PharmaCoNets of Cortisone-acetate (SPCN: 101.91 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Cortisone-acetatehsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Cortisone-acetatehsa00071Fatty acid degradation3.77E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Cortisone-acetatehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Cortisone-acetatehsa00500Starch and sucrose metabolism2.10E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Cortisone-acetatehsa00970Aminoacyl-tRNA biosynthesis9.32E-033O95363, P54136, Q15046FARS2, RARS1, KARSMore
Cortisone-acetatehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Cortisone-acetatehsa03013RNA transport8.19E-047Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2More
Cortisone-acetatehsa03040Spliceosome3.98E-024Q15427, P38159, P61978, P11142SF3B4, RBMX, HNRPK, HSPA8More
Cortisone-acetatehsa03060Protein export9.07E-042P37108, Q15005SRP14, SPCS2More
Cortisone-acetatehsa04012ErbB signaling pathway3.74E-023P21860, Q13557, O14944ERBB3, CAMK2D, EREGMore
Cortisone-acetatehsa04020Calcium signaling pathway2.19E-0510Q96DU7, Q08828, P45880, Q13557, P21860, P61073, P0DP24, P05141, P51828, P23634ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, CXCR4, CALM2, SLC25A5, ADCY7, ATP2B4More
Cortisone-acetatehsa04022cGMP-PKG signaling pathway2.45E-038Q99941, P18848, P23634, Q08828, P51828, P05141, P45880, P0DP24CREBL1, ATF4, ATP2B4, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2More
Cortisone-acetatehsa04061Viral protein interaction with cytokine and cytokine receptor1.91E-023Q8NHW4, P61073, Q13651CCL4L2, CXCR4, IL10RAMore
Cortisone-acetatehsa04064NF-kappa B signaling pathway1.06E-0515P10415, Q13489, O00463, Q13546, P01584, Q04759, Q9UDY8, Q16548, Q13315, P63279, P24522, Q8NHW4, P09341, Q9UNE0, Q9NQC7BCL2, BIRC3, TRAF5, RIPK1, IL1B, PRKCQ, MALT1, BCL2A1, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, EDAR, CYLDMore
Cortisone-acetatehsa04071Sphingolipid signaling pathway1.19E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Cortisone-acetatehsa04080Neuroactive ligand-receptor interaction1.23E-0310P08311, P48058, Q15722, P21453, Q9H228, P43657, O00398, P21730, P07550, P35318CTSG, GRIA4, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, C5AR1, ADRB2, ADMMore
Cortisone-acetatehsa04114Oocyte meiosis4.36E-025Q13557, P0DP24, Q08828, P51828, P27348CAMK2D, CALM2, ADCY1, ADCY7, YWHAQMore
Cortisone-acetatehsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Cortisone-acetatehsa04141Protein processing in endoplasmic reticulum3.64E-025Q99941, O75460, P11142, Q9H3Z4, P07900CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Cortisone-acetatehsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Cortisone-acetatehsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Cortisone-acetatehsa04211Longevity regulating pathway3.41E-037Q12778, Q08828, P51828, Q99941, P18848, Q9UEF7, Q96KQ7FOXO1, ADCY1, ADCY7, CREBL1, ATF4, KL, EHMT2More
Cortisone-acetatehsa04217Necroptosis6.23E-0410P01568, P23458, Q13489, Q9NQC7, Q13546, P05141, P01584, P0C0S5, Q13557, Q9H444IFNA21, JAK1, BIRC3, CYLD, RIPK1, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4BMore
Cortisone-acetatehsa04261Adrenergic signaling in cardiomyocytes1.60E-037Q08828, P51828, Q99941, P18848, P0DP24, Q13557, P23634ADCY1, ADCY7, CREBL1, ATF4, CALM2, CAMK2D, ATP2B4More
Cortisone-acetatehsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Cortisone-acetatehsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Cortisone-acetatehsa04380Osteoclast differentiation4.98E-024Q9NQC7, Q9UQC2, P23458, P01584CYLD, GAB2, JAK1, IL1BMore
Cortisone-acetatehsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Cortisone-acetatehsa04613Neutrophil extracellular trap formation4.93E-028O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, P21730TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, C5AR1More
Cortisone-acetatehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Cortisone-acetatehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Cortisone-acetatehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Cortisone-acetatehsa04623Cytosolic DNA-sensing pathway5.86E-054P01584, P01568, Q13546, Q8NHW4IL1B, IFNA21, RIPK1, CCL4L2More
Cortisone-acetatehsa04640Hematopoietic cell lineage1.13E-028P13612, P14778, P27930, P15144, P07766, P09693, P01732, P01730ITGA4, IL1R1, IL1R2, ANPEP, CD3E, CD3G, CD8A, CD4More
Cortisone-acetatehsa04650Natural killer cell mediated cytotoxicity2.11E-049P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Cortisone-acetatehsa04658Th1 and Th2 cell differentiation4.60E-0711Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P13765PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, HLA-DOBMore
Cortisone-acetatehsa04659Th17 cell differentiation1.39E-0511Q04759, Q16539, P01730, P06239, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, CD4, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Cortisone-acetatehsa04660T cell receptor signaling pathway2.30E-0513Q9UDY8, Q04759, P10747, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841MALT1, PRKCQ, CD28, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Cortisone-acetatehsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Cortisone-acetatehsa04713Circadian entrainment1.91E-024P0DP24, Q13557, Q08828, P51828CALM2, CAMK2D, ADCY1, ADCY7More
Cortisone-acetatehsa04720Long-term potentiation1.91E-024Q13557, P0DP24, P18848, Q08828CAMK2D, CALM2, ATF4, ADCY1More
Cortisone-acetatehsa04725Cholinergic synapse3.77E-024Q08828, P51828, P18848, Q13557ADCY1, ADCY7, ATF4, CAMK2DMore
Cortisone-acetatehsa04728Dopaminergic synapse2.67E-025Q99941, P18848, Q13557, P0DP24, O15516CREBL1, ATF4, CAMK2D, CALM2, CLOCKMore
Cortisone-acetatehsa04750Inflammatory mediator regulation of TRP channels4.53E-045P01584, Q08828, P51828, Q13557, P0DP24IL1B, ADCY1, ADCY7, CAMK2D, CALM2More
Cortisone-acetatehsa04911Insulin secretion2.95E-055Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Cortisone-acetatehsa04912GnRH signaling pathway6.99E-035Q08828, P51828, P18848, Q13557, P0DP24ADCY1, ADCY7, ATF4, CAMK2D, CALM2More
Cortisone-acetatehsa04915Estrogen signaling pathway4.72E-024Q99941, P51828, P07900, P11142CREBL1, ADCY7, HSP90AA1, HSPA8More
Cortisone-acetatehsa04916Melanogenesis7.61E-034Q13557, P0DP24, Q08828, P51828CAMK2D, CALM2, ADCY1, ADCY7More
Cortisone-acetatehsa04918Thyroid hormone synthesis4.47E-035Q08828, P51828, Q99941, P18848, P02768ADCY1, ADCY7, CREBL1, ATF4, ALBMore
Cortisone-acetatehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Cortisone-acetatehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Cortisone-acetatehsa04925Aldosterone synthesis and secretion8.00E-067Q99941, P18848, Q08828, P51828, P0DP24, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4More
Cortisone-acetatehsa04927Cortisol synthesis and secretion4.16E-034Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Cortisone-acetatehsa04928Parathyroid hormone synthesis, secretion and action3.92E-038Q14643, Q08828, P51828, P22694, P23771, Q99941, P18848, P10415ITPR1, ADCY1, ADCY7, PRKACB, GATA3, CREBL1, ATF4, BCL2More
Cortisone-acetatehsa04932Non-alcoholic fatty liver disease3.45E-025P18848, O75460, P01584, P12074, O15239ATF4, ERN1, IL1B, COX6A1, NDUFA1More
Cortisone-acetatehsa04934Cushing syndrome2.69E-066Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Cortisone-acetatehsa04935Growth hormone synthesis, secretion and action4.98E-024Q08828, P51828, Q99941, P18848ADCY1, ADCY7, CREBL1, ATF4More
Cortisone-acetatehsa04970Salivary secretion3.54E-023Q08828, P51828, P0DP24ADCY1, ADCY7, CALM2More
Cortisone-acetatehsa04971Gastric acid secretion2.95E-055Q08828, P51828, P15311, P0DP24, Q13557ADCY1, ADCY7, VIL2, CALM2, CAMK2DMore
Cortisone-acetatehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Cortisone-acetatehsa05010Alzheimer disease2.62E-0414Q92542, O15239, P05496, P12074, Q00535, O75460, P0DP24, P01584, P18848, O15169, P05141, P45880, P28070, P43686NCSTN, NDUFA1, ATP5G1, COX6A1, CDK5, ERN1, CALM2, IL1B, ATF4, AXIN1, SLC25A5, VDAC2, PSMB4, PSMC4More
Cortisone-acetatehsa05012Parkinson disease7.90E-039O15239, P12074, P05141, O75460, P18848, P28070, P43686, P0DP24, Q13557NDUFA1, COX6A1, SLC25A5, ERN1, ATF4, PSMB4, PSMC4, CALM2, CAMK2DMore
Cortisone-acetatehsa05016Huntington disease3.54E-028O15239, P12074, P24928, P62487, P05141, O75460, P28070, P43686NDUFA1, COX6A1, POLR2A, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4More
Cortisone-acetatehsa05020Prion disease1.76E-0312P01584, P46531, P11142, O15239, P05496, P12074, P18848, P05141, P45880, P28070, P43686, Q99941IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX6A1, ATF4, SLC25A5, VDAC2, PSMB4, PSMC4, CREBL1More
Cortisone-acetatehsa05022Pathways of neurodegeneration - multiple diseases1.74E-0313O15239, P12074, Q8TEV9, O75460, P18848, P05141, Q00535, O15169, P01584, P0DP24, Q13557, P28070, P43686NDUFA1, COX6A1, SMCR8, ERN1, ATF4, SLC25A5, CDK5, AXIN1, IL1B, CALM2, CAMK2D, PSMB4, PSMC4More
Cortisone-acetatehsa05030Cocaine addiction3.54E-023Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Cortisone-acetatehsa05031Amphetamine addiction7.61E-034P0DP24, Q13557, Q99941, P18848CALM2, CAMK2D, CREBL1, ATF4More
Cortisone-acetatehsa05120Epithelial cell signaling in Helicobacter pylori infection3.76E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Cortisone-acetatehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Cortisone-acetatehsa05135Yersinia infection1.52E-026P13612, P06239, Q16539, P49841, P01730, P01732ITGA4, LCK, MAPK14, GSK3B, CD4, CD8AMore
Cortisone-acetatehsa05146Amoebiasis2.10E-026P09341, P14778, P27930, P05089, P12814, P08311CXCL1, IL1R1, IL1R2, ARG1, ACTN1, CTSGMore
Cortisone-acetatehsa05163Human cytomegalovirus infection2.62E-0410P0DP24, Q8NHW4, Q08828, P51828, P23458, P01584, P61073, Q13651, Q99941, P18848CALM2, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, CXCR4, IL10RA, CREBL1, ATF4More
Cortisone-acetatehsa05202Transcriptional misregulation in cancer2.90E-029Q12778, Q13315, P14780, Q16548, O15550, P05164, P08246, Q9C0K0, P24522FOXO1, ATM, MMP9, BCL2A1, UTX, MPO, ELA2, BCL11B, GADD45AMore
Cortisone-acetatehsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Cortisone-acetatehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Cortisone-acetatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.09E-049P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, P01730CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, CD4More
Cortisone-acetatehsa05321Inflammatory bowel disease1.17E-035O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Cortisone-acetatehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Cortisone-acetatehsa05332Graft-versus-host disease3.45E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Cortisone-acetatehsa05340Primary immunodeficiency3.76E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Cortisone-acetatehsa05415Diabetic cardiomyopathy3.59E-021P11413G6PDMore
Hydrocortisone-acetatehsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Hydrocortisone-acetatehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Hydrocortisone-acetatehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Hydrocortisone-acetatehsa00220Arginine biosynthesis1.94E-033P15104, P05089, P49448GLUL, ARG1, GLUD2More
Hydrocortisone-acetatehsa00250Alanine, aspartate and glutamate metabolism4.32E-022P49448, P15104GLUD2, GLULMore
Hydrocortisone-acetatehsa00480Glutathione metabolism2.60E-055Q9UJ14, P11413, Q16772, P09211, P30041GGTL3, G6PD, GSTA3, GSTP1, PRDX6More
Hydrocortisone-acetatehsa00500Starch and sucrose metabolism2.51E-063O43451, P46976, P06737MGAM, GYG1, PYGLMore
Hydrocortisone-acetatehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Hydrocortisone-acetatehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Hydrocortisone-acetatehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Hydrocortisone-acetatehsa00730Thiamine metabolism5.11E-052P05186, P24666ALPL, ACP1More
Hydrocortisone-acetatehsa00910Nitrogen metabolism4.32E-022P15104, P49448GLUL, GLUD2More
Hydrocortisone-acetatehsa00970Aminoacyl-tRNA biosynthesis1.21E-021P14868DARSMore
Hydrocortisone-acetatehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-054Q16772, P78417, P09211, P11712GSTA3, GSTO1, GSTP1, CYP2C9More
Hydrocortisone-acetatehsa00982Drug metabolism - cytochrome P4501.77E-044P11712, Q16772, P09211, P78417CYP2C9, GSTA3, GSTP1, GSTO1More
Hydrocortisone-acetatehsa00983Drug metabolism - other enzymes8.59E-044P32320, P05164, Q16772, P09211CDA, MPO, GSTA3, GSTP1More
Hydrocortisone-acetatehsa01100Metabolic pathways3.55E-0334Q9NR34, P35790, P05089, Q16772, P09211, Q9UJ14, P30041, P32320, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, Q7KZN9, P05186, P24666, P15121, Q9HCC0, P33121, Q9UHK6, Q86VZ5, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q9BQB6MAN1C1, CHKA, ARG1, GSTA3, GSTP1, GGTL3, PRDX6, CDA, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, COX15, ALPL, ACP1, AKR1B1, MCCC2, ACSL1, AMACR, SGMS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, VKORC1More
Hydrocortisone-acetatehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Hydrocortisone-acetatehsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Hydrocortisone-acetatehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Hydrocortisone-acetatehsa03013RNA transport9.39E-059Q15287, Q9UBU9, P35658, P63279, P68104, P55884, O15371, P20042, Q14232RNPS1, NXF1, NUP214, UBE2I, EEF1A1, EIF3B, EIF3D, EIF2S2, EIF2B1More
Hydrocortisone-acetatehsa03040Spliceosome3.98E-024Q15427, P38159, P61978, P11142SF3B4, RBMX, HNRPK, HSPA8More
Hydrocortisone-acetatehsa03060Protein export9.07E-042P37108, Q15005SRP14, SPCS2More
Hydrocortisone-acetatehsa04012ErbB signaling pathway3.74E-023P21860, Q13557, O14944ERBB3, CAMK2D, EREGMore
Hydrocortisone-acetatehsa04020Calcium signaling pathway2.19E-0510Q96DU7, Q08828, P45880, Q13557, P21860, P61073, P0DP24, P05141, P51828, P23634ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, CXCR4, CALM2, SLC25A5, ADCY7, ATP2B4More
Hydrocortisone-acetatehsa04022cGMP-PKG signaling pathway2.45E-038Q99941, P18848, P23634, Q08828, P51828, P05141, P45880, P0DP24CREBL1, ATF4, ATP2B4, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2More
Hydrocortisone-acetatehsa04061Viral protein interaction with cytokine and cytokine receptor9.15E-049Q8NHW4, P09341, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P01375CCL4L2, CXCL1, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, TNFMore
Hydrocortisone-acetatehsa04062Chemokine signaling pathway3.13E-028P25024, P25025, P07948, P42338, P63218, P50151, P49407, P49841CXCR1, CXCR2, LYN, PIK3CB, GNG5, GNG10, ARRB1, GSK3BMore
Hydrocortisone-acetatehsa04064NF-kappa B signaling pathway1.32E-0618P10415, Q13489, O00463, Q13546, P14778, P01584, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q9UNE0, Q9NQC7BCL2, BIRC3, TRAF5, RIPK1, IL1R1, IL1B, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, EDAR, CYLDMore
Hydrocortisone-acetatehsa04071Sphingolipid signaling pathway7.26E-047P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Hydrocortisone-acetatehsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Hydrocortisone-acetatehsa04114Oocyte meiosis4.36E-025Q13557, P0DP24, Q08828, P51828, P27348CAMK2D, CALM2, ADCY1, ADCY7, YWHAQMore
Hydrocortisone-acetatehsa04120Ubiquitin mediated proteolysis2.57E-024Q14145, Q13042, Q93034, Q15751KEAP1, CDC16, CUL5, HERC1More
Hydrocortisone-acetatehsa04140Autophagy - animal3.05E-036Q9NQL2, P22694, Q14643, P10415, Q9H1Y0, Q04759RRAGD, PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Hydrocortisone-acetatehsa04141Protein processing in endoplasmic reticulum5.75E-037Q99941, O75460, P17861, P11142, Q9H3Z4, P07900, Q9NR31CREBL1, ERN1, XBP1, HSPA8, DNAJC5, HSP90AA1, SAR1AMore
Hydrocortisone-acetatehsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Hydrocortisone-acetatehsa04150mTOR signaling pathway2.72E-024P42338, Q9NQL2, Q13322, P49841PIK3CB, RRAGD, GRB10, GSK3BMore
Hydrocortisone-acetatehsa04210Apoptosis4.11E-039Q13315, P10415, O76075, P01375, Q9NR28, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ITPR1More
Hydrocortisone-acetatehsa04211Longevity regulating pathway3.41E-037Q12778, Q08828, P51828, Q99941, P18848, Q9UEF7, Q96KQ7FOXO1, ADCY1, ADCY7, CREBL1, ATF4, KL, EHMT2More
Hydrocortisone-acetatehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Hydrocortisone-acetatehsa04217Necroptosis6.23E-0410P01568, P23458, Q13489, Q9NQC7, Q13546, P05141, P01584, P0C0S5, Q13557, Q9H444IFNA21, JAK1, BIRC3, CYLD, RIPK1, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4BMore
Hydrocortisone-acetatehsa04261Adrenergic signaling in cardiomyocytes1.60E-037Q08828, P51828, Q99941, P18848, P0DP24, Q13557, P23634ADCY1, ADCY7, CREBL1, ATF4, CALM2, CAMK2D, ATP2B4More
Hydrocortisone-acetatehsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Hydrocortisone-acetatehsa04340Hedgehog signaling pathway2.61E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Hydrocortisone-acetatehsa04380Osteoclast differentiation6.08E-0310Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P42338, P01584, P14778, O75015, Q8N149CYLD, GAB2, MAPK14, JAK1, LCK, PIK3CB, IL1B, IL1R1, FCGR3B, LILRA2More
Hydrocortisone-acetatehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Hydrocortisone-acetatehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Hydrocortisone-acetatehsa04612Antigen processing and presentation9.00E-059P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P30511, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, HLA-F, TNFMore
Hydrocortisone-acetatehsa04613Neutrophil extracellular trap formation1.04E-0519P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, O43315, Q16539ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, AQP9, MAPK14More
Hydrocortisone-acetatehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Hydrocortisone-acetatehsa04621NOD-like receptor signaling pathway4.42E-0518Q16539, Q14643, P52630, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, Q13546, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838MAPK14, ITPR1, STAT2, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Hydrocortisone-acetatehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Hydrocortisone-acetatehsa04623Cytosolic DNA-sensing pathway5.86E-054P01584, P01568, Q13546, Q8NHW4IL1B, IFNA21, RIPK1, CCL4L2More
Hydrocortisone-acetatehsa04625C-type lectin receptor signaling pathway2.17E-023P52630, P20749, P01375STAT2, BCL3, TNFMore
Hydrocortisone-acetatehsa04640Hematopoietic cell lineage1.10E-029P13612, P14778, P27930, P15144, P25063, P09693, P01732, P13765, P01375ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Hydrocortisone-acetatehsa04650Natural killer cell mediated cytotoxicity3.18E-059P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Hydrocortisone-acetatehsa04657IL-17 signaling pathway3.07E-057O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Hydrocortisone-acetatehsa04658Th1 and Th2 cell differentiation2.17E-0812Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3More
Hydrocortisone-acetatehsa04659Th17 cell differentiation8.69E-0611Q04759, Q16539, P01730, P06239, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, CD4, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Hydrocortisone-acetatehsa04660T cell receptor signaling pathway2.32E-0616P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Hydrocortisone-acetatehsa04662B cell receptor signaling pathway2.80E-036P49841, P42338, P60033, P07948, P21854, Q8N149GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2More
Hydrocortisone-acetatehsa04664Fc epsilon RI signaling pathway1.80E-024Q16539, P42338, P07948, P09917MAPK14, PIK3CB, LYN, ALOX5More
Hydrocortisone-acetatehsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Hydrocortisone-acetatehsa04713Circadian entrainment1.91E-024P0DP24, Q13557, Q08828, P51828CALM2, CAMK2D, ADCY1, ADCY7More
Hydrocortisone-acetatehsa04720Long-term potentiation1.91E-024Q13557, P0DP24, P18848, Q08828CAMK2D, CALM2, ATF4, ADCY1More
Hydrocortisone-acetatehsa04723Retrograde endocannabinoid signaling3.86E-024P63218, P50151, P48058, Q16539GNG5, GNG10, GRIA4, MAPK14More
Hydrocortisone-acetatehsa04724Glutamatergic synapse7.09E-035P48058, P43003, P63218, P50151, P15104GRIA4, SLC1A3, GNG5, GNG10, GLULMore
Hydrocortisone-acetatehsa04725Cholinergic synapse3.77E-024Q08828, P51828, P18848, Q13557ADCY1, ADCY7, ATF4, CAMK2DMore
Hydrocortisone-acetatehsa04728Dopaminergic synapse1.73E-0311P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407, P0DP24, O15516, P48058GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, CALM2, CLOCK, GRIA4More
Hydrocortisone-acetatehsa04750Inflammatory mediator regulation of TRP channels7.58E-0510P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, Q14643, Q04759, P0DP24IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, ITPR1, PRKCQ, CALM2More
Hydrocortisone-acetatehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Hydrocortisone-acetatehsa04911Insulin secretion2.95E-055Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Hydrocortisone-acetatehsa04912GnRH signaling pathway6.99E-035Q08828, P51828, P18848, Q13557, P0DP24ADCY1, ADCY7, ATF4, CAMK2D, CALM2More
Hydrocortisone-acetatehsa04915Estrogen signaling pathway4.72E-024Q99941, P51828, P07900, P11142CREBL1, ADCY7, HSP90AA1, HSPA8More
Hydrocortisone-acetatehsa04916Melanogenesis7.61E-034Q13557, P0DP24, Q08828, P51828CAMK2D, CALM2, ADCY1, ADCY7More
Hydrocortisone-acetatehsa04918Thyroid hormone synthesis4.47E-035Q08828, P51828, Q99941, P18848, P02768ADCY1, ADCY7, CREBL1, ATF4, ALBMore
Hydrocortisone-acetatehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Hydrocortisone-acetatehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Hydrocortisone-acetatehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Hydrocortisone-acetatehsa04925Aldosterone synthesis and secretion8.00E-067Q99941, P18848, Q08828, P51828, P0DP24, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4More
Hydrocortisone-acetatehsa04927Cortisol synthesis and secretion4.16E-034Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Hydrocortisone-acetatehsa04928Parathyroid hormone synthesis, secretion and action3.92E-038Q14643, Q08828, P51828, P22694, P23771, Q99941, P18848, P10415ITPR1, ADCY1, ADCY7, PRKACB, GATA3, CREBL1, ATF4, BCL2More
Hydrocortisone-acetatehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Hydrocortisone-acetatehsa04932Non-alcoholic fatty liver disease3.45E-025P18848, O75460, P01584, P12074, O15239ATF4, ERN1, IL1B, COX6A1, NDUFA1More
Hydrocortisone-acetatehsa04934Cushing syndrome2.69E-066Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Hydrocortisone-acetatehsa04935Growth hormone synthesis, secretion and action4.98E-024Q08828, P51828, Q99941, P18848ADCY1, ADCY7, CREBL1, ATF4More
Hydrocortisone-acetatehsa04940Type I diabetes mellitus1.58E-022P30511, P01375HLA-F, TNFMore
Hydrocortisone-acetatehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Hydrocortisone-acetatehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Hydrocortisone-acetatehsa04970Salivary secretion3.54E-023Q08828, P51828, P0DP24ADCY1, ADCY7, CALM2More
Hydrocortisone-acetatehsa04971Gastric acid secretion2.95E-055Q08828, P51828, P15311, P0DP24, Q13557ADCY1, ADCY7, VIL2, CALM2, CAMK2DMore
Hydrocortisone-acetatehsa04973Carbohydrate digestion and absorption1.57E-022O43451, P42338MGAM, PIK3CBMore
Hydrocortisone-acetatehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Hydrocortisone-acetatehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Hydrocortisone-acetatehsa05010Alzheimer disease2.56E-0517Q92542, O15239, P05496, Q06055, P12074, Q00535, O75460, P0DP24, P01584, P18848, O15169, P05141, P45880, P17861, P28070, P43686, P62195NCSTN, NDUFA1, ATP5G1, ATP5G2, COX6A1, CDK5, ERN1, CALM2, IL1B, ATF4, AXIN1, SLC25A5, VDAC2, XBP1, PSMB4, PSMC4, PSMC5More
Hydrocortisone-acetatehsa05012Parkinson disease5.28E-0412O15239, P12074, Q06055, P05141, O75460, P18848, P17861, P28070, P43686, P62195, P0DP24, Q13557NDUFA1, COX6A1, ATP5G2, SLC25A5, ERN1, ATF4, XBP1, PSMB4, PSMC4, PSMC5, CALM2, CAMK2DMore
Hydrocortisone-acetatehsa05014Amyotrophic lateral sclerosis1.01E-023Q06055, P17861, P62195ATP5G2, XBP1, PSMC5More
Hydrocortisone-acetatehsa05016Huntington disease3.54E-028O15239, P12074, P24928, P62487, P05141, O75460, P28070, P43686NDUFA1, COX6A1, POLR2A, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4More
Hydrocortisone-acetatehsa05017Spinocerebellar ataxia1.42E-022P17861, P62195XBP1, PSMC5More
Hydrocortisone-acetatehsa05020Prion disease1.76E-0312P01584, P46531, P11142, O15239, P05496, P12074, P18848, P05141, P45880, P28070, P43686, Q99941IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX6A1, ATF4, SLC25A5, VDAC2, PSMB4, PSMC4, CREBL1More
Hydrocortisone-acetatehsa05022Pathways of neurodegeneration - multiple diseases2.12E-0416O15239, P12074, Q06055, Q8TEV9, O75460, P18848, P17861, P05141, Q00535, O15169, P01584, P0DP24, Q13557, P28070, P43686, P62195NDUFA1, COX6A1, ATP5G2, SMCR8, ERN1, ATF4, XBP1, SLC25A5, CDK5, AXIN1, IL1B, CALM2, CAMK2D, PSMB4, PSMC4, PSMC5More
Hydrocortisone-acetatehsa05030Cocaine addiction3.54E-023Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Hydrocortisone-acetatehsa05031Amphetamine addiction7.61E-034P0DP24, Q13557, Q99941, P18848CALM2, CAMK2D, CREBL1, ATF4More
Hydrocortisone-acetatehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Hydrocortisone-acetatehsa05120Epithelial cell signaling in Helicobacter pylori infection1.61E-035Q16539, P09341, P25024, P25025, P07948MAPK14, CXCL1, CXCR1, CXCR2, LYNMore
Hydrocortisone-acetatehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Hydrocortisone-acetatehsa05133Pertussis4.20E-021P0C0L4C4AMore
Hydrocortisone-acetatehsa05134Legionellosis5.53E-032Q9NR31, P68104SAR1A, EEF1A1More
Hydrocortisone-acetatehsa05135Yersinia infection1.11E-038P13612, P06239, Q16539, P01375, P42338, P49841, P01730, P01732ITGA4, LCK, MAPK14, TNF, PIK3CB, GSK3B, CD4, CD8AMore
Hydrocortisone-acetatehsa05140Leishmaniasis1.99E-037P13612, O75015, P13765, O60603, P01375, P49006, Q16539ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MARCKSL1, MAPK14More
Hydrocortisone-acetatehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Hydrocortisone-acetatehsa05144Malaria9.96E-057P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Hydrocortisone-acetatehsa05146Amoebiasis1.14E-049P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSGMore
Hydrocortisone-acetatehsa05150Staphylococcus aureus infection1.02E-037P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Hydrocortisone-acetatehsa05160Hepatitis C9.27E-034P52630, P60033, P49841, P01375STAT2, CD81, GSK3B, TNFMore
Hydrocortisone-acetatehsa05163Human cytomegalovirus infection1.21E-0722P42338, P01375, P63218, P50151, Q14643, P0DP24, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463PIK3CB, TNF, GNG5, GNG10, ITPR1, CALM2, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5More
Hydrocortisone-acetatehsa05165Human papillomavirus infection1.76E-025P49841, P24821, P01375, P52630, P30511GSK3B, TNC, TNF, STAT2, HLA-FMore
Hydrocortisone-acetatehsa05169Epstein-Barr virus infection2.32E-029Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, P07766, P20963HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, CD3E, CD247More
Hydrocortisone-acetatehsa05202Transcriptional misregulation in cancer4.24E-0416Q12778, Q13315, P14780, P27930, Q15744, Q16548, P11215, O15550, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522FOXO1, ATM, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, UTX, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45AMore
Hydrocortisone-acetatehsa05203Viral carcinogenesis2.10E-048Q12933, P42229, Q13547, Q15283, P58876, P62807, Q16778, O60814TRAF2, STAT5A, HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Hydrocortisone-acetatehsa05204Chemical carcinogenesis1.77E-044Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Hydrocortisone-acetatehsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Hydrocortisone-acetatehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Hydrocortisone-acetatehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Hydrocortisone-acetatehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Hydrocortisone-acetatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer7.43E-0611P42338, O95267, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, P01730PIK3CB, RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, CD4More
Hydrocortisone-acetatehsa05310Asthma5.14E-043P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Hydrocortisone-acetatehsa05321Inflammatory bowel disease3.54E-066O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Hydrocortisone-acetatehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Hydrocortisone-acetatehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Hydrocortisone-acetatehsa05330Allograft rejection2.30E-022P30511, P01375HLA-F, TNFMore
Hydrocortisone-acetatehsa05332Graft-versus-host disease1.82E-056P13765, P30511, P10747, P01375, P26715, Q13241HLA-DOB, HLA-F, CD28, TNF, KLRC1, KLRD1More
Hydrocortisone-acetatehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Hydrocortisone-acetatehsa05415Diabetic cardiomyopathy3.59E-021P11413G6PDMore
Hydrocortisone-acetatehsa05418Fluid shear stress and atherosclerosis3.86E-038Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2More

Community members of Cortisone-acetate (SDC: 5.49)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)