PharmaCoNets of Copanlisib (SPCN: 49.36 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Copanlisibhsa00040Pentose and glucuronate interconversions4.00E-021P15121AKR1B1More
Copanlisibhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Copanlisibhsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Copanlisibhsa00600Sphingolipid metabolism2.77E-023Q9BX95, Q8TCT0, P15289SGPP1, CERK, ARSAMore
Copanlisibhsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Copanlisibhsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Copanlisibhsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Copanlisibhsa00790Folate biosynthesis2.02E-021P15121AKR1B1More
Copanlisibhsa00980Metabolism of xenobiotics by cytochrome P4504.00E-021P09211GSTP1More
Copanlisibhsa00983Drug metabolism - other enzymes1.64E-023P04183, P32320, P05164TK1, CDA, MPOMore
Copanlisibhsa01040Biosynthesis of unsaturated fatty acids2.92E-022P22307, Q9H5J4SCP2, ELOVL6More
Copanlisibhsa01522Endocrine resistance4.48E-024P22694, Q02750, Q9UM47, P46527PRKACB, MAP2K1, NOTCH3, CDKN1BMore
Copanlisibhsa01524Platinum drug resistance4.78E-021P31751AKT2More
Copanlisibhsa03010Ribosome2.25E-045P40429, Q07020, P27635, P05386, P62249RPL13A, RPL18, RPL10, RPLP1, RPS16More
Copanlisibhsa03040Spliceosome4.19E-025Q14562, O60508, P08579, Q01130, O43447DHX8, CDC40, SNRPB2, SFRS2, PPIHMore
Copanlisibhsa04014Ras signaling pathway5.91E-038Q02750, P31751, Q15389, P17252, P21359, P0DP23, P62879, P22694MAP2K1, AKT2, ANGPT1, PRKCA, NF1, CALM1, GNB2, PRKACBMore
Copanlisibhsa04015Rap1 signaling pathway6.14E-032P31751, P0DP23AKT2, CALM1More
Copanlisibhsa04022cGMP-PKG signaling pathway5.07E-032P31751, P0DP23AKT2, CALM1More
Copanlisibhsa04024cAMP signaling pathway3.23E-032P31751, P0DP23AKT2, CALM1More
Copanlisibhsa04060Cytokine-cytokine receptor interaction4.71E-022P78552, O75509IL13RA1, TNFRSF21More
Copanlisibhsa04066HIF-1 signaling pathway4.48E-024P17252, Q15389, Q02750, P46527PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Copanlisibhsa04072Phospholipase D signaling pathway9.70E-032Q92529, Q14344SHC3, GNA13More
Copanlisibhsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Copanlisibhsa04218Cellular senescence3.65E-032P31751, P0DP23AKT2, CALM1More
Copanlisibhsa04261Adrenergic signaling in cardiomyocytes4.57E-032P31751, P0DP23AKT2, CALM1More
Copanlisibhsa04370VEGF signaling pathway3.60E-021P31751AKT2More
Copanlisibhsa04371Apelin signaling pathway3.23E-032P31751, P0DP23AKT2, CALM1More
Copanlisibhsa04380Osteoclast differentiation2.72E-048Q9NQC7, Q9UQC2, Q16539, P31751, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, AKT2, IL1R1, FCGR3B, TNF, LILRA2More
Copanlisibhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Copanlisibhsa04540Gap junction2.03E-024P17252, P22694, P68371, Q02750PRKCA, PRKACB, TUBB2C, MAP2K1More
Copanlisibhsa04620Toll-like receptor signaling pathway4.78E-021P31751AKT2More
Copanlisibhsa04622RIG-I-like receptor signaling pathway1.81E-021Q9NQC7CYLDMore
Copanlisibhsa04625C-type lectin receptor signaling pathway2.27E-047Q9ULY5, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Copanlisibhsa04657IL-17 signaling pathway1.36E-025O00463, Q16539, P49841, P14780, P01375TRAF5, MAPK14, GSK3B, MMP9, TNFMore
Copanlisibhsa04662B cell receptor signaling pathway1.60E-046P31751, P42338, P60033, P07948, P21854, Q8N149AKT2, PIK3CB, CD81, LYN, CD72, LILRA2More
Copanlisibhsa04664Fc epsilon RI signaling pathway5.75E-047P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P09917TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, ALOX5More
Copanlisibhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Copanlisibhsa04720Long-term potentiation1.25E-036P17252, Q15418, P51812, P18848, P22694, Q02750PRKCA, RPS6KA1, RPS6KA3, ATF4, PRKACB, MAP2K1More
Copanlisibhsa04722Neurotrophin signaling pathway2.83E-032P31751, P0DP23AKT2, CALM1More
Copanlisibhsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Copanlisibhsa04725Cholinergic synapse2.59E-037P22694, P17252, P62879, P63218, P50151, P42338, Q02750PRKACB, PRKCA, GNB2, GNG5, GNG10, PIK3CB, MAP2K1More
Copanlisibhsa04726Serotonergic synapse2.43E-024P22694, P17252, P62879, Q02750PRKACB, PRKCA, GNB2, MAP2K1More
Copanlisibhsa04727GABAergic synapse1.08E-037P62879, P63218, P50151, P15104, P22694, O60296, P17252GNB2, GNG5, GNG10, GLUL, PRKACB, TRAK2, PRKCAMore
Copanlisibhsa04728Dopaminergic synapse3.23E-032P31751, P0DP23AKT2, CALM1More
Copanlisibhsa04730Long-term depression3.52E-021Q14344GNA13More
Copanlisibhsa04740Olfactory transduction2.41E-021P0DP23CALM1More
Copanlisibhsa04744Phototransduction1.81E-021P0DP23CALM1More
Copanlisibhsa04910Insulin signaling pathway9.82E-042P0DP23, P31751CALM1, AKT2More
Copanlisibhsa04915Estrogen signaling pathway5.07E-032P31751, P0DP23AKT2, CALM1More
Copanlisibhsa04916Melanogenesis4.78E-021P0DP23CALM1More
Copanlisibhsa04917Prolactin signaling pathway2.41E-021P31751AKT2More
Copanlisibhsa04918Thyroid hormone synthesis4.48E-022P18848, P05543ATF4, SERPINA7More
Copanlisibhsa04919Thyroid hormone signaling pathway2.22E-025P17252, Q02750, P22694, Q12778, Q9UM47PRKCA, MAP2K1, PRKACB, FOXO1, NOTCH3More
Copanlisibhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Copanlisibhsa04922Glucagon signaling pathway1.79E-032P31751, P0DP23AKT2, CALM1More
Copanlisibhsa04923Regulation of lipolysis in adipocytes3.01E-021P31751AKT2More
Copanlisibhsa04924Renin secretion3.01E-021P0DP23CALM1More
Copanlisibhsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P49407PIK3CB, GNG5, GNG10, VEGFC, ARRB1More
Copanlisibhsa04928Parathyroid hormone synthesis, secretion and action4.48E-024P22694, Q02750, P17252, Q9Y5Q3PRKACB, MAP2K1, PRKCA, MAFBMore
Copanlisibhsa04929GnRH secretion3.61E-033P42338, P31751, P49407PIK3CB, AKT2, ARRB1More
Copanlisibhsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Copanlisibhsa04970Salivary secretion9.00E-034P22694, P17252, P0DP23, P49913PRKACB, PRKCA, CALM1, CAMPMore
Copanlisibhsa04971Gastric acid secretion4.78E-021P0DP23CALM1More
Copanlisibhsa04973Carbohydrate digestion and absorption2.41E-021P31751AKT2More
Copanlisibhsa05010Alzheimer disease5.38E-047P13073, Q00535, P0DP23, P18848, P67870, P31751, P05141COX4I1, CDK5, CALM1, ATF4, CSNK2B, AKT2, SLC25A5More
Copanlisibhsa05020Prion disease3.29E-024P13073, P18848, P05141, P67870COX4I1, ATF4, SLC25A5, CSNK2BMore
Copanlisibhsa05022Pathways of neurodegeneration - multiple diseases1.60E-034Q06055, Q00535, O15020, P0DP23ATP5G2, CDK5, SPTBN2, CALM1More
Copanlisibhsa05030Cocaine addiction4.19E-021Q00535CDK5More
Copanlisibhsa05031Amphetamine addiction4.78E-021P0DP23CALM1More
Copanlisibhsa05130Pathogenic Escherichia coli infection4.08E-023Q15438, P35579, P55061PSCD1, MYH9, TEGTMore
Copanlisibhsa05152Tuberculosis9.92E-032P0DP23, P31751CALM1, AKT2More
Copanlisibhsa05163Human cytomegalovirus infection8.39E-038P31751, P01375, P0DP23, P49841, P14778, P25025, Q16539, O00463AKT2, TNF, CALM1, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Copanlisibhsa05165Human papillomavirus infection4.71E-0310P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATMMore
Copanlisibhsa05167Kaposi sarcoma-associated herpesvirus infection5.07E-032P31751, P0DP23AKT2, CALM1More
Copanlisibhsa05169Epstein-Barr virus infection3.72E-026Q13547, P42338, P07948, Q13761, O75293, P07766HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3EMore
Copanlisibhsa05170Human immunodeficiency virus 1 infection6.71E-032P31751, P0DP23AKT2, CALM1More
Copanlisibhsa05171Coronavirus disease - COVID-193.87E-045P62249, P40429, P27635, Q07020, P05386RPS16, RPL13A, RPL10, RPL18, RPLP1More
Copanlisibhsa05200Pathways in cancer3.07E-022P31751, P0DP23AKT2, CALM1More
Copanlisibhsa05202Transcriptional misregulation in cancer3.76E-027Q12778, Q13315, Q15744, P46527, P05164, P08246, Q9C0K0FOXO1, ATM, CEBPE, CDKN1B, MPO, ELA2, BCL11BMore
Copanlisibhsa05204Chemical carcinogenesis4.00E-021P09211GSTP1More
Copanlisibhsa05206MicroRNAs in cancer3.66E-026P46527, Q9UM47, P16070, Q13315, P17252, Q02750CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1More
Copanlisibhsa05211Renal cell carcinoma4.78E-021P31751AKT2More
Copanlisibhsa05212Pancreatic cancer4.78E-021P31751AKT2More
Copanlisibhsa05213Endometrial cancer3.60E-021P31751AKT2More
Copanlisibhsa05214Glioma5.75E-042P0DP23, P31751CALM1, AKT2More
Copanlisibhsa05218Melanoma3.01E-021P31751AKT2More
Copanlisibhsa05220Chronic myeloid leukemia4.19E-021P31751AKT2More
Copanlisibhsa05221Acute myeloid leukemia4.19E-021P31751AKT2More
Copanlisibhsa05222Small cell lung cancer4.78E-021P31751AKT2More
Copanlisibhsa05223Non-small cell lung cancer2.41E-021P31751AKT2More
Copanlisibhsa05225Hepatocellular carcinoma1.85E-022Q92529, P51531SHC3, SMARCA2More
Copanlisibhsa05226Gastric cancer3.60E-021P31751AKT2More
Copanlisibhsa05230Central carbon metabolism in cancer4.78E-021P31751AKT2More
Copanlisibhsa05418Fluid shear stress and atherosclerosis6.43E-059Q16539, P31751, Q14145, P10599, P14780, P01375, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2, CALM1More

Community members of Copanlisib (SDC: 4.34)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P09211GSTP1Glutathione SNonetransferase PPredicted00.32040.35230.45661.3213
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)