PharmaCoNets

PharmaCoNets of Cytarabine (S_PCN: 83.04 )

Cytarabine regulated-network (S_DN: 21.46)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Cytarabine

hsa00010

Glycolysis / Gluconeogenesis

4.41E-02

P04075, P06733, P04406, P60174

ALDOA, ENO1, GAPDH, TPI1

Cytarabine

hsa00030

Pentose phosphate pathway

1.95E-02

P51854, P08237, P37837

TKTL1, PFKM, TALDO1

Cytarabine

hsa00051

Fructose and mannose metabolism

2.21E-02

O14772, P60174, P04075

FPGT, TPI1, ALDOA

Cytarabine

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Cytarabine

hsa00120

Primary bile acid biosynthesis

3.72E-02

P22680, P22307

CYP7A1, SCP2

Cytarabine

hsa00190

Oxidative phosphorylation

3.20E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Cytarabine

hsa00240

Pyrimidine metabolism

8.44E-04

P31350, P21589, P32320, P04183

RRM2, NT5E, CDA, TK1

Cytarabine

hsa00280

Valine, leucine and isoleucine degradation

3.41E-03

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Cytarabine

hsa00500

Starch and sucrose metabolism

6.17E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Cytarabine

hsa00531

Glycosaminoglycan degradation

4.51E-02

P22304, P06865

IDS, HEXA

Cytarabine

hsa00561

Glycerolipid metabolism

2.51E-02

P51648, P23743

ALDH3A2, DGKA

Cytarabine

hsa00562

Inositol phosphate metabolism

7.30E-04

P27987, Q96PE3, P19174, P42338

ITPKB, INPP4A, PLCG1, PIK3CB

Cytarabine

hsa00620

Pyruvate metabolism

2.51E-02

P40925, P51648

MDH1, ALDH3A2

Cytarabine

hsa00630

Glyoxylate and dicarboxylate metabolism

4.69E-10

P40925, P15104

MDH1, GLUL

Cytarabine

hsa00730

Thiamine metabolism

2.27E-02

P05186, P24666

ALPL, ACP1

Cytarabine

hsa00980

Metabolism of xenobiotics by cytochrome P450

3.20E-02

P78417, P11766

GSTO1, ADH5

Cytarabine

hsa00982

Drug metabolism - cytochrome P450

3.20E-02

P78417, P11766

GSTO1, ADH5

Cytarabine

hsa00983

Drug metabolism - other enzymes

3.83E-04

P04183, P32320, P31350, P05164

TK1, CDA, RRM2, MPO

Cytarabine

hsa01040

Biosynthesis of unsaturated fatty acids

4.28E-02

P22307

SCP2

Cytarabine

hsa01100

Metabolic pathways

1.47E-03

Q9Y234, P35790, Q16772, P15144, P30041, P15104, P51648, P42338, Q96PE3, P19174, O14732, P27987, Q13370, Q02153, Q16774, P20839, P00918, P40925, P10768, P55809, P06280, Q9Y6K0, P08237, P23743, P21399, Q9UHK6, P51854, P43034, Q86VZ5, P09917, Q9BVK2, P15907, O96024, Q53FZ2, P37837, P50213, P43490, Q969G6, Q13029, Q9NVH6

LIPT1, CHKA, GSTA3, ANPEP, PRDX6, GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, IMPA2, ITPKB, PDE3B, GUCY1B3, GUK1, IMPDH1, CA2, MDH1, ESD, OXCT1, GLA, CEPT1, PFKM, DGKA, ACO1, AMACR, TKTL1, PAFAH1B1, SGMS1, ALOX5, ALG8, ST6GAL1, B3GALT4, ACSM3, TALDO1, IDH3A, PBEF1, RFK, PRDM2, TMLHE

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q9Y234	LIPT1	Lipoyltransferase 1, mitochondrial	0.778
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P35790	CHKA	Choline kinase alpha	-0.856
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q16772	GSTA3	Glutathione S-transferase A3	-0.768
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P15144	ANPEP	Aminopeptidase N	0.846
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P30041	PRDX6	Peroxiredoxin-6	0.785
P06746	POLB	DNA polymerase beta	P15104	GLUL	Glutamine synthetase	-0.71
P06746	POLB	DNA polymerase beta	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	0.845
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P06746	POLB	DNA polymerase beta	Q96PE3	INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.711
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	O14732	IMPA2	Inositol monophosphatase 2	0.738
P06746	POLB	DNA polymerase beta	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.835
P06746	POLB	DNA polymerase beta	Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	-0.758
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q02153	GUCY1B3	Guanylate cyclase soluble subunit beta-1	-0.774
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q16774	GUK1	Guanylate kinase	0.757
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	1
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P00918	CA2	Carbonic anhydrase 2	0.772
P06746	POLB	DNA polymerase beta	P40925	MDH1	Malate dehydrogenase, cytoplasmic	0.837
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P10768	ESD	S-formylglutathione hydrolase	-0.701
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.744
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P06280	GLA	Alpha-galactosidase A	0.728
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q9Y6K0	CEPT1	Choline/ethanolaminephosphotransferase 1	0.771
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P08237	PFKM	ATP-dependent 6-phosphofructokinase, muscle type	0.868
P06746	POLB	DNA polymerase beta	P23743	DGKA	Diacylglycerol kinase alpha	0.814
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P21399	ACO1	Cytoplasmic aconitate hydratase	-0.739
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.784
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P51854	TKTL1	Transketolase-like protein 1	-0.753
P06746	POLB	DNA polymerase beta	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	0.726
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.81
P06746	POLB	DNA polymerase beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.789
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q9BVK2	ALG8	Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase	-0.726
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P15907	ST6GAL1	Beta-galactoside alpha-2,6-sialyltransferase 1	-0.827
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	O96024	B3GALT4	Beta-1,3-galactosyltransferase 4	0.797
P06746	POLB	DNA polymerase beta	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	-0.744
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P37837	TALDO1	Transaldolase	0.732
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P50213	IDH3A	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	-0.732
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.702
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q969G6	RFK	Riboflavin kinase	0.705
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q13029	PRDM2	PR domain zinc finger protein 2	0.744
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	-0.721

Cytarabine

hsa01200

Carbon metabolism

3.30E-04

P04075, P51854, P04406, P08237, P60174, P37837, P06733, O14521, Q9P2R7, P50213, P21399, P10768, Q02252

ALDOA, TKTL1, GAPDH, PFKM, TPI1, TALDO1, ENO1, SDHD, SUCLA2, IDH3A, ACO1, ESD, ALDH6A1

Cytarabine

hsa01210

2-Oxocarboxylic acid metabolism

1.73E-02

P21399, P50213

ACO1, IDH3A

Cytarabine

hsa01230

Biosynthesis of amino acids

2.08E-04

P60174, P04406, P06733, P04075, P08237, P51854, Q99707, P21399, P50213, P37837

TPI1, GAPDH, ENO1, ALDOA, PFKM, TKTL1, MTR, ACO1, IDH3A, TALDO1

Cytarabine

hsa01521

EGFR tyrosine kinase inhibitor resistance

7.30E-04

Q92529, P19174, P42338, Q9NRA1

SHC3, PLCG1, PIK3CB, PDGFC

Cytarabine

hsa01522

Endocrine resistance

2.84E-02

P22694, Q9UM47, P46527

PRKACB, NOTCH3, CDKN1B

Cytarabine

hsa01524

Platinum drug resistance

7.33E-03

Q13489, P98170, P78417, P43246, P52701

BIRC3, BIRC4, GSTO1, MSH2, MSH6

Cytarabine

hsa03013

RNA transport

4.13E-02

Q09161, P35658, P47813, Q14152, O75822, P51114

NCBP1, NUP214, EIF1AX, EIF3A, EIF3J, FXR1

Cytarabine

hsa03040

Spliceosome

3.06E-09

Q14562, O43143, O60508, O14776, P08579, P26368, O75940, P52298, P09651, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, O95777, O43447, P61326

DHX8, DHX15, CDC40, TCERG1, SNRPB2, U2AF2, SMNDC1, NCBP2, HNRNPA1, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, LSM8, PPIH, MAGOH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.708
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.732
P27707	DCK	Deoxycytidine kinase	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.726
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P11142	HSPA8	Heat shock cognate 71 kDa protein	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.789
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.809
P27707	DCK	Deoxycytidine kinase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.816
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O60508	CDC40	Pre-mRNA-processing factor 17	-0.837
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P27707	DCK	Deoxycytidine kinase	O14776	TCERG1	Transcription elongation regulator 1	0.757
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.702
P11142	HSPA8	Heat shock cognate 71 kDa protein	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.752
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.811
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.702
P27707	DCK	Deoxycytidine kinase	O75940	SMNDC1	Survival of motor neuron-related-splicing factor 30	0.84
P27707	DCK	Deoxycytidine kinase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.769
P27707	DCK	Deoxycytidine kinase	P09651	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	0.736
P27707	DCK	Deoxycytidine kinase	O75494	FUSIP1	Serine/arginine-rich splicing factor 10	0.824
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.879
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.824
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.806
P27707	DCK	Deoxycytidine kinase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.804
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.835
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.701
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.703
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.772
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.731
P27707	DCK	Deoxycytidine kinase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.757
P11142	HSPA8	Heat shock cognate 71 kDa protein	P11142	HSPA8	Heat shock cognate 71 kDa protein	1
P27707	DCK	Deoxycytidine kinase	O95777	LSM8	U6 snRNA-associated Sm-like protein LSm8	0.797
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.761
P11142	HSPA8	Heat shock cognate 71 kDa protein	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.872
P27707	DCK	Deoxycytidine kinase	P61326	MAGOH	Protein mago nashi homolog	0.732

Cytarabine

hsa04012

ErbB signaling pathway

9.49E-03

Q92529, P19174, P42338

SHC3, PLCG1, PIK3CB

Cytarabine

hsa04014

Ras signaling pathway

2.29E-04

P42338, Q92529, Q9NRA1, P49767, P63218, P50151, P19174

PIK3CB, SHC3, PDGFC, VEGFC, GNG5, GNG10, PLCG1

Cytarabine

hsa04015

Rap1 signaling pathway

3.91E-02

Q9NRA1, P49767, P42338, P19174

PDGFC, VEGFC, PIK3CB, PLCG1

Cytarabine

hsa04020

Calcium signaling pathway

3.46E-05

P27987, P21796, P45880, Q13557, P30679, P19174, P0DP23, P05141, P23634, Q9NRA1, P49767

ITPKB, VDAC1, VDAC2, CAMK2D, GNA15, PLCG1, CALM1, SLC25A5, ATP2B4, PDGFC, VEGFC

Cytarabine

hsa04022

cGMP-PKG signaling pathway

2.26E-03

Q14814, Q99941, P18848, P05141, P21796, P45880, P0DP23, P01042

MEF2D, CREBL1, ATF4, SLC25A5, VDAC1, VDAC2, CALM1, KNG1

Cytarabine

hsa04024

cAMP signaling pathway

4.38E-02

P42338, P0DP23, Q13370, Q13009

PIK3CB, CALM1, PDE3B, TIAM1

Cytarabine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.28E-02

P51684, P09341, P25024, P25025, P47992, Q9UBD3, P01375

CCR6, CXCL1, CXCR1, CXCR2, XCL1, XCL2, TNF

Cytarabine

hsa04062

Chemokine signaling pathway

6.93E-04

P07948, P42338, P19174, Q92529, P62873, P63218, P50151, P43250, Q13009

LYN, PIK3CB, PLCG1, SHC3, GNB1, GNG5, GNG10, GRK6, TIAM1

Cytarabine

hsa04064

NF-kappa B signaling pathway

2.37E-04

P10415, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522, P09341

BCL2, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45A, CXCL1

Cytarabine

hsa04070

Phosphatidylinositol signaling system

4.76E-06

P19174, P0DP23, P42338, O14986, P23743, Q96PE3, P27987

PLCG1, CALM1, PIK3CB, PIP5K1B, DGKA, INPP4A, ITPKB

Cytarabine

hsa04071

Sphingolipid signaling pathway

1.39E-03

P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Cytarabine

hsa04072

Phospholipase D signaling pathway

3.52E-05

P42338, Q92529, Q9UQC2, P19174, Q14344, Q8WYR1, Q15438, P51828, P23743, Q9NRA1

PIK3CB, SHC3, GAB2, PLCG1, GNA13, PIK3R5, PSCD1, ADCY7, DGKA, PDGFC

Cytarabine

hsa04115

p53 signaling pathway

3.35E-03

P24522, Q13315, P31350, O95067, P10415

GADD45A, ATM, RRM2, CCNB2, BCL2

Cytarabine

hsa04141

Protein processing in endoplasmic reticulum

6.42E-03

P18848, P30101, Q15437, Q15436, Q99941, P11142, P07900, P08238

ATF4, PDIA3, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, HSP90AB1

Cytarabine

hsa04142

Lysosome

3.32E-03

P06865, P22304, Q13510, P07602, P61916, Q04900

HEXA, IDS, ASAH1, PSAP, NPC2, CD164

Cytarabine

hsa04145

Phagosome

1.73E-03

Q15080, P68371, P05164, P78380, P35443, P13765

NCF4, TUBB2C, MPO, OLR1, THBS4, HLA-DOB

Cytarabine

hsa04151

PI3K-Akt signaling pathway

1.85E-04

P62753, P42338, P27348, Q9NRA1, P49767, P07900, P08238, P62873, P63218, P50151, O15335, Q16363, P22105, P14784, Q99941, P18848, P30279

RPS6, PIK3CB, YWHAQ, PDGFC, VEGFC, HSP90AA1, HSP90AB1, GNB1, GNG5, GNG10, CHAD, LAMA4, TNXB, IL2RB, CREBL1, ATF4, CCND2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11142	HSPA8	Heat shock cognate 71 kDa protein	P62753	RPS6	40S ribosomal protein S6	0.75
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P11142	HSPA8	Heat shock cognate 71 kDa protein	P27348	YWHAQ	14-3-3 protein theta	0.729
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P11142	HSPA8	Heat shock cognate 71 kDa protein	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P11142	HSPA8	Heat shock cognate 71 kDa protein	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.876
P11142	HSPA8	Heat shock cognate 71 kDa protein	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.746
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P11142	HSPA8	Heat shock cognate 71 kDa protein	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q16363	LAMA4	Laminin subunit alpha-4	0.793
P11142	HSPA8	Heat shock cognate 71 kDa protein	P22105	TNXB	Tenascin-X	0.715
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P11142	HSPA8	Heat shock cognate 71 kDa protein	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.831
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.715
P11142	HSPA8	Heat shock cognate 71 kDa protein	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.83
P11142	HSPA8	Heat shock cognate 71 kDa protein	P30279	CCND2	G1/S-specific cyclin-D2	0.731

Cytarabine

hsa04213

Longevity regulating pathway - multiple species

3.03E-02

P51828, P0DMV8

ADCY7, HSPA1A

Cytarabine

hsa04217

Necroptosis

4.49E-04

P01568, Q13489, P98170, P42224, P07900, P08238, P15104, P05141, Q13557, P21796, P45880

IFNA21, BIRC3, BIRC4, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, CAMK2D, VDAC1, VDAC2

Cytarabine

hsa04261

Adrenergic signaling in cardiomyocytes

3.85E-04

P67936, P07550, P51828, P22694, Q8WYR1, P18848, Q13362, P0DP24

TPM4, ADRB2, ADCY7, PRKACB, PIK3R5, ATF4, PPP2R5C, CALM2

Cytarabine

hsa04270

Vascular smooth muscle contraction

1.86E-02

P0DP24, P51828, P35579, P35749

CALM2, ADCY7, MYH9, MYH11

Cytarabine

hsa04310

Wnt signaling pathway

5.60E-03

P30279, Q13485, O43318

CCND2, SMAD4, MAP3K7

Cytarabine

hsa04330

Notch signaling pathway

3.28E-03

Q92542, P49768, Q92830, P78504

NCSTN, PSEN1, KAT2A, JAG1

Cytarabine

hsa04360

Axon guidance

1.71E-02

P20827, O95631, P42338, P23528

EFNA1, NTN1, PIK3CB, CFL1

Cytarabine

hsa04370

VEGF signaling pathway

1.56E-02

P19174, P42338

PLCG1, PIK3CB

Cytarabine

hsa04371

Apelin signaling pathway

2.64E-06

P62873, P63218, P50151, Q13370, Q14344, Q13485, P84022, Q16566, P0DP23

GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD4, SMAD3, CAMK4, CALM1

Cytarabine

hsa04380

Osteoclast differentiation

1.02E-02

Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2

Cytarabine

hsa04510

Focal adhesion

1.55E-02

P42338, O15335, Q9NRA1, P49767, Q92529

PIK3CB, CHAD, PDGFC, VEGFC, SHC3

Cytarabine

hsa04520

Adherens junction

3.91E-02

Q13485, O43318

SMAD4, MAP3K7

Cytarabine

hsa04610

Complement and coagulation cascades

2.46E-02

P00734, P0C0L4, P21730

F2, C4A, C5AR1

Cytarabine

hsa04611

Platelet activation

4.11E-02

P42338, Q14344, P07948

PIK3CB, GNA13, LYN

Cytarabine

hsa04612

Antigen processing and presentation

4.72E-02

P13765, P48382, P26715, P26717

HLA-DOB, RFX5, KLRC1, KLRC2

Cytarabine

hsa04613

Neutrophil extracellular trap formation

1.02E-02

O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Cytarabine

hsa04621

NOD-like receptor signaling pathway

5.72E-03

Q16539, Q14643, P25963, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838

MAPK14, ITPR1, NFKBIA, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4

Cytarabine

hsa04625

C-type lectin receptor signaling pathway

3.87E-02

Q9ULY5, P20749, P01375, Q16539

CLEC4E, BCL3, TNF, MAPK14

Cytarabine

hsa04657

IL-17 signaling pathway

1.36E-02

O00463, Q16539, P49841, P14780, P01375

TRAF5, MAPK14, GSK3B, MMP9, TNF

Cytarabine

hsa04658

Th1 and Th2 cell differentiation

4.29E-04

Q04759, P07766, P20963, P09693, Q16539, P19174, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Cytarabine

hsa04659

Th17 cell differentiation

3.69E-04

P19174, P42224, P14784, P40189, P07900, P08238, P07766

PLCG1, STAT1, IL2RB, IL6ST, HSP90AA1, HSP90AB1, CD3E

Cytarabine

hsa04660

T cell receptor signaling pathway

2.57E-03

P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539

TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14

Cytarabine

hsa04662

B cell receptor signaling pathway

1.21E-04

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Cytarabine

hsa04664

Fc epsilon RI signaling pathway

8.77E-06

P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917

TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5

Cytarabine

hsa04666

Fc gamma R-mediated phagocytosis

1.32E-03

P07948, P42338, P19174, P23528, P14598

LYN, PIK3CB, PLCG1, CFL1, NCF1

Cytarabine

hsa04668

TNF signaling pathway

2.21E-02

P01375, O00463, Q16539, P20749, P14780

TNF, TRAF5, MAPK14, BCL3, MMP9

Cytarabine

hsa04713

Circadian entrainment

3.99E-04

O15399, P0DP23, Q13557, P62873, P63218, P50151

GRIN2D, CALM1, CAMK2D, GNB1, GNG5, GNG10

Cytarabine

hsa04720

Long-term potentiation

2.33E-02

Q16566, P0DP23, O15399

CAMK4, CALM1, GRIN2D

Cytarabine

hsa04722

Neurotrophin signaling pathway

4.87E-02

P42338, P19174, Q92529

PIK3CB, PLCG1, SHC3

Cytarabine

hsa04724

Glutamatergic synapse

9.56E-07

O15399, P62873, P63218, P50151, P15104

GRIN2D, GNB1, GNG5, GNG10, GLUL

Cytarabine

hsa04725

Cholinergic synapse

1.05E-05

P62873, P63218, P50151, P18848, Q16566, Q13557, P42338

GNB1, GNG5, GNG10, ATF4, CAMK4, CAMK2D, PIK3CB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11142	HSPA8	Heat shock cognate 71 kDa protein	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.746
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.747
P11142	HSPA8	Heat shock cognate 71 kDa protein	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.752
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P11142	HSPA8	Heat shock cognate 71 kDa protein	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.83
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q16566	CAMK4	Calcium/calmodulin-dependent protein kinase type IV	0.708
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.745
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	1

Cytarabine

hsa04726

Serotonergic synapse

2.09E-03

P62873, P63218, P50151, P09917

GNB1, GNG5, GNG10, ALOX5

Cytarabine

hsa04727

GABAergic synapse

6.52E-07

P62873, P63218, P50151, P15104, P46459

GNB1, GNG5, GNG10, GLUL, NSF

Cytarabine

hsa04728

Dopaminergic synapse

1.87E-02

P62873, P63218, Q99941, P18848, Q13557, P0DP23

GNB1, GNG5, CREBL1, ATF4, CAMK2D, CALM1

Cytarabine

hsa04730

Long-term depression

9.88E-04

Q14344, P07948

GNA13, LYN

Cytarabine

hsa04740

Olfactory transduction

9.79E-03

P62873, Q13557, P0DP23

GNB1, CAMK2D, CALM1

Cytarabine

hsa04744

Phototransduction

5.65E-06

P62873, P0DP23

GNB1, CALM1

Cytarabine

hsa04750

Inflammatory mediator regulation of TRP channels

1.61E-02

Q13557, P19174, P24723, P0DP23, P01042

CAMK2D, PLCG1, PRKCH, CALM1, KNG1

Cytarabine

hsa04910

Insulin signaling pathway

4.11E-02

Q92529, Q13370, P42338

SHC3, PDE3B, PIK3CB

Cytarabine

hsa04911

Insulin secretion

4.31E-02

P22694, P18848

PRKACB, ATF4

Cytarabine

hsa04914

Progesterone-mediated oocyte maturation

2.17E-03

P42338, Q13370, P08238

PIK3CB, PDE3B, HSP90AB1

Cytarabine

hsa04915

Estrogen signaling pathway

1.33E-05

Q99941, P18848, P51828, P42338, Q92529, P07900, P08238, P0DMV8, P11142, P0DP24, P0DP23, Q15788

CREBL1, ATF4, ADCY7, PIK3CB, SHC3, HSP90AA1, HSP90AB1, HSPA1A, HSPA8, CALM2, CALM1, NCOA1

Cytarabine

hsa04918

Thyroid hormone synthesis

4.31E-02

P22694, P18848

PRKACB, ATF4

Cytarabine

hsa04921

Oxytocin signaling pathway

2.92E-02

P0DP24, P51828, Q96RR4, Q8WYR1

CALM2, ADCY7, CAMKK2, PIK3R5

Cytarabine

hsa04923

Regulation of lipolysis in adipocytes

3.20E-03

P22694, P07550, Q13370, P42338

PRKACB, ADRB2, PDE3B, PIK3CB

Cytarabine

hsa04924

Renin secretion

2.22E-03

P22694, P07550, Q13370, P0DP23

PRKACB, ADRB2, PDE3B, CALM1

Cytarabine

hsa04925

Aldosterone synthesis and secretion

3.35E-02

Q99941, P18848, P0DP23, Q13557

CREBL1, ATF4, CALM1, CAMK2D

Cytarabine

hsa04926

Relaxin signaling pathway

3.85E-06

P42338, P63218, P50151, P49767, Q92529, P30679, P49407

PIK3CB, GNG5, GNG10, VEGFC, SHC3, GNA15, ARRB1

Cytarabine

hsa04927

Cortisol synthesis and secretion

1.86E-02

P18848, P22694

ATF4, PRKACB

Cytarabine

hsa04929

GnRH secretion

4.62E-02

P42338, P49407

PIK3CB, ARRB1

Cytarabine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

4.11E-02

P42338, P49767, P19174

PIK3CB, VEGFC, PLCG1

Cytarabine

hsa04934

Cushing syndrome

2.84E-02

P18848, P22694, P46527

ATF4, PRKACB, CDKN1B

Cytarabine

hsa04935

Growth hormone synthesis, secretion and action

2.78E-02

P19174, P42338, Q92529

PLCG1, PIK3CB, SHC3

Cytarabine

hsa04940

Type I diabetes mellitus

2.99E-02

P10747, P01375

CD28, TNF

Cytarabine

hsa04970

Salivary secretion

1.23E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

Cytarabine

hsa05010

Alzheimer disease

4.56E-02

P19404, P13073, P0DP23, P18848, Q71U36, Q13509, P05141, P21796, P45880

NDUFV2, COX4I1, CALM1, ATF4, TUBA1A, TUBB3, SLC25A5, VDAC1, VDAC2

Cytarabine

hsa05012

Parkinson disease

6.70E-04

P19404, P13073, P05141, P21796, P45880, P18848, P19174, P0DP23, Q13557, Q71U36, Q13509

NDUFV2, COX4I1, SLC25A5, VDAC1, VDAC2, ATF4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3

Cytarabine

hsa05016

Huntington disease

9.64E-03

P19404, P13073, Q13547, P30876, P62487, P05141, P21796, P45880, Q71U36, Q13509

NDUFV2, COX4I1, HDAC1, POLR2B, POLR2G, SLC25A5, VDAC1, VDAC2, TUBA1A, TUBB3

Cytarabine

hsa05017

Spinocerebellar ataxia

2.16E-02

Q8TB72, P21796

PUM2, VDAC1

Cytarabine

hsa05020

Prion disease

9.64E-03

P11142, P19404, P13073, P18848, P05141, P21796, P45880, Q71U36, Q13509, Q99941

HSPA8, NDUFV2, COX4I1, ATF4, SLC25A5, VDAC1, VDAC2, TUBA1A, TUBB3, CREBL1

Cytarabine

hsa05022

Pathways of neurodegeneration - multiple diseases

1.36E-02

Q71U36, Q13509, P19404, P13073, P21796, P18848, P19174, P05141, P45880, P20333, P0DP23, Q13557

TUBA1A, TUBB3, NDUFV2, COX4I1, VDAC1, ATF4, PLCG1, SLC25A5, VDAC2, TNFRSF1B, CALM1, CAMK2D

Cytarabine

hsa05030

Cocaine addiction

4.31E-02

P22694, P18848

PRKACB, ATF4

Cytarabine

hsa05031

Amphetamine addiction

6.57E-03

P0DP23, Q13557, Q99941, P18848, Q13547

CALM1, CAMK2D, CREBL1, ATF4, HDAC1

Cytarabine

hsa05032

Morphine addiction

2.28E-05

P62873, P63218, P50151, Q13370, Q07343, P43250

GNB1, GNG5, GNG10, PDE3B, PDE4B, GRK6

Cytarabine

hsa05034

Alcoholism

1.63E-04

O15399, Q99941, P18848, Q16566, Q13547, P0DP23, P62873, P63218, P50151, Q93079, O60814

GRIN2D, CREBL1, ATF4, CAMK4, HDAC1, CALM1, GNB1, GNG5, GNG10, H2BC9, H2BC12

Cytarabine

hsa05100

Bacterial invasion of epithelial cells

3.64E-02

P42338, Q92529

PIK3CB, SHC3

Cytarabine

hsa05132

Salmonella infection

2.35E-03

P25963, P08238, Q13489, P10415, P04406, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P49754

NFKBIA, HSP90AB1, BIRC3, BCL2, GAPDH, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, VPS41

Cytarabine

hsa05134

Legionellosis

3.35E-02

P11215, P68104, P11142, P19875

ITGAM, EEF1A1, HSPA8, CXCL2

Cytarabine

hsa05140

Leishmaniasis

2.25E-02

P14598, P42224, O60603, P25963, P29350, Q15080

NCF1, STAT1, TLR2, NFKBIA, PTPN6, NCF4

Cytarabine

hsa05144

Malaria

3.09E-02

P69905, P68871, O60603, P10145

HBA2, HBB, TLR2, IL8

Cytarabine

hsa05145

Toxoplasmosis

3.55E-02

P23458, Q8WYR1, P0DMV8

JAK1, PIK3R5, HSPA1A

Cytarabine

hsa05146

Amoebiasis

3.11E-02

P09341, P27930, P01375, O60603, P05089, P22694, P08311

CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Cytarabine

hsa05150

Staphylococcus aureus infection

4.05E-04

P0C0L4, P21730, P21462, O75015, P13765, P13646, Q14532, P59665, P59666, P12838, P49913

C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Cytarabine

hsa05152

Tuberculosis

1.88E-05

Q13488, Q15075, P0DP23, O75015, P42224, P48382, P25208, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, Q16539, P51617

TCIRG1, EEA1, CALM1, FCGR3B, STAT1, RFX5, NFYB, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, MAPK14, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P27707	DCK	Deoxycytidine kinase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.828
P27707	DCK	Deoxycytidine kinase	Q15075	EEA1	Early endosome antigen 1	0.719
P27707	DCK	Deoxycytidine kinase	P0DP23	CALM1	Calmodulin-1	-0.759
P32320	CDA	Cytidine deaminase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.812
P27707	DCK	Deoxycytidine kinase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.7
P04183	TK1	Thymidine kinase, cytosolic	P48382	RFX5	DNA-binding protein RFX5	-0.739
P32320	CDA	Cytidine deaminase	P48382	RFX5	DNA-binding protein RFX5	-0.849
P27707	DCK	Deoxycytidine kinase	P25208	NFYB	Nuclear transcription factor Y subunit beta	0.767
P27707	DCK	Deoxycytidine kinase	O60603	TLR2	Toll-like receptor 2	-0.781
P32320	CDA	Cytidine deaminase	O60603	TLR2	Toll-like receptor 2	0.864
P32320	CDA	Cytidine deaminase	P01375	TNF	Tumor necrosis factor	0.806
P04183	TK1	Thymidine kinase, cytosolic	P10415	BCL2	Apoptosis regulator Bcl-2	-0.763
P27707	DCK	Deoxycytidine kinase	P10415	BCL2	Apoptosis regulator Bcl-2	0.781
P32320	CDA	Cytidine deaminase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.84
P04183	TK1	Thymidine kinase, cytosolic	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.75
P32320	CDA	Cytidine deaminase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.783
P27707	DCK	Deoxycytidine kinase	P01568	IFNA21	Interferon alpha-21	0.798
P32320	CDA	Cytidine deaminase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.735
P04183	TK1	Thymidine kinase, cytosolic	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.738
P27707	DCK	Deoxycytidine kinase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.828
P32320	CDA	Cytidine deaminase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.864
P32320	CDA	Cytidine deaminase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.701
P04183	TK1	Thymidine kinase, cytosolic	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.756

Cytarabine

hsa05162

Measles

3.91E-02

P14784, P07766, P42338, P11142

IL2RB, CD3E, PIK3CB, HSPA8

Cytarabine

hsa05163

Human cytomegalovirus infection

7.31E-05

P42338, P01375, P62873, P63218, P50151, P0DP23, Q14344, P49841, P14778, P25025, Q16539, O00463, P30101, P01568

PIK3CB, TNF, GNB1, GNG5, GNG10, CALM1, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5, PDIA3, IFNA21

Cytarabine

hsa05165

Human papillomavirus infection

9.48E-04

P46527, P35443, P01375, Q08999, Q9UM47, P22694, Q13362, Q13315

CDKN1B, THBS4, TNF, RBL2, NOTCH3, PRKACB, PPP2R5C, ATM

Cytarabine

hsa05166

Human T-cell leukemia virus 1 infection

4.93E-02

P22694, P18848, P25963, P25208, Q13315, P01375

PRKACB, ATF4, NFKBIA, NFYB, ATM, TNF

Cytarabine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

9.86E-05

P01568, P42224, P42338, P62873, P63218, P50151, P19875, P19174, P07948, P0DP23

IFNA21, STAT1, PIK3CB, GNB1, GNG5, GNG10, CXCL2, PLCG1, LYN, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P11142	HSPA8	Heat shock cognate 71 kDa protein	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.754
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P11142	HSPA8	Heat shock cognate 71 kDa protein	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.746
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P11142	HSPA8	Heat shock cognate 71 kDa protein	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P11142	HSPA8	Heat shock cognate 71 kDa protein	P19875	CXCL2	C-X-C motif chemokine 2	-0.813
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P11142	HSPA8	Heat shock cognate 71 kDa protein	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.936
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P11142	HSPA8	Heat shock cognate 71 kDa protein	P07948	LYN	Tyrosine-protein kinase Lyn	-0.732
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P07948	LYN	Tyrosine-protein kinase Lyn	0.767
P11142	HSPA8	Heat shock cognate 71 kDa protein	P0DP23	CALM1	Calmodulin-1	0.804
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724

Cytarabine

hsa05168

Herpes simplex virus 1 infection

7.49E-06

O60603, P25963, P01568, Q05823, P42224, Q07955, Q01130, P84103, Q13243, Q13489, P30101, P42338, Q13398, P51522, Q9NR11, Q9HCX3, P17097, Q03923, P52738, O75820, Q9NZL3, Q9UDV6, P10415

TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS3, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF83, ZNF302, ZNF304, ZNF7, ZNF85, ZNF140, ZNF189, ZNF224, ZNF212, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P27707	DCK	Deoxycytidine kinase	O60603	TLR2	Toll-like receptor 2	-0.781
P27707	DCK	Deoxycytidine kinase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.89
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P27707	DCK	Deoxycytidine kinase	P01568	IFNA21	Interferon alpha-21	0.798
P27707	DCK	Deoxycytidine kinase	Q05823	RNASEL	2-5A-dependent ribonuclease	-0.752
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P27707	DCK	Deoxycytidine kinase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.7
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.806
P27707	DCK	Deoxycytidine kinase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.804
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.703
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.731
P27707	DCK	Deoxycytidine kinase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.757
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
P27707	DCK	Deoxycytidine kinase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.731
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P29375	JARID1A	Lysine-specific demethylase 5A	Q13398	ZNF211	Zinc finger protein 211	0.763
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13398	ZNF211	Zinc finger protein 211	-0.886
P27707	DCK	Deoxycytidine kinase	Q13398	ZNF211	Zinc finger protein 211	-0.719
P27707	DCK	Deoxycytidine kinase	P51522	ZNF83	Zinc finger protein 83	0.811
P27707	DCK	Deoxycytidine kinase	Q9NR11	ZNF302	Zinc finger protein 302	0.759
P27707	DCK	Deoxycytidine kinase	Q9HCX3	ZNF304	Zinc finger protein 304	0.737
P27707	DCK	Deoxycytidine kinase	P17097	ZNF7	Zinc finger protein 7	0.8
P29375	JARID1A	Lysine-specific demethylase 5A	Q03923	ZNF85	Zinc finger protein 85	-0.73
P27707	DCK	Deoxycytidine kinase	Q03923	ZNF85	Zinc finger protein 85	0.731
P27707	DCK	Deoxycytidine kinase	P52738	ZNF140	Zinc finger protein 140	0.789
P27707	DCK	Deoxycytidine kinase	O75820	ZNF189	Zinc finger protein 189	0.801
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q9NZL3	ZNF224	Zinc finger protein 224	-0.762
P29375	JARID1A	Lysine-specific demethylase 5A	Q9UDV6	ZNF212	Zinc finger protein 212	0.776
P27707	DCK	Deoxycytidine kinase	P10415	BCL2	Apoptosis regulator Bcl-2	0.781

Cytarabine

hsa05169

Epstein-Barr virus infection

5.43E-04

Q13547, P42338, P07948, P30101, Q13761, O75293, P30279, P42224, P07766

HDAC1, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, CCND2, STAT1, CD3E

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13547	HDAC1	Histone deacetylase 1	-0.774
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q13547	HDAC1	Histone deacetylase 1	0.713
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	1
P06746	POLB	DNA polymerase beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.804
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07948	LYN	Tyrosine-protein kinase Lyn	0.735
P11142	HSPA8	Heat shock cognate 71 kDa protein	P07948	LYN	Tyrosine-protein kinase Lyn	-0.732
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P11142	HSPA8	Heat shock cognate 71 kDa protein	P30101	PDIA3	Protein disulfide-isomerase A3	0.881
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13761	RUNX3	Runt-related transcription factor 3	-0.708
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q13761	RUNX3	Runt-related transcription factor 3	0.772
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.768
P11142	HSPA8	Heat shock cognate 71 kDa protein	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.772
P11142	HSPA8	Heat shock cognate 71 kDa protein	P30279	CCND2	G1/S-specific cyclin-D2	0.731
P11142	HSPA8	Heat shock cognate 71 kDa protein	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.754
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.77
P11142	HSPA8	Heat shock cognate 71 kDa protein	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.748

Cytarabine

hsa05170

Human immunodeficiency virus 1 infection

1.83E-04

P42338, P62873, P63218, P50151, P0DP23, P01375, O00463, P30101, Q14643, P01568, Q16539, O60603, Q13315, P19174, P23528, P07766, P09693, P20963, P10415, Q93034, Q9Y6Q5

PIK3CB, GNB1, GNG5, GNG10, CALM1, TNF, TRAF5, PDIA3, ITPR1, IFNA21, MAPK14, TLR2, ATM, PLCG1, CFL1, CD3E, CD3G, CD247, BCL2, CUL5, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
P32320	CDA	Cytidine deaminase	P01375	TNF	Tumor necrosis factor	0.806
P32320	CDA	Cytidine deaminase	O00463	TRAF5	TNF receptor-associated factor 5	-0.888
P06746	POLB	DNA polymerase beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
P32320	CDA	Cytidine deaminase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.895
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P32320	CDA	Cytidine deaminase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.701
P32320	CDA	Cytidine deaminase	O60603	TLR2	Toll-like receptor 2	0.864
P32320	CDA	Cytidine deaminase	Q13315	ATM	Serine-protein kinase ATM	-0.748
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P23528	CFL1	Cofilin-1	0.738
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P32320	CDA	Cytidine deaminase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.776
P32320	CDA	Cytidine deaminase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.749
P32320	CDA	Cytidine deaminase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.84
P32320	CDA	Cytidine deaminase	Q93034	CUL5	Cullin-5	-0.72
P32320	CDA	Cytidine deaminase	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.736

Cytarabine

hsa05200

Pathways in cancer

7.63E-09

Q16363, Q13751, P42338, P07900, P08238, P42224, P19174, P43246, P84022, Q13485, P20585, P52701, Q13547, P14923, P30279, Q13489, P98170, P49767, P62873, P63218, P50151, Q14344, P78417, O75293, P0DP23, Q13557, P01568, P14784, P40189, P01042

LAMA4, LAMB3, PIK3CB, HSP90AA1, HSP90AB1, STAT1, PLCG1, MSH2, SMAD3, SMAD4, MSH3, MSH6, HDAC1, JUP, CCND2, BIRC3, BIRC4, VEGFC, GNB1, GNG5, GNG10, GNA13, GSTO1, GADD45B, CALM1, CAMK2D, IFNA21, IL2RB, IL6ST, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q16363	LAMA4	Laminin subunit alpha-4	0.793
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13751	LAMB3	Laminin subunit beta-3	0.868
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P11142	HSPA8	Heat shock cognate 71 kDa protein	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P11142	HSPA8	Heat shock cognate 71 kDa protein	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.876
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.724
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P11142	HSPA8	Heat shock cognate 71 kDa protein	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.754
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P11142	HSPA8	Heat shock cognate 71 kDa protein	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.936
P29375	JARID1A	Lysine-specific demethylase 5A	P43246	MSH2	DNA mismatch repair protein Msh2	0.87
P11142	HSPA8	Heat shock cognate 71 kDa protein	P43246	MSH2	DNA mismatch repair protein Msh2	0.802
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P43246	MSH2	DNA mismatch repair protein Msh2	-0.742
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.847
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.794
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.899
P11142	HSPA8	Heat shock cognate 71 kDa protein	P20585	MSH3	DNA mismatch repair protein Msh3	0.715
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P52701	MSH6	DNA mismatch repair protein Msh6	0.91
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q13547	HDAC1	Histone deacetylase 1	0.713
P29375	JARID1A	Lysine-specific demethylase 5A	P14923	JUP	Junction plakoglobin	-0.735
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P30279	CCND2	G1/S-specific cyclin-D2	0.704
P11142	HSPA8	Heat shock cognate 71 kDa protein	P30279	CCND2	G1/S-specific cyclin-D2	0.731
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P98170	BIRC4	E3 ubiquitin-protein ligase XIAP	0.716
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P11142	HSPA8	Heat shock cognate 71 kDa protein	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.746
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.707
P11142	HSPA8	Heat shock cognate 71 kDa protein	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P78417	GSTO1	Glutathione S-transferase omega-1	-0.849
P11142	HSPA8	Heat shock cognate 71 kDa protein	P78417	GSTO1	Glutathione S-transferase omega-1	-0.715
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P78417	GSTO1	Glutathione S-transferase omega-1	0.754
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P11142	HSPA8	Heat shock cognate 71 kDa protein	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.772
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.708
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P11142	HSPA8	Heat shock cognate 71 kDa protein	P0DP23	CALM1	Calmodulin-1	0.804
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
P11142	HSPA8	Heat shock cognate 71 kDa protein	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.745
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P11142	HSPA8	Heat shock cognate 71 kDa protein	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.831
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83
P11142	HSPA8	Heat shock cognate 71 kDa protein	P01042	KNG1	Kininogen-1	-0.742
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01042	KNG1	Kininogen-1	0.708

Cytarabine

hsa05202

Transcriptional misregulation in cancer

1.24E-04

Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13077, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P24522

SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P32320	CDA	Cytidine deaminase	Q15532	SS18	Protein SSXT	-0.722
P04183	TK1	Thymidine kinase, cytosolic	Q13315	ATM	Serine-protein kinase ATM	-0.765
P32320	CDA	Cytidine deaminase	Q13315	ATM	Serine-protein kinase ATM	-0.748
P49913	CAMP	Cathelicidin antimicrobial peptide	Q13315	ATM	Serine-protein kinase ATM	-0.775
P32320	CDA	Cytidine deaminase	P41732	TSPAN7	Tetraspanin-7	0.736
P32320	CDA	Cytidine deaminase	P14780	MMP9	Matrix metalloproteinase-9	0.951
P32320	CDA	Cytidine deaminase	P27930	IL1R2	Interleukin-1 receptor type 2	0.766
P04183	TK1	Thymidine kinase, cytosolic	P14923	JUP	Junction plakoglobin	-0.774
P04183	TK1	Thymidine kinase, cytosolic	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.781
P32320	CDA	Cytidine deaminase	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.761
P32320	CDA	Cytidine deaminase	Q16548	BCL2A1	Bcl-2-related protein A1	0.852
P32320	CDA	Cytidine deaminase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.723
P49913	CAMP	Cathelicidin antimicrobial peptide	P46527	CDKN1B	Cyclin-dependent kinase inhibitor 1B	-0.8
P32320	CDA	Cytidine deaminase	P35226	BMI1	Polycomb complex protein BMI-1	-0.828
P49913	CAMP	Cathelicidin antimicrobial peptide	P35226	BMI1	Polycomb complex protein BMI-1	-0.723
P32320	CDA	Cytidine deaminase	P35226	BMI1	Polycomb complex protein BMI-1	-0.828
P49913	CAMP	Cathelicidin antimicrobial peptide	P35226	BMI1	Polycomb complex protein BMI-1	-0.723
P04183	TK1	Thymidine kinase, cytosolic	P05164	MPO	Myeloperoxidase	0.917
P32320	CDA	Cytidine deaminase	P05164	MPO	Myeloperoxidase	0.909
P32320	CDA	Cytidine deaminase	P12838	DEFA4	Neutrophil defensin 4	0.822
P49913	CAMP	Cathelicidin antimicrobial peptide	P12838	DEFA4	Neutrophil defensin 4	0.718
P04183	TK1	Thymidine kinase, cytosolic	P08246	ELA2	Neutrophil elastase	0.838
P32320	CDA	Cytidine deaminase	P08246	ELA2	Neutrophil elastase	0.92
P49913	CAMP	Cathelicidin antimicrobial peptide	P08246	ELA2	Neutrophil elastase	0.807
P04183	TK1	Thymidine kinase, cytosolic	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P32320	CDA	Cytidine deaminase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.867
P04183	TK1	Thymidine kinase, cytosolic	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.718
P32320	CDA	Cytidine deaminase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819

Cytarabine

hsa05203

Viral carcinogenesis

1.03E-04

Q08999, Q99941, P18848, P06746, P07948, P30279, P27348, P29083, Q7KZF4, P46527, Q13547, P06396, P25963, P22694, O60814

RBL2, CREBL1, ATF4, POLB, LYN, CCND2, YWHAQ, GTF2E1, SND1, CDKN1B, HDAC1, GSN, NFKBIA, PRKACB, H2BC12

Cytarabine

hsa05206

MicroRNAs in cancer

1.67E-02

P46527, Q9UM47, P35226, Q13315

CDKN1B, NOTCH3, BMI1, ATM

Cytarabine

hsa05210

Colorectal cancer

7.33E-03

P84022, Q13485, P43246, P52701, O75293

SMAD3, SMAD4, MSH2, MSH6, GADD45B

Cytarabine

hsa05212

Pancreatic cancer

1.38E-03

P42338, P42224, P84022, Q13485, O75293

PIK3CB, STAT1, SMAD3, SMAD4, GADD45B

Cytarabine

hsa05214

Glioma

2.44E-06

P0DP23, Q16566, Q13557, Q92529, P42338, P19174, O75293

CALM1, CAMK4, CAMK2D, SHC3, PIK3CB, PLCG1, GADD45B

Cytarabine

hsa05215

Prostate cancer

4.87E-02

Q9NRA1, P08238, P42338

PDGFC, HSP90AB1, PIK3CB

Cytarabine

hsa05218

Melanoma

3.64E-02

Q9NRA1, P42338

PDGFC, PIK3CB

Cytarabine

hsa05221

Acute myeloid leukemia

3.29E-02

P14923, Q15744, P05164

JUP, CEBPE, MPO

Cytarabine

hsa05222

Small cell lung cancer

3.80E-02

Q13751, Q13489, P98170, O75293

LAMB3, BIRC3, BIRC4, GADD45B

Cytarabine

hsa05231

Choline metabolism in cancer

1.17E-03

P42338, Q9NRA1, P19174, P23743

PIK3CB, PDGFC, PLCG1, DGKA

Cytarabine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

3.11E-02

O95267, P20963, P09693, O60603, P10747, Q04759, Q16539

RASGRP1, CD247, CD3G, TLR2, CD28, PRKCQ, MAPK14

Cytarabine

hsa05310

Asthma

1.68E-03

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Cytarabine

hsa05321

Inflammatory bowel disease

2.47E-03

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Cytarabine

hsa05322

Systemic lupus erythematosus

4.61E-02

O75015, P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455

FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSB

Cytarabine

hsa05323

Rheumatoid arthritis

2.84E-02

P01375, P13765, P10747, P09341, O60603

TNF, HLA-DOB, CD28, CXCL1, TLR2

Cytarabine

hsa05330

Allograft rejection

4.31E-02

P10747, P01375

CD28, TNF

Cytarabine

hsa05332

Graft-versus-host disease

3.93E-03

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

Cytarabine

hsa05418

Fluid shear stress and atherosclerosis

1.40E-04

Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P14778, P27930, P0DP23, P08238

MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, IL1R1, IL1R2, CALM1, HSP90AB1

Community members of Cytarabine (S_DC: 3.87)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

POLB

DNA polymerase beta

Reported

0.4573

0.1868

0.4856

1.0878

Q15788

NCOA1

Nuclear receptor coactivator 1

Predicted

0.4368

0.0828

0.3114

0.6954

P04183

TK1

Thymidine kinase, cytosolic

Predicted

0.2717

0.1637

0.1653

0.6286

P32320

CDA

Cytidine deaminase

Predicted

0.0516

0.0569

0.1653

0.3049

P26358

DNMT1

DNA

Predicted

0.3404

0.2809

0.2659

0.998

Q96KQ7

EHMT2

HistoneNonelysine NNonemethyltransferase EHMT2

Predicted

0.0728

0.2165

0.2909

0.7603

P27707

DCK

Deoxycytidine kinase

Predicted

0.0574

0.0614

0.1653

0.3169

P42338

PIK3CB

Phosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoform

Predicted

0.0447

0.9416

2.9055

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

P11142

HSPA8

Heat shock cognate 71 kDa protein

Predicted

0.9682

0.0773

0.6729

1.3115

Q53EL6

PDCD4

Programmed cell death protein 4

Predicted

0.3899

0.0653

0.3202

0.6457

P04406

GAPDH

GlyceraldehydeNone3Nonephosphate dehydrogenase

Predicted

0.4535

0.1223

0.4666

0.938

P20839

IMPDH1

InosineNone5'Nonemonophosphate dehydrogenase 1

Predicted

0.1928

0.1307

0.1653

0.5231

O43318

MAP3K7

MitogenNoneactivated protein kinase kinase kinase 7

Predicted

0.0059

0.3649

1.7327

P29375

JARID1A

LysineNonespecific demethylase 5A

Predicted

0.3605

0.7052

1.5906

P49913

CAMP

Cathelicidin antimicrobial peptide

Predicted

0.3356

0.0407

0.5275

0.7766

PharmaCoNets of Cytarabine (SPCN: 83.04 )

Cytarabine regulated-network (SDN: 21.46)

Community members of Cytarabine (SDC: 3.87)

PharmaCoNets of Cytarabine (S_PCN: 83.04 )

Cytarabine regulated-network (S_DN: 21.46)

Community members of Cytarabine (S_DC: 3.87)