| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Chlorcyclizine | hsa00040 | Pentose and glucuronate interconversions | 4.00E-02 | 1 | P15121 | AKR1B1 | More | | | Chlorcyclizine | hsa00190 | Oxidative phosphorylation | 5.61E-05 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Chlorcyclizine | hsa00220 | Arginine biosynthesis | 1.97E-02 | 2 | P15104, P49448 | GLUL, GLUD2 | More | | | Chlorcyclizine | hsa00230 | Purine metabolism | 1.81E-02 | 2 | P20839, Q02153 | IMPDH1, GUCY1B3 | More | | | Chlorcyclizine | hsa00250 | Alanine, aspartate and glutamate metabolism | 1.97E-02 | 2 | P49448, P15104 | GLUD2, GLUL | More | | | Chlorcyclizine | hsa00260 | Glycine, serine and threonine metabolism | 1.99E-02 | 1 | P22557 | ALAS2 | More | | | Chlorcyclizine | hsa00565 | Ether lipid metabolism | 3.94E-02 | 1 | Q8N661 | TMEM86B | More | | | Chlorcyclizine | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Chlorcyclizine | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Chlorcyclizine | hsa00760 | Nicotinate and nicotinamide metabolism | 3.52E-02 | 1 | P21589 | NT5E | More | | | Chlorcyclizine | hsa00770 | Pantothenate and CoA biosynthesis | 1.15E-02 | 2 | O95498, Q9NRN7 | VNN2, AASDHPPT | More | | | Chlorcyclizine | hsa00790 | Folate biosynthesis | 2.02E-02 | 1 | P15121 | AKR1B1 | More | | | Chlorcyclizine | hsa00910 | Nitrogen metabolism | 1.97E-02 | 2 | P15104, P49448 | GLUL, GLUD2 | More | | | Chlorcyclizine | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 6.38E-04 | 3 | P78417, P09211, P11712 | GSTO1, GSTP1, CYP2C9 | More | | | Chlorcyclizine | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | | Chlorcyclizine | hsa00983 | Drug metabolism - other enzymes | 3.50E-02 | 3 | P04183, P32320, P05164 | TK1, CDA, MPO | More | | | Chlorcyclizine | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 1.82E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa01522 | Endocrine resistance | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa02010 | ABC transporters | 2.29E-02 | 2 | P45844, P08183 | ABCG1, ABCB1 | More | | | Chlorcyclizine | hsa03010 | Ribosome | 2.25E-04 | 5 | P40429, Q07020, P27635, P05386, P62249 | RPL13A, RPL18, RPL10, RPLP1, RPS16 | More | | | Chlorcyclizine | hsa03013 | RNA transport | 3.98E-02 | 9 | P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5 | NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P10415 | BCL2 | Apoptosis regulator Bcl-2 | P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | 0.888 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | 0.742 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O14893 | GEMIN2 | Gem-associated protein 2 | 0.853 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q7Z3B4 | NUP54 | Nucleoporin p54 | 0.774 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35658 | NUP214 | Nuclear pore complex protein Nup214 | -0.751 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | 0.734 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | 0.837 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P78345 | RPP38 | Ribonuclease P protein subunit p38 | 0.852 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9Y6A5 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | -0.812 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | 0.956 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | 0.888 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | 0.742 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O14893 | GEMIN2 | Gem-associated protein 2 | 0.925 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O14893 | GEMIN2 | Gem-associated protein 2 | 0.853 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P61326 | MAGOH | Protein mago nashi homolog | 0.761 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q7Z3B4 | NUP54 | Nucleoporin p54 | 0.854 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q7Z3B4 | NUP54 | Nucleoporin p54 | 0.774 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P35658 | NUP214 | Nuclear pore complex protein Nup214 | -0.79 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35658 | NUP214 | Nuclear pore complex protein Nup214 | -0.751 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | 0.715 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | 0.734 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | 0.793 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | 0.837 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P78345 | RPP38 | Ribonuclease P protein subunit p38 | 0.819 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P78345 | RPP38 | Ribonuclease P protein subunit p38 | 0.852 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9Y6A5 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | -0.891 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9Y6A5 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | -0.812 |
| | Chlorcyclizine | hsa03022 | Basal transcription factors | 3.32E-02 | 2 | O00268, Q15544 | TAF4, TAF11 | More | | | Chlorcyclizine | hsa04010 | MAPK signaling pathway | 4.15E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa04014 | Ras signaling pathway | 3.65E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa04015 | Rap1 signaling pathway | 2.99E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa04060 | Cytokine-cytokine receptor interaction | 4.71E-02 | 2 | P78552, O75509 | IL13RA1, TNFRSF21 | More | | | Chlorcyclizine | hsa04064 | NF-kappa B signaling pathway | 1.60E-02 | 8 | P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341 | BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1 | More | | | Chlorcyclizine | hsa04066 | HIF-1 signaling pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa04068 | FoxO signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa04071 | Sphingolipid signaling pathway | 3.76E-03 | 7 | P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415 | S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P05164 | MPO | Myeloperoxidase | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | -0.823 | | P05164 | MPO | Myeloperoxidase | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.876 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.901 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P05164 | MPO | Myeloperoxidase | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.75 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.828 | | P05164 | MPO | Myeloperoxidase | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.714 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.869 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P05164 | MPO | Myeloperoxidase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.81 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.765 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P17252 | PRKCA | Protein kinase C alpha type | 0.769 | | P05164 | MPO | Myeloperoxidase | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | -0.823 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | 0.773 | | P05164 | MPO | Myeloperoxidase | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.876 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.901 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P17252 | PRKCA | Protein kinase C alpha type | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.745 | | P05164 | MPO | Myeloperoxidase | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.75 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.828 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.799 | | P17252 | PRKCA | Protein kinase C alpha type | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | 0.816 | | P05164 | MPO | Myeloperoxidase | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.714 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.869 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | 0.917 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | P05164 | MPO | Myeloperoxidase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.81 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.765 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.94 | | Q02156 | PRKCE | Protein kinase C epsilon type | Q12933 | TRAF2 | TNF receptor-associated factor 2 | -0.78 | | Q02156 | PRKCE | Protein kinase C epsilon type | Q02156 | PRKCE | Protein kinase C epsilon type | 1 |
| | Chlorcyclizine | hsa04072 | Phospholipase D signaling pathway | 9.70E-03 | 2 | Q92529, Q14344 | SHC3, GNA13 | More | | | Chlorcyclizine | hsa04080 | Neuroactive ligand-receptor interaction | 3.22E-02 | 7 | P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581 | CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1 | More | | | Chlorcyclizine | hsa04114 | Oocyte meiosis | 2.99E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa04115 | p53 signaling pathway | 3.98E-02 | 5 | P24522, Q13315, Q53FA7, O95067, P10415 | GADD45A, ATM, TP53I3, CCNB2, BCL2 | More | | | Chlorcyclizine | hsa04120 | Ubiquitin mediated proteolysis | 2.51E-03 | 6 | Q14145, Q13042, P62837, Q15751, O95071, P0CG47 | KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBB | More | | | Chlorcyclizine | hsa04137 | Mitophagy - animal | 9.52E-03 | 2 | Q07817, P0CG47 | BCL2L1, UBB | More | | | Chlorcyclizine | hsa04140 | Autophagy - animal | 2.82E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa04145 | Phagosome | 1.66E-03 | 9 | Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765 | NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.951 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.844 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.809 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.766 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | -0.718 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P05164 | MPO | Myeloperoxidase | -0.81 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35443 | THBS4 | Thrombospondin-4 | -0.765 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.754 | | P17252 | PRKCA | Protein kinase C alpha type | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.836 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.919 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.951 | | P17252 | PRKCA | Protein kinase C alpha type | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.821 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.857 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.844 | | P17252 | PRKCA | Protein kinase C alpha type | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.756 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.846 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.809 | | P17252 | PRKCA | Protein kinase C alpha type | P68371 | TUBB2C | Tubulin beta-4B chain | -0.842 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.783 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.766 | | P17252 | PRKCA | Protein kinase C alpha type | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | -0.779 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | -0.716 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | -0.718 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P05164 | MPO | Myeloperoxidase | -0.758 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P05164 | MPO | Myeloperoxidase | -0.81 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O60603 | TLR2 | Toll-like receptor 2 | -0.862 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P35443 | THBS4 | Thrombospondin-4 | -0.755 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35443 | THBS4 | Thrombospondin-4 | -0.765 | | P17252 | PRKCA | Protein kinase C alpha type | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.709 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.754 |
| | Chlorcyclizine | hsa04150 | mTOR signaling pathway | 2.32E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa04151 | PI3K-Akt signaling pathway | 3.96E-02 | 8 | P43657, P09603, Q9GZP0, P63218, P50151, P13612, O15335, Q13751 | P2RY5, CSF1, PDGFD, GNG5, GNG10, ITGA4, CHAD, LAMB3 | More | | | Chlorcyclizine | hsa04152 | AMPK signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa04210 | Apoptosis | 3.77E-02 | 8 | Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643 | ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1 | More | | | Chlorcyclizine | hsa04211 | Longevity regulating pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa04213 | Longevity regulating pathway - multiple species | 1.66E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa04217 | Necroptosis | 2.24E-04 | 12 | P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752 | TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPID | More | | | Chlorcyclizine | hsa04340 | Hedgehog signaling pathway | 3.46E-02 | 4 | P49841, P22694, Q13635, P10415 | GSK3B, PRKACB, PTCH1, BCL2 | More | | | Chlorcyclizine | hsa04510 | Focal adhesion | 3.48E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa04512 | ECM-receptor interaction | 4.41E-02 | 3 | Q13751, P13612, O15335 | LAMB3, ITGA4, CHAD | More | | | Chlorcyclizine | hsa04520 | Adherens junction | 8.29E-03 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa04530 | Tight junction | 3.29E-02 | 3 | P16989, P56750, Q14247 | CSDA, CLDN17, CTTN | More | | | Chlorcyclizine | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa04612 | Antigen processing and presentation | 2.26E-03 | 8 | P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375 | HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF | More | | | Chlorcyclizine | hsa04613 | Neutrophil extracellular trap formation | 6.94E-04 | 18 | O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539 | TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.9 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P04908 | H2AC4; H2AC8 | Histone H2A type 1-B/E | 0.734 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.74 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.737 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.913 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.869 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20160 | AZU1 | Azurocidin | 0.734 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08311 | CTSG | Cathepsin G | 0.79 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.928 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.942 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.912 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | O43315 | AQP9 | Aquaporin-9 | -0.764 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O43315 | AQP9 | Aquaporin-9 | 0.837 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | -0.744 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | P17252 | PRKCA | Protein kinase C alpha type | P08246 | ELA2 | Neutrophil elastase | -0.735 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.9 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P04908 | H2AC4; H2AC8 | Histone H2A type 1-B/E | 0.734 | | P17252 | PRKCA | Protein kinase C alpha type | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | -0.83 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.74 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.737 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.913 | | P17252 | PRKCA | Protein kinase C alpha type | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.783 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | | P17252 | PRKCA | Protein kinase C alpha type | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.821 | | P17252 | PRKCA | Protein kinase C alpha type | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.836 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.869 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20160 | AZU1 | Azurocidin | 0.734 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08311 | CTSG | Cathepsin G | 0.79 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.928 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.942 | | P17252 | PRKCA | Protein kinase C alpha type | P21462 | FPR1 | fMet-Leu-Phe receptor | -0.731 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.912 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | O43315 | AQP9 | Aquaporin-9 | -0.764 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O43315 | AQP9 | Aquaporin-9 | 0.837 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | -0.744 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 |
| | Chlorcyclizine | hsa04621 | NOD-like receptor signaling pathway | 2.62E-02 | 11 | Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838 | MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4 | More | | | Chlorcyclizine | hsa04623 | Cytosolic DNA-sensing pathway | 3.15E-02 | 2 | P01568, P25963 | IFNA21, NFKBIA | More | | | Chlorcyclizine | hsa04657 | IL-17 signaling pathway | 3.91E-02 | 7 | O00463, Q16539, P49841, P09341, P14780, P80188, P01375 | TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF | More | | | Chlorcyclizine | hsa04658 | Th1 and Th2 cell differentiation | 1.12E-02 | 8 | Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765 | PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOB | More | | | Chlorcyclizine | hsa04660 | T cell receptor signaling pathway | 3.76E-03 | 11 | P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841 | TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3B | More | | | Chlorcyclizine | hsa04666 | Fc gamma R-mediated phagocytosis | 2.42E-02 | 5 | P23528, P06396, O14494, P14598, P17252 | CFL1, GSN, PLPP1, NCF1, PRKCA | More | | | Chlorcyclizine | hsa04672 | Intestinal immune network for IgA production | 1.62E-02 | 3 | P29965, P10747, P13765 | CD40LG, CD28, HLA-DOB | More | | | Chlorcyclizine | hsa04714 | Thermogenesis | 5.21E-03 | 4 | Q16539, P33121, Q16718, O14521 | MAPK14, ACSL1, NDUFA5, SDHD | More | | | Chlorcyclizine | hsa04721 | Synaptic vesicle cycle | 3.15E-02 | 2 | Q13488, P31645 | TCIRG1, SLC6A4 | More | | | Chlorcyclizine | hsa04722 | Neurotrophin signaling pathway | 3.27E-02 | 3 | P49841, O43524, P48023 | GSK3B, FOXO3, FASLG | More | | | Chlorcyclizine | hsa04724 | Glutamatergic synapse | 9.51E-03 | 4 | O15399, P63218, P50151, P15104 | GRIN2D, GNG5, GNG10, GLUL | More | | | Chlorcyclizine | hsa04725 | Cholinergic synapse | 4.83E-02 | 4 | P22694, Q14643, P18848, P10415 | PRKACB, ITPR1, ATF4, BCL2 | More | | | Chlorcyclizine | hsa04727 | GABAergic synapse | 2.33E-02 | 3 | P63218, P50151, P15104 | GNG5, GNG10, GLUL | More | | | Chlorcyclizine | hsa04730 | Long-term depression | 1.26E-03 | 3 | Q14344, P08069, P07948 | GNA13, IGF1R, LYN | More | | | Chlorcyclizine | hsa04744 | Phototransduction | 2.80E-02 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Chlorcyclizine | hsa04913 | Ovarian steroidogenesis | 1.16E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa04914 | Progesterone-mediated oocyte maturation | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa04915 | Estrogen signaling pathway | 2.96E-02 | 5 | P14780, P22694, P18848, Q14643, P10415 | MMP9, PRKACB, ATF4, ITPR1, BCL2 | More | | | Chlorcyclizine | hsa04916 | Melanogenesis | 4.80E-02 | 4 | P0DP23, Q9UJU2, P17252, P04628 | CALM1, LEF1, PRKCA, WNT1 | More | | | Chlorcyclizine | hsa04918 | Thyroid hormone synthesis | 3.50E-02 | 3 | P22694, P18848, Q14643 | PRKACB, ATF4, ITPR1 | More | | | Chlorcyclizine | hsa04927 | Cortisol synthesis and secretion | 8.60E-03 | 3 | Q14643, P18848, P22694 | ITPR1, ATF4, PRKACB | More | | | Chlorcyclizine | hsa04928 | Parathyroid hormone synthesis, secretion and action | 2.13E-02 | 5 | Q14643, P22694, P23771, P18848, P10415 | ITPR1, PRKACB, GATA3, ATF4, BCL2 | More | | | Chlorcyclizine | hsa04932 | Non-alcoholic fatty liver disease | 2.44E-03 | 5 | P01375, P49841, P48023, Q16718, O14521 | TNF, GSK3B, FASLG, NDUFA5, SDHD | More | | | Chlorcyclizine | hsa04940 | Type I diabetes mellitus | 1.87E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Chlorcyclizine | hsa04960 | Aldosterone-regulated sodium reabsorption | 4.38E-02 | 1 | P48048 | KCNJ1 | More | | | Chlorcyclizine | hsa04976 | Bile secretion | 3.32E-02 | 2 | O43315, P08183 | AQP9, ABCB1 | More | | | Chlorcyclizine | hsa05010 | Alzheimer disease | 4.39E-02 | 6 | O15399, Q9NZJ5, Q13564, Q71U36, P09603, P21796 | GRIN2D, EIF2AK3, APPBP1, TUBA1A, CSF1, VDAC1 | More | | | Chlorcyclizine | hsa05020 | Prion disease | 3.80E-02 | 4 | Q16718, O14521, P49841, Q16539 | NDUFA5, SDHD, GSK3B, MAPK14 | More | | | Chlorcyclizine | hsa05022 | Pathways of neurodegeneration - multiple diseases | 1.24E-02 | 6 | P49841, Q16718, O14521, Q13561, Q16539, Q08752 | GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID | More | | | Chlorcyclizine | hsa05032 | Morphine addiction | 1.34E-02 | 4 | P63218, P50151, Q07343, P43250 | GNG5, GNG10, PDE4B, GRK6 | More | | | Chlorcyclizine | hsa05034 | Alcoholism | 2.89E-03 | 4 | Q93077, P62807, O60814, P68431 | HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Chlorcyclizine | hsa05132 | Salmonella infection | 2.93E-02 | 10 | P51617, Q9UJU2, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371 | IRAK1, LEF1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P10415 | BCL2 | Apoptosis regulator Bcl-2 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.807 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.908 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.848 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 1 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O75369 | FLNB | Filamin-B | -0.762 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | 0.929 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13561 | DCTN2 | Dynactin subunit 2 | -0.843 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.809 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.766 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.741 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.807 | | P17252 | PRKCA | Protein kinase C alpha type | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.881 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.825 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.908 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.769 | | P17252 | PRKCA | Protein kinase C alpha type | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.849 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.794 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.848 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.94 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 1 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O75369 | FLNB | Filamin-B | -0.746 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O75369 | FLNB | Filamin-B | -0.762 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O60603 | TLR2 | Toll-like receptor 2 | -0.862 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P17252 | PRKCA | Protein kinase C alpha type | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | 0.701 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | 0.924 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | 0.929 | | P17252 | PRKCA | Protein kinase C alpha type | Q13561 | DCTN2 | Dynactin subunit 2 | -0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13561 | DCTN2 | Dynactin subunit 2 | -0.809 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13561 | DCTN2 | Dynactin subunit 2 | -0.843 | | P17252 | PRKCA | Protein kinase C alpha type | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.756 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.846 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.809 | | P17252 | PRKCA | Protein kinase C alpha type | P68371 | TUBB2C | Tubulin beta-4B chain | -0.842 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.783 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.766 |
| | Chlorcyclizine | hsa05140 | Leishmaniasis | 9.39E-04 | 11 | P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, Q15080 | ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, NCF4 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P14780 | MMP9 | Matrix metalloproteinase-9 | P13612 | ITGA4 | Integrin alpha-4 | -0.7 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.928 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.798 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.787 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.714 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.768 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P29350 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | 0.808 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.869 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.758 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P13612 | ITGA4 | Integrin alpha-4 | -0.7 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.928 | | P17252 | PRKCA | Protein kinase C alpha type | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.821 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.798 | | P17252 | PRKCA | Protein kinase C alpha type | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.706 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.787 | | P17252 | PRKCA | Protein kinase C alpha type | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.709 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.714 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.768 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P17252 | PRKCA | Protein kinase C alpha type | P29350 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | -0.754 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P29350 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | 0.808 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P17252 | PRKCA | Protein kinase C alpha type | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.836 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.869 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.758 |
| | Chlorcyclizine | hsa05143 | African trypanosomiasis | 2.72E-02 | 2 | P01375, P48023 | TNF, FASLG | More | | | Chlorcyclizine | hsa05146 | Amoebiasis | 3.91E-02 | 7 | P09341, P27930, P01375, O60603, P05089, P22694, P08311 | CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG | More | | | Chlorcyclizine | hsa05152 | Tuberculosis | 5.68E-03 | 9 | Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617 | TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | -0.718 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P0DP23 | CALM1 | Calmodulin-1 | -0.772 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P48382 | RFX5 | DNA-binding protein RFX5 | 0.856 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 1 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.754 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P01568 | IFNA21 | Interferon alpha-21 | 0.721 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.94 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.807 | | P17252 | PRKCA | Protein kinase C alpha type | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | -0.779 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | -0.716 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | -0.718 | | P17252 | PRKCA | Protein kinase C alpha type | P0DP23 | CALM1 | Calmodulin-1 | -0.776 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P0DP23 | CALM1 | Calmodulin-1 | -0.772 | | P17252 | PRKCA | Protein kinase C alpha type | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.706 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P48382 | RFX5 | DNA-binding protein RFX5 | 0.797 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P48382 | RFX5 | DNA-binding protein RFX5 | 0.856 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P25208 | NFYB | Nuclear transcription factor Y subunit beta | 0.742 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O60603 | TLR2 | Toll-like receptor 2 | -0.862 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.94 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 1 | | P17252 | PRKCA | Protein kinase C alpha type | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.709 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.754 | | P17252 | PRKCA | Protein kinase C alpha type | P01568 | IFNA21 | Interferon alpha-21 | 0.733 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P01568 | IFNA21 | Interferon alpha-21 | 0.716 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P01568 | IFNA21 | Interferon alpha-21 | 0.721 | | P17252 | PRKCA | Protein kinase C alpha type | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.769 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 1 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.94 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.741 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.807 |
| | Chlorcyclizine | hsa05160 | Hepatitis C | 1.27E-02 | 4 | P60033, P49841, P01375, P48023 | CD81, GSK3B, TNF, FASLG | More | | | Chlorcyclizine | hsa05168 | Herpes simplex virus 1 infection | 3.38E-03 | 12 | P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6 | NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P09960 | LTA4H | Leukotriene A-4 hydrolase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.768 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P01568 | IFNA21 | Interferon alpha-21 | -0.764 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q05823 | RNASEL | 2-5A-dependent ribonuclease | 0.752 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.787 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.732 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.819 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.721 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13398 | ZNF211 | Zinc finger protein 211 | 0.729 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q9HCX3 | ZNF304 | Zinc finger protein 304 | -0.746 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P52738 | ZNF140 | Zinc finger protein 140 | -0.724 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | O75820 | ZNF189 | Zinc finger protein 189 | -0.722 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q9UDV6 | ZNF212 | Zinc finger protein 212 | 0.824 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.768 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P01568 | IFNA21 | Interferon alpha-21 | -0.764 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q05823 | RNASEL | 2-5A-dependent ribonuclease | 0.752 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.787 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.732 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.819 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.721 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13398 | ZNF211 | Zinc finger protein 211 | 0.729 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13398 | ZNF211 | Zinc finger protein 211 | 0.763 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q9HCX3 | ZNF304 | Zinc finger protein 304 | -0.746 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q03923 | ZNF85 | Zinc finger protein 85 | -0.73 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P52738 | ZNF140 | Zinc finger protein 140 | -0.724 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | O75820 | ZNF189 | Zinc finger protein 189 | -0.722 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q9UDV6 | ZNF212 | Zinc finger protein 212 | 0.824 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q9UDV6 | ZNF212 | Zinc finger protein 212 | 0.776 |
| | Chlorcyclizine | hsa05170 | Human immunodeficiency virus 1 infection | 5.94E-03 | 12 | P62873, P0DP23, P17252, O00463, Q14643, P01568, P51617, O60603, P23528, P10415, Q93034, Q9Y6Q5 | GNB1, CALM1, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, CFL1, BCL2, CUL5, AP1M2 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P10415 | BCL2 | Apoptosis regulator Bcl-2 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.777 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P0DP23 | CALM1 | Calmodulin-1 | -0.772 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P17252 | PRKCA | Protein kinase C alpha type | 0.844 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.773 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.858 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P01568 | IFNA21 | Interferon alpha-21 | 0.721 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.807 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P23528 | CFL1 | Cofilin-1 | 0.741 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 1 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q93034 | CUL5 | Cullin-5 | 0.704 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.901 | | P17252 | PRKCA | Protein kinase C alpha type | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.852 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.701 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.777 | | P17252 | PRKCA | Protein kinase C alpha type | P0DP23 | CALM1 | Calmodulin-1 | -0.776 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P0DP23 | CALM1 | Calmodulin-1 | -0.772 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P17252 | PRKCA | Protein kinase C alpha type | 0.769 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P17252 | PRKCA | Protein kinase C alpha type | 0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.769 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.773 | | P17252 | PRKCA | Protein kinase C alpha type | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.786 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.823 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.858 | | P17252 | PRKCA | Protein kinase C alpha type | P01568 | IFNA21 | Interferon alpha-21 | 0.733 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P01568 | IFNA21 | Interferon alpha-21 | 0.716 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P01568 | IFNA21 | Interferon alpha-21 | 0.721 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.741 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.807 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O60603 | TLR2 | Toll-like receptor 2 | -0.862 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P17252 | PRKCA | Protein kinase C alpha type | Q13315 | ATM | Serine-protein kinase ATM | 0.739 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13315 | ATM | Serine-protein kinase ATM | 0.758 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P23528 | CFL1 | Cofilin-1 | 0.741 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.94 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 1 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q93034 | CUL5 | Cullin-5 | 0.704 | | P17252 | PRKCA | Protein kinase C alpha type | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.829 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.946 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.901 |
| | Chlorcyclizine | hsa05171 | Coronavirus disease - COVID-19 | 3.87E-04 | 5 | P62249, P40429, P27635, Q07020, P05386 | RPS16, RPL13A, RPL10, RPL18, RPLP1 | More | | | Chlorcyclizine | hsa05202 | Transcriptional misregulation in cancer | 1.39E-05 | 20 | Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522 | FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q12778 | FOXO1 | Forkhead box protein O1 | 0.794 | | P05164 | MPO | Myeloperoxidase | Q15532 | SS18 | Protein SSXT | -0.719 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q15532 | SS18 | Protein SSXT | 0.877 | | P05164 | MPO | Myeloperoxidase | Q13315 | ATM | Serine-protein kinase ATM | -0.725 | | P05164 | MPO | Myeloperoxidase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P14780 | MMP9 | Matrix metalloproteinase-9 | 1 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.765 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.851 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14923 | JUP | Junction plakoglobin | 0.861 | | P05164 | MPO | Myeloperoxidase | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.799 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.7 | | P05164 | MPO | Myeloperoxidase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.782 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.921 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.746 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.848 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.758 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.816 | | P05164 | MPO | Myeloperoxidase | O15550 | UTX | Lysine-specific demethylase 6A | 0.763 | | P08069 | IGF1R | Insulin-like growth factor 1 receptor | P08069 | IGF1R | Insulin-like growth factor 1 receptor | 1 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.78 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.78 | | P05164 | MPO | Myeloperoxidase | P05164 | MPO | Myeloperoxidase | 1 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P05164 | MPO | Myeloperoxidase | -0.81 | | P05164 | MPO | Myeloperoxidase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.733 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.858 | | P05164 | MPO | Myeloperoxidase | P08246 | ELA2 | Neutrophil elastase | 0.903 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P08246 | ELA2 | Neutrophil elastase | -0.942 | | P05164 | MPO | Myeloperoxidase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.854 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.752 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.766 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12980 | LYL1 | Protein lyl-1 | 0.716 | | P05164 | MPO | Myeloperoxidase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.765 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q12778 | FOXO1 | Forkhead box protein O1 | 0.777 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q12778 | FOXO1 | Forkhead box protein O1 | 0.794 | | P05164 | MPO | Myeloperoxidase | Q15532 | SS18 | Protein SSXT | -0.719 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q15532 | SS18 | Protein SSXT | 0.763 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q15532 | SS18 | Protein SSXT | 0.877 | | P05164 | MPO | Myeloperoxidase | Q13315 | ATM | Serine-protein kinase ATM | -0.725 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13315 | ATM | Serine-protein kinase ATM | 0.758 | | P05164 | MPO | Myeloperoxidase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P14780 | MMP9 | Matrix metalloproteinase-9 | 1 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.767 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.765 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.851 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P14923 | JUP | Junction plakoglobin | 0.845 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14923 | JUP | Junction plakoglobin | 0.861 | | P05164 | MPO | Myeloperoxidase | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.799 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.7 | | P05164 | MPO | Myeloperoxidase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.782 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.921 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.746 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.794 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.848 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.758 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.754 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.816 | | P05164 | MPO | Myeloperoxidase | O15550 | UTX | Lysine-specific demethylase 6A | 0.763 | | P08069 | IGF1R | Insulin-like growth factor 1 receptor | P08069 | IGF1R | Insulin-like growth factor 1 receptor | 1 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.805 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.78 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.805 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.78 | | P05164 | MPO | Myeloperoxidase | P05164 | MPO | Myeloperoxidase | 1 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P05164 | MPO | Myeloperoxidase | -0.758 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P05164 | MPO | Myeloperoxidase | -0.81 | | P05164 | MPO | Myeloperoxidase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.733 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.858 | | P05164 | MPO | Myeloperoxidase | P08246 | ELA2 | Neutrophil elastase | 0.903 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P08246 | ELA2 | Neutrophil elastase | -0.896 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P08246 | ELA2 | Neutrophil elastase | -0.942 | | P05164 | MPO | Myeloperoxidase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.854 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.752 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.787 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.766 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12980 | LYL1 | Protein lyl-1 | 0.716 | | P05164 | MPO | Myeloperoxidase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.765 |
| | Chlorcyclizine | hsa05203 | Viral carcinogenesis | 4.85E-02 | 3 | Q15283, P62807, O60814 | RASA2, HIST1H2BC, H2BC12 | More | | | Chlorcyclizine | hsa05204 | Chemical carcinogenesis | 1.09E-03 | 3 | P09211, P78417, P11712 | GSTP1, GSTO1, CYP2C9 | More | | | Chlorcyclizine | hsa05205 | Proteoglycans in cancer | 4.93E-03 | 11 | Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P08069, P04628, Q13635, P08962 | TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, IGF1R, WNT1, PTCH1, CD63 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.75 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q12955 | ANK3 | Ankyrin-3 | 0.708 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.858 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O75369 | FLNB | Filamin-B | -0.762 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.765 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P17252 | PRKCA | Protein kinase C alpha type | 0.844 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P08069 | IGF1R | Insulin-like growth factor 1 receptor | P08069 | IGF1R | Insulin-like growth factor 1 receptor | 1 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P04628 | WNT1 | Proto-oncogene Wnt-1 | 0.703 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13635 | PTCH1 | Protein patched homolog 1 | 0.836 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P08962 | CD63 | CD63 antigen | -0.862 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.711 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.75 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q12955 | ANK3 | Ankyrin-3 | 0.708 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.823 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.858 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O75369 | FLNB | Filamin-B | -0.746 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O75369 | FLNB | Filamin-B | -0.762 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.767 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.765 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P17252 | PRKCA | Protein kinase C alpha type | 0.769 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P17252 | PRKCA | Protein kinase C alpha type | 0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O60603 | TLR2 | Toll-like receptor 2 | -0.862 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P08069 | IGF1R | Insulin-like growth factor 1 receptor | P08069 | IGF1R | Insulin-like growth factor 1 receptor | 1 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P04628 | WNT1 | Proto-oncogene Wnt-1 | 0.829 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P04628 | WNT1 | Proto-oncogene Wnt-1 | 0.703 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13635 | PTCH1 | Protein patched homolog 1 | 0.85 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13635 | PTCH1 | Protein patched homolog 1 | 0.836 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P08962 | CD63 | CD63 antigen | -0.782 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P08962 | CD63 | CD63 antigen | -0.862 |
| | Chlorcyclizine | hsa05214 | Glioma | 9.95E-03 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa05215 | Prostate cancer | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa05218 | Melanoma | 6.63E-03 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa05224 | Breast cancer | 1.49E-02 | 1 | P08069 | IGF1R | More | | | Chlorcyclizine | hsa05225 | Hepatocellular carcinoma | 6.30E-04 | 3 | Q92529, P08069, P51531 | SHC3, IGF1R, SMARCA2 | More | | | Chlorcyclizine | hsa05310 | Asthma | 2.81E-02 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Chlorcyclizine | hsa05320 | Autoimmune thyroid disease | 8.64E-03 | 4 | P13765, P29965, P01568, P10747 | HLA-DOB, CD40LG, IFNA21, CD28 | More | | | Chlorcyclizine | hsa05321 | Inflammatory bowel disease | 2.00E-04 | 7 | O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R | More | | | Chlorcyclizine | hsa05322 | Systemic lupus erythematosus | 1.31E-04 | 5 | P09871, Q93077, P62807, O60814, P68431 | C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Chlorcyclizine | hsa05330 | Allograft rejection | 2.72E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Chlorcyclizine | hsa05332 | Graft-versus-host disease | 9.76E-05 | 6 | P13765, P48023, P10747, P01375, P26715, Q13241 | HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1 | More | | | Chlorcyclizine | hsa05415 | Diabetic cardiomyopathy | 4.54E-04 | 8 | P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406 | PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P09960 | LTA4H | Leukotriene A-4 hydrolase | P17252 | PRKCA | Protein kinase C alpha type | -0.732 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.798 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.758 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16718 | NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | 0.757 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q16718 | NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | -0.816 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | O14521 | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | 0.732 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | O14521 | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | -0.799 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | -0.744 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P49841 | GSK3B | Glycogen synthase kinase-3 beta | -0.714 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P04406 | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | 0.725 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P17252 | PRKCA | Protein kinase C alpha type | -0.732 | | P17252 | PRKCA | Protein kinase C alpha type | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.821 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.798 | | P17252 | PRKCA | Protein kinase C alpha type | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.836 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.758 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16718 | NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | 0.757 | | P17252 | PRKCA | Protein kinase C alpha type | Q16718 | NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | 0.811 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q16718 | NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | -0.816 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | O14521 | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | 0.732 | | P17252 | PRKCA | Protein kinase C alpha type | O14521 | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | 0.822 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | O14521 | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | -0.799 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | -0.744 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P49841 | GSK3B | Glycogen synthase kinase-3 beta | -0.714 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P04406 | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | 0.725 |
| | Cyclizine | hsa00040 | Pentose and glucuronate interconversions | 4.00E-02 | 1 | P15121 | AKR1B1 | More | | | Cyclizine | hsa00190 | Oxidative phosphorylation | 1.21E-06 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Cyclizine | hsa00230 | Purine metabolism | 1.81E-02 | 2 | P20839, Q02153 | IMPDH1, GUCY1B3 | More | | | Cyclizine | hsa00260 | Glycine, serine and threonine metabolism | 1.99E-02 | 1 | P22557 | ALAS2 | More | | | Cyclizine | hsa00565 | Ether lipid metabolism | 3.94E-02 | 1 | Q8N661 | TMEM86B | More | | | Cyclizine | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Cyclizine | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Cyclizine | hsa00600 | Sphingolipid metabolism | 4.77E-02 | 3 | Q9BX95, O14494, P06280 | SGPP1, PLPP1, GLA | More | | | Cyclizine | hsa00630 | Glyoxylate and dicarboxylate metabolism | 4.29E-03 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Cyclizine | hsa00760 | Nicotinate and nicotinamide metabolism | 3.52E-02 | 1 | P21589 | NT5E | More | | | Cyclizine | hsa00770 | Pantothenate and CoA biosynthesis | 1.15E-02 | 2 | O95498, Q9NRN7 | VNN2, AASDHPPT | More | | | Cyclizine | hsa00790 | Folate biosynthesis | 2.02E-02 | 1 | P15121 | AKR1B1 | More | | | Cyclizine | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 6.38E-04 | 3 | P78417, P09211, P11712 | GSTO1, GSTP1, CYP2C9 | More | | | Cyclizine | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | | Cyclizine | hsa00983 | Drug metabolism - other enzymes | 3.48E-03 | 3 | P04183, P32320, P05164 | TK1, CDA, MPO | More | | | Cyclizine | hsa01100 | Metabolic pathways | 4.11E-02 | 7 | P30041, P20839, P08237, Q86XP1, Q9UHK6, Q86VZ5, Q9NVH6 | PRDX6, IMPDH1, PFKM, DGKH, AMACR, SGMS1, TMLHE | More | | | Cyclizine | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 1.82E-02 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa01522 | Endocrine resistance | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa01523 | Antifolate resistance | 3.80E-02 | 2 | Q92820, P04818 | GGH, TYMS | More | | | Cyclizine | hsa02010 | ABC transporters | 2.29E-02 | 2 | P45844, P08183 | ABCG1, ABCB1 | More | | | Cyclizine | hsa03010 | Ribosome | 2.25E-04 | 5 | P40429, Q07020, P27635, P05386, P62249 | RPL13A, RPL18, RPL10, RPLP1, RPS16 | More | | | Cyclizine | hsa03013 | RNA transport | 2.59E-03 | 10 | P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5 | NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P10415 | BCL2 | Apoptosis regulator Bcl-2 | P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | 0.888 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | 0.742 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O14893 | GEMIN2 | Gem-associated protein 2 | 0.853 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q7Z3B4 | NUP54 | Nucleoporin p54 | 0.774 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35658 | NUP214 | Nuclear pore complex protein Nup214 | -0.751 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | 0.734 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | 0.837 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P78345 | RPP38 | Ribonuclease P protein subunit p38 | 0.852 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9Y6A5 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | -0.812 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | 0.956 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | 0.888 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | 0.742 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O14893 | GEMIN2 | Gem-associated protein 2 | 0.925 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O14893 | GEMIN2 | Gem-associated protein 2 | 0.853 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P61326 | MAGOH | Protein mago nashi homolog | 0.761 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q7Z3B4 | NUP54 | Nucleoporin p54 | 0.854 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q7Z3B4 | NUP54 | Nucleoporin p54 | 0.774 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P35658 | NUP214 | Nuclear pore complex protein Nup214 | -0.79 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35658 | NUP214 | Nuclear pore complex protein Nup214 | -0.751 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | 0.715 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | 0.734 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | 0.793 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | 0.837 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P78345 | RPP38 | Ribonuclease P protein subunit p38 | 0.819 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P78345 | RPP38 | Ribonuclease P protein subunit p38 | 0.852 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9Y6A5 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | -0.891 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9Y6A5 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | -0.812 |
| | Cyclizine | hsa03022 | Basal transcription factors | 3.32E-02 | 2 | O00268, Q15544 | TAF4, TAF11 | More | | | Cyclizine | hsa03040 | Spliceosome | 6.28E-03 | 6 | Q14562, O43143, O60508, Q07955, Q01130, Q13243 | DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5 | More | | | Cyclizine | hsa04010 | MAPK signaling pathway | 1.23E-03 | 3 | P08069, Q9H2K8, Q12933 | IGF1R, TAOK3, TRAF2 | More | | | Cyclizine | hsa04014 | Ras signaling pathway | 3.65E-02 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa04015 | Rap1 signaling pathway | 2.99E-02 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa04024 | cAMP signaling pathway | 4.38E-02 | 4 | P42338, P0DP23, Q13370, Q13009 | PIK3CB, CALM1, PDE3B, TIAM1 | More | | | Cyclizine | hsa04060 | Cytokine-cytokine receptor interaction | 4.71E-02 | 2 | P78552, O75509 | IL13RA1, TNFRSF21 | More | | | Cyclizine | hsa04064 | NF-kappa B signaling pathway | 1.90E-03 | 11 | P10415, Q13489, O00463, P29965, Q04759, Q9UDY8, Q16548, Q8WV28, Q13315, P24522, P09341 | BCL2, BIRC3, TRAF5, CD40LG, PRKCQ, MALT1, BCL2A1, BLNK, ATM, GADD45A, CXCL1 | More | | | Cyclizine | hsa04066 | HIF-1 signaling pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa04068 | FoxO signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa04070 | Phosphatidylinositol signaling system | 4.22E-03 | 6 | P0DP23, Q14643, P42338, P23743, P27987, P17252 | CALM1, ITPR1, PIK3CB, DGKA, ITPKB, PRKCA | More | | | Cyclizine | hsa04071 | Sphingolipid signaling pathway | 1.76E-05 | 10 | P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q12933, Q02156 | PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, TRAF2, PRKCE | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P05164 | MPO | Myeloperoxidase | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | -0.823 | | P05164 | MPO | Myeloperoxidase | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.876 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.901 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P05164 | MPO | Myeloperoxidase | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.75 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.828 | | P05164 | MPO | Myeloperoxidase | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.714 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.869 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P05164 | MPO | Myeloperoxidase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.81 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.765 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P17252 | PRKCA | Protein kinase C alpha type | 0.769 | | P05164 | MPO | Myeloperoxidase | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | -0.823 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | 0.773 | | P05164 | MPO | Myeloperoxidase | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.876 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.901 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P17252 | PRKCA | Protein kinase C alpha type | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.745 | | P05164 | MPO | Myeloperoxidase | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.75 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.828 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.799 | | P17252 | PRKCA | Protein kinase C alpha type | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | 0.816 | | P05164 | MPO | Myeloperoxidase | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.714 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.869 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | 0.917 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | P05164 | MPO | Myeloperoxidase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.81 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.765 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.94 | | Q02156 | PRKCE | Protein kinase C epsilon type | Q12933 | TRAF2 | TNF receptor-associated factor 2 | -0.78 | | Q02156 | PRKCE | Protein kinase C epsilon type | Q02156 | PRKCE | Protein kinase C epsilon type | 1 |
| | Cyclizine | hsa04072 | Phospholipase D signaling pathway | 9.70E-03 | 2 | Q92529, Q14344 | SHC3, GNA13 | More | | | Cyclizine | hsa04080 | Neuroactive ligand-receptor interaction | 3.22E-02 | 7 | P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581 | CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1 | More | | | Cyclizine | hsa04110 | Cell cycle | 6.80E-03 | 6 | P06493, O75293, P30304, P33981, P42773, P01106 | CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC | More | | | Cyclizine | hsa04114 | Oocyte meiosis | 2.99E-02 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa04115 | p53 signaling pathway | 3.98E-02 | 5 | P24522, Q13315, Q53FA7, O95067, P10415 | GADD45A, ATM, TP53I3, CCNB2, BCL2 | More | | | Cyclizine | hsa04120 | Ubiquitin mediated proteolysis | 2.51E-03 | 6 | Q14145, Q13042, P62837, Q15751, O95071, P0CG47 | KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBB | More | | | Cyclizine | hsa04137 | Mitophagy - animal | 9.52E-03 | 2 | Q07817, P0CG47 | BCL2L1, UBB | More | | | Cyclizine | hsa04140 | Autophagy - animal | 2.82E-02 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa04145 | Phagosome | 1.38E-07 | 9 | Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765 | NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.951 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.844 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.809 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.766 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | -0.718 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P05164 | MPO | Myeloperoxidase | -0.81 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35443 | THBS4 | Thrombospondin-4 | -0.765 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.754 | | P17252 | PRKCA | Protein kinase C alpha type | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.836 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.919 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.951 | | P17252 | PRKCA | Protein kinase C alpha type | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.821 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.857 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.844 | | P17252 | PRKCA | Protein kinase C alpha type | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.756 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.846 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.809 | | P17252 | PRKCA | Protein kinase C alpha type | P68371 | TUBB2C | Tubulin beta-4B chain | -0.842 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.783 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.766 | | P17252 | PRKCA | Protein kinase C alpha type | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | -0.779 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | -0.716 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | -0.718 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P05164 | MPO | Myeloperoxidase | -0.758 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P05164 | MPO | Myeloperoxidase | -0.81 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O60603 | TLR2 | Toll-like receptor 2 | -0.862 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P35443 | THBS4 | Thrombospondin-4 | -0.755 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35443 | THBS4 | Thrombospondin-4 | -0.765 | | P17252 | PRKCA | Protein kinase C alpha type | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.709 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.754 |
| | Cyclizine | hsa04150 | mTOR signaling pathway | 2.32E-02 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa04151 | PI3K-Akt signaling pathway | 4.50E-02 | 9 | P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252 | F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCA | More | | | Cyclizine | hsa04152 | AMPK signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa04210 | Apoptosis | 3.77E-02 | 8 | Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643 | ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1 | More | | | Cyclizine | hsa04211 | Longevity regulating pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa04213 | Longevity regulating pathway - multiple species | 1.66E-02 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa04217 | Necroptosis | 7.46E-06 | 13 | P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, P10415, O43633, Q08752 | TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP2A, PPID | More | | | Cyclizine | hsa04218 | Cellular senescence | 4.79E-02 | 4 | P01106, O75293, P30304, P06493 | MYC, GADD45B, CDC25A, CDK1 | More | | | Cyclizine | hsa04261 | Adrenergic signaling in cardiomyocytes | 2.84E-02 | 5 | P09493, Q13362, P0DP23, P17252, P10415 | TPM1, PPP2R5C, CALM1, PRKCA, BCL2 | More | | | Cyclizine | hsa04330 | Notch signaling pathway | 7.49E-03 | 2 | Q92542, P49768 | NCSTN, PSEN1 | More | | | Cyclizine | hsa04340 | Hedgehog signaling pathway | 3.46E-02 | 4 | P49841, P22694, Q13635, P10415 | GSK3B, PRKACB, PTCH1, BCL2 | More | | | Cyclizine | hsa04360 | Axon guidance | 1.71E-02 | 4 | P20827, O95631, P42338, P23528 | EFNA1, NTN1, PIK3CB, CFL1 | More | | | Cyclizine | hsa04510 | Focal adhesion | 3.48E-02 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa04520 | Adherens junction | 8.29E-03 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa04530 | Tight junction | 3.29E-02 | 3 | P16989, P56750, Q14247 | CSDA, CLDN17, CTTN | More | | | Cyclizine | hsa04540 | Gap junction | 1.29E-02 | 4 | P17252, Q13509, P68371, Q14643 | PRKCA, TUBB3, TUBB2C, ITPR1 | More | | | Cyclizine | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa04612 | Antigen processing and presentation | 2.26E-03 | 8 | P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375 | HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF | More | | | Cyclizine | hsa04613 | Neutrophil extracellular trap formation | 8.65E-05 | 20 | P17252, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539 | PRKCA, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.9 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P04908 | H2AC4; H2AC8 | Histone H2A type 1-B/E | 0.734 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.74 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.737 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.913 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.869 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20160 | AZU1 | Azurocidin | 0.734 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08311 | CTSG | Cathepsin G | 0.79 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.928 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.942 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.912 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | O43315 | AQP9 | Aquaporin-9 | -0.764 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O43315 | AQP9 | Aquaporin-9 | 0.837 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | -0.744 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | P17252 | PRKCA | Protein kinase C alpha type | P08246 | ELA2 | Neutrophil elastase | -0.735 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.9 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P04908 | H2AC4; H2AC8 | Histone H2A type 1-B/E | 0.734 | | P17252 | PRKCA | Protein kinase C alpha type | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | -0.83 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.74 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.737 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.913 | | P17252 | PRKCA | Protein kinase C alpha type | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.783 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | | P17252 | PRKCA | Protein kinase C alpha type | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.821 | | P17252 | PRKCA | Protein kinase C alpha type | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.836 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.869 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20160 | AZU1 | Azurocidin | 0.734 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08311 | CTSG | Cathepsin G | 0.79 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.928 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.942 | | P17252 | PRKCA | Protein kinase C alpha type | P21462 | FPR1 | fMet-Leu-Phe receptor | -0.731 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.912 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | O43315 | AQP9 | Aquaporin-9 | -0.764 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O43315 | AQP9 | Aquaporin-9 | 0.837 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | -0.744 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 |
| | Cyclizine | hsa04621 | NOD-like receptor signaling pathway | 2.62E-02 | 11 | Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838 | MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4 | More | | | Cyclizine | hsa04622 | RIG-I-like receptor signaling pathway | 2.47E-02 | 1 | Q12933 | TRAF2 | More | | | Cyclizine | hsa04623 | Cytosolic DNA-sensing pathway | 3.15E-02 | 2 | P01568, P25963 | IFNA21, NFKBIA | More | | | Cyclizine | hsa04640 | Hematopoietic cell lineage | 3.69E-02 | 4 | P21926, P07766, P01730, P09564 | CD9, CD3E, CD4, CD7 | More | | | Cyclizine | hsa04657 | IL-17 signaling pathway | 3.91E-02 | 7 | O00463, Q16539, P49841, P09341, P14780, P80188, P01375 | TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF | More | | | Cyclizine | hsa04658 | Th1 and Th2 cell differentiation | 1.12E-02 | 8 | Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765 | PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOB | More | | | Cyclizine | hsa04659 | Th17 cell differentiation | 4.38E-02 | 4 | P42224, P14784, P40189, P08238 | STAT1, IL2RB, IL6ST, HSP90AB1 | More | | | Cyclizine | hsa04660 | T cell receptor signaling pathway | 3.76E-03 | 11 | P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841 | TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3B | More | | | Cyclizine | hsa04666 | Fc gamma R-mediated phagocytosis | 2.25E-03 | 6 | P42338, P23528, P06396, O14494, P14598, P17252 | PIK3CB, CFL1, GSN, PLPP1, NCF1, PRKCA | More | | | Cyclizine | hsa04672 | Intestinal immune network for IgA production | 1.24E-04 | 3 | P29965, P10747, P13765 | CD40LG, CD28, HLA-DOB | More | | | Cyclizine | hsa04713 | Circadian entrainment | 2.60E-02 | 4 | P0DP23, P17252, P62873, Q14643 | CALM1, PRKCA, GNB1, ITPR1 | More | | | Cyclizine | hsa04714 | Thermogenesis | 5.21E-03 | 4 | Q16539, P33121, Q16718, O14521 | MAPK14, ACSL1, NDUFA5, SDHD | More | | | Cyclizine | hsa04720 | Long-term potentiation | 3.89E-02 | 3 | P17252, P0DP23, Q14643 | PRKCA, CALM1, ITPR1 | More | | | Cyclizine | hsa04721 | Synaptic vesicle cycle | 3.15E-02 | 2 | Q13488, P31645 | TCIRG1, SLC6A4 | More | | | Cyclizine | hsa04722 | Neurotrophin signaling pathway | 3.27E-02 | 3 | P49841, O43524, P48023 | GSK3B, FOXO3, FASLG | More | | | Cyclizine | hsa04723 | Retrograde endocannabinoid signaling | 1.88E-02 | 4 | Q14643, P17252, P62873, Q16718 | ITPR1, PRKCA, GNB1, NDUFA5 | More | | | Cyclizine | hsa04725 | Cholinergic synapse | 2.42E-03 | 6 | P22694, Q14643, P17252, P62873, P18848, P10415 | PRKACB, ITPR1, PRKCA, GNB1, ATF4, BCL2 | More | | | Cyclizine | hsa04728 | Dopaminergic synapse | 3.55E-02 | 5 | Q14643, P17252, P62873, Q13362, P0DP23 | ITPR1, PRKCA, GNB1, PPP2R5C, CALM1 | More | | | Cyclizine | hsa04730 | Long-term depression | 1.55E-03 | 2 | Q14344, P08069 | GNA13, IGF1R | More | | | Cyclizine | hsa04740 | Olfactory transduction | 2.52E-02 | 1 | Q9H255 | OR51E2 | More | | | Cyclizine | hsa04742 | Taste transduction | 1.01E-02 | 1 | P30939 | HTR1F | More | | | Cyclizine | hsa04744 | Phototransduction | 3.21E-04 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Cyclizine | hsa04912 | GnRH signaling pathway | 3.89E-02 | 3 | P17252, Q14643, P0DP23 | PRKCA, ITPR1, CALM1 | More | | | Cyclizine | hsa04913 | Ovarian steroidogenesis | 1.16E-02 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa04914 | Progesterone-mediated oocyte maturation | 1.31E-02 | 4 | P08069, P42338, Q13370, P08238 | IGF1R, PIK3CB, PDE3B, HSP90AB1 | More | | | Cyclizine | hsa04915 | Estrogen signaling pathway | 2.96E-02 | 5 | P14780, P22694, P18848, Q14643, P10415 | MMP9, PRKACB, ATF4, ITPR1, BCL2 | More | | | Cyclizine | hsa04916 | Melanogenesis | 4.80E-02 | 4 | P0DP23, Q9UJU2, P17252, P04628 | CALM1, LEF1, PRKCA, WNT1 | More | | | Cyclizine | hsa04918 | Thyroid hormone synthesis | 3.50E-02 | 3 | P22694, P18848, Q14643 | PRKACB, ATF4, ITPR1 | More | | | Cyclizine | hsa04919 | Thyroid hormone signaling pathway | 3.71E-02 | 2 | P26678, P08237 | PLN, PFKM | More | | | Cyclizine | hsa04922 | Glucagon signaling pathway | 3.47E-02 | 4 | Q12778, Q13370, P0DP23, Q14643 | FOXO1, PDE3B, CALM1, ITPR1 | More | | | Cyclizine | hsa04924 | Renin secretion | 6.88E-04 | 3 | Q14643, Q13370, P0DP23 | ITPR1, PDE3B, CALM1 | More | | | Cyclizine | hsa04927 | Cortisol synthesis and secretion | 8.60E-03 | 3 | Q14643, P18848, P22694 | ITPR1, ATF4, PRKACB | More | | | Cyclizine | hsa04928 | Parathyroid hormone synthesis, secretion and action | 2.13E-02 | 5 | Q14643, P22694, P23771, P18848, P10415 | ITPR1, PRKACB, GATA3, ATF4, BCL2 | More | | | Cyclizine | hsa04930 | Type II diabetes mellitus | 2.47E-02 | 1 | Q02156 | PRKCE | More | | | Cyclizine | hsa04932 | Non-alcoholic fatty liver disease | 2.44E-03 | 5 | P01375, P49841, P48023, Q16718, O14521 | TNF, GSK3B, FASLG, NDUFA5, SDHD | More | | | Cyclizine | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.27E-02 | 5 | P42224, P10415, Q12778, P49767, P17252 | STAT1, BCL2, FOXO1, VEGFC, PRKCA | More | | | Cyclizine | hsa04940 | Type I diabetes mellitus | 1.87E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Cyclizine | hsa04960 | Aldosterone-regulated sodium reabsorption | 4.38E-02 | 1 | P48048 | KCNJ1 | More | | | Cyclizine | hsa04961 | Endocrine and other factor-regulated calcium reabsorption | 2.68E-02 | 3 | P20020, Q9UEF7, P17252 | ATP2B1, KL, PRKCA | More | | | Cyclizine | hsa04966 | Collecting duct acid secretion | 2.86E-02 | 2 | Q13488, Q9Y666 | TCIRG1, SLC12A7 | More | | | Cyclizine | hsa04972 | Pancreatic secretion | 2.68E-02 | 3 | Q14643, P20020, P17252 | ITPR1, ATP2B1, PRKCA | More | | | Cyclizine | hsa04974 | Protein digestion and absorption | 2.47E-02 | 1 | Q7Z2H8 | SLC36A1 | More | | | Cyclizine | hsa04976 | Bile secretion | 3.32E-02 | 2 | O43315, P08183 | AQP9, ABCB1 | More | | | Cyclizine | hsa05010 | Alzheimer disease | 3.55E-02 | 7 | Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752 | NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPID | More | | | Cyclizine | hsa05012 | Parkinson disease | 2.25E-02 | 6 | Q16718, O14521, Q14643, P0DP23, Q13509, P68371 | NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C | More | | | Cyclizine | hsa05020 | Prion disease | 1.31E-03 | 9 | Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539 | NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14 | More | | | Cyclizine | hsa05022 | Pathways of neurodegeneration - multiple diseases | 2.00E-04 | 12 | Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, Q13561, P17252, Q16539, Q08752, P0DP23 | ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, MAPK14, PPID, CALM1 | More | | | Cyclizine | hsa05034 | Alcoholism | 2.89E-03 | 4 | Q93077, P62807, O60814, P68431 | HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Cyclizine | hsa05131 | Shigellosis | 3.33E-03 | 10 | Q12933, P68431, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752 | TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID | More | | | Cyclizine | hsa05132 | Salmonella infection | 2.23E-05 | 11 | P51617, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371 | IRAK1, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P10415 | BCL2 | Apoptosis regulator Bcl-2 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.807 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.908 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.848 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 1 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O75369 | FLNB | Filamin-B | -0.762 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | 0.929 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13561 | DCTN2 | Dynactin subunit 2 | -0.843 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.809 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.766 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.741 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.807 | | P17252 | PRKCA | Protein kinase C alpha type | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.881 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.825 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.908 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.769 | | P17252 | PRKCA | Protein kinase C alpha type | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.849 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.794 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.848 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.94 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 1 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O75369 | FLNB | Filamin-B | -0.746 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O75369 | FLNB | Filamin-B | -0.762 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O60603 | TLR2 | Toll-like receptor 2 | -0.862 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P17252 | PRKCA | Protein kinase C alpha type | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | 0.701 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | 0.924 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9BQS8 | FYCO1 | FYVE and coiled-coil domain-containing protein 1 | 0.929 | | P17252 | PRKCA | Protein kinase C alpha type | Q13561 | DCTN2 | Dynactin subunit 2 | -0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13561 | DCTN2 | Dynactin subunit 2 | -0.809 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13561 | DCTN2 | Dynactin subunit 2 | -0.843 | | P17252 | PRKCA | Protein kinase C alpha type | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.756 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.846 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.809 | | P17252 | PRKCA | Protein kinase C alpha type | P68371 | TUBB2C | Tubulin beta-4B chain | -0.842 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.783 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.766 |
| | Cyclizine | hsa05140 | Leishmaniasis | 9.55E-06 | 11 | P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, Q15080 | ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, NCF4 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P14780 | MMP9 | Matrix metalloproteinase-9 | P13612 | ITGA4 | Integrin alpha-4 | -0.7 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.928 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.798 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.787 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.714 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.768 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P29350 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | 0.808 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.869 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.758 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P13612 | ITGA4 | Integrin alpha-4 | -0.7 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.928 | | P17252 | PRKCA | Protein kinase C alpha type | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.821 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.798 | | P17252 | PRKCA | Protein kinase C alpha type | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.706 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.787 | | P17252 | PRKCA | Protein kinase C alpha type | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.709 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.714 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.768 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P17252 | PRKCA | Protein kinase C alpha type | P29350 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | -0.754 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P29350 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | 0.808 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P17252 | PRKCA | Protein kinase C alpha type | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.836 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.869 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.758 |
| | Cyclizine | hsa05143 | African trypanosomiasis | 2.72E-02 | 2 | P01375, P48023 | TNF, FASLG | More | | | Cyclizine | hsa05145 | Toxoplasmosis | 1.11E-02 | 6 | P10415, Q13489, P42224, P13765, O60603, P29965 | BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG | More | | | Cyclizine | hsa05146 | Amoebiasis | 3.91E-02 | 7 | P09341, P27930, P01375, O60603, P05089, P22694, P08311 | CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG | More | | | Cyclizine | hsa05152 | Tuberculosis | 8.62E-07 | 11 | Q13488, P0DP23, P42224, P48382, P25208, O60603, P10415, P13765, P01568, Q9UDY8, P51617 | TCIRG1, CALM1, STAT1, RFX5, NFYB, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | -0.718 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P0DP23 | CALM1 | Calmodulin-1 | -0.772 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P48382 | RFX5 | DNA-binding protein RFX5 | 0.856 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 1 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.754 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P01568 | IFNA21 | Interferon alpha-21 | 0.721 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.94 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.807 | | P17252 | PRKCA | Protein kinase C alpha type | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | -0.779 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | -0.716 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | -0.718 | | P17252 | PRKCA | Protein kinase C alpha type | P0DP23 | CALM1 | Calmodulin-1 | -0.776 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P0DP23 | CALM1 | Calmodulin-1 | -0.772 | | P17252 | PRKCA | Protein kinase C alpha type | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.706 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P48382 | RFX5 | DNA-binding protein RFX5 | 0.797 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P48382 | RFX5 | DNA-binding protein RFX5 | 0.856 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P25208 | NFYB | Nuclear transcription factor Y subunit beta | 0.742 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O60603 | TLR2 | Toll-like receptor 2 | -0.862 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.94 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 1 | | P17252 | PRKCA | Protein kinase C alpha type | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.709 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.754 | | P17252 | PRKCA | Protein kinase C alpha type | P01568 | IFNA21 | Interferon alpha-21 | 0.733 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P01568 | IFNA21 | Interferon alpha-21 | 0.716 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P01568 | IFNA21 | Interferon alpha-21 | 0.721 | | P17252 | PRKCA | Protein kinase C alpha type | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.769 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 1 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.94 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.741 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.807 |
| | Cyclizine | hsa05160 | Hepatitis C | 1.27E-02 | 4 | P60033, P49841, P01375, P48023 | CD81, GSK3B, TNF, FASLG | More | | | Cyclizine | hsa05165 | Human papillomavirus infection | 3.10E-02 | 8 | P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315 | ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM | More | | | Cyclizine | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 4.73E-02 | 6 | P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2 | IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1 | More | | | Cyclizine | hsa05168 | Herpes simplex virus 1 infection | 1.38E-04 | 15 | P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P42338, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9UDV6 | NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PIK3CB, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P09960 | LTA4H | Leukotriene A-4 hydrolase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.768 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P01568 | IFNA21 | Interferon alpha-21 | -0.764 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q05823 | RNASEL | 2-5A-dependent ribonuclease | 0.752 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.787 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.732 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.819 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.721 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13398 | ZNF211 | Zinc finger protein 211 | 0.729 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q9HCX3 | ZNF304 | Zinc finger protein 304 | -0.746 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P52738 | ZNF140 | Zinc finger protein 140 | -0.724 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | O75820 | ZNF189 | Zinc finger protein 189 | -0.722 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q9UDV6 | ZNF212 | Zinc finger protein 212 | 0.824 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.768 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P01568 | IFNA21 | Interferon alpha-21 | -0.764 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q05823 | RNASEL | 2-5A-dependent ribonuclease | 0.752 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.787 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.732 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.819 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.721 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13398 | ZNF211 | Zinc finger protein 211 | 0.729 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13398 | ZNF211 | Zinc finger protein 211 | 0.763 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q9HCX3 | ZNF304 | Zinc finger protein 304 | -0.746 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q03923 | ZNF85 | Zinc finger protein 85 | -0.73 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P52738 | ZNF140 | Zinc finger protein 140 | -0.724 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | O75820 | ZNF189 | Zinc finger protein 189 | -0.722 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q9UDV6 | ZNF212 | Zinc finger protein 212 | 0.824 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q9UDV6 | ZNF212 | Zinc finger protein 212 | 0.776 |
| | Cyclizine | hsa05170 | Human immunodeficiency virus 1 infection | 9.96E-06 | 14 | P62873, P0DP23, P17252, Q13546, O00463, Q14643, P01568, P51617, O60603, Q13315, P23528, P10415, Q93034, Q9Y6Q5 | GNB1, CALM1, PRKCA, RIPK1, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, ATM, CFL1, BCL2, CUL5, AP1M2 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P10415 | BCL2 | Apoptosis regulator Bcl-2 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.777 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P0DP23 | CALM1 | Calmodulin-1 | -0.772 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P17252 | PRKCA | Protein kinase C alpha type | 0.844 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.773 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.858 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P01568 | IFNA21 | Interferon alpha-21 | 0.721 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.807 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P23528 | CFL1 | Cofilin-1 | 0.741 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 1 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q93034 | CUL5 | Cullin-5 | 0.704 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.901 | | P17252 | PRKCA | Protein kinase C alpha type | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.852 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.701 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.777 | | P17252 | PRKCA | Protein kinase C alpha type | P0DP23 | CALM1 | Calmodulin-1 | -0.776 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P0DP23 | CALM1 | Calmodulin-1 | -0.772 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P17252 | PRKCA | Protein kinase C alpha type | 0.769 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P17252 | PRKCA | Protein kinase C alpha type | 0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.769 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.773 | | P17252 | PRKCA | Protein kinase C alpha type | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.786 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.823 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.858 | | P17252 | PRKCA | Protein kinase C alpha type | P01568 | IFNA21 | Interferon alpha-21 | 0.733 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P01568 | IFNA21 | Interferon alpha-21 | 0.716 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P01568 | IFNA21 | Interferon alpha-21 | 0.721 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.741 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.807 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O60603 | TLR2 | Toll-like receptor 2 | -0.862 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P17252 | PRKCA | Protein kinase C alpha type | Q13315 | ATM | Serine-protein kinase ATM | 0.739 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13315 | ATM | Serine-protein kinase ATM | 0.758 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P23528 | CFL1 | Cofilin-1 | 0.741 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.94 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 1 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q93034 | CUL5 | Cullin-5 | 0.704 | | P17252 | PRKCA | Protein kinase C alpha type | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.829 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.946 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.901 |
| | Cyclizine | hsa05171 | Coronavirus disease - COVID-19 | 3.87E-04 | 5 | P62249, P40429, P27635, Q07020, P05386 | RPS16, RPL13A, RPL10, RPL18, RPLP1 | More | | | Cyclizine | hsa05200 | Pathways in cancer | 6.34E-03 | 18 | P42338, P08238, P42224, Q9UJU2, P17252, P43246, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, O75293, P0DP23, P01568, P14784, P40189 | PIK3CB, HSP90AB1, STAT1, LEF1, PRKCA, MSH2, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST | More | | | Cyclizine | hsa05202 | Transcriptional misregulation in cancer | 8.41E-07 | 20 | Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522 | FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q12778 | FOXO1 | Forkhead box protein O1 | 0.794 | | P05164 | MPO | Myeloperoxidase | Q15532 | SS18 | Protein SSXT | -0.719 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q15532 | SS18 | Protein SSXT | 0.877 | | P05164 | MPO | Myeloperoxidase | Q13315 | ATM | Serine-protein kinase ATM | -0.725 | | P05164 | MPO | Myeloperoxidase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P14780 | MMP9 | Matrix metalloproteinase-9 | 1 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.765 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.851 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14923 | JUP | Junction plakoglobin | 0.861 | | P05164 | MPO | Myeloperoxidase | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.799 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.7 | | P05164 | MPO | Myeloperoxidase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.782 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.921 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.746 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.848 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.758 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.816 | | P05164 | MPO | Myeloperoxidase | O15550 | UTX | Lysine-specific demethylase 6A | 0.763 | | P08069 | IGF1R | Insulin-like growth factor 1 receptor | P08069 | IGF1R | Insulin-like growth factor 1 receptor | 1 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.78 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.78 | | P05164 | MPO | Myeloperoxidase | P05164 | MPO | Myeloperoxidase | 1 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P05164 | MPO | Myeloperoxidase | -0.81 | | P05164 | MPO | Myeloperoxidase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.733 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.858 | | P05164 | MPO | Myeloperoxidase | P08246 | ELA2 | Neutrophil elastase | 0.903 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P08246 | ELA2 | Neutrophil elastase | -0.942 | | P05164 | MPO | Myeloperoxidase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.854 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.752 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.766 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12980 | LYL1 | Protein lyl-1 | 0.716 | | P05164 | MPO | Myeloperoxidase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.765 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q12778 | FOXO1 | Forkhead box protein O1 | 0.777 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q12778 | FOXO1 | Forkhead box protein O1 | 0.794 | | P05164 | MPO | Myeloperoxidase | Q15532 | SS18 | Protein SSXT | -0.719 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q15532 | SS18 | Protein SSXT | 0.763 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q15532 | SS18 | Protein SSXT | 0.877 | | P05164 | MPO | Myeloperoxidase | Q13315 | ATM | Serine-protein kinase ATM | -0.725 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13315 | ATM | Serine-protein kinase ATM | 0.758 | | P05164 | MPO | Myeloperoxidase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P14780 | MMP9 | Matrix metalloproteinase-9 | 1 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.767 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.765 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.851 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P14923 | JUP | Junction plakoglobin | 0.845 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14923 | JUP | Junction plakoglobin | 0.861 | | P05164 | MPO | Myeloperoxidase | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.799 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.7 | | P05164 | MPO | Myeloperoxidase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.782 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.921 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.746 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.794 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.848 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.758 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.754 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.816 | | P05164 | MPO | Myeloperoxidase | O15550 | UTX | Lysine-specific demethylase 6A | 0.763 | | P08069 | IGF1R | Insulin-like growth factor 1 receptor | P08069 | IGF1R | Insulin-like growth factor 1 receptor | 1 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.805 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.78 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.805 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.78 | | P05164 | MPO | Myeloperoxidase | P05164 | MPO | Myeloperoxidase | 1 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P05164 | MPO | Myeloperoxidase | -0.758 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P05164 | MPO | Myeloperoxidase | -0.81 | | P05164 | MPO | Myeloperoxidase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.733 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.858 | | P05164 | MPO | Myeloperoxidase | P08246 | ELA2 | Neutrophil elastase | 0.903 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P08246 | ELA2 | Neutrophil elastase | -0.896 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P08246 | ELA2 | Neutrophil elastase | -0.942 | | P05164 | MPO | Myeloperoxidase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.854 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.752 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.787 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.766 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12980 | LYL1 | Protein lyl-1 | 0.716 | | P05164 | MPO | Myeloperoxidase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.765 |
| | Cyclizine | hsa05203 | Viral carcinogenesis | 4.85E-02 | 3 | Q15283, P62807, O60814 | RASA2, HIST1H2BC, H2BC12 | More | | | Cyclizine | hsa05204 | Chemical carcinogenesis | 1.09E-03 | 3 | P09211, P78417, P11712 | GSTP1, GSTO1, CYP2C9 | More | | | Cyclizine | hsa05205 | Proteoglycans in cancer | 2.86E-04 | 11 | Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P08069, P04628, Q13635, P08962 | TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, IGF1R, WNT1, PTCH1, CD63 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.75 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q12955 | ANK3 | Ankyrin-3 | 0.708 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.858 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O75369 | FLNB | Filamin-B | -0.762 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.765 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P17252 | PRKCA | Protein kinase C alpha type | 0.844 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P08069 | IGF1R | Insulin-like growth factor 1 receptor | P08069 | IGF1R | Insulin-like growth factor 1 receptor | 1 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P04628 | WNT1 | Proto-oncogene Wnt-1 | 0.703 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13635 | PTCH1 | Protein patched homolog 1 | 0.836 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P08962 | CD63 | CD63 antigen | -0.862 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.711 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.75 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q12955 | ANK3 | Ankyrin-3 | 0.708 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.823 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.858 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O75369 | FLNB | Filamin-B | -0.746 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O75369 | FLNB | Filamin-B | -0.762 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.767 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.765 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P17252 | PRKCA | Protein kinase C alpha type | 0.769 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P17252 | PRKCA | Protein kinase C alpha type | 0.844 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | O60603 | TLR2 | Toll-like receptor 2 | -0.862 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P08069 | IGF1R | Insulin-like growth factor 1 receptor | P08069 | IGF1R | Insulin-like growth factor 1 receptor | 1 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P04628 | WNT1 | Proto-oncogene Wnt-1 | 0.829 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P04628 | WNT1 | Proto-oncogene Wnt-1 | 0.703 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Q13635 | PTCH1 | Protein patched homolog 1 | 0.85 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13635 | PTCH1 | Protein patched homolog 1 | 0.836 | | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | P08962 | CD63 | CD63 antigen | -0.782 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P08962 | CD63 | CD63 antigen | -0.862 |
| | Cyclizine | hsa05212 | Pancreatic cancer | 1.72E-02 | 3 | P42338, P42224, O75293 | PIK3CB, STAT1, GADD45B | More | | | Cyclizine | hsa05214 | Glioma | 1.88E-03 | 4 | P08069, P0DP23, P42338, O75293 | IGF1R, CALM1, PIK3CB, GADD45B | More | | | Cyclizine | hsa05215 | Prostate cancer | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa05216 | Thyroid cancer | 3.80E-02 | 2 | P01106, O75293 | MYC, GADD45B | More | | | Cyclizine | hsa05218 | Melanoma | 6.63E-03 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa05223 | Non-small cell lung cancer | 1.39E-02 | 3 | P10826, Q9HC35, O75293 | RARB, EML4, GADD45B | More | | | Cyclizine | hsa05224 | Breast cancer | 1.49E-02 | 1 | P08069 | IGF1R | More | | | Cyclizine | hsa05225 | Hepatocellular carcinoma | 6.30E-04 | 3 | Q92529, P08069, P51531 | SHC3, IGF1R, SMARCA2 | More | | | Cyclizine | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 1.09E-02 | 4 | P07766, P06239, Q9HC35, P01730 | CD3E, LCK, EML4, CD4 | More | | | Cyclizine | hsa05310 | Asthma | 2.81E-02 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Cyclizine | hsa05320 | Autoimmune thyroid disease | 2.92E-05 | 4 | P13765, P29965, P01568, P10747 | HLA-DOB, CD40LG, IFNA21, CD28 | More | | | Cyclizine | hsa05321 | Inflammatory bowel disease | 2.00E-04 | 7 | O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R | More | | | Cyclizine | hsa05322 | Systemic lupus erythematosus | 4.80E-06 | 10 | P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P62807, O60814, P68431 | ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Cyclizine | hsa05323 | Rheumatoid arthritis | 1.29E-02 | 4 | P13765, Q13488, P10747, O60603 | HLA-DOB, TCIRG1, CD28, TLR2 | More | | | Cyclizine | hsa05330 | Allograft rejection | 1.04E-03 | 5 | P13765, P29965, P48023, P10747, P01375 | HLA-DOB, CD40LG, FASLG, CD28, TNF | More | | | Cyclizine | hsa05332 | Graft-versus-host disease | 9.76E-05 | 6 | P13765, P48023, P10747, P01375, P26715, Q13241 | HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1 | More | | | Cyclizine | hsa05340 | Primary immunodeficiency | 1.28E-03 | 4 | P01730, P11912, P07766, P06239 | CD4, CD79A, CD3E, LCK | More | | | Cyclizine | hsa05415 | Diabetic cardiomyopathy | 5.60E-05 | 8 | P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406 | PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P09960 | LTA4H | Leukotriene A-4 hydrolase | P17252 | PRKCA | Protein kinase C alpha type | -0.732 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.798 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.758 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16718 | NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | 0.757 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q16718 | NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | -0.816 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | O14521 | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | 0.732 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | O14521 | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | -0.799 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | -0.744 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P49841 | GSK3B | Glycogen synthase kinase-3 beta | -0.714 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P04406 | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | 0.725 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P17252 | PRKCA | Protein kinase C alpha type | -0.732 | | P17252 | PRKCA | Protein kinase C alpha type | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.821 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.798 | | P17252 | PRKCA | Protein kinase C alpha type | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.836 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.758 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16718 | NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | 0.757 | | P17252 | PRKCA | Protein kinase C alpha type | Q16718 | NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | 0.811 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q16718 | NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | -0.816 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | O14521 | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | 0.732 | | P17252 | PRKCA | Protein kinase C alpha type | O14521 | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | 0.822 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | O14521 | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | -0.799 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | -0.744 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P49841 | GSK3B | Glycogen synthase kinase-3 beta | -0.714 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P04406 | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | 0.725 |
| | Cyclizine | hsa05416 | Viral myocarditis | 2.62E-02 | 3 | P13765, P29965, P10747 | HLA-DOB, CD40LG, CD28 | More | | | Cyclizine | hsa05418 | Fluid shear stress and atherosclerosis | 3.73E-02 | 4 | P42338, P14598, P0DP23, P08238 | PIK3CB, NCF1, CALM1, HSP90AB1 | More | |
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