicted10.04830.01130.33040.3772
Q8NHW4CCL4L2CNoneC motif chemokine 4NonelikePredicted10.02950.0050.46730.492
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)