PharmaCoNets of Cobimetinib (SPCN: 2.13 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Cobimetinibhsa00230Purine metabolism3.35E-022Q7LG56, P51828RRM2B, ADCY7More
Cobimetinibhsa00330Arginine and proline metabolism2.73E-021P17707AMD1More
Cobimetinibhsa00520Amino sugar and nucleotide sugar metabolism2.11E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Cobimetinibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Cobimetinibhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Cobimetinibhsa04114Oocyte meiosis2.05E-025Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Cobimetinibhsa04370VEGF signaling pathway1.29E-023P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Cobimetinibhsa04727GABAergic synapse4.60E-022P51828, P46459ADCY7, NSFMore
Cobimetinibhsa04912GnRH signaling pathway3.96E-022P51828, P45985ADCY7, MAP2K4More
Cobimetinibhsa04914Progesterone-mediated oocyte maturation2.66E-024Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Cobimetinibhsa04935Growth hormone synthesis, secretion and action4.60E-022P51828, P45985ADCY7, MAP2K4More

Community members of Cobimetinib (SDC: 1.91)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Reported00.3120.512912.1819
P45985MAP2K4Dual specificity mitogenNoneactivated protein kinase kinase 4Predicted00.42480.24730.74031.4474
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
MAP2K1Q02750IC500.9
MAP2K1Q02750IC504.2