PharmaCoNets of Cyclosporine (SPCN: 53.43 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Cyclosporinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Cyclosporinehsa00061Fatty acid biosynthesis4.07E-021P33121ACSL1More
Cyclosporinehsa00190Oxidative phosphorylation1.48E-022Q16718, O14521NDUFA5, SDHDMore
Cyclosporinehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Cyclosporinehsa00512Mucin type O-glycan biosynthesis1.42E-022O95395, Q8N4A0GCNT3, GALNT4More
Cyclosporinehsa00565Ether lipid metabolism4.26E-021Q8N661TMEM86BMore
Cyclosporinehsa00590Arachidonic acid metabolism3.13E-032P11712, P09960CYP2C9, LTA4HMore
Cyclosporinehsa00591Linoleic acid metabolism1.63E-031P11712CYP2C9More
Cyclosporinehsa00630Glyoxylate and dicarboxylate metabolism2.52E-032P40925, P15104MDH1, GLULMore
Cyclosporinehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Cyclosporinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Cyclosporinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Cyclosporinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Cyclosporinehsa01100Metabolic pathways1.25E-0211O14521, Q13370, P11712, P24666, P23743, O60701, P33121, Q9NY28, P09960, Q9Y2B2, Q16718SDHD, PDE3B, CYP2C9, ACP1, DGKA, UGDH, ACSL1, GALNT8, LTA4H, PIGL, NDUFA5More
Cyclosporinehsa01521EGFR tyrosine kinase inhibitor resistance2.60E-022P17252, Q9NRA1PRKCA, PDGFCMore
Cyclosporinehsa01524Platinum drug resistance4.45E-024P10415, Q13489, P78417, P43246BCL2, BIRC3, GSTO1, MSH2More
Cyclosporinehsa02010ABC transporters4.26E-021Q8IZY2ABCA7More
Cyclosporinehsa03013RNA transport7.27E-0312O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, EIF4A2, TACC3, FXR1More
Cyclosporinehsa03022Basal transcription factors2.17E-022O00268, Q15544TAF4, TAF11More
Cyclosporinehsa03040Spliceosome1.38E-0812Q14562, O43143, O60508, P17844, P08579, P26368, Q15365, Q07955, Q01130, Q13243, P11142, O43447DHX8, DHX15, CDC40, DDX5, SNRPB2, U2AF2, PCBP1, SFRS1, SFRS2, SFRS5, HSPA8, PPIHMore
Cyclosporinehsa03060Protein export4.22E-022P37108, Q15005SRP14, SPCS2More
Cyclosporinehsa03320PPAR signaling pathway2.93E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Cyclosporinehsa03430Mismatch repair4.50E-022P43246, Q04837MSH2, SSBP1More
Cyclosporinehsa03440Homologous recombination4.50E-022Q9Y620, Q04837RAD54B, SSBP1More
Cyclosporinehsa04014Ras signaling pathway6.63E-0613P31751, P42338, P20827, Q9NRA1, P49767, Q13009, P17252, Q15311, Q14644, P0DP23, P62873, P63218, P19174AKT2, PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, PRKCA, RALBP1, RASA3, CALM1, GNB1, GNG5, PLCG1More
Cyclosporinehsa04015Rap1 signaling pathway1.07E-0412P20827, Q9NRA1, P49767, P25116, Q13009, Q08828, P51828, P31751, P0DP23, P08514, P17252, P19174EFNA1, PDGFC, VEGFC, F2R, TIAM1, ADCY1, ADCY7, AKT2, CALM1, ITGA2B, PRKCA, PLCG1More
Cyclosporinehsa04020Calcium signaling pathway5.19E-0914P27987, Q08828, Q13557, P17252, O15399, P19174, P25116, P61073, P0DP23, P51828, P20020, P23634, Q9NRA1, P49767ITPKB, ADCY1, CAMK2D, PRKCA, GRIN2D, PLCG1, F2R, CXCR4, CALM1, ADCY7, ATP2B1, ATP2B4, PDGFC, VEGFCMore
Cyclosporinehsa04022cGMP-PKG signaling pathway1.28E-024Q14814, P21796, P0DP23, P01042MEF2D, VDAC1, CALM1, KNG1More
Cyclosporinehsa04024cAMP signaling pathway5.93E-0512Q08828, P51828, P42338, P31751, P0DP23, P20020, P23634, Q13557, Q13370, O15399, P25116, Q13009ADCY1, ADCY7, PIK3CB, AKT2, CALM1, ATP2B1, ATP2B4, CAMK2D, PDE3B, GRIN2D, F2R, TIAM1More
Cyclosporinehsa04061Viral protein interaction with cytokine and cytokine receptor3.57E-038Q8NHW4, P09341, P19875, P25024, P25025, P61073, Q13651, P14784CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, CXCR4, IL10RA, IL2RBMore
Cyclosporinehsa04062Chemokine signaling pathway1.29E-0317P51684, P25024, P25025, P09341, P19875, Q8NHW4, P42338, P19174, P62873, P63218, P50151, Q08828, P51828, Q13009, P14598, P42224, P31751CCR6, CXCR1, CXCR2, CXCL1, CXCL2, CCL4L2, PIK3CB, PLCG1, GNB1, GNG5, GNG10, ADCY1, ADCY7, TIAM1, NCF1, STAT1, AKT2More
Cyclosporinehsa04064NF-kappa B signaling pathway6.49E-0717P10415, Q13489, P51617, P14778, P01584, P29965, P19174, Q04759, P67870, P06239, P63279, O75293, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, IRAK1, IL1R1, IL1B, CD40LG, PLCG1, PRKCQ, CSNK2B, LCK, UBE2I, GADD45B, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Cyclosporinehsa04068FoxO signaling pathway4.30E-024P42338, P30279, O75293, Q13485PIK3CB, CCND2, GADD45B, SMAD4More
Cyclosporinehsa04070Phosphatidylinositol signaling system5.66E-046P19174, P0DP23, P23743, P48426, P27987, P17252PLCG1, CALM1, DGKA, PIP4K2A, ITPKB, PRKCAMore
Cyclosporinehsa04071Sphingolipid signaling pathway5.25E-049P17252, Q9H228, P01375, Q13510, Q13362, Q9BX95, P10415, Q9UQC2, P01042PRKCA, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, BCL2, GAB2, KNG1More
Cyclosporinehsa04072Phospholipase D signaling pathway7.28E-0614P31751, P42338, P43657, P25116, P25024, P25025, P19174, P17252, Q15438, Q08828, P51828, P23743, Q9NRA1, P00734AKT2, PIK3CB, P2RY5, F2R, CXCR1, CXCR2, PLCG1, PRKCA, PSCD1, ADCY1, ADCY7, DGKA, PDGFC, F2More
Cyclosporinehsa04114Oocyte meiosis2.44E-035Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Cyclosporinehsa04140Autophagy - animal2.58E-027P31751, Q7L523, Q96RR4, O75460, P10415, Q96GC9, Q8TEV9AKT2, RRAGA, CAMKK2, ERN1, BCL2, TMEM49, SMCR8More
Cyclosporinehsa04144Endocytosis8.99E-0312P11142, Q9H444, O43633, O75351, Q9NZZ3, Q15438, Q14161, P14784, Q96QK1, Q9UMY4, Q9Y5X3, Q9UNH7HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, PSCD1, GIT2, IL2RB, VPS35, SNX12, SNX5, SNX6More
Cyclosporinehsa04150mTOR signaling pathway4.20E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Cyclosporinehsa04151PI3K-Akt signaling pathway5.22E-0418P25116, O43521, P27348, P20827, Q9NRA1, P49767, Q13362, P08238, P62873, P08514, P16144, P14784, P23458, P01568, P18848, P10415, P17252, Q6ZUJ8F2R, BCL2L11, YWHAQ, EFNA1, PDGFC, VEGFC, PPP2R5C, HSP90AB1, GNB1, ITGA2B, ITGB4, IL2RB, JAK1, IFNA21, ATF4, BCL2, PRKCA, PIK3AP1More
Cyclosporinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Cyclosporinehsa04213Longevity regulating pathway - multiple species2.34E-034P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Cyclosporinehsa04217Necroptosis3.39E-0815P01568, P23458, Q13489, Q9NQC7, P42224, P08238, P01584, P0C0S5, Q6FI13, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351IFNA21, JAK1, BIRC3, CYLD, STAT1, HSP90AB1, IL1B, H2AFZ, H2AC18; H2AC19, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4BMore
Cyclosporinehsa04218Cellular senescence7.85E-035P42338, P30279, O75293, P0DP23, P21796PIK3CB, CCND2, GADD45B, CALM1, VDAC1More
Cyclosporinehsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Cyclosporinehsa04261Adrenergic signaling in cardiomyocytes5.62E-0712P09493, Q08828, P51828, P31751, P18848, Q13362, P0DP23, Q13557, P17252, P10415, P20020, P23634TPM1, ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B1, ATP2B4More
Cyclosporinehsa04340Hedgehog signaling pathway3.15E-034P49841, P22694, O43791, P30279GSK3B, PRKACB, SPOP, CCND2More
Cyclosporinehsa04360Axon guidance8.44E-048P61073, P16333, P20827, O95631, P17252, Q13557, P23528, P19174CXCR4, NCK1, EFNA1, NTN1, PRKCA, CAMK2D, CFL1, PLCG1More
Cyclosporinehsa04370VEGF signaling pathway1.66E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Cyclosporinehsa04371Apelin signaling pathway1.70E-039P62873, P63218, P31751, Q08828, P51828, Q13370, Q14814, Q13485, P0DP23GNB1, GNG5, AKT2, ADCY1, ADCY7, PDE3B, MEF2D, SMAD4, CALM1More
Cyclosporinehsa04380Osteoclast differentiation4.18E-027Q9NQC7, Q9UQC2, P23458, P42224, P01584, Q15080, P14598CYLD, GAB2, JAK1, STAT1, IL1B, NCF4, NCF1More
Cyclosporinehsa04510Focal adhesion1.89E-039P16144, P08514, O75369, Q15942, P17252, Q13489, P10415, Q9NRA1, P49767ITGB4, ITGA2B, FLNB, ZYX, PRKCA, BIRC3, BCL2, PDGFC, VEGFCMore
Cyclosporinehsa04512ECM-receptor interaction3.19E-022P07359, P08514GP1BA, ITGA2BMore
Cyclosporinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Cyclosporinehsa04540Gap junction1.11E-036P17252, Q13509, P68371, Q08828, P51828, Q9NRA1PRKCA, TUBB3, TUBB2C, ADCY1, ADCY7, PDGFCMore
Cyclosporinehsa04610Complement and coagulation cascades1.72E-031P0C0L4C4AMore
Cyclosporinehsa04611Platelet activation7.90E-033P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Cyclosporinehsa04613Neutrophil extracellular trap formation1.12E-037P17252, Q93077, P62807, O60814, P68431, P08514, P07359PRKCA, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ITGA2B, GP1BAMore
Cyclosporinehsa04620Toll-like receptor signaling pathway1.33E-025P51617, P01568, P31751, P42224, Q8NHW4IRAK1, IFNA21, AKT2, STAT1, CCL4L2More
Cyclosporinehsa04621NOD-like receptor signaling pathway3.16E-029P01584, P08238, P23458, P42224, P01568, Q9H3M7, Q13489, P43490, P10415IL1B, HSP90AB1, JAK1, STAT1, IFNA21, TXNIP, BIRC3, PBEF1, BCL2More
Cyclosporinehsa04623Cytosolic DNA-sensing pathway1.55E-033P01584, P01568, Q8NHW4IL1B, IFNA21, CCL4L2More
Cyclosporinehsa04630JAK-STAT signaling pathway1.16E-028P31751, P10415, P42224, P23458, P14784, P16871, Q13651, P01568AKT2, BCL2, STAT1, JAK1, IL2RB, IL7R, IL10RA, IFNA21More
Cyclosporinehsa04640Hematopoietic cell lineage1.56E-0310P07359, P08514, P14778, P27930, P11215, P25063, P07766, P01732, P09564, P04141GP1BA, ITGA2B, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7, CSF2More
Cyclosporinehsa04650Natural killer cell mediated cytotoxicity6.98E-0613P16298, P50591, P19174, P06239, O60880, P20963, P42338, Q02750, Q13241, P48551, P26718, O14931, Q07444PPP3CB, TNFSF10, PLCG1, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, IFNAR2, KLRK1, NCR3, KLRC3More
Cyclosporinehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Cyclosporinehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Cyclosporinehsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Cyclosporinehsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Cyclosporinehsa04662B cell receptor signaling pathway4.24E-022P16298, Q02750PPP3CB, MAP2K1More
Cyclosporinehsa04664Fc epsilon RI signaling pathway2.60E-022P04141, P17252CSF2, PRKCAMore
Cyclosporinehsa04666Fc gamma R-mediated phagocytosis2.78E-026P08575, P19174, P23528, Q9UQC2, P14598, P17252PTPRC, PLCG1, CFL1, GAB2, NCF1, PRKCAMore
Cyclosporinehsa04713Circadian entrainment8.01E-078O15399, P0DP23, Q13557, P17252, P62873, P63218, Q08828, P51828GRIN2D, CALM1, CAMK2D, PRKCA, GNB1, GNG5, ADCY1, ADCY7More
Cyclosporinehsa04714Thermogenesis1.99E-023P33121, Q16718, O14521ACSL1, NDUFA5, SDHDMore
Cyclosporinehsa04720Long-term potentiation2.13E-049P17252, Q13557, P16298, P0DP23, P51812, P18848, O15399, Q08828, Q02750PRKCA, CAMK2D, PPP3CB, CALM1, RPS6KA3, ATF4, GRIN2D, ADCY1, MAP2K1More
Cyclosporinehsa04723Retrograde endocannabinoid signaling3.83E-022P17252, P62873PRKCA, GNB1More
Cyclosporinehsa04724Glutamatergic synapse7.37E-058O15399, Q08828, P51828, P17252, P62873, P63218, P15104, Q9NSB8GRIN2D, ADCY1, ADCY7, PRKCA, GNB1, GNG5, GLUL, HOMER2More
Cyclosporinehsa04725Cholinergic synapse6.48E-058Q08828, P51828, P17252, P62873, P18848, Q13557, P31751, P10415ADCY1, ADCY7, PRKCA, GNB1, ATF4, CAMK2D, AKT2, BCL2More
Cyclosporinehsa04726Serotonergic synapse2.87E-045P17252, P31645, P62873, P11712, P18054PRKCA, SLC6A4, GNB1, CYP2C9, ALOX12More
Cyclosporinehsa04727GABAergic synapse3.36E-035Q08828, P51828, P62873, P46459, P17252ADCY1, ADCY7, GNB1, NSF, PRKCAMore
Cyclosporinehsa04740Olfactory transduction2.61E-023P62873, Q13557, P0DP23GNB1, CAMK2D, CALM1More
Cyclosporinehsa04744Phototransduction1.30E-052P62873, P0DP23GNB1, CALM1More
Cyclosporinehsa04750Inflammatory mediator regulation of TRP channels1.64E-0813P14778, P01584, P18054, Q08828, P51828, Q13557, P19174, P42338, P17252, P24723, Q04759, P0DP23, P01042IL1R1, IL1B, ALOX12, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCA, PRKCH, PRKCQ, CALM1, KNG1More
Cyclosporinehsa04810Regulation of actin cytoskeleton2.06E-023P08514, Q9NRA1, P25116ITGA2B, PDGFC, F2RMore
Cyclosporinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Cyclosporinehsa04911Insulin secretion3.47E-024Q08828, P17252, P18848, Q13557ADCY1, PRKCA, ATF4, CAMK2DMore
Cyclosporinehsa04912GnRH signaling pathway2.85E-025P17252, Q08828, P18848, Q13557, P0DP23PRKCA, ADCY1, ATF4, CAMK2D, CALM1More
Cyclosporinehsa04914Progesterone-mediated oocyte maturation1.13E-0310Q17RY0, Q08828, P51828, P31751, Q13370, Q9UJX4, Q9Y6D9, P08238, P51812, Q02750CPEB4, ADCY1, ADCY7, AKT2, PDE3B, ANAPC5, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1More
Cyclosporinehsa04915Estrogen signaling pathway3.51E-0410P18848, Q08828, P51828, P42338, P31751, P08238, P11142, P0DP23, Q15788, P10415ATF4, ADCY1, ADCY7, PIK3CB, AKT2, HSP90AB1, HSPA8, CALM1, NCOA1, BCL2More
Cyclosporinehsa04918Thyroid hormone synthesis1.14E-022P17252, P27824PRKCA, CANXMore
Cyclosporinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Cyclosporinehsa04923Regulation of lipolysis in adipocytes1.20E-037Q08828, P51828, P07550, Q13370, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PDE3B, PIK3CB, IRS2, AKT2More
Cyclosporinehsa04925Aldosterone synthesis and secretion6.45E-047P18848, Q08828, P51828, P0DP23, P17252, Q13557, P23634ATF4, ADCY1, ADCY7, CALM1, PRKCA, CAMK2D, ATP2B4More
Cyclosporinehsa04926Relaxin signaling pathway1.14E-023P62873, P49767, P17252GNB1, VEGFC, PRKCAMore
Cyclosporinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Cyclosporinehsa04932Non-alcoholic fatty liver disease1.24E-026O43521, O75460, P01584, P13073, P12074, O15239BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFA1More
Cyclosporinehsa04933AGE-RAGE signaling pathway in diabetic complications2.04E-068Q13485, P01584, P42224, P10415, P31751, P49767, P17252, P19174SMAD4, IL1B, STAT1, BCL2, AKT2, VEGFC, PRKCA, PLCG1More
Cyclosporinehsa04935Growth hormone synthesis, secretion and action3.93E-026P19174, Q08828, P51828, P17252, P31751, P42224PLCG1, ADCY1, ADCY7, PRKCA, AKT2, STAT1More
Cyclosporinehsa04961Endocrine and other factor-regulated calcium reabsorption1.48E-022P20020, P17252ATP2B1, PRKCAMore
Cyclosporinehsa04964Proximal tubule bicarbonate reclamation4.26E-021P00918CA2More
Cyclosporinehsa04966Collecting duct acid secretion4.26E-021P00918CA2More
Cyclosporinehsa04970Salivary secretion2.39E-046Q08828, P51828, P20020, P23634, P17252, P0DP23ADCY1, ADCY7, ATP2B1, ATP2B4, PRKCA, CALM1More
Cyclosporinehsa04972Pancreatic secretion1.16E-046P20020, P23634, P17252, Q08828, P51828, P62491ATP2B1, ATP2B4, PRKCA, ADCY1, ADCY7, RAB11AMore
Cyclosporinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Cyclosporinehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Cyclosporinehsa05010Alzheimer disease2.21E-0210O15239, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P67870, P28070NDUFA1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, CSNK2B, PSMB4More
Cyclosporinehsa05016Huntington disease2.93E-024Q16718, O14521, O00268, Q13561NDUFA5, SDHD, TAF4, DCTN2More
Cyclosporinehsa05017Spinocerebellar ataxia8.81E-049P17252, O75460, Q8TB72, O15399, P42338, P31751, P28070, O00232, P21796PRKCA, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, PSMB4, PSMD12, VDAC1More
Cyclosporinehsa05020Prion disease3.80E-024P11142, O15399, P21796, P42338HSPA8, GRIN2D, VDAC1, PIK3CBMore
Cyclosporinehsa05022Pathways of neurodegeneration - multiple diseases1.91E-025Q16718, O14521, Q13561, P17252, Q08752NDUFA5, SDHD, DCTN2, PRKCA, PPIDMore
Cyclosporinehsa05031Amphetamine addiction2.23E-036O15399, P0DP23, Q13557, P18848, P17252, Q13547GRIN2D, CALM1, CAMK2D, ATF4, PRKCA, HDAC1More
Cyclosporinehsa05032Morphine addiction7.65E-035Q08828, P51828, P62873, Q13370, P17252ADCY1, ADCY7, GNB1, PDE3B, PRKCAMore
Cyclosporinehsa05034Alcoholism3.99E-048O15399, Q13547, P0DP23, P63218, Q93077, P62807, O60814, P68431GRIN2D, HDAC1, CALM1, GNG5, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Cyclosporinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Cyclosporinehsa05130Pathogenic Escherichia coli infection3.65E-023Q14247, P68371, P25116CTTN, TUBB2C, F2RMore
Cyclosporinehsa05132Salmonella infection3.99E-0413P51617, P01584, P08238, Q96RF0, Q13489, P10415, P08575, O75369, Q13561, Q13509, P68371, P49754, Q9NP90IRAK1, IL1B, HSP90AB1, SNAG1, BIRC3, BCL2, PTPRC, FLNB, DCTN2, TUBB3, TUBB2C, VPS41, RAB9BMore
Cyclosporinehsa05133Pertussis5.35E-056P0DP23, P01584, P23528, P09871, P0C0L4, P51617CALM1, IL1B, CFL1, C1S, C4A, IRAK1More
Cyclosporinehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Cyclosporinehsa05135Yersinia infection1.63E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Cyclosporinehsa05143African trypanosomiasis3.87E-023P01584, P17252, P01042IL1B, PRKCA, KNG1More
Cyclosporinehsa05145Toxoplasmosis5.28E-059P51617, P10415, Q13489, P23458, P42224, P31751, P11142, P29965, Q13651IRAK1, BCL2, BIRC3, JAK1, STAT1, AKT2, HSPA8, CD40LG, IL10RAMore
Cyclosporinehsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Cyclosporinehsa05150Staphylococcus aureus infection1.13E-022P0C0L4, P13646C4A, KRT13More
Cyclosporinehsa05161Hepatitis B1.31E-0410P17252, P18848, P23458, Q13485, P31751, P10415, P27348, P01568, P42224, P51617PRKCA, ATF4, JAK1, SMAD4, AKT2, BCL2, YWHAQ, IFNA21, STAT1, IRAK1More
Cyclosporinehsa05162Measles2.66E-0512P51617, P01568, P23458, P42224, P14784, P42338, P31751, P11142, P01584, Q9NP90, P30279, P10415IRAK1, IFNA21, JAK1, STAT1, IL2RB, PIK3CB, AKT2, HSPA8, IL1B, RAB9B, CCND2, BCL2More
Cyclosporinehsa05163Human cytomegalovirus infection3.30E-0517P31751, P42338, P62873, P63218, P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, P61073, P17252, Q13651, P18848, P30101, P61769, P01568AKT2, PIK3CB, GNB1, GNG5, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, CXCR4, PRKCA, IL10RA, ATF4, PDIA3, B2M, IFNA21More
Cyclosporinehsa05167Kaposi sarcoma-associated herpesvirus infection4.30E-024P42338, P63218, P19875, P0DP23PIK3CB, GNG5, CXCL2, CALM1More
Cyclosporinehsa05168Herpes simplex virus 1 infection2.45E-0518P01568, P01584, Q9UBU9, P23458, P42224, Q07955, Q01130, Q13243, Q13489, P51617, P61769, P31751, Q13398, Q6P280, Q03923, Q9UDV6, P10415, Q14232IFNA21, IL1B, NXF1, JAK1, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, B2M, AKT2, ZNF211, ZNF529, ZNF85, ZNF212, BCL2, EIF2B1More
Cyclosporinehsa05169Epstein-Barr virus infection2.76E-025Q13547, P42338, P30101, O75293, P30279HDAC1, PIK3CB, PDIA3, GADD45B, CCND2More
Cyclosporinehsa05170Human immunodeficiency virus 1 infection4.77E-0616P31751, Q02750, P62873, P62879, P16298, P0DP23, P61073, Q05397, P17252, P61769, P01568, P51617, P19174, P23528, P10415, Q9Y6Q5AKT2, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, CXCR4, PTK2, PRKCA, B2M, IFNA21, IRAK1, PLCG1, CFL1, BCL2, AP1M2More
Cyclosporinehsa05200Pathways in cancer7.38E-1234P08514, P42338, P23458, P08238, P42224, P19174, Q15311, P17252, P43246, Q13485, Q13547, P14923, P30279, P10415, Q13489, P49767, P31751, P25116, Q08828, P51828, P62873, P63218, P61073, P78417, O75293, Q15788, P0DP23, Q13557, O43521, P01568, P14784, P16871, P00734, P01042ITGA2B, PIK3CB, JAK1, HSP90AB1, STAT1, PLCG1, RALBP1, PRKCA, MSH2, SMAD4, HDAC1, JUP, CCND2, BCL2, BIRC3, VEGFC, AKT2, F2R, ADCY1, ADCY7, GNB1, GNG5, CXCR4, GSTO1, GADD45B, NCOA1, CALM1, CAMK2D, BCL2L11, IFNA21, IL2RB, IL7R, F2, KNG1More
Cyclosporinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Cyclosporinehsa05204Chemical carcinogenesis2.59E-044P00325, P78417, P11712, P33260ADH1B, GSTO1, CYP2C9, CYP2C18More
Cyclosporinehsa05205Proteoglycans in cancer4.43E-023Q12955, Q14247, P17252ANK3, CTTN, PRKCAMore
Cyclosporinehsa05210Colorectal cancer8.44E-034P42338, Q13485, P43246, O75293PIK3CB, SMAD4, MSH2, GADD45BMore
Cyclosporinehsa05212Pancreatic cancer1.66E-047P42338, P31751, Q15311, P23458, P42224, Q13485, O75293PIK3CB, AKT2, RALBP1, JAK1, STAT1, SMAD4, GADD45BMore
Cyclosporinehsa05214Glioma7.48E-077P0DP23, Q13557, P17252, P42338, P31751, P19174, O75293CALM1, CAMK2D, PRKCA, PIK3CB, AKT2, PLCG1, GADD45BMore
Cyclosporinehsa05218Melanoma3.32E-022P42338, O75293PIK3CB, GADD45BMore
Cyclosporinehsa05220Chronic myeloid leukemia5.21E-034Q13547, Q13485, P42338, O75293HDAC1, SMAD4, PIK3CB, GADD45BMore
Cyclosporinehsa05231Choline metabolism in cancer2.29E-033Q9NRA1, P23743, P17252PDGFC, DGKA, PRKCAMore
Cyclosporinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Cyclosporinehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Cyclosporinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.26E-021P54284CACNB3More
Cyclosporinehsa05415Diabetic cardiomyopathy4.17E-035P17252, P30405, Q16718, O14521, P37173PRKCA, PPIF, NDUFA5, SDHD, TGFBR2More
Cyclosporinehsa05418Fluid shear stress and atherosclerosis2.08E-026P14598, P78417, P10415, P0DP23, P08238, Q92974NCF1, GSTO1, BCL2, CALM1, HSP90AB1, ARHGEF2More

Community members of Cyclosporine (SDC: 2.83)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P30405PPIFPeptidylNoneprolyl cisNonetrans isomerase F, mitochondrialReported00.10.00670.65320.7166
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
Q08752PPIDPeptidylNoneprolyl cisNonetrans isomerase DPredicted00.20150.03360.51080.6787
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1APredicted10.4320.269500.7551
P68106FKBP1BPeptidylNoneprolyl cisNonetrans isomerase FKBP1BPredicted00.08140.038100.1169
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
O43447PPIHPeptidylNoneprolyl cisNonetrans isomerase HPredicted00.07550.00380.2850.3303
Q99653CHPCalcineurin B homologous protein 1Predicted00.37380.022700.2323
O75838CIB2Calcium and integrinNonebinding family member 2Predicted00.08730.022200.0879
P0DP23CALM1CalmodulinNone1Predicted00.45520.147911.5235
P0DP25CALM3CalmodulinNone3Predicted00.56610.147900.5789
P0DP24CALM2CalmodulinNone2Predicted00.43760.147900.5147
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)