PharmaCoNets of Cyproterone-acetate (SPCN: 29.53 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Cyproterone-acetatehsa00030Pentose phosphate pathway5.07E-033P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Cyproterone-acetatehsa00220Arginine biosynthesis1.54E-022P05089, P49448ARG1, GLUD2More
Cyproterone-acetatehsa00500Starch and sucrose metabolism3.86E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Cyproterone-acetatehsa00630Glyoxylate and dicarboxylate metabolism1.29E-022P40925, P15104MDH1, GLULMore
Cyproterone-acetatehsa00790Folate biosynthesis4.05E-022Q92820, P42330GGH, AKR1C3More
Cyproterone-acetatehsa00910Nitrogen metabolism2.93E-022P22748, P49448CA4, GLUD2More
Cyproterone-acetatehsa00970Aminoacyl-tRNA biosynthesis5.32E-033O95363, P54136, Q15046FARS2, RARS1, KARSMore
Cyproterone-acetatehsa00983Drug metabolism - other enzymes6.73E-053P04183, P32320, P05164TK1, CDA, MPOMore
Cyproterone-acetatehsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Cyproterone-acetatehsa03013RNA transport4.09E-029P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Cyproterone-acetatehsa04060Cytokine-cytokine receptor interaction1.74E-0417P14784, P27930, P14778, P08476, P26842, Q06643, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, P01375, P09341, P19875, P18510, P01730, Q93038IL2RB, IL1R2, IL1R1, INHBA, CD27, LTB, IL10RA, IL21R, CXCR1, XCL2, XCL1, TNF, CXCL1, CXCL2, IL1RN, CD4, TNFRSF25More
Cyproterone-acetatehsa04061Viral protein interaction with cytokine and cytokine receptor3.36E-049P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Cyproterone-acetatehsa04062Chemokine signaling pathway5.37E-039P25024, P09341, P19875, P07948, P42338, P19174, P63218, P50151, P43250CXCR1, CXCL1, CXCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6More
Cyproterone-acetatehsa04064NF-kappa B signaling pathway2.99E-1222P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q13315, P24522, O75293, P09341, P19875, Q06643, Q9UNE0BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, ATM, GADD45A, GADD45B, CXCL1, CXCL2, LTB, EDARMore
Cyproterone-acetatehsa04071Sphingolipid signaling pathway2.55E-057P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Cyproterone-acetatehsa04080Neuroactive ligand-receptor interaction6.59E-069P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2More
Cyproterone-acetatehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Cyproterone-acetatehsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Cyproterone-acetatehsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Cyproterone-acetatehsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Cyproterone-acetatehsa04145Phagosome2.10E-049Q15080, P14598, Q13509, Q13488, P05164, P78380, O60603, P35443, P13765NCF4, NCF1, TUBB3, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Cyproterone-acetatehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Cyproterone-acetatehsa04210Apoptosis1.26E-0412Q13315, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, P18848, Q14643ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ATF4, ITPR1More
Cyproterone-acetatehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Cyproterone-acetatehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Cyproterone-acetatehsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Cyproterone-acetatehsa04340Hedgehog signaling pathway3.16E-033P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Cyproterone-acetatehsa04360Axon guidance1.50E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Cyproterone-acetatehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Cyproterone-acetatehsa04530Tight junction2.08E-023P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Cyproterone-acetatehsa04612Antigen processing and presentation2.25E-088P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Cyproterone-acetatehsa04613Neutrophil extracellular trap formation1.45E-0513P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, P21730, P21462PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1More
Cyproterone-acetatehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Cyproterone-acetatehsa04621NOD-like receptor signaling pathway7.18E-0413Q14643, P01568, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q13546, Q05823, P01375, P49913, P12838ITPR1, IFNA21, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RIPK1, RNASEL, TNF, CAMP, DEFA4More
Cyproterone-acetatehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Cyproterone-acetatehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Cyproterone-acetatehsa04640Hematopoietic cell lineage2.66E-0413P13612, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNFMore
Cyproterone-acetatehsa04650Natural killer cell mediated cytotoxicity2.76E-1014P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O75015, P26717, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Cyproterone-acetatehsa04657IL-17 signaling pathway8.05E-047O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Cyproterone-acetatehsa04658Th1 and Th2 cell differentiation3.58E-1414Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Cyproterone-acetatehsa04659Th17 cell differentiation7.60E-1014Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, CD3E, CD3G, CD247More
Cyproterone-acetatehsa04660T cell receptor signaling pathway3.21E-0918P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Cyproterone-acetatehsa04662B cell receptor signaling pathway1.07E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Cyproterone-acetatehsa04664Fc epsilon RI signaling pathway1.29E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Cyproterone-acetatehsa04668TNF signaling pathway2.36E-039P01375, O00463, Q13489, Q16539, P25963, P09341, P20749, Q13077, P14780TNF, TRAF5, BIRC3, MAPK14, NFKBIA, CXCL1, BCL3, TRAF1, MMP9More
Cyproterone-acetatehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Cyproterone-acetatehsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Cyproterone-acetatehsa04720Long-term potentiation1.15E-036P16298, P51812, P18848, P22694, Q02750, Q14643PPP3CB, RPS6KA3, ATF4, PRKACB, MAP2K1, ITPR1More
Cyproterone-acetatehsa04724Glutamatergic synapse2.81E-024P43003, P63218, P50151, P15104SLC1A3, GNG5, GNG10, GLULMore
Cyproterone-acetatehsa04725Cholinergic synapse3.86E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Cyproterone-acetatehsa04750Inflammatory mediator regulation of TRP channels4.06E-038P14778, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759IL1R1, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQMore
Cyproterone-acetatehsa04912GnRH signaling pathway2.62E-023P18848, Q14643, P22694ATF4, ITPR1, PRKACBMore
Cyproterone-acetatehsa04913Ovarian steroidogenesis4.05E-022P42330, P22694AKR1C3, PRKACBMore
Cyproterone-acetatehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Cyproterone-acetatehsa04915Estrogen signaling pathway1.67E-035P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Cyproterone-acetatehsa04918Thyroid hormone synthesis7.24E-043P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Cyproterone-acetatehsa04920Adipocytokine signaling pathway4.71E-036P25963, Q06124, P33121, Q9Y478, Q04759, P01375NFKBIA, PTPN11, ACSL1, PRKAB1, PRKCQ, TNFMore
Cyproterone-acetatehsa04922Glucagon signaling pathway2.36E-035P22694, P06737, P18848, Q12778, Q14643PRKACB, PYGL, ATF4, FOXO1, ITPR1More
Cyproterone-acetatehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Cyproterone-acetatehsa04925Aldosterone synthesis and secretion4.95E-023Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Cyproterone-acetatehsa04927Cortisol synthesis and secretion3.17E-053Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Cyproterone-acetatehsa04928Parathyroid hormone synthesis, secretion and action1.14E-045Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Cyproterone-acetatehsa04934Cushing syndrome4.06E-025Q14643, P22694, P49841, Q9UJU2, O00170ITPR1, PRKACB, GSK3B, LEF1, AIPMore
Cyproterone-acetatehsa04964Proximal tubule bicarbonate reclamation2.93E-022P22748, P49448CA4, GLUD2More
Cyproterone-acetatehsa04970Salivary secretion4.49E-024P22694, Q14643, P17252, P49913PRKACB, ITPR1, PRKCA, CAMPMore
Cyproterone-acetatehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Cyproterone-acetatehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Cyproterone-acetatehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P07948CXCL1, CXCL2, PLCG1, CXCR1, LYNMore
Cyproterone-acetatehsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Cyproterone-acetatehsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Cyproterone-acetatehsa05132Salmonella infection2.05E-0314P51617, P25963, P01375, Q9UJU2, Q13546, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371IRAK1, NFKBIA, TNF, LEF1, RIPK1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Cyproterone-acetatehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Cyproterone-acetatehsa05135Yersinia infection4.26E-026P13612, P06239, Q16539, P01375, P49841, P01732ITGA4, LCK, MAPK14, TNF, GSK3B, CD8AMore
Cyproterone-acetatehsa05140Leishmaniasis1.18E-027P14598, P13765, O60603, P25963, P01375, P51617, Q15080NCF1, HLA-DOB, TLR2, NFKBIA, TNF, IRAK1, NCF4More
Cyproterone-acetatehsa05144Malaria1.80E-024O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Cyproterone-acetatehsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Cyproterone-acetatehsa05146Amoebiasis1.05E-0813Q13751, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311LAMB3, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Cyproterone-acetatehsa05152Tuberculosis3.11E-039Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Cyproterone-acetatehsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Cyproterone-acetatehsa05163Human cytomegalovirus infection2.64E-027P42338, P63218, P50151, P01106, P14778, Q13651, P30101PIK3CB, GNG5, GNG10, MYC, IL1R1, IL10RA, PDIA3More
Cyproterone-acetatehsa05167Kaposi sarcoma-associated herpesvirus infection4.22E-0412P42338, P62879, P63218, P50151, P09341, P19875, P19174, P16298, Q02750, P07948, P01106, P0CG47PIK3CB, GNB2, GNG5, GNG10, CXCL1, CXCL2, PLCG1, PPP3CB, MAP2K1, LYN, MYC, UBBMore
Cyproterone-acetatehsa05169Epstein-Barr virus infection1.27E-029P01106, Q13547, P42338, P07948, P30101, Q13761, O75293, P07766, P20963MYC, HDAC1, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, CD3E, CD247More
Cyproterone-acetatehsa05170Human immunodeficiency virus 1 infection3.39E-0626P42338, Q02750, P62879, P63218, P50151, P16298, P01375, Q05397, P17252, O00463, P30101, Q14643, P01730, P51617, P25963, O60603, Q13315, O95067, P19174, P07766, P20963, P10415, Q13619, Q93034, Q9Y6Q5, P20333PIK3CB, MAP2K1, GNB2, GNG5, GNG10, PPP3CB, TNF, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, CD4, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CD3E, CD247, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Cyproterone-acetatehsa05202Transcriptional misregulation in cancer5.01E-0917Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Cyproterone-acetatehsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Cyproterone-acetatehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Cyproterone-acetatehsa05217Basal cell carcinoma3.39E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Cyproterone-acetatehsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Cyproterone-acetatehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Cyproterone-acetatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer5.82E-0612P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, CD4More
Cyproterone-acetatehsa05310Asthma6.09E-073P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Cyproterone-acetatehsa05321Inflammatory bowel disease3.06E-137O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Cyproterone-acetatehsa05322Systemic lupus erythematosus4.90E-039P08246, P08311, P01375, P10747, P13765, Q6FI13, Q16778, P12814, P05455ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST2H2BE, ACTN1, SSBMore
Cyproterone-acetatehsa05323Rheumatoid arthritis1.09E-035P01375, P13765, P10747, P09341, O60603TNF, HLA-DOB, CD28, CXCL1, TLR2More
Cyproterone-acetatehsa05332Graft-versus-host disease1.24E-095P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More

Community members of Cyproterone-acetate (SDC: 2.66)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)