PharmaCoNets

PharmaCoNets of Dabrafenib (S_PCN: 105.70 )

Dabrafenib regulated-network (S_DN: 19.18)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Dabrafenib

hsa00030

Pentose phosphate pathway

4.23E-02

P51854, P37837

TKTL1, TALDO1

Dabrafenib

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Dabrafenib

hsa00071

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Dabrafenib

hsa00100

Steroid biosynthesis

3.94E-02

P35610

SOAT1

Dabrafenib

hsa00220

Arginine biosynthesis

2.64E-04

P15104, P49448

GLUL, GLUD2

Dabrafenib

hsa00250

Alanine, aspartate and glutamate metabolism

4.40E-03

P49448, P15104

GLUD2, GLUL

Dabrafenib

hsa00471

D-Glutamine and D-glutamate metabolism

3.94E-02

P49448

GLUD2

Dabrafenib

hsa00500

Starch and sucrose metabolism

2.38E-06

O43451, P46976, P35573, P06737

MGAM, GYG1, AGL, PYGL

Dabrafenib

hsa00562

Inositol phosphate metabolism

4.55E-02

P27987, P42338

ITPKB, PIK3CB

Dabrafenib

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Dabrafenib

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Dabrafenib

hsa00630

Glyoxylate and dicarboxylate metabolism

5.34E-03

P40925, P15104

MDH1, GLUL

Dabrafenib

hsa00730

Thiamine metabolism

1.55E-03

P05186, P24666

ALPL, ACP1

Dabrafenib

hsa00910

Nitrogen metabolism

4.40E-03

P15104, P49448

GLUL, GLUD2

Dabrafenib

hsa00970

Aminoacyl-tRNA biosynthesis

1.17E-02

O95363, P14868, Q15046

FARS2, DARS, KARS

Dabrafenib

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Dabrafenib

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Dabrafenib

hsa00983

Drug metabolism - other enzymes

2.83E-02

P20839, P32320, P05164

IMPDH1, CDA, MPO

Dabrafenib

hsa01100

Metabolic pathways

3.02E-03

Q9NR34, P05089, P21953, P15104, P42338, P27987, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P53004, P05186, P24666, Q9HCC0, P33121, P09917, P57054, Q9UNP4, Q9BX95, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, BCKDHB, GLUL, PIK3CB, ITPKB, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, BLVRA, ALPL, ACP1, MCCC2, ACSL1, ALOX5, PIGP, ST3GAL5, SGPP1, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P21953	BCKDHB	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial	0.765
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P15104	GLUL	Glutamine synthetase	-0.819
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.733
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.745
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P53004	BLVRA	Biliverdin reductase A	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.705
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P32321	DCTD	Deoxycytidylate deaminase	0.79
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	-0.798
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P46976	GYG1	Glycogenin-1	-0.82
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Dabrafenib

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P04049

RAF1

Dabrafenib

hsa01522

Endocrine resistance

2.16E-02

P04049

RAF1

Dabrafenib

hsa03010

Ribosome

7.34E-03

P62753, P62829, P62888, P61927, P61513, P36578

RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4

Dabrafenib

hsa03013

RNA transport

2.99E-02

P38919, P37198, P35658, P55884

EIF4A3, NUP62, NUP214, EIF3B

Dabrafenib

hsa03020

RNA polymerase

2.51E-02

P24928, P62487

POLR2A, POLR2G

Dabrafenib

hsa03040

Spliceosome

4.19E-02

Q14562, O60508, P08579, Q01130, O43447

DHX8, CDC40, SNRPB2, SFRS2, PPIH

Dabrafenib

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Dabrafenib

hsa04010

MAPK signaling pathway

4.15E-02

P04049

RAF1

Dabrafenib

hsa04012

ErbB signaling pathway

1.82E-02

P04049

RAF1

Dabrafenib

hsa04014

Ras signaling pathway

3.65E-02

P04049

RAF1

Dabrafenib

hsa04015

Rap1 signaling pathway

2.99E-02

P04049

RAF1

Dabrafenib

hsa04022

cGMP-PKG signaling pathway

3.15E-02

P04049

RAF1

Dabrafenib

hsa04024

cAMP signaling pathway

2.49E-02

P04049

RAF1

Dabrafenib

hsa04062

Chemokine signaling pathway

7.18E-03

P07948, P42338, P50151, P49407, P04049

LYN, PIK3CB, GNG10, ARRB1, RAF1

Dabrafenib

hsa04064

NF-kappa B signaling pathway

2.99E-02

O00463, P14778, Q13077, Q16548, Q8WV28, P24522, P09341

TRAF5, IL1R1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1

Dabrafenib

hsa04068

FoxO signaling pathway

1.99E-02

P04049

RAF1

Dabrafenib

hsa04070

Phosphatidylinositol signaling system

1.62E-03

P19174, P49619, Q86XP1, P27987, Q96DU7

PLCG1, DGKG, DGKH, ITPKB, ITPKC

Dabrafenib

hsa04071

Sphingolipid signaling pathway

9.73E-03

P04049, P21453, Q9H228, P01375, Q13362, Q9BX95

RAF1, S1PR1, EDG8, TNF, PPP2R5C, SGPP1

Dabrafenib

hsa04072

Phospholipase D signaling pathway

2.82E-02

P04049

RAF1

Dabrafenib

hsa04080

Neuroactive ligand-receptor interaction

2.16E-02

P08311, Q15722, P21453, Q9H228, P21462, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, FPR1, C5AR1, ADRB2

Dabrafenib

hsa04110

Cell cycle

2.90E-02

P06493, P30304, P33981, P01106, Q13547

CDK1, CDC25A, TTK, MYC, HDAC1

Dabrafenib

hsa04114

Oocyte meiosis

6.23E-03

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Dabrafenib

hsa04140

Autophagy - animal

2.82E-02

P04049

RAF1

Dabrafenib

hsa04145

Phagosome

2.24E-02

O75015, Q15080, P05164, P78380, P35443, P13765

FCGR3B, NCF4, MPO, OLR1, THBS4, HLA-DOB

Dabrafenib

hsa04150

mTOR signaling pathway

2.32E-02

P04049

RAF1

Dabrafenib

hsa04210

Apoptosis

2.16E-02

P04049

RAF1

Dabrafenib

hsa04217

Necroptosis

1.44E-03

Q9NQC7, P07900, P15104, P01584, Q9H444

CYLD, HSP90AA1, GLUL, IL1B, CHMP4B

Dabrafenib

hsa04218

Cellular senescence

2.49E-02

P04049

RAF1

Dabrafenib

hsa04270

Vascular smooth muscle contraction

2.75E-03

P04049, P35579, P35318

RAF1, MYH9, ADM

Dabrafenib

hsa04310

Wnt signaling pathway

1.79E-02

P17612, P67870

PRKACA, CSNK2B

Dabrafenib

hsa04330

Notch signaling pathway

2.77E-02

Q92542, P49768

NCSTN, PSEN1

Dabrafenib

hsa04340

Hedgehog signaling pathway

3.91E-02

P17612

PRKACA

Dabrafenib

hsa04360

Axon guidance

4.71E-03

P42338, P04049, O14639, P24844

PIK3CB, RAF1, ABLIM1, MYL9

Dabrafenib

hsa04370

VEGF signaling pathway

2.77E-04

P16298, Q05397, Q02750, P04049

PPP3CB, PTK2, MAP2K1, RAF1

Dabrafenib

hsa04371

Apelin signaling pathway

2.65E-02

P04049

RAF1

Dabrafenib

hsa04380

Osteoclast differentiation

1.02E-02

Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2

Dabrafenib

hsa04510

Focal adhesion

3.48E-02

P04049

RAF1

Dabrafenib

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Dabrafenib

hsa04540

Gap junction

1.33E-02

P04049

RAF1

Dabrafenib

hsa04550

Signaling pathways regulating pluripotency of stem cells

9.61E-03

Q13873, P04049, Q02750, Q86SE9

BMPR2, RAF1, MAP2K1, PCGF5

Dabrafenib

hsa04611

Platelet activation

2.12E-02

Q9Y490, P17612

TLN1, PRKACA

Dabrafenib

hsa04612

Antigen processing and presentation

2.55E-04

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Dabrafenib

hsa04613

Neutrophil extracellular trap formation

5.57E-06

P19174, P04049, P11215, P05164, P08246, Q9UM07, Q13547, Q93077, P62807, Q16778, O60814, P68431, Q15080, P20160, P08311, P49913, O75015, P21730, P21462

PLCG1, RAF1, ITGAM, MPO, ELA2, PADI4, HDAC1, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51955	NEK2	Serine/threonine-protein kinase Nek2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.785
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P51955	NEK2	Serine/threonine-protein kinase Nek2	P11215	ITGAM	Integrin alpha-M	0.795
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P05164	MPO	Myeloperoxidase	-0.817
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P08246	ELA2	Neutrophil elastase	-0.772
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.809
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q13547	HDAC1	Histone deacetylase 1	-0.731
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P51955	NEK2	Serine/threonine-protein kinase Nek2	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.702
P51955	NEK2	Serine/threonine-protein kinase Nek2	Q16778	HIST2H2BE	Histone H2B type 2-E	0.728
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q15080	NCF4	Neutrophil cytosol factor 4	-0.742
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P20160	AZU1	Azurocidin	-0.771
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P08311	CTSG	Cathepsin G	-0.847
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P49913	CAMP	Cathelicidin antimicrobial peptide	-0.722
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.704
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.779
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P21462	FPR1	fMet-Leu-Phe receptor	-0.737

Dabrafenib

hsa04621

NOD-like receptor signaling pathway

2.92E-02

P01584, P07900, P43490

IL1B, HSP90AA1, PBEF1

Dabrafenib

hsa04625

C-type lectin receptor signaling pathway

6.37E-03

Q9ULY5, P04049, P20749, P01375, Q16539

CLEC4E, RAF1, BCL3, TNF, MAPK14

Dabrafenib

hsa04630

JAK-STAT signaling pathway

2.69E-03

P01106, P42224, P14784, Q13651, P04049

MYC, STAT1, IL2RB, IL10RA, RAF1

Dabrafenib

hsa04650

Natural killer cell mediated cytotoxicity

1.70E-06

P16298, P50591, P01375, P78314, O60880, P20963, Q02750, P04049, Q13241, P26718, O75015, P26717, P26715

PPP3CB, TNFSF10, TNF, SH3BP2, SH2D1A, CD247, MAP2K1, RAF1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P01375	TNF	Tumor necrosis factor	-0.813
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	O60880	SH2D1A	SH2 domain-containing protein 1A	0.912
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.776
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q13241	KLRD1	Natural killer cells antigen CD94	0.883
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P26718	KLRK1	NKG2-D type II integral membrane protein	0.794
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.704
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P26717	KLRC2	NKG2-C type II integral membrane protein	0.972
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.972

Dabrafenib

hsa04657

IL-17 signaling pathway

1.95E-05

P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Dabrafenib

hsa04658

Th1 and Th2 cell differentiation

1.65E-05

Q04759, P07766, P20963, P19174, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, PLCG1, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Dabrafenib

hsa04659

Th17 cell differentiation

4.07E-03

P19174, P06239, P42224, P14784, P07766

PLCG1, LCK, STAT1, IL2RB, CD3E

Dabrafenib

hsa04660

T cell receptor signaling pathway

2.44E-05

P01375, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, P04049, Q16539, P49841

TNF, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, RAF1, MAPK14, GSK3B

Dabrafenib

hsa04662

B cell receptor signaling pathway

3.03E-06

P42338, P60033, P07948, P21854, Q8N149, P04049

PIK3CB, CD81, LYN, CD72, LILRA2, RAF1

Dabrafenib

hsa04664

Fc epsilon RI signaling pathway

2.67E-07

P01375, Q16539, P42338, Q9UQC2, P07948, P04049, P09917, P20292

TNF, MAPK14, PIK3CB, GAB2, LYN, RAF1, ALOX5, ALOX5AP

Dabrafenib

hsa04666

Fc gamma R-mediated phagocytosis

2.32E-02

P04049

RAF1

Dabrafenib

hsa04668

TNF signaling pathway

2.21E-02

P01375, O00463, Q16539, P20749, P14780

TNF, TRAF5, MAPK14, BCL3, MMP9

Dabrafenib

hsa04710

Circadian rhythm

4.40E-02

O15516

CLOCK

Dabrafenib

hsa04720

Long-term potentiation

4.88E-03

P16298, P51812, Q02750, P04049

PPP3CB, RPS6KA3, MAP2K1, RAF1

Dabrafenib

hsa04722

Neurotrophin signaling pathway

2.32E-02

P04049

RAF1

Dabrafenib

hsa04724

Glutamatergic synapse

5.94E-03

O15399, P63218, P50151, P15104

GRIN2D, GNG5, GNG10, GLUL

Dabrafenib

hsa04725

Cholinergic synapse

4.10E-02

P63218, P50151, P42338

GNG5, GNG10, PIK3CB

Dabrafenib

hsa04726

Serotonergic synapse

1.33E-02

P04049

RAF1

Dabrafenib

hsa04727

GABAergic synapse

1.37E-03

P63218, P50151, P15104

GNG5, GNG10, GLUL

Dabrafenib

hsa04730

Long-term depression

1.16E-02

P04049

RAF1

Dabrafenib

hsa04742

Taste transduction

3.91E-02

P17612

PRKACA

Dabrafenib

hsa04810

Regulation of actin cytoskeleton

3.81E-02

P04049

RAF1

Dabrafenib

hsa04910

Insulin signaling pathway

1.49E-02

P04049

RAF1

Dabrafenib

hsa04912

GnRH signaling pathway

1.82E-02

P04049

RAF1

Dabrafenib

hsa04914

Progesterone-mediated oocyte maturation

1.91E-03

Q17RY0, Q9Y6D9, P51812, Q02750, P04049

CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1

Dabrafenib

hsa04915

Estrogen signaling pathway

2.99E-02

P04049

RAF1

Dabrafenib

hsa04916

Melanogenesis

1.33E-02

P04049

RAF1

Dabrafenib

hsa04917

Prolactin signaling pathway

6.63E-03

P04049

RAF1

Dabrafenib

hsa04919

Thyroid hormone signaling pathway

1.99E-03

P19174, P04049, P42224, Q13547, P01106

PLCG1, RAF1, STAT1, HDAC1, MYC

Dabrafenib

hsa04921

Oxytocin signaling pathway

2.32E-02

P04049

RAF1

Dabrafenib

hsa04924

Renin secretion

1.55E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Dabrafenib

hsa04926

Relaxin signaling pathway

1.05E-04

P42338, P63218, P50151, P49767, P04049, P49407

PIK3CB, GNG5, GNG10, VEGFC, RAF1, ARRB1

Dabrafenib

hsa04928

Parathyroid hormone synthesis, secretion and action

1.99E-02

P04049

RAF1

Dabrafenib

hsa04929

GnRH secretion

1.07E-04

P42338, P49407, P04049

PIK3CB, ARRB1, RAF1

Dabrafenib

hsa04932

Non-alcoholic fatty liver disease

3.44E-02

P01584, P12074, O15239

IL1B, COX6A1, NDUFA1

Dabrafenib

hsa04935

Growth hormone synthesis, secretion and action

2.16E-02

P04049

RAF1

Dabrafenib

hsa04940

Type I diabetes mellitus

1.55E-02

P10747, P13765, P01375

CD28, HLA-DOB, TNF

Dabrafenib

hsa04960

Aldosterone-regulated sodium reabsorption

4.40E-02

O00141

SGK

Dabrafenib

hsa04962

Vasopressin-regulated water reabsorption

7.22E-03

P52566, P62491

ARHGDIB, RAB11A

Dabrafenib

hsa04970

Salivary secretion

1.74E-02

P07550, P22694, Q14643, P49913

ADRB2, PRKACB, ITPR1, CAMP

Dabrafenib

hsa05034

Alcoholism

6.43E-06

Q13547, Q96RR4, P04049, Q93077, P62807, Q16778, O60814, P84243, P68431

HDAC1, CAMKK2, RAF1, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Dabrafenib

hsa05100

Bacterial invasion of epithelial cells

2.85E-02

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Dabrafenib

hsa05110

Vibrio cholerae infection

2.11E-03

Q99437, P17612

ATP6V0B, PRKACA

Dabrafenib

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.45E-02

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Dabrafenib

hsa05132

Salmonella infection

4.98E-02

P04049

RAF1

Dabrafenib

hsa05135

Yersinia infection

3.29E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Dabrafenib

hsa05140

Leishmaniasis

2.69E-02

O75015, P13765, O60603, P49006, Q16539

FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14

Dabrafenib

hsa05144

Malaria

3.30E-02

P60033, O60603, P35443, P26718

CD81, TLR2, THBS4, KLRK1

Dabrafenib

hsa05146

Amoebiasis

5.82E-03

P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311

CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Dabrafenib

hsa05150

Staphylococcus aureus infection

2.66E-03

P21730, P21462, O75015, P13765, P12838, P49913

C5AR1, FPR1, FCGR3B, HLA-DOB, DEFA4, CAMP

Dabrafenib

hsa05152

Tuberculosis

3.98E-02

P04049

RAF1

Dabrafenib

hsa05160

Hepatitis C

1.99E-02

P04049

RAF1

Dabrafenib

hsa05161

Hepatitis B

1.99E-02

P04049

RAF1

Dabrafenib

hsa05163

Human cytomegalovirus infection

4.07E-03

P04049, P01375, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463

RAF1, TNF, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5

Dabrafenib

hsa05164

Influenza A

3.65E-02

P04049

RAF1

Dabrafenib

hsa05167

Kaposi sarcoma-associated herpesvirus infection

3.15E-02

P04049

RAF1

Dabrafenib

hsa05169

Epstein-Barr virus infection

3.90E-03

P01106, Q13547, P42338, P07948, Q13761, O75293, P42224, P07766

MYC, HDAC1, PIK3CB, LYN, RUNX3, GADD45B, STAT1, CD3E

Dabrafenib

hsa05170

Human immunodeficiency virus 1 infection

3.48E-02

P04049

RAF1

Dabrafenib

hsa05171

Coronavirus disease - COVID-19

3.18E-03

P01584, P62753, P36578, P62888, P61927, P61513, P62829

IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23

Dabrafenib

hsa05202

Transcriptional misregulation in cancer

3.18E-03

Q12778, Q13315, P41732, P14780, Q15744, Q16548, P35226, P05164, P12838, P08246, Q9C0K0

FOXO1, ATM, TSPAN7, MMP9, CEBPE, BCL2A1, BMI1, MPO, DEFA4, ELA2, BCL11B

Dabrafenib

hsa05203

Viral carcinogenesis

1.29E-03

Q13547, Q15283, P12814, P06493, P62807, Q16778, O60814

HDAC1, RASA2, ACTN1, CDK1, HIST1H2BC, HIST2H2BE, H2BC12

Dabrafenib

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Dabrafenib

hsa05205

Proteoglycans in cancer

3.48E-02

P04049

RAF1

Dabrafenib

hsa05206

MicroRNAs in cancer

3.15E-02

P04049

RAF1

Dabrafenib

hsa05210

Colorectal cancer

1.66E-02

P04049

RAF1

Dabrafenib

hsa05211

Renal cell carcinoma

1.16E-02

P04049

RAF1

Dabrafenib

hsa05212

Pancreatic cancer

1.16E-02

P04049

RAF1

Dabrafenib

hsa05213

Endometrial cancer

9.95E-03

P04049

RAF1

Dabrafenib

hsa05214

Glioma

9.95E-03

P04049

RAF1

Dabrafenib

hsa05215

Prostate cancer

1.33E-02

P04049

RAF1

Dabrafenib

hsa05218

Melanoma

6.63E-03

P04049

RAF1

Dabrafenib

hsa05219

Bladder cancer

5.65E-03

P14780, P04637, P04049

MMP9, TP53, RAF1

Dabrafenib

hsa05220

Chronic myeloid leukemia

9.95E-03

P04049

RAF1

Dabrafenib

hsa05221

Acute myeloid leukemia

8.29E-03

P04049

RAF1

Dabrafenib

hsa05223

Non-small cell lung cancer

6.63E-03

P04049

RAF1

Dabrafenib

hsa05224

Breast cancer

1.24E-02

P04049, P49841, Q92837, P04637, P24522

RAF1, GSK3B, FRAT1, TP53, GADD45A

Dabrafenib

hsa05225

Hepatocellular carcinoma

1.33E-02

P04049

RAF1

Dabrafenib

hsa05226

Gastric cancer

8.29E-03

P04049

RAF1

Dabrafenib

hsa05230

Central carbon metabolism in cancer

9.95E-03

P04049

RAF1

Dabrafenib

hsa05231

Choline metabolism in cancer

1.94E-03

P04049, Q9Y259, P19174, P49619

RAF1, CHKB, PLCG1, DGKG

Dabrafenib

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

6.42E-05

O95267, P19174, P07766, P09693, P06239, P04049, P42224, O60603, Q16539, Q9HC35, P01730

RASGRP1, PLCG1, CD3E, CD3G, LCK, RAF1, STAT1, TLR2, MAPK14, EML4, CD4

Dabrafenib

hsa05310

Asthma

6.83E-03

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Dabrafenib

hsa05321

Inflammatory bowel disease

2.27E-03

P01375, P13765, Q14765, Q9UL17, P23771

TNF, HLA-DOB, STAT4, TBX21, GATA3

Dabrafenib

hsa05322

Systemic lupus erythematosus

1.16E-05

O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q93077, P62807, Q16778, O60814, P68431, P12814

FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1