PharmaCoNets

PharmaCoNets of Clozapine (S_PCN: 75.73 )

Clozapine regulated-network (S_DN: 14.16)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Clozapine

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Clozapine

hsa00040

Pentose and glucuronate interconversions

2.33E-04

P15121, P14550

AKR1B1, AKR1A1

Clozapine

hsa00051

Fructose and mannose metabolism

4.00E-02

P60174, P04075

TPI1, ALDOA

Clozapine

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Clozapine

hsa00220

Arginine biosynthesis

3.83E-02

P05089, P49448

ARG1, GLUD2

Clozapine

hsa00500

Starch and sucrose metabolism

1.47E-02

O43451, P46976, P06737

MGAM, GYG1, PYGL

Clozapine

hsa00510

N-Glycan biosynthesis

3.15E-02

P15907, Q9NR34

ST6GAL1, MAN1C1

Clozapine

hsa00561

Glycerolipid metabolism

2.62E-02

P15121, P14550

AKR1B1, AKR1A1

Clozapine

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Clozapine

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Clozapine

hsa00730

Thiamine metabolism

2.70E-03

P05186, P24666

ALPL, ACP1

Clozapine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Clozapine

hsa00790

Folate biosynthesis

2.02E-02

P15121

AKR1B1

Clozapine

hsa00830

Retinol metabolism

3.93E-02

P00352, Q9BPW9, O75911

ALDH1A1, DHRS9, DHRS3

Clozapine

hsa00980

Metabolism of xenobiotics by cytochrome P450

6.38E-04

P78417, P09211, P11712

GSTO1, GSTP1, CYP2C9

Clozapine

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Clozapine

hsa00983

Drug metabolism - other enzymes

1.63E-02

P20839, Q16772

IMPDH1, GSTA3

Clozapine

hsa01100

Metabolic pathways

6.45E-03

Q9NR34, P35790, P05089, Q16772, P30041, P32320, P20839, P22748, P55809, P06280, O94777, Q16875, O43286, O43451, P05186, P24666, P15121, O95861, P14550, Q9HCC0, P33121, Q9UHK6, Q86VZ5, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q9NVH6

MAN1C1, CHKA, ARG1, GSTA3, PRDX6, CDA, IMPDH1, CA4, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, AKR1B1, BPNT1, AKR1A1, MCCC2, ACSL1, AMACR, SGMS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, TMLHE

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16772	GSTA3	Glutathione S-transferase A3	P35790	CHKA	Choline kinase alpha	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16772	GSTA3	Glutathione S-transferase A3	Q16772	GSTA3	Glutathione S-transferase A3	1
Q16772	GSTA3	Glutathione S-transferase A3	P30041	PRDX6	Peroxiredoxin-6	-0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16772	GSTA3	Glutathione S-transferase A3	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	-0.768
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16772	GSTA3	Glutathione S-transferase A3	O94777	DPM2	Dolichol phosphate-mannose biosynthesis regulatory protein	-0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16772	GSTA3	Glutathione S-transferase A3	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	-0.793
Q16772	GSTA3	Glutathione S-transferase A3	O95861	BPNT1	3'(2'),5'-bisphosphate nucleotidase 1	0.7
Q16772	GSTA3	Glutathione S-transferase A3	P14550	AKR1A1	Aldo-keto reductase family 1 member A1	-0.706
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16772	GSTA3	Glutathione S-transferase A3	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	0.787
Q16772	GSTA3	Glutathione S-transferase A3	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	0.907
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
Q16772	GSTA3	Glutathione S-transferase A3	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	0.736

Clozapine

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Clozapine

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Clozapine

hsa01523

Antifolate resistance

1.68E-02

Q92820, P04818

GGH, TYMS

Clozapine

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Clozapine

hsa03010

Ribosome

1.13E-06

P26373, P42677, P40429, P62917, P46776, Q9H0U6, Q07020, Q02878, P27635, P05386, P62249, P23396

RPL13, RPS27, RPL13A, RPL8, RPL27A, MRPL18, RPL18, RPL6, RPL10, RPLP1, RPS16, RPS3

Clozapine

hsa03020

RNA polymerase

1.81E-02

P24928

POLR2A

Clozapine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Clozapine

hsa03040

Spliceosome

3.17E-02

Q14562, O43143, Q07955, Q13243, P11142, O75643

DHX8, DHX15, SFRS1, SFRS5, HSPA8, ASCC3L1

Clozapine

hsa03050

Proteasome

1.21E-02

P28074

PSMB5

Clozapine

hsa04012

ErbB signaling pathway

1.72E-02

Q13153, P16333, P19174, P01106

PAK1, NCK1, PLCG1, MYC

Clozapine

hsa04024

cAMP signaling pathway

4.80E-02

Q13153

PAK1

Clozapine

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Clozapine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

9.53E-04

P09341, P25024, P02775, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCR1, PPBP, XCL1, XCL2, IL10RA, IL2RB

Clozapine

hsa04062

Chemokine signaling pathway

6.73E-03

P25024, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881

CXCR1, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITK

Clozapine

hsa04064

NF-kappa B signaling pathway

7.57E-06

P10415, O00463, P14778, P01375, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P24522, P09341, Q06643

BCL2, TRAF5, IL1R1, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, GADD45A, CXCL1, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P10415	BCL2	Apoptosis regulator Bcl-2	0.744
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O00463	TRAF5	TNF receptor-associated factor 5	0.945
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09341	CXCL1	Growth-regulated alpha protein	-0.802
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846

Clozapine

hsa04070

Phosphatidylinositol signaling system

2.56E-02

P19174, P0DP23, P23743, P27987

PLCG1, CALM1, DGKA, ITPKB

Clozapine

hsa04071

Sphingolipid signaling pathway

1.19E-02

P21453, Q9H228, P01375, Q13362

S1PR1, EDG8, TNF, PPP2R5C

Clozapine

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

Clozapine

hsa04110

Cell cycle

6.63E-04

P06493, O60566, P30304, P33981, P42773, P01106

CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC

Clozapine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Clozapine

hsa04140

Autophagy - animal

4.55E-02

P22694, Q14643, P10415, Q9H1Y0, Q04759

PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Clozapine

hsa04141

Protein processing in endoplasmic reticulum

3.07E-02

P30101, P60604, P11142, P08238, Q9UNL2

PDIA3, UBE2G2, HSPA8, HSP90AB1, SSR3

Clozapine

hsa04145

Phagosome

3.90E-03

O75015, Q15080, P05164, P78380, O60603, P35443, P13765

FCGR3B, NCF4, MPO, OLR1, TLR2, THBS4, HLA-DOB

Clozapine

hsa04216

Ferroptosis

2.75E-02

P04637, Q9H1Y0, P33121

TP53, ATG5, ACSL1

Clozapine

hsa04217

Necroptosis

2.34E-02

P01375, P48023, Q14765, Q99878

TNF, FASLG, STAT4, H2AC14

Clozapine

hsa04218

Cellular senescence

2.35E-02

P30281, P01889, P10321, P12236

CCND3, HLA-B, HLA-C, SLC25A6

Clozapine

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Clozapine

hsa04371

Apelin signaling pathway

1.96E-02

P62873, P63218, Q13370, Q14814, P0DP23

GNB1, GNG5, PDE3B, MEF2D, CALM1

Clozapine

hsa04392

Hippo signaling pathway - multiple species

1.51E-02

Q13153

PAK1

Clozapine

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Clozapine

hsa04612

Antigen processing and presentation

1.91E-05

P13765, P48382, P01730, Q14953, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Clozapine

hsa04613

Neutrophil extracellular trap formation

1.86E-04

P19174, P11215, Q13547, P04908, Q93077, P62807, O60814, P68431, P60709, O43315, Q16539

PLCG1, ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTB, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	1
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	P11215	ITGAM	Integrin alpha-M	-0.913
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	Q13547	HDAC1	Histone deacetylase 1	0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.742
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.833
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.833
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	O60814	H2BC12	Histone H2B type 1-K	-0.732
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	P60709	ACTB	Actin, cytoplasmic 1	0.726
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Clozapine

hsa04625

C-type lectin receptor signaling pathway

3.31E-02

Q13153

PAK1

Clozapine

hsa04640

Hematopoietic cell lineage

1.56E-05

P13612, P14778, P27930, P15144, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375

ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF

Clozapine

hsa04650

Natural killer cell mediated cytotoxicity

5.99E-08

P01375, P06239, O60880, P20963, Q13153, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715

TNF, LCK, SH2D1A, CD247, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60880	SH2D1A	SH2 domain-containing protein 1A	0.862
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q13153	PAK1	Serine/threonine-protein kinase PAK 1	Q13153	PAK1	Serine/threonine-protein kinase PAK 1	1
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26718	KLRK1	NKG2-D type II integral membrane protein	0.922
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.943
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Clozapine

hsa04657

IL-17 signaling pathway

4.80E-04

O00463, Q16539, P49841, P09341, P19875, P14780, Q9UJX4, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, ANAPC5, LCN2, TNF

Clozapine

hsa04658

Th1 and Th2 cell differentiation

1.73E-10

Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P07305	H1-0	Histone H1.0	Q04759	PRKCQ	Protein kinase C theta type	-0.706
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.805
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	1
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P07305	H1-0	Histone H1.0	P06239	LCK	Tyrosine-protein kinase Lck	-0.716
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.851
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q14765	STAT4	Signal transducer and activator of transcription 4	0.904
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
P07305	H1-0	Histone H1.0	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.772
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.842
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P07305	H1-0	Histone H1.0	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.859
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	Q13761	RUNX3	Runt-related transcription factor 3	0.789
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85

Clozapine

hsa04659

Th17 cell differentiation

4.69E-08

Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P08238, P07766, P09693, P20963

PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P07305	H1-0	Histone H1.0	Q04759	PRKCQ	Protein kinase C theta type	-0.706
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	1
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P07305	H1-0	Histone H1.0	P06239	LCK	Tyrosine-protein kinase Lck	-0.716
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.851
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.842
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P07305	H1-0	Histone H1.0	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.859
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9HBE5	IL21R	Interleukin-21 receptor	0.713
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
P07305	H1-0	Histone H1.0	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.772
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.869
P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.805
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839

Clozapine

hsa04660

T cell receptor signaling pathway

1.12E-06

P01375, Q9UDY8, Q04759, O95267, Q08881, Q13153, P07766, P20963, P09693, P01730, P01732, Q13191, P06239

TNF, MALT1, PRKCQ, RASGRP1, ITK, PAK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK

Clozapine

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

Clozapine

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Clozapine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Clozapine

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Clozapine

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Clozapine

hsa04744

Phototransduction

8.50E-03

P62873, P0DP23

GNB1, CALM1

Clozapine

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Clozapine

hsa04919

Thyroid hormone signaling pathway

2.48E-02

P19174, P42224, P60709, Q13547, P01106

PLCG1, STAT1, ACTB, HDAC1, MYC

Clozapine

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Clozapine

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Clozapine

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Clozapine

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Clozapine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Clozapine

hsa04970

Salivary secretion

1.91E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

Clozapine

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Clozapine

hsa05017

Spinocerebellar ataxia

2.43E-02

P28074

PSMB5

Clozapine

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Clozapine

hsa05022

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Clozapine

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Clozapine

hsa05032

Morphine addiction

1.90E-02

P62873, P63218, Q13370, P43250

GNB1, GNG5, PDE3B, GRK6

Clozapine

hsa05034

Alcoholism

1.76E-05

Q13547, P0DP23, P62873, P63218, Q93077, P62807, O60814, P68431

HDAC1, CALM1, GNB1, GNG5, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Clozapine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

3.10E-03

Q16539, Q13153, P09341, P25024, P25025

MAPK14, PAK1, CXCL1, CXCR1, CXCR2

Clozapine

hsa05134

Legionellosis

4.28E-02

P11215, P11142, P19875

ITGAM, HSPA8, CXCL2

Clozapine

hsa05140

Leishmaniasis

2.26E-04

P13612, O75015, P13765, O60603, P01375, P49006, Q16539, Q15080

ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MARCKSL1, MAPK14, NCF4

Clozapine

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Clozapine

hsa05144

Malaria

6.75E-04

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Clozapine

hsa05146

Amoebiasis

7.98E-06

P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, ACTN1, CTSG

Clozapine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Clozapine

hsa05163

Human cytomegalovirus infection

3.64E-02

Q14643, P49841, P14778, P25025, Q16539, P04637, O00463

ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5

Clozapine

hsa05165

Human papillomavirus infection

2.26E-02

Q16363, P30281, Q9UM47, P01889, P10321, Q99437

LAMA4, CCND3, NOTCH3, HLA-B, HLA-C, ATP6V0B

Clozapine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

8.64E-03

P42224, P62873, P63218, P19875, P19174, P01106, P0DP23

STAT1, GNB1, GNG5, CXCL2, PLCG1, MYC, CALM1

Clozapine

hsa05169

Epstein-Barr virus infection

5.82E-04

P13765, P01106, Q13547, O00463, P07948, P30101, Q13761, P24522, O75293, P42224, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, CD3E, CD3G, CD247

Clozapine

hsa05171

Coronavirus disease - COVID-19

3.03E-05

P23396, P62249, P42677, P40429, Q02878, P62917, P27635, P26373, Q07020, P46776, P05386

RPS3, RPS16, RPS27, RPL13A, RPL6, RPL8, RPL10, RPL13, RPL18, RPL27A, RPLP1

Clozapine

hsa05200

Pathways in cancer

2.60E-02

P08238, P42224, P19174, P01106, P43246, P20585, Q13547, P62873, P63218, O75293, P0DP23, P14784

HSP90AB1, STAT1, PLCG1, MYC, MSH2, MSH3, HDAC1, GNB1, GNG5, GADD45B, CALM1, IL2RB

Clozapine

hsa05202

Transcriptional misregulation in cancer

2.35E-02

Q13315, P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522

ATM, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Clozapine

hsa05203

Viral carcinogenesis

6.28E-04

P06746, P30281, P29083, Q13547, Q15283, P06396, P12814, P01889, P10321, P62807, O60814

POLB, CCND3, GTF2E1, HDAC1, RASA2, GSN, ACTN1, HLA-B, HLA-C, HIST1H2BC, H2BC12

Clozapine

hsa05204

Chemical carcinogenesis

1.09E-03

P09211, P78417, P11712

GSTP1, GSTO1, CYP2C9

Clozapine

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Clozapine

hsa05206

MicroRNAs in cancer

3.17E-02

P30304, P09493, P01106, Q9Y4H2, Q13547, P19174

CDC25A, TPM1, MYC, IRS2, HDAC1, PLCG1

Clozapine

hsa05211

Renal cell carcinoma

2.42E-02

Q13153

PAK1

Clozapine

hsa05214

Glioma

4.28E-02

P0DP23, P19174, O75293

CALM1, PLCG1, GADD45B

Clozapine

hsa05219

Bladder cancer

2.70E-03

P14780, P04637

MMP9, TP53

Clozapine

hsa05224

Breast cancer

5.68E-03

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Clozapine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.32E-03

O95267, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730

RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4

Clozapine

hsa05310

Asthma

1.03E-03

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Clozapine

hsa05321

Inflammatory bowel disease

1.17E-05

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Clozapine

hsa05322

Systemic lupus erythematosus

8.24E-05

P09871, Q93077, P62807, O60814, P68431, P12814

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1

Clozapine

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Clozapine

hsa05332

Graft-versus-host disease

7.43E-06

P13765, P48023, P01375, P26715, Q13241

HLA-DOB, FASLG, TNF, KLRC1, KLRD1

Clozapine

hsa05340

Primary immunodeficiency

2.19E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Clozapine

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Clozapine

hsa05418

Fluid shear stress and atherosclerosis

2.62E-02

Q16539, P10599, P14780, P04637, P14778, P27930

MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2

Community members of Clozapine (S_DC: 5.35)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

DRD2

D(2) dopamine receptor

Reported

0.0604

0.4779

2.5081

P09211

GSTP1

Glutathione SNonetransferase P

Reported

0.3204

0.3523

0.4566

1.3213

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P07305

H1None0

Histone H1.0

Predicted

0.054

0.0801

0.1872

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

Q13153

PAK1

Serine/threonineNoneprotein kinase PAK 1

Predicted

0.4647

0.3471

0.7819

1.7084

Q9NQU5

PAK6

Serine/threonineNoneprotein kinase PAK 6

Predicted

0.409

0.2669

0.5003

1.2386

Q08881

ITK

TyrosineNoneprotein kinase ITK/TSK

Predicted

0.1635

0.5545

0.422

1.6127

P19174

PLCG1

1Nonephosphatidylinositol 4,5Nonebisphosphate phosphodiesterase gammaNone1

Predicted

0.0696

0.0397

1.1142

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

P28074

PSMB5

Proteasome subunit beta typeNone5

Predicted

0.2839

0.4723

0.5439

1.6305

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

P42857

NSG1

Neuronal vesicle traffickingNoneassociated protein 1

Predicted

0.0324

0.0051

0.0264

Q16772

GSTA3

Glutathione SNonetransferase A3

Predicted

0.4624

0.0336

0.425

0.7234

Gene name	UniProt_ID	Bioactivity	Value (nM)
DRD2	P14416	IC50	9
DRD2	P14416	IC50	113
DRD2	P14416	IC50	204.17
DRD2	P14416	Ki	7.1
DRD2	P14416	Ki	28
DRD2	P14416	Ki	32

PharmaCoNets of Clozapine (SPCN: 75.73 )

Clozapine regulated-network (SDN: 14.16)

Community members of Clozapine (SDC: 5.35)

PharmaCoNets of Clozapine (S_PCN: 75.73 )

Clozapine regulated-network (S_DN: 14.16)

Community members of Clozapine (S_DC: 5.35)