PharmaCoNets of D-serine (SPCN: 1.93 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
D-Serinehsa00220Arginine biosynthesis1.50E-033P15104, P05089, P49448GLUL, ARG1, GLUD2More
D-Serinehsa00330Arginine and proline metabolism4.10E-021P17707AMD1More
D-Serinehsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
D-Serinehsa00600Sphingolipid metabolism2.19E-022P07602, Q13510PSAP, ASAH1More
D-Serinehsa00670One carbon pool by folate3.91E-022O95954, Q99707FTCD, MTRMore
D-Serinehsa00830Retinol metabolism4.10E-021P00325ADH1BMore
D-Serinehsa01100Metabolic pathways3.37E-0236P05089, Q9UJ14, P15104, O14986, P48426, Q14642, Q96DU7, P07195, Q08828, Q02153, Q16875, O43286, O43451, Q86XP1, Q14739, Q9UHK6, P11511, Q86VZ5, Q08477, P15907, Q9UNP4, Q9H4F1, P32321, P60891, P49448, P15586, P00352, Q9BPW9, P43490, P46976, P05166, P13073, P05496, O15239, O15047, Q9NVH6ARG1, GGTL3, GLUL, PIP5K1B, PIP4K2A, INPP5A, ITPKC, LDHB, ADCY1, GUCY1B3, PFKFB3, B4GALT5, MGAM, DGKH, LBR, AMACR, CYP19A1, SGMS1, CYP4F3, ST6GAL1, ST3GAL5, ST6GALNAC4, DCTD, PRPS1, GLUD2, GNS, ALDH1A1, DHRS9, PBEF1, GYG1, PCCB, COX4I1, ATP5G1, NDUFA1, SETD1A, TMLHEMore
D-Serinehsa03013RNA transport4.72E-027O14980, Q09161, P35658, P47813, Q14152, O75822, P51114XPO1, NCBP1, NUP214, EIF1AX, EIF3A, EIF3J, FXR1More
D-Serinehsa03050Proteasome1.40E-021P55036PSMD4More
D-Serinehsa04060Cytokine-cytokine receptor interaction4.33E-0211P27930, P14778, P01584, Q13651, Q9HBE5, Q9UBD3, P47992, P09341, P32248, P18510, P01730IL1R2, IL1R1, IL1B, IL10RA, IL21R, XCL2, XCL1, CXCL1, CCR7, IL1RN, CD4More
D-Serinehsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
D-Serinehsa04151PI3K-Akt signaling pathway2.51E-0216P21860, P43657, P01106, P27348, O14944, Q9GZP0, P07900, P62873, P50151, P13612, P26012, P24821, Q16363, P22105, Q99941, P18848ERBB3, P2RY5, MYC, YWHAQ, EREG, PDGFD, HSP90AA1, GNB1, GNG10, ITGA4, ITGB8, TNC, LAMA4, TNXB, CREBL1, ATF4More
D-Serinehsa04270Vascular smooth muscle contraction2.01E-023P0DP24, P35579, P35318CALM2, MYH9, ADMMore
D-Serinehsa04512ECM-receptor interaction4.68E-025Q16363, P24821, P22105, P13612, P26012LAMA4, TNC, TNXB, ITGA4, ITGB8More
D-Serinehsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
D-Serinehsa04640Hematopoietic cell lineage6.74E-0310P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P13765, P01584ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, HLA-DOB, IL1BMore
D-Serinehsa04658Th1 and Th2 cell differentiation3.62E-0411Q04759, P07766, P20963, P09693, P01730, P06239, P23771, Q9UL17, P46531, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, CD4, LCK, GATA3, TBX21, NOTCH1, HLA-DOB, RUNX3More
D-Serinehsa04659Th17 cell differentiation8.31E-0513Q04759, P01730, P06239, P13765, P14778, Q9HBE5, Q9UL17, P23771, P01584, P07900, P07766, P09693, P20963PRKCQ, CD4, LCK, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, IL1B, HSP90AA1, CD3E, CD3G, CD247More
D-Serinehsa04660T cell receptor signaling pathway4.36E-0310Q04759, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
D-Serinehsa04750Inflammatory mediator regulation of TRP channels3.28E-026P14778, P01584, Q08828, Q13557, P24723, Q04759IL1R1, IL1B, ADCY1, CAMK2D, PRKCH, PRKCQMore
D-Serinehsa04934Cushing syndrome2.63E-026Q99941, P18848, Q08828, O15169, Q13557, O00170CREBL1, ATF4, ADCY1, AXIN1, CAMK2D, AIPMore
D-Serinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
D-Serinehsa04960Aldosterone-regulated sodium reabsorption4.10E-021O00141SGKMore
D-Serinehsa05032Morphine addiction1.09E-022P78334, P32298GABRE, GRK4More
D-Serinehsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
D-Serinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
D-Serinehsa05146Amoebiasis7.62E-039P01584, Q16363, P09341, P14778, P27930, P05089, Q08828, P12814, P08311IL1B, LAMA4, CXCL1, IL1R1, IL1R2, ARG1, ADCY1, ACTN1, CTSGMore
D-Serinehsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
D-Serinehsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
D-Serinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.83E-027O95267, P07766, P20963, P09693, P06239, Q04759, P01730RASGRP1, CD3E, CD247, CD3G, LCK, PRKCQ, CD4More
D-Serinehsa05321Inflammatory bowel disease4.68E-025P13765, Q9UL17, P23771, P01584, Q9HBE5HLA-DOB, TBX21, GATA3, IL1B, IL21RMore
D-Serinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
D-Serinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
D-Serinehsa05340Primary immunodeficiency3.99E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore

Community members of D-serine (SDC: 0.43)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)