PharmaCoNets

PharmaCoNets of Cloxacillin (S_PCN: 1.69 )

Cloxacillin regulated-network (S_DN: 2.22)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Cloxacillin

hsa00500

Starch and sucrose metabolism

1.33E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Cloxacillin

hsa00564

Glycerophospholipid metabolism

2.00E-02

P48651, Q9Y6K0, P35790, Q9Y259

PTDSS1, CEPT1, CHKA, CHKB

Cloxacillin

hsa00730

Thiamine metabolism

2.43E-03

P05186, P24666

ALPL, ACP1

Cloxacillin

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Cloxacillin

hsa04015

Rap1 signaling pathway

2.26E-02

P25116, Q8TEU7, P08514

F2R, RAPGEF6, ITGA2B

Cloxacillin

hsa04022

cGMP-PKG signaling pathway

1.05E-02

P24844, Q8WYR1, Q15746

MYL9, PIK3R5, MYLK

Cloxacillin

hsa04024

cAMP signaling pathway

1.40E-02

P48058, P25116, P24844

GRIA4, F2R, MYL9

Cloxacillin

hsa04064

NF-kappa B signaling pathway

1.53E-04

P10415, Q12933, O00463, P14778, P01375, P19174, Q04759, Q13077, P19784, Q16548, P07948, P06239, Q8WV28, P24522, P09341, Q06643

BCL2, TRAF2, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, TRAF1, CSNK2A2, BCL2A1, LYN, LCK, BLNK, GADD45A, CXCL1, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q12933	TRAF2	TNF receptor-associated factor 2	0.871
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P14778	IL1R1	Interleukin-1 receptor type 1	-0.728
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.804
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19784	CSNK2A2	Casein kinase II subunit alpha'	0.82
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P07948	LYN	Tyrosine-protein kinase Lyn	-0.742
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P06239	LCK	Tyrosine-protein kinase Lck	0.791
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q06643	LTB	Lymphotoxin-beta	0.774
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74

Cloxacillin

hsa04071

Sphingolipid signaling pathway

2.06E-02

Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2

EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.716
P06737	PYGL	Glycogen phosphorylase, liver form	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.781
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.716
P06737	PYGL	Glycogen phosphorylase, liver form	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.781
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.716
P06737	PYGL	Glycogen phosphorylase, liver form	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.781
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.822

Cloxacillin

hsa04080

Neuroactive ligand-receptor interaction

2.54E-02

P08311, Q15722, Q9H228, P21462, P21730, Q16581, P35318

CTSG, LTB4R, EDG8, FPR1, C5AR1, C3AR1, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	Q15722	LTB4R	Leukotriene B4 receptor 1	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.808
P06737	PYGL	Glycogen phosphorylase, liver form	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.727
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	Q15722	LTB4R	Leukotriene B4 receptor 1	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.808
P06737	PYGL	Glycogen phosphorylase, liver form	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.727
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	Q15722	LTB4R	Leukotriene B4 receptor 1	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.808
P06737	PYGL	Glycogen phosphorylase, liver form	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.727

Cloxacillin

hsa04270

Vascular smooth muscle contraction

4.65E-02

Q15746, P24844

MYLK, MYL9

Cloxacillin

hsa04340

Hedgehog signaling pathway

1.43E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Cloxacillin

hsa04510

Focal adhesion

3.36E-02

P08514, Q15746, P24844

ITGA2B, MYLK, MYL9

Cloxacillin

hsa04512

ECM-receptor interaction

2.44E-02

P07359, P08514

GP1BA, ITGA2B

Cloxacillin

hsa04514

Cell adhesion molecules

4.65E-02

P16109, O00501

SELP, CLDN5

Cloxacillin

hsa04530

Tight junction

7.42E-04

Q8TEU7, O00501, Q14247, P24844

RAPGEF6, CLDN5, CTTN, MYL9

Cloxacillin

hsa04610

Complement and coagulation cascades

3.68E-04

P25116, P0C0L4, P12259, P10909, P11215, P05107

F2R, C4A, F5, CLU, ITGAM, ITGB2

Cloxacillin

hsa04611

Platelet activation

1.59E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Cloxacillin

hsa04613

Neutrophil extracellular trap formation

2.11E-04

P19174, P57764, P11215, O60603, P05164, P08246, P05107, Q9UM07, Q13547, Q93077, P62807, Q16778, O60814, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

PLCG1, GSDMDC1, ITGAM, TLR2, MPO, ELA2, ITGB2, PADI4, HDAC1, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.804
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P57764	GSDMDC1	Gasdermin-D	0.725
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P11215	ITGAM	Integrin alpha-M	-0.862
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P05107	ITGB2	Integrin beta-2	0.769
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q13547	HDAC1	Histone deacetylase 1	0.784
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.748
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.888
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.888
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q16778	HIST2H2BE	Histone H2B type 2-E	-0.881
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	O60814	H2BC12	Histone H2B type 1-K	-0.776
P06737	PYGL	Glycogen phosphorylase, liver form	Q15080	NCF4	Neutrophil cytosol factor 4	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P20160	AZU1	Azurocidin	0.781
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	O43315	AQP9	Aquaporin-9	0.897
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P06737	PYGL	Glycogen phosphorylase, liver form	Q15080	NCF4	Neutrophil cytosol factor 4	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P20160	AZU1	Azurocidin	0.781
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	O43315	AQP9	Aquaporin-9	0.897
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P06737	PYGL	Glycogen phosphorylase, liver form	Q15080	NCF4	Neutrophil cytosol factor 4	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P20160	AZU1	Azurocidin	0.781
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	O43315	AQP9	Aquaporin-9	0.897
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863

Cloxacillin

hsa04621

NOD-like receptor signaling pathway

2.64E-02

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.804
P06737	PYGL	Glycogen phosphorylase, liver form	P10599	TXN	Thioredoxin	0.764
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H1Y0	ATG5	Autophagy protein 5	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.912
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.804
P06737	PYGL	Glycogen phosphorylase, liver form	P10599	TXN	Thioredoxin	0.764
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H1Y0	ATG5	Autophagy protein 5	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.912
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.804
P06737	PYGL	Glycogen phosphorylase, liver form	P10599	TXN	Thioredoxin	0.764
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H1Y0	ATG5	Autophagy protein 5	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.912
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7

Cloxacillin

hsa04657

IL-17 signaling pathway

1.62E-03

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P06737	PYGL	Glycogen phosphorylase, liver form	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P06737	PYGL	Glycogen phosphorylase, liver form	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P06737	PYGL	Glycogen phosphorylase, liver form	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759

Cloxacillin

hsa04658

Th1 and Th2 cell differentiation

8.55E-06

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, P42224, Q14765, P42226, P23771, Q9UL17, P14784, P78504, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT1, STAT4, STAT6, GATA3, TBX21, IL2RB, JAG1, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.805
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.769
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.804
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P06239	LCK	Tyrosine-protein kinase Lck	0.791
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.762
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.741
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P78504	JAG1	Protein jagged-1	0.907
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q13761	RUNX3	Runt-related transcription factor 3	0.849
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P13612	ITGA4	Integrin alpha-4	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.729
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P13612	ITGA4	Integrin alpha-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.85
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P13612	ITGA4	Integrin alpha-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.764
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P13612	ITGA4	Integrin alpha-4	Q9UL17	TBX21	T-box transcription factor TBX21	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P13612	ITGA4	Integrin alpha-4	Q13761	RUNX3	Runt-related transcription factor 3	0.78
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845

Cloxacillin

hsa04659

Th17 cell differentiation

1.01E-03

Q04759, Q16539, P19174, P06239, P42224, P42226, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, MAPK14, PLCG1, LCK, STAT1, STAT6, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.804
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P06239	LCK	Tyrosine-protein kinase Lck	0.791
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.762
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.741
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P14778	IL1R1	Interleukin-1 receptor type 1	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.805
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.769
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728

Cloxacillin

hsa04660

T cell receptor signaling pathway

1.07E-02

P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q16539, P49841

TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.8
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.72
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.73
P13612	ITGA4	Integrin alpha-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.834
P06737	PYGL	Glycogen phosphorylase, liver form	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.8
P13612	ITGA4	Integrin alpha-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P13612	ITGA4	Integrin alpha-4	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.729
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P13612	ITGA4	Integrin alpha-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.85
P06737	PYGL	Glycogen phosphorylase, liver form	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.72
P13612	ITGA4	Integrin alpha-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.7
P13612	ITGA4	Integrin alpha-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.83
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.8
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.72
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815

Cloxacillin

hsa04724

Glutamatergic synapse

2.94E-02

P48058, Q9NSB8

GRIA4, HOMER2

Cloxacillin

hsa04810

Regulation of actin cytoskeleton

1.38E-03

P24844, Q15746, P08514, P25116

MYL9, MYLK, ITGA2B, F2R

Cloxacillin

hsa04921

Oxytocin signaling pathway

6.37E-03

Q15746, P24844, Q8WYR1

MYLK, MYL9, PIK3R5

Cloxacillin

hsa05034

Alcoholism

4.17E-03

Q13547, P63218, P50151, Q93077, P62807, Q16778, O60814

HDAC1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12

Cloxacillin

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.45E-02

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Cloxacillin

hsa05130

Pathogenic Escherichia coli infection

2.51E-02

Q14247, O00501, P25116

CTTN, CLDN5, F2R

Cloxacillin

hsa05133

Pertussis

1.56E-02

P11215, P05107, P0C0L4

ITGAM, ITGB2, C4A

Cloxacillin

hsa05140

Leishmaniasis

2.69E-02

O75015, P13765, O60603, P49006, Q16539

FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14

Cloxacillin

hsa05146

Amoebiasis

4.55E-02

P09341, P14778, P27930, O60603, P05089

CXCL1, IL1R1, IL1R2, TLR2, ARG1

Cloxacillin

hsa05150

Staphylococcus aureus infection

4.37E-02

P21730, P21462, O75015, P13765, Q16581, P12838

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, DEFA4

Cloxacillin

hsa05163

Human cytomegalovirus infection

3.64E-02

Q14643, P49841, P14778, P25025, Q16539, P04637, O00463

ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5

Cloxacillin

hsa05169

Epstein-Barr virus infection

4.32E-02

P13765, O00463, P16070, P10415, Q16539, P24522, Q8WV28, P01375, O60603, P09693, P20963

HLA-DOB, TRAF5, CD44, BCL2, MAPK14, GADD45A, BLNK, TNF, TLR2, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P16070	CD44	CD44 antigen	0.803
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P16070	CD44	CD44 antigen	0.803
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P16070	CD44	CD44 antigen	0.803
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728

Cloxacillin

hsa05202

Transcriptional misregulation in cancer

8.07E-04

Q15532, P14780, P27930, Q16548, Q13077, Q15652, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P24522

SS18, MMP9, IL1R2, BCL2A1, TRAF1, JMJD1C, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q15532	SS18	Protein SSXT	-0.772
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P06737	PYGL	Glycogen phosphorylase, liver form	P27930	IL1R2	Interleukin-1 receptor type 2	0.881
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P06737	PYGL	Glycogen phosphorylase, liver form	Q15652	JMJD1C	Probable JmjC domain-containing histone demethylation protein 2C	0.754
P06737	PYGL	Glycogen phosphorylase, liver form	O15550	UTX	Lysine-specific demethylase 6A	0.724
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.742
P06737	PYGL	Glycogen phosphorylase, liver form	P41182	BCL6	B-cell lymphoma 6 protein	0.847
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q15532	SS18	Protein SSXT	-0.772
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P06737	PYGL	Glycogen phosphorylase, liver form	P27930	IL1R2	Interleukin-1 receptor type 2	0.881
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P06737	PYGL	Glycogen phosphorylase, liver form	Q15652	JMJD1C	Probable JmjC domain-containing histone demethylation protein 2C	0.754
P06737	PYGL	Glycogen phosphorylase, liver form	O15550	UTX	Lysine-specific demethylase 6A	0.724
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.742
P06737	PYGL	Glycogen phosphorylase, liver form	P41182	BCL6	B-cell lymphoma 6 protein	0.847
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q15532	SS18	Protein SSXT	-0.772
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P06737	PYGL	Glycogen phosphorylase, liver form	P27930	IL1R2	Interleukin-1 receptor type 2	0.881
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P06737	PYGL	Glycogen phosphorylase, liver form	Q15652	JMJD1C	Probable JmjC domain-containing histone demethylation protein 2C	0.754
P06737	PYGL	Glycogen phosphorylase, liver form	O15550	UTX	Lysine-specific demethylase 6A	0.724
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.742
P06737	PYGL	Glycogen phosphorylase, liver form	P41182	BCL6	B-cell lymphoma 6 protein	0.847
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822

Cloxacillin

hsa05203

Viral carcinogenesis

9.87E-03

Q12933, P06746, P07948, Q13547, P12814, P62807, Q16778, O60814

TRAF2, POLB, LYN, HDAC1, ACTN1, HIST1H2BC, HIST2H2BE, H2BC12

Cloxacillin

hsa05217

Basal cell carcinoma

1.43E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Cloxacillin

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Cloxacillin

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Cloxacillin

hsa05231

Choline metabolism in cancer

3.79E-02

O15245, P35790, Q9Y259, P19174

SLC22A1, CHKA, CHKB, PLCG1

Cloxacillin

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.22E-03

O95267, P19174, P07766, P20963, P09693, P06239, P42224, O60603, Q16539, P19784, P01730

RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, MAPK14, CSNK2A2, CD4

Cloxacillin

hsa05321

Inflammatory bowel disease

7.62E-04

O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753

Cloxacillin

hsa05322

Systemic lupus erythematosus

1.92E-03

P0C0L4, Q93077, P62807, Q16778, O60814, P12814

C4A, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, ACTN1

Cloxacillin

hsa05418

Fluid shear stress and atherosclerosis

2.62E-02

Q16539, P10599, P14780, P04637, P14778, P27930

MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2

Dicloxacillin

hsa00500

Starch and sucrose metabolism

1.33E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Dicloxacillin

hsa00524

Neomycin, kanamycin and gentamicin biosynthesis

2.03E-02

P35557

GCK

Dicloxacillin

hsa00730

Thiamine metabolism

3.82E-05

Q9Y6K8, P05186, P24666

AK5, ALPL, ACP1

Dicloxacillin

hsa00740

Riboflavin metabolism

4.03E-02

P24666

ACP1

Dicloxacillin

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Dicloxacillin

hsa03060

Protein export

1.90E-02

Q15070, O76094

OXA1L, SRP72

Dicloxacillin

hsa04064

NF-kappa B signaling pathway

2.45E-03

P10415, O00463, P14778, P01375, Q04759, Q13077, Q16548, Q8WV28, P24522, P09341

BCL2, TRAF5, IL1R1, TNF, PRKCQ, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q12933	TRAF2	TNF receptor-associated factor 2	0.871
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P14778	IL1R1	Interleukin-1 receptor type 1	-0.728
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.804
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19784	CSNK2A2	Casein kinase II subunit alpha'	0.82
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P07948	LYN	Tyrosine-protein kinase Lyn	-0.742
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P06239	LCK	Tyrosine-protein kinase Lck	0.791
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q06643	LTB	Lymphotoxin-beta	0.774
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74

Dicloxacillin

hsa04071

Sphingolipid signaling pathway

2.06E-02

Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2

EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.716
P06737	PYGL	Glycogen phosphorylase, liver form	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.781
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.716
P06737	PYGL	Glycogen phosphorylase, liver form	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.781
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.716
P06737	PYGL	Glycogen phosphorylase, liver form	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.781
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.822

Dicloxacillin

hsa04080

Neuroactive ligand-receptor interaction

2.54E-02

P08311, Q15722, Q9H228, P21462, P21730, Q16581, P35318

CTSG, LTB4R, EDG8, FPR1, C5AR1, C3AR1, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	Q15722	LTB4R	Leukotriene B4 receptor 1	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.808
P06737	PYGL	Glycogen phosphorylase, liver form	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.727
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	Q15722	LTB4R	Leukotriene B4 receptor 1	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.808
P06737	PYGL	Glycogen phosphorylase, liver form	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.727
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	Q15722	LTB4R	Leukotriene B4 receptor 1	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.808
P06737	PYGL	Glycogen phosphorylase, liver form	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.727

Dicloxacillin

hsa04340

Hedgehog signaling pathway

1.43E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Dicloxacillin

hsa04613

Neutrophil extracellular trap formation

1.37E-02

O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.804
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P57764	GSDMDC1	Gasdermin-D	0.725
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P11215	ITGAM	Integrin alpha-M	-0.862
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P05107	ITGB2	Integrin beta-2	0.769
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q13547	HDAC1	Histone deacetylase 1	0.784
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.748
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.888
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.888
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q16778	HIST2H2BE	Histone H2B type 2-E	-0.881
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	O60814	H2BC12	Histone H2B type 1-K	-0.776
P06737	PYGL	Glycogen phosphorylase, liver form	Q15080	NCF4	Neutrophil cytosol factor 4	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P20160	AZU1	Azurocidin	0.781
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	O43315	AQP9	Aquaporin-9	0.897
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P06737	PYGL	Glycogen phosphorylase, liver form	Q15080	NCF4	Neutrophil cytosol factor 4	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P20160	AZU1	Azurocidin	0.781
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	O43315	AQP9	Aquaporin-9	0.897
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P06737	PYGL	Glycogen phosphorylase, liver form	Q15080	NCF4	Neutrophil cytosol factor 4	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P20160	AZU1	Azurocidin	0.781
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	O43315	AQP9	Aquaporin-9	0.897
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863

Dicloxacillin

hsa04621

NOD-like receptor signaling pathway

2.64E-02

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.804
P06737	PYGL	Glycogen phosphorylase, liver form	P10599	TXN	Thioredoxin	0.764
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H1Y0	ATG5	Autophagy protein 5	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.912
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.804
P06737	PYGL	Glycogen phosphorylase, liver form	P10599	TXN	Thioredoxin	0.764
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H1Y0	ATG5	Autophagy protein 5	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.912
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.804
P06737	PYGL	Glycogen phosphorylase, liver form	P10599	TXN	Thioredoxin	0.764
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H1Y0	ATG5	Autophagy protein 5	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.912
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7

Dicloxacillin

hsa04650

Natural killer cell mediated cytotoxicity

2.95E-02

P06239, P20963, Q13241, P26718, O14931, P26717, P26715

LCK, CD247, KLRD1, KLRK1, NCR3, KLRC2, KLRC1

Dicloxacillin

hsa04657

IL-17 signaling pathway

1.62E-03

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P06737	PYGL	Glycogen phosphorylase, liver form	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P06737	PYGL	Glycogen phosphorylase, liver form	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P06737	PYGL	Glycogen phosphorylase, liver form	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759

Dicloxacillin

hsa04658

Th1 and Th2 cell differentiation

5.14E-05

Q04759, P07766, P20963, P09693, Q16539, P06239, Q14765, P42226, P23771, Q9UL17, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, LCK, STAT4, STAT6, GATA3, TBX21, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.805
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.769
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.804
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P06239	LCK	Tyrosine-protein kinase Lck	0.791
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.762
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.741
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P78504	JAG1	Protein jagged-1	0.907
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q13761	RUNX3	Runt-related transcription factor 3	0.849
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P13612	ITGA4	Integrin alpha-4	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.729
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P13612	ITGA4	Integrin alpha-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.85
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P13612	ITGA4	Integrin alpha-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.764
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P13612	ITGA4	Integrin alpha-4	Q9UL17	TBX21	T-box transcription factor TBX21	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P13612	ITGA4	Integrin alpha-4	Q13761	RUNX3	Runt-related transcription factor 3	0.78
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845

Dicloxacillin

hsa04659

Th17 cell differentiation

3.18E-02

Q04759, Q16539, P42226, P13765, Q9UL17, P23771, P09693, P20963

PRKCQ, MAPK14, STAT6, HLA-DOB, TBX21, GATA3, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.804
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P06239	LCK	Tyrosine-protein kinase Lck	0.791
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.762
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.741
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P14778	IL1R1	Interleukin-1 receptor type 1	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.805
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.769
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728

Dicloxacillin

hsa04660

T cell receptor signaling pathway

3.58E-04

P01375, Q04759, O95267, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.8
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.72
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.73
P13612	ITGA4	Integrin alpha-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.834
P06737	PYGL	Glycogen phosphorylase, liver form	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.8
P13612	ITGA4	Integrin alpha-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P13612	ITGA4	Integrin alpha-4	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.729
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P13612	ITGA4	Integrin alpha-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.85
P06737	PYGL	Glycogen phosphorylase, liver form	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.72
P13612	ITGA4	Integrin alpha-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.7
P13612	ITGA4	Integrin alpha-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.83
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.8
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.72
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815

Dicloxacillin

hsa04950

Maturity onset diabetes of the young

2.03E-02

P35557

GCK

Dicloxacillin

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.45E-02

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Dicloxacillin

hsa05140

Leishmaniasis

2.69E-02

O75015, P13765, O60603, P49006, Q16539

FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14

Dicloxacillin

hsa05146

Amoebiasis

4.55E-02

P09341, P14778, P27930, O60603, P05089

CXCL1, IL1R1, IL1R2, TLR2, ARG1

Dicloxacillin

hsa05150

Staphylococcus aureus infection

4.37E-02

P21730, P21462, O75015, P13765, Q16581, P12838

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, DEFA4

Dicloxacillin

hsa05163

Human cytomegalovirus infection

3.64E-02

Q14643, P49841, P14778, P25025, Q16539, P04637, O00463

ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5

Dicloxacillin

hsa05169

Epstein-Barr virus infection

4.32E-02

P13765, O00463, P16070, P10415, Q16539, P24522, Q8WV28, P01375, O60603, P09693, P20963

HLA-DOB, TRAF5, CD44, BCL2, MAPK14, GADD45A, BLNK, TNF, TLR2, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P16070	CD44	CD44 antigen	0.803
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P16070	CD44	CD44 antigen	0.803
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P16070	CD44	CD44 antigen	0.803
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728

Dicloxacillin

hsa05202

Transcriptional misregulation in cancer

8.07E-04

Q15532, P14780, P27930, Q16548, Q13077, Q15652, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P24522

SS18, MMP9, IL1R2, BCL2A1, TRAF1, JMJD1C, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q15532	SS18	Protein SSXT	-0.772
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P06737	PYGL	Glycogen phosphorylase, liver form	P27930	IL1R2	Interleukin-1 receptor type 2	0.881
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P06737	PYGL	Glycogen phosphorylase, liver form	Q15652	JMJD1C	Probable JmjC domain-containing histone demethylation protein 2C	0.754
P06737	PYGL	Glycogen phosphorylase, liver form	O15550	UTX	Lysine-specific demethylase 6A	0.724
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.742
P06737	PYGL	Glycogen phosphorylase, liver form	P41182	BCL6	B-cell lymphoma 6 protein	0.847
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q15532	SS18	Protein SSXT	-0.772
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P06737	PYGL	Glycogen phosphorylase, liver form	P27930	IL1R2	Interleukin-1 receptor type 2	0.881
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P06737	PYGL	Glycogen phosphorylase, liver form	Q15652	JMJD1C	Probable JmjC domain-containing histone demethylation protein 2C	0.754
P06737	PYGL	Glycogen phosphorylase, liver form	O15550	UTX	Lysine-specific demethylase 6A	0.724
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.742
P06737	PYGL	Glycogen phosphorylase, liver form	P41182	BCL6	B-cell lymphoma 6 protein	0.847
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q15532	SS18	Protein SSXT	-0.772
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P06737	PYGL	Glycogen phosphorylase, liver form	P27930	IL1R2	Interleukin-1 receptor type 2	0.881
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P06737	PYGL	Glycogen phosphorylase, liver form	Q15652	JMJD1C	Probable JmjC domain-containing histone demethylation protein 2C	0.754
P06737	PYGL	Glycogen phosphorylase, liver form	O15550	UTX	Lysine-specific demethylase 6A	0.724
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.742
P06737	PYGL	Glycogen phosphorylase, liver form	P41182	BCL6	B-cell lymphoma 6 protein	0.847
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822

Dicloxacillin

hsa05217

Basal cell carcinoma

1.43E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Dicloxacillin

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Dicloxacillin

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Dicloxacillin

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

4.55E-02

O95267, P09693, O60603, Q16539, P01730

RASGRP1, CD3G, TLR2, MAPK14, CD4

Dicloxacillin

hsa05321

Inflammatory bowel disease

7.62E-04

O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753

Dicloxacillin

hsa05418

Fluid shear stress and atherosclerosis

2.62E-02

Q16539, P10599, P14780, P04637, P14778, P27930

MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2

Flucloxacillin

hsa00500

Starch and sucrose metabolism

3.88E-02

O43451, P46976, P06737

MGAM, GYG1, PYGL

Flucloxacillin

hsa00730

Thiamine metabolism

3.79E-02

P05186, P24666

ALPL, ACP1

Flucloxacillin

hsa04064

NF-kappa B signaling pathway

2.69E-02

P10415, O00463, P01375, Q04759, Q13077, Q16548, Q8WV28, P24522, P09341

BCL2, TRAF5, TNF, PRKCQ, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q12933	TRAF2	TNF receptor-associated factor 2	0.871
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P14778	IL1R1	Interleukin-1 receptor type 1	-0.728
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.804
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19784	CSNK2A2	Casein kinase II subunit alpha'	0.82
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P07948	LYN	Tyrosine-protein kinase Lyn	-0.742
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P06239	LCK	Tyrosine-protein kinase Lck	0.791
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q06643	LTB	Lymphotoxin-beta	0.774
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74

Flucloxacillin

hsa04071

Sphingolipid signaling pathway

2.06E-02

Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2

EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.716
P06737	PYGL	Glycogen phosphorylase, liver form	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.781
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.716
P06737	PYGL	Glycogen phosphorylase, liver form	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.781
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.716
P06737	PYGL	Glycogen phosphorylase, liver form	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.781
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.822

Flucloxacillin

hsa04080

Neuroactive ligand-receptor interaction

2.54E-02

P08311, Q15722, Q9H228, P21462, P21730, Q16581, P35318

CTSG, LTB4R, EDG8, FPR1, C5AR1, C3AR1, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	Q15722	LTB4R	Leukotriene B4 receptor 1	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.808
P06737	PYGL	Glycogen phosphorylase, liver form	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.727
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	Q15722	LTB4R	Leukotriene B4 receptor 1	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.808
P06737	PYGL	Glycogen phosphorylase, liver form	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.727
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	Q15722	LTB4R	Leukotriene B4 receptor 1	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.808
P06737	PYGL	Glycogen phosphorylase, liver form	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.727

Flucloxacillin

hsa04340

Hedgehog signaling pathway

1.43E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Flucloxacillin

hsa04613

Neutrophil extracellular trap formation

1.37E-02

O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.804
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P57764	GSDMDC1	Gasdermin-D	0.725
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P11215	ITGAM	Integrin alpha-M	-0.862
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P05107	ITGB2	Integrin beta-2	0.769
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q13547	HDAC1	Histone deacetylase 1	0.784
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.748
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.888
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.888
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q16778	HIST2H2BE	Histone H2B type 2-E	-0.881
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	O60814	H2BC12	Histone H2B type 1-K	-0.776
P06737	PYGL	Glycogen phosphorylase, liver form	Q15080	NCF4	Neutrophil cytosol factor 4	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P20160	AZU1	Azurocidin	0.781
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	O43315	AQP9	Aquaporin-9	0.897
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P06737	PYGL	Glycogen phosphorylase, liver form	Q15080	NCF4	Neutrophil cytosol factor 4	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P20160	AZU1	Azurocidin	0.781
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	O43315	AQP9	Aquaporin-9	0.897
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P06737	PYGL	Glycogen phosphorylase, liver form	Q15080	NCF4	Neutrophil cytosol factor 4	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P20160	AZU1	Azurocidin	0.781
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P06737	PYGL	Glycogen phosphorylase, liver form	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P06737	PYGL	Glycogen phosphorylase, liver form	O43315	AQP9	Aquaporin-9	0.897
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863

Flucloxacillin

hsa04621

NOD-like receptor signaling pathway

2.64E-02

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.804
P06737	PYGL	Glycogen phosphorylase, liver form	P10599	TXN	Thioredoxin	0.764
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H1Y0	ATG5	Autophagy protein 5	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.912
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.804
P06737	PYGL	Glycogen phosphorylase, liver form	P10599	TXN	Thioredoxin	0.764
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H1Y0	ATG5	Autophagy protein 5	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.912
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.804
P06737	PYGL	Glycogen phosphorylase, liver form	P10599	TXN	Thioredoxin	0.764
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H1Y0	ATG5	Autophagy protein 5	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.912
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7

Flucloxacillin

hsa04657

IL-17 signaling pathway

1.28E-02

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P06737	PYGL	Glycogen phosphorylase, liver form	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P06737	PYGL	Glycogen phosphorylase, liver form	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P06737	PYGL	Glycogen phosphorylase, liver form	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759

Flucloxacillin

hsa04658

Th1 and Th2 cell differentiation

3.21E-03

Q04759, P20963, P09693, Q16539, Q14765, P42226, P23771, Q9UL17, P13765

PRKCQ, CD247, CD3G, MAPK14, STAT4, STAT6, GATA3, TBX21, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.805
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.769
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.804
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P06239	LCK	Tyrosine-protein kinase Lck	0.791
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.762
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.741
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P78504	JAG1	Protein jagged-1	0.907
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	Q13761	RUNX3	Runt-related transcription factor 3	0.849
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P13612	ITGA4	Integrin alpha-4	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.729
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P13612	ITGA4	Integrin alpha-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.85
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P13612	ITGA4	Integrin alpha-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.764
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P13612	ITGA4	Integrin alpha-4	Q9UL17	TBX21	T-box transcription factor TBX21	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P13612	ITGA4	Integrin alpha-4	Q13761	RUNX3	Runt-related transcription factor 3	0.78
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845

Flucloxacillin

hsa04659

Th17 cell differentiation

3.18E-02

Q04759, Q16539, P42226, P13765, Q9UL17, P23771, P09693, P20963

PRKCQ, MAPK14, STAT6, HLA-DOB, TBX21, GATA3, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.804
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P06239	LCK	Tyrosine-protein kinase Lck	0.791
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.762
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.741
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P14778	IL1R1	Interleukin-1 receptor type 1	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.805
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.769
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728

Flucloxacillin

hsa04660

T cell receptor signaling pathway

1.07E-02

P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q16539, P49841

TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.8
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.72
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.73
P13612	ITGA4	Integrin alpha-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.834
P06737	PYGL	Glycogen phosphorylase, liver form	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.8
P13612	ITGA4	Integrin alpha-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P13612	ITGA4	Integrin alpha-4	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.729
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P13612	ITGA4	Integrin alpha-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.85
P06737	PYGL	Glycogen phosphorylase, liver form	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.72
P13612	ITGA4	Integrin alpha-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.7
P13612	ITGA4	Integrin alpha-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.83
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P06737	PYGL	Glycogen phosphorylase, liver form	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.8
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.72
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815

Flucloxacillin

hsa05150

Staphylococcus aureus infection

4.37E-02

P21730, P21462, O75015, P13765, Q16581, P12838

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, DEFA4

Flucloxacillin

hsa05169

Epstein-Barr virus infection

4.32E-02

P13765, O00463, P16070, P10415, Q16539, P24522, Q8WV28, P01375, O60603, P09693, P20963

HLA-DOB, TRAF5, CD44, BCL2, MAPK14, GADD45A, BLNK, TNF, TLR2, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P16070	CD44	CD44 antigen	0.803
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P16070	CD44	CD44 antigen	0.803
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P06737	PYGL	Glycogen phosphorylase, liver form	P16070	CD44	CD44 antigen	0.803
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728

Flucloxacillin

hsa05202

Transcriptional misregulation in cancer

8.07E-04

Q15532, P14780, P27930, Q16548, Q13077, Q15652, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P24522

SS18, MMP9, IL1R2, BCL2A1, TRAF1, JMJD1C, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q15532	SS18	Protein SSXT	-0.772
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P06737	PYGL	Glycogen phosphorylase, liver form	P27930	IL1R2	Interleukin-1 receptor type 2	0.881
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P06737	PYGL	Glycogen phosphorylase, liver form	Q15652	JMJD1C	Probable JmjC domain-containing histone demethylation protein 2C	0.754
P06737	PYGL	Glycogen phosphorylase, liver form	O15550	UTX	Lysine-specific demethylase 6A	0.724
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.742
P06737	PYGL	Glycogen phosphorylase, liver form	P41182	BCL6	B-cell lymphoma 6 protein	0.847
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q15532	SS18	Protein SSXT	-0.772
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P06737	PYGL	Glycogen phosphorylase, liver form	P27930	IL1R2	Interleukin-1 receptor type 2	0.881
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P06737	PYGL	Glycogen phosphorylase, liver form	Q15652	JMJD1C	Probable JmjC domain-containing histone demethylation protein 2C	0.754
P06737	PYGL	Glycogen phosphorylase, liver form	O15550	UTX	Lysine-specific demethylase 6A	0.724
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.742
P06737	PYGL	Glycogen phosphorylase, liver form	P41182	BCL6	B-cell lymphoma 6 protein	0.847
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P06737	PYGL	Glycogen phosphorylase, liver form	Q15532	SS18	Protein SSXT	-0.772
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P06737	PYGL	Glycogen phosphorylase, liver form	P27930	IL1R2	Interleukin-1 receptor type 2	0.881
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P06737	PYGL	Glycogen phosphorylase, liver form	Q15652	JMJD1C	Probable JmjC domain-containing histone demethylation protein 2C	0.754
P06737	PYGL	Glycogen phosphorylase, liver form	O15550	UTX	Lysine-specific demethylase 6A	0.724
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.742
P06737	PYGL	Glycogen phosphorylase, liver form	P41182	BCL6	B-cell lymphoma 6 protein	0.847
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822

Flucloxacillin

hsa05217

Basal cell carcinoma

1.43E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Flucloxacillin

hsa05321

Inflammatory bowel disease

7.62E-04

O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753