PharmaCoNets of Cysteine (SPCN: 1.47 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Acetylcysteinehsa00310Lysine degradation1.53E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Acetylcysteinehsa00562Inositol phosphate metabolism2.54E-034P27987, Q13572, Q96PE3, P42338ITPKB, ITPK1, INPP4A, PIK3CBMore
Acetylcysteinehsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Acetylcysteinehsa03040Spliceosome3.94E-048Q14562, O43143, O60508, P08579, P26368, Q13595, Q01130, O43447DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS2, PPIHMore
Acetylcysteinehsa03060Protein export4.36E-021Q15005SPCS2More
Acetylcysteinehsa03450Non-homologous end-joining3.29E-021P13010XRCC5More
Acetylcysteinehsa04014Ras signaling pathway3.62E-025P42338, P49767, P0DP23, P63218, P50151PIK3CB, VEGFC, CALM1, GNG5, GNG10More
Acetylcysteinehsa04020Calcium signaling pathway5.15E-058P27987, P21796, Q16566, P30679, O15399, P0DP23, P23634, P49767ITPKB, VDAC1, CAMK4, GNA15, GRIN2D, CALM1, ATP2B4, VEGFCMore
Acetylcysteinehsa04024cAMP signaling pathway2.46E-036P42338, P0DP23, P23634, Q16566, Q09472, O15399PIK3CB, CALM1, ATP2B4, CAMK4, EP300, GRIN2DMore
Acetylcysteinehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Acetylcysteinehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Acetylcysteinehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Acetylcysteinehsa04070Phosphatidylinositol signaling system1.49E-035P0DP23, P42338, Q96PE3, Q13572, P27987CALM1, PIK3CB, INPP4A, ITPK1, ITPKBMore
Acetylcysteinehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Acetylcysteinehsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Acetylcysteinehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Acetylcysteinehsa04371Apelin signaling pathway7.45E-035P63218, P50151, Q13485, Q16566, P0DP23GNG5, GNG10, SMAD4, CAMK4, CALM1More
Acetylcysteinehsa04640Hematopoietic cell lineage2.18E-039P14778, P27930, P11215, P25063, P07766, P01732, P01730, P06127, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD4, CD5, CD7More
Acetylcysteinehsa04650Natural killer cell mediated cytotoxicity2.48E-038P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3More
Acetylcysteinehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Acetylcysteinehsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Acetylcysteinehsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Acetylcysteinehsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Acetylcysteinehsa04666Fc gamma R-mediated phagocytosis4.10E-023P07948, P42338, P23528LYN, PIK3CB, CFL1More
Acetylcysteinehsa04713Circadian entrainment8.43E-034O15399, P0DP23, P63218, P50151GRIN2D, CALM1, GNG5, GNG10More
Acetylcysteinehsa04720Long-term potentiation1.63E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Acetylcysteinehsa04724Glutamatergic synapse4.10E-023O15399, P63218, P50151GRIN2D, GNG5, GNG10More
Acetylcysteinehsa04725Cholinergic synapse5.94E-034P63218, P50151, Q16566, P42338GNG5, GNG10, CAMK4, PIK3CBMore
Acetylcysteinehsa04726Serotonergic synapse1.52E-024P63218, P50151, P33260, P09917GNG5, GNG10, CYP2C18, ALOX5More
Acetylcysteinehsa04728Dopaminergic synapse4.47E-024P63218, P50151, P0DP23, O00327GNG5, GNG10, CALM1, ARNTLMore
Acetylcysteinehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Acetylcysteinehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Acetylcysteinehsa04925Aldosterone synthesis and secretion3.14E-023P0DP23, Q16566, P23634CALM1, CAMK4, ATP2B4More
Acetylcysteinehsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P30679PIK3CB, GNG5, GNG10, VEGFC, GNA15More
Acetylcysteinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Acetylcysteinehsa05017Spinocerebellar ataxia5.94E-034Q8TB72, O15399, P42338, P21796PUM2, GRIN2D, PIK3CB, VDAC1More
Acetylcysteinehsa05034Alcoholism3.62E-025O15399, Q16566, P0DP23, P63218, P50151GRIN2D, CAMK4, CALM1, GNG5, GNG10More
Acetylcysteinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Acetylcysteinehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Acetylcysteinehsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Acetylcysteinehsa05163Human cytomegalovirus infection4.19E-025P42338, P63218, P50151, P0DP23, P30101PIK3CB, GNG5, GNG10, CALM1, PDIA3More
Acetylcysteinehsa05167Kaposi sarcoma-associated herpesvirus infection4.19E-025P42338, P63218, P50151, P07948, P0DP23PIK3CB, GNG5, GNG10, LYN, CALM1More
Acetylcysteinehsa05170Human immunodeficiency virus 1 infection3.27E-026P42338, P63218, P50151, P0DP23, P30101, P23528PIK3CB, GNG5, GNG10, CALM1, PDIA3, CFL1More
Acetylcysteinehsa05204Chemical carcinogenesis4.62E-022P78417, P33260GSTO1, CYP2C18More
Acetylcysteinehsa05214Glioma2.32E-023P0DP23, Q16566, P42338CALM1, CAMK4, PIK3CBMore
Acetylcysteinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Cysteinehsa00410beta-Alanine metabolism4.50E-021Q6ZQY3GADL1More
Cysteinehsa00471D-Glutamine and D-glutamate metabolism2.28E-021Q7Z3D6C14orf159More
Cysteinehsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis4.50E-021Q14442PIGHMore
Cysteinehsa00565Ether lipid metabolism4.50E-021Q8N661TMEM86BMore
Cysteinehsa00770Pantothenate and CoA biosynthesis2.28E-021Q6ZQY3GADL1More
Cysteinehsa04062Chemokine signaling pathway1.81E-023P10145, P09769, Q13009IL8, FGR, TIAM1More
Cysteinehsa04145Phagosome4.44E-023P60709, P63261, P30511ACTB, ACTG1, HLA-FMore
Cysteinehsa04151PI3K-Akt signaling pathway4.97E-025P23229, P48551, P16871, P15336, Q16513ITGA6, IFNAR2, IL7R, ATF2, PKN2More
Cysteinehsa04217Necroptosis1.93E-024P48551, P52630, P07384, Q99878IFNAR2, STAT2, CAPN1, H2AC14More
Cysteinehsa04530Tight junction3.85E-023P60709, P63261, P60660ACTB, ACTG1, MYL6More
Cysteinehsa04621NOD-like receptor signaling pathway7.28E-035P52630, P48551, P59665, P59666, Q16513STAT2, IFNAR2, DEFA1; DEFA1B, DEFA3, PKN2More
Cysteinehsa04630JAK-STAT signaling pathway1.44E-024P52630, P48551, P16871, Q06124STAT2, IFNAR2, IL7R, PTPN11More
Cysteinehsa04714Thermogenesis2.84E-034P15336, P60709, P63261, P36542ATF2, ACTB, ACTG1, ATP5C1More
Cysteinehsa04728Dopaminergic synapse4.44E-023P14416, P15336, P07101DRD2, ATF2, THMore
Cysteinehsa04921Oxytocin signaling pathway2.81E-023P60660, P60709, P63261MYL6, ACTB, ACTG1More
Cysteinehsa05030Cocaine addiction1.35E-033P14416, P07101, P15336DRD2, TH, ATF2More
Cysteinehsa05034Alcoholism2.21E-024P07101, P15336, P14416, Q99878TH, ATF2, DRD2, H2AC14More
Cysteinehsa05100Bacterial invasion of epithelial cells2.44E-022P60709, P63261ACTB, ACTG1More
Cysteinehsa05110Vibrio cholerae infection2.44E-022P60709, P63261ACTB, ACTG1More
Cysteinehsa05120Epithelial cell signaling in Helicobacter pylori infection6.89E-032Q99437, P10145ATP6V0B, IL8More
Cysteinehsa05130Pathogenic Escherichia coli infection2.21E-024P60709, P63261, Q06124, O95487ACTB, ACTG1, PTPN11, SEC24BMore
Cysteinehsa05135Yersinia infection2.81E-023P60709, P63261, Q16513ACTB, ACTG1, PKN2More
Cysteinehsa05143African trypanosomiasis2.44E-022P69905, P68871HBA2, HBBMore
Cysteinehsa05164Influenza A8.62E-034P48551, P52630, P60709, P63261IFNAR2, STAT2, ACTB, ACTG1More
Cysteinehsa05323Rheumatoid arthritis4.28E-022Q99437, P10145ATP6V0B, IL8More
Cysteinehsa05410Hypertrophic cardiomyopathy1.57E-023P23229, P60709, P63261ITGA6, ACTB, ACTG1More
Cysteinehsa05412Arrhythmogenic right ventricular cardiomyopathy1.24E-023P23229, P60709, P63261ITGA6, ACTB, ACTG1More
Cysteinehsa05414Dilated cardiomyopathy1.57E-023P23229, P60709, P63261ITGA6, ACTB, ACTG1More
Cysteinehsa05416Viral myocarditis2.29E-033P30511, P60709, P63261HLA-F, ACTB, ACTG1More

Community members of Cysteine (SDC: 0.38)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48506GCLCGlutamateNoneNonecysteine ligase catalytic subunitReported10.18260.01330.26030.3783
Q6ZQY3GADL1Acidic amino acid decarboxylase GADL1Predicted00.17670.01760.16780.2912
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)