| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Cocaine | hsa00020 | Citrate cycle (TCA cycle) | 3.41E-02 | 2 | P50213, O14521 | IDH3A, SDHD | More | | | Cocaine | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Cocaine | hsa00190 | Oxidative phosphorylation | 4.50E-06 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Cocaine | hsa00230 | Purine metabolism | 2.11E-02 | 3 | Q7LG56, P31350, P21589 | RRM2B, RRM2, NT5E | More | | | Cocaine | hsa00240 | Pyrimidine metabolism | 1.86E-06 | 5 | Q7LG56, P31350, P21589, P04183, P04818 | RRM2B, RRM2, NT5E, TK1, TYMS | More | | | Cocaine | hsa00480 | Glutathione metabolism | 3.85E-02 | 2 | Q7LG56, P31350 | RRM2B, RRM2 | More | | | Cocaine | hsa00565 | Ether lipid metabolism | 4.93E-02 | 1 | Q8N661 | TMEM86B | More | | | Cocaine | hsa00604 | Glycosphingolipid biosynthesis - ganglio series | 2.87E-03 | 3 | P06865, O15466, Q9H4F1 | HEXA, ST8SIA5, ST6GALNAC4 | More | | | Cocaine | hsa00770 | Pantothenate and CoA biosynthesis | 1.15E-02 | 2 | O95498, Q9NRN7 | VNN2, AASDHPPT | More | | | Cocaine | hsa00830 | Retinol metabolism | 3.49E-02 | 1 | P00325 | ADH1B | More | | | Cocaine | hsa00983 | Drug metabolism - other enzymes | 6.98E-05 | 4 | P04183, Q7LG56, P31350, P05164 | TK1, RRM2B, RRM2, MPO | More | | | Cocaine | hsa01230 | Biosynthesis of amino acids | 3.91E-02 | 3 | P51854, Q99707, P50213 | TKTL1, MTR, IDH3A | More | | | Cocaine | hsa01240 | Biosynthesis of cofactors | 2.52E-02 | 2 | Q9BQB6, P14550 | VKORC1, AKR1A1 | More | | | Cocaine | hsa02010 | ABC transporters | 2.17E-03 | 3 | P45844, P08183, Q8IZY2 | ABCG1, ABCB1, ABCA7 | More | | | Cocaine | hsa03008 | Ribosome biogenesis in eukaryotes | 8.16E-03 | 3 | Q9NYH9, P78345, Q9GZY0 | UTP6, RPP38, NXF2; NXF2B | More | | | Cocaine | hsa03015 | mRNA surveillance pathway | 3.37E-02 | 3 | O43148, Q9GZY0, P52298 | RNMT, NXF2; NXF2B, NCBP2 | More | | | Cocaine | hsa03022 | Basal transcription factors | 3.32E-02 | 2 | O00268, Q15544 | TAF4, TAF11 | More | | | Cocaine | hsa03040 | Spliceosome | 6.29E-03 | 7 | Q14562, O43143, O75940, O75494, Q07955, Q13243, O75643 | DHX8, DHX15, SMNDC1, FUSIP1, SFRS1, SFRS5, ASCC3L1 | More | | | Cocaine | hsa03050 | Proteasome | 4.83E-02 | 1 | P55036 | PSMD4 | More | | | Cocaine | hsa03410 | Base excision repair | 2.52E-02 | 2 | P49005, P29372 | POLD2, MPG | More | | | Cocaine | hsa04010 | MAPK signaling pathway | 1.53E-02 | 2 | Q9H2K8, Q12933 | TAOK3, TRAF2 | More | | | Cocaine | hsa04012 | ErbB signaling pathway | 3.69E-02 | 3 | P16333, P19174, P01106 | NCK1, PLCG1, MYC | More | | | Cocaine | hsa04014 | Ras signaling pathway | 4.65E-02 | 3 | Q15311, P0DP23, P17612 | RALBP1, CALM1, PRKACA | More | | | Cocaine | hsa04064 | NF-kappa B signaling pathway | 1.34E-03 | 8 | P10415, Q13489, Q13546, P29965, Q9UDY8, Q8WV28, Q13315, Q9UNE0 | BCL2, BIRC3, RIPK1, CD40LG, MALT1, BLNK, ATM, EDAR | More | | | Cocaine | hsa04070 | Phosphatidylinositol signaling system | 1.90E-03 | 7 | P19174, P0DP23, Q14643, P23743, P49619, P27987, P17252 | PLCG1, CALM1, ITPR1, DGKA, DGKG, ITPKB, PRKCA | More | | | Cocaine | hsa04071 | Sphingolipid signaling pathway | 4.58E-03 | 6 | P17252, Q13362, Q9BX95, P10415, Q12933, Q02156 | PRKCA, PPP2R5C, SGPP1, BCL2, TRAF2, PRKCE | More | | | Cocaine | hsa04114 | Oocyte meiosis | 2.15E-02 | 3 | P0DP23, P17612, Q13362 | CALM1, PRKACA, PPP2R5C | More | | | Cocaine | hsa04115 | p53 signaling pathway | 1.74E-03 | 4 | Q7LG56, P31350, Q9HA38, P04637 | RRM2B, RRM2, ZMAT3, TP53 | More | | | Cocaine | hsa04120 | Ubiquitin mediated proteolysis | 3.44E-02 | 4 | Q14145, Q13042, P62837, Q15751 | KEAP1, CDC16, UBE2D2, HERC1 | More | | | Cocaine | hsa04144 | Endocytosis | 4.07E-03 | 5 | Q9H444, O75351, P42566, Q15438, Q14161 | CHMP4B, VPS4B, EPS15, PSCD1, GIT2 | More | | | Cocaine | hsa04145 | Phagosome | 1.59E-03 | 7 | Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765 | NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOB | More | | | Cocaine | hsa04151 | PI3K-Akt signaling pathway | 4.50E-02 | 9 | P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252 | F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCA | More | | | Cocaine | hsa04211 | Longevity regulating pathway | 1.18E-02 | 3 | Q12778, Q9UEF7, Q96KQ7 | FOXO1, KL, EHMT2 | More | | | Cocaine | hsa04213 | Longevity regulating pathway - multiple species | 2.85E-02 | 2 | Q9Y4H2, Q13547 | IRS2, HDAC1 | More | | | Cocaine | hsa04217 | Necroptosis | 1.73E-06 | 16 | P01375, P01568, P23458, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, Q6FI13, Q99878, P10415, Q9H444, O43633, O75351, Q08752 | TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, H2AC18; H2AC19, H2AC14, BCL2, CHMP4B, CHMP2A, VPS4B, PPID | More | | | Cocaine | hsa04261 | Adrenergic signaling in cardiomyocytes | 3.44E-03 | 6 | P09493, P17612, Q13362, P0DP23, P17252, P10415 | TPM1, PRKACA, PPP2R5C, CALM1, PRKCA, BCL2 | More | | | Cocaine | hsa04360 | Axon guidance | 4.39E-02 | 4 | P16333, P20827, O95631, P19174 | NCK1, EFNA1, NTN1, PLCG1 | More | | | Cocaine | hsa04540 | Gap junction | 1.29E-02 | 4 | P17252, Q13509, P68371, Q14643 | PRKCA, TUBB3, TUBB2C, ITPR1 | More | | | Cocaine | hsa04610 | Complement and coagulation cascades | 6.23E-06 | 1 | P0C0L4 | C4A | More | | | Cocaine | hsa04613 | Neutrophil extracellular trap formation | 1.84E-05 | 19 | P19174, P17252, P11215, O60603, P08246, Q13547, P04908, Q6FI13, Q93077, P62807, P58876, Q16778, O60814, P68431, P14598, Q15080, P21462, O43315, Q16539 | PLCG1, PRKCA, ITGAM, TLR2, ELA2, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14 | More | | | Cocaine | hsa04620 | Toll-like receptor signaling pathway | 4.16E-02 | 2 | Q13546, P01568 | RIPK1, IFNA21 | More | | | Cocaine | hsa04621 | NOD-like receptor signaling pathway | 4.72E-02 | 3 | P01568, Q13489, Q13546 | IFNA21, BIRC3, RIPK1 | More | | | Cocaine | hsa04622 | RIG-I-like receptor signaling pathway | 1.28E-03 | 3 | P01568, Q13546, Q12933 | IFNA21, RIPK1, TRAF2 | More | | | Cocaine | hsa04623 | Cytosolic DNA-sensing pathway | 2.20E-03 | 2 | P01568, Q13546 | IFNA21, RIPK1 | More | | | Cocaine | hsa04672 | Intestinal immune network for IgA production | 3.76E-03 | 3 | P29965, P10747, P13765 | CD40LG, CD28, HLA-DOB | More | | | Cocaine | hsa04713 | Circadian entrainment | 3.30E-03 | 5 | P0DP23, P17252, P62873, Q14643, P17612 | CALM1, PRKCA, GNB1, ITPR1, PRKACA | More | | | Cocaine | hsa04714 | Thermogenesis | 5.21E-03 | 4 | Q16539, P33121, Q16718, O14521 | MAPK14, ACSL1, NDUFA5, SDHD | More | | | Cocaine | hsa04720 | Long-term potentiation | 6.75E-03 | 4 | P17252, P0DP23, P17612, Q14643 | PRKCA, CALM1, PRKACA, ITPR1 | More | | | Cocaine | hsa04721 | Synaptic vesicle cycle | 1.80E-02 | 2 | Q13488, P31645 | TCIRG1, SLC6A4 | More | | | Cocaine | hsa04722 | Neurotrophin signaling pathway | 3.27E-02 | 3 | P49841, O43524, P48023 | GSK3B, FOXO3, FASLG | More | | | Cocaine | hsa04723 | Retrograde endocannabinoid signaling | 1.88E-02 | 4 | Q14643, P17252, P62873, Q16718 | ITPR1, PRKCA, GNB1, NDUFA5 | More | | | Cocaine | hsa04725 | Cholinergic synapse | 1.88E-02 | 4 | Q14643, P17252, P62873, P10415 | ITPR1, PRKCA, GNB1, BCL2 | More | | | Cocaine | hsa04728 | Dopaminergic synapse | 2.36E-03 | 6 | P17612, Q14643, P17252, P62873, Q13362, P0DP23 | PRKACA, ITPR1, PRKCA, GNB1, PPP2R5C, CALM1 | More | | | Cocaine | hsa04740 | Olfactory transduction | 6.71E-03 | 2 | P0DP23, P17612 | CALM1, PRKACA | More | | | Cocaine | hsa04744 | Phototransduction | 7.74E-05 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Cocaine | hsa04910 | Insulin signaling pathway | 3.62E-02 | 2 | P0DP23, P17612 | CALM1, PRKACA | More | | | Cocaine | hsa04912 | GnRH signaling pathway | 3.89E-02 | 3 | P17252, Q14643, P0DP23 | PRKCA, ITPR1, CALM1 | More | | | Cocaine | hsa04916 | Melanogenesis | 2.87E-02 | 2 | P17612, P0DP23 | PRKACA, CALM1 | More | | | Cocaine | hsa04921 | Oxytocin signaling pathway | 1.84E-02 | 3 | P0DP23, P17612, Q96RR4 | CALM1, PRKACA, CAMKK2 | More | | | Cocaine | hsa04922 | Glucagon signaling pathway | 3.47E-02 | 4 | Q12778, Q13370, P0DP23, Q14643 | FOXO1, PDE3B, CALM1, ITPR1 | More | | | Cocaine | hsa04924 | Renin secretion | 3.15E-04 | 4 | P17612, Q14643, Q13370, P0DP23 | PRKACA, ITPR1, PDE3B, CALM1 | More | | | Cocaine | hsa04930 | Type II diabetes mellitus | 2.47E-02 | 1 | Q02156 | PRKCE | More | | | Cocaine | hsa04932 | Non-alcoholic fatty liver disease | 2.44E-03 | 5 | P01375, P49841, P48023, Q16718, O14521 | TNF, GSK3B, FASLG, NDUFA5, SDHD | More | | | Cocaine | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.27E-02 | 5 | P42224, P10415, Q12778, P49767, P17252 | STAT1, BCL2, FOXO1, VEGFC, PRKCA | More | | | Cocaine | hsa04940 | Type I diabetes mellitus | 1.87E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Cocaine | hsa04964 | Proximal tubule bicarbonate reclamation | 4.93E-02 | 1 | P00918 | CA2 | More | | | Cocaine | hsa04966 | Collecting duct acid secretion | 7.14E-05 | 4 | Q13488, P02730, P00918, Q9Y666 | TCIRG1, SLC4A1, CA2, SLC12A7 | More | | | Cocaine | hsa04970 | Salivary secretion | 2.20E-02 | 2 | P17612, P0DP23 | PRKACA, CALM1 | More | | | Cocaine | hsa04971 | Gastric acid secretion | 2.87E-02 | 2 | P17612, P0DP23 | PRKACA, CALM1 | More | | | Cocaine | hsa04974 | Protein digestion and absorption | 2.47E-02 | 1 | Q7Z2H8 | SLC36A1 | More | | | Cocaine | hsa04975 | Fat digestion and absorption | 2.80E-02 | 1 | O14494 | PLPP1 | More | | | Cocaine | hsa04976 | Bile secretion | 1.74E-03 | 4 | O43315, P17612, P08183, Q14032 | AQP9, PRKACA, ABCB1, BAAT | More | | | Cocaine | hsa05010 | Alzheimer disease | 3.55E-02 | 7 | Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752 | NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPID | More | | | Cocaine | hsa05012 | Parkinson disease | 2.25E-02 | 6 | Q16718, O14521, Q14643, P0DP23, Q13509, P68371 | NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C | More | | | Cocaine | hsa05020 | Prion disease | 1.31E-03 | 9 | Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539 | NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14 | More | | | Cocaine | hsa05022 | Pathways of neurodegeneration - multiple diseases | 2.00E-04 | 12 | Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, Q13561, P17252, Q16539, Q08752, P0DP23 | ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, MAPK14, PPID, CALM1 | More | | | Cocaine | hsa05031 | Amphetamine addiction | 2.87E-02 | 2 | P0DP23, P17612 | CALM1, PRKACA | More | | | Cocaine | hsa05034 | Alcoholism | 1.34E-05 | 10 | P17612, Q13547, P0DP23, Q96RR4, P62873, Q93077, P62807, P58876, Q16778, O60814 | PRKACA, HDAC1, CALM1, CAMKK2, GNB1, HIST1H2AC, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12 | More | | | Cocaine | hsa05131 | Shigellosis | 3.33E-03 | 10 | Q12933, P68431, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752 | TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID | More | | | Cocaine | hsa05132 | Salmonella infection | 5.51E-04 | 10 | Q9UJU2, Q13546, Q13489, P10415, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371 | LEF1, RIPK1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C | More | | | Cocaine | hsa05133 | Pertussis | 4.24E-03 | 1 | P0C0L4 | C4A | More | | | Cocaine | hsa05140 | Leishmaniasis | 3.69E-06 | 8 | P14598, P11215, P42224, P13765, O60603, P25963, P29350, Q15080 | NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, NCF4 | More | | | Cocaine | hsa05143 | African trypanosomiasis | 7.50E-04 | 4 | P01375, P69905, P68871, P48023 | TNF, HBA2, HBB, FASLG | More | | | Cocaine | hsa05144 | Malaria | 3.09E-02 | 2 | P69905, P68871 | HBA2, HBB | More | | | Cocaine | hsa05145 | Toxoplasmosis | 1.11E-02 | 6 | P10415, Q13489, P42224, P13765, O60603, P29965 | BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG | More | | | Cocaine | hsa05152 | Tuberculosis | 7.93E-04 | 8 | Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8 | TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1 | More | | | Cocaine | hsa05160 | Hepatitis C | 1.27E-02 | 4 | P60033, P49841, P01375, P48023 | CD81, GSK3B, TNF, FASLG | More | | | Cocaine | hsa05165 | Human papillomavirus infection | 3.10E-02 | 8 | P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315 | ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM | More | | | Cocaine | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 4.73E-02 | 6 | P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2 | IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1 | More | | | Cocaine | hsa05170 | Human immunodeficiency virus 1 infection | 4.67E-03 | 9 | P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5 | GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2 | More | | | Cocaine | hsa05200 | Pathways in cancer | 4.99E-02 | 12 | P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568 | STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21 | More | | | Cocaine | hsa05202 | Transcriptional misregulation in cancer | 7.83E-04 | 9 | Q15532, P27930, P14923, P11215, O15550, P04637, P05164, Q13547, P12980 | SS18, IL1R2, JUP, ITGAM, UTX, TP53, MPO, HDAC1, LYL1 | More | | | Cocaine | hsa05203 | Viral carcinogenesis | 6.44E-03 | 4 | Q13547, P58876, Q16778, O60814 | HDAC1, H2BC5, HIST2H2BE, H2BC12 | More | | | Cocaine | hsa05212 | Pancreatic cancer | 2.87E-02 | 2 | Q15311, P23458 | RALBP1, JAK1 | More | | | Cocaine | hsa05214 | Glioma | 3.69E-02 | 3 | P0DP23, P19174, O75293 | CALM1, PLCG1, GADD45B | More | | | Cocaine | hsa05218 | Melanoma | 1.07E-02 | 3 | P09619, Q9GZP0, Q02750 | PDGFRB, PDGFD, MAP2K1 | More | | | Cocaine | hsa05231 | Choline metabolism in cancer | 1.30E-03 | 7 | Q02750, P09619, Q9GZP0, O15245, Q9Y259, P19174, P49619 | MAP2K1, PDGFRB, PDGFD, SLC22A1, CHKB, PLCG1, DGKG | More | | | Cocaine | hsa05320 | Autoimmune thyroid disease | 1.27E-03 | 4 | P13765, P29965, P01568, P10747 | HLA-DOB, CD40LG, IFNA21, CD28 | More | | | Cocaine | hsa05322 | Systemic lupus erythematosus | 2.33E-04 | 10 | P08246, P09871, P10747, P13765, P29965, Q6FI13, P58876, Q16778, O60814, P68431 | ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Cocaine | hsa05323 | Rheumatoid arthritis | 1.29E-02 | 4 | P13765, Q13488, P10747, O60603 | HLA-DOB, TCIRG1, CD28, TLR2 | More | | | Cocaine | hsa05330 | Allograft rejection | 1.04E-03 | 5 | P13765, P29965, P48023, P10747, P01375 | HLA-DOB, CD40LG, FASLG, CD28, TNF | More | | | Cocaine | hsa05332 | Graft-versus-host disease | 3.70E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Cocaine | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 5.12E-03 | 3 | Q8IZS8, P54284, P13612 | CACNA2D3, CACNB3, ITGA4 | More | | | Cocaine | hsa05414 | Dilated cardiomyopathy | 2.11E-02 | 4 | Q8IZS8, P54284, P13612, P26678 | CACNA2D3, CACNB3, ITGA4, PLN | More | | | Cocaine | hsa05415 | Diabetic cardiomyopathy | 1.58E-03 | 7 | P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841 | PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B | More | | | Cocaine | hsa05416 | Viral myocarditis | 2.62E-02 | 3 | P13765, P29965, P10747 | HLA-DOB, CD40LG, CD28 | More | |
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