PharmaCoNets

PharmaCoNets of Clotiazepam (S_PCN: 97.20 )

Clotiazepam regulated-network (S_DN: 15.09)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Clotiazepam

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Clotiazepam

hsa00190

Oxidative phosphorylation

1.00E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Clotiazepam

hsa00230

Purine metabolism

4.02E-02

P31350, P21589

RRM2, NT5E

Clotiazepam

hsa00240

Pyrimidine metabolism

2.54E-04

P31350, P21589, P04818

RRM2, NT5E, TYMS

Clotiazepam

hsa00380

Tryptophan metabolism

4.14E-02

Q16613

AANAT

Clotiazepam

hsa00500

Starch and sucrose metabolism

1.72E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Clotiazepam

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Clotiazepam

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Clotiazepam

hsa00730

Thiamine metabolism

1.44E-03

P05186, P24666

ALPL, ACP1

Clotiazepam

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Clotiazepam

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Clotiazepam

hsa01523

Antifolate resistance

2.05E-04

Q92820, P04818

GGH, TYMS

Clotiazepam

hsa03008

Ribosome biogenesis in eukaryotes

4.94E-02

P19784, P67870

CSNK2A2, CSNK2B

Clotiazepam

hsa03010

Ribosome

1.88E-02

P62753, P25398, P32969, P62829, P18077, P36578

RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4

Clotiazepam

hsa03013

RNA transport

4.09E-02

P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Clotiazepam

hsa03020

RNA polymerase

2.06E-05

P30876, P62487, Q9GZM3, P52435

POLR2B, POLR2G, POLR2J2, POLR2J

Clotiazepam

hsa03050

Proteasome

2.84E-05

P55036

PSMD4

Clotiazepam

hsa04024

cAMP signaling pathway

3.37E-02

P63092, P26678, P61586

GNAS, PLN, RHOA

Clotiazepam

hsa04064

NF-kappa B signaling pathway

2.75E-06

P10415, Q13489, P25963, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522, P09341

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45A, CXCL1

Clotiazepam

hsa04071

Sphingolipid signaling pathway

6.99E-05

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Clotiazepam

hsa04072

Phospholipase D signaling pathway

2.75E-02

P61586, O14986, P63092

RHOA, PIP5K1B, GNAS

Clotiazepam

hsa04080

Neuroactive ligand-receptor interaction

3.44E-04

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, ADRB2

Clotiazepam

hsa04110

Cell cycle

2.89E-05

P06493, O60566, P30304, P33981, P42773, P01106

CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC

Clotiazepam

hsa04114

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Clotiazepam

hsa04115

p53 signaling pathway

5.07E-03

P24522, Q13315, P31350, Q53FA7, P06493, O95067, P10415

GADD45A, ATM, RRM2, TP53I3, CDK1, CCNB2, BCL2

Clotiazepam

hsa04120

Ubiquitin mediated proteolysis

6.89E-03

Q14145, Q13042, Q13191, Q15751, Q7Z6Z7

KEAP1, CDC16, CBLB, HERC1, HUWE1

Clotiazepam

hsa04137

Mitophagy - animal

2.52E-02

P19784, P67870

CSNK2A2, CSNK2B

Clotiazepam

hsa04140

Autophagy - animal

3.19E-02

P22694, Q14643, P10415, Q04759

PRKACB, ITPR1, BCL2, PRKCQ

Clotiazepam

hsa04141

Protein processing in endoplasmic reticulum

4.88E-02

P18848, O60337, P11142, P07900

ATF4, MARH6, HSPA8, HSP90AA1

Clotiazepam

hsa04145

Phagosome

2.60E-03

Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765

NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Clotiazepam

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Clotiazepam

hsa04210

Apoptosis

1.54E-03

Q13315, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, Q14643

ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ITPR1

Clotiazepam

hsa04217

Necroptosis

7.72E-06

P01568, Q13489, P42224, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q93077, Q13557, O43633, Q08752

IFNA21, BIRC3, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, HIST1H2AC, CAMK2D, CHMP2A, PPID

Clotiazepam

hsa04310

Wnt signaling pathway

4.17E-03

P61586, P19784, P67870

RHOA, CSNK2A2, CSNK2B

Clotiazepam

hsa04340

Hedgehog signaling pathway

2.62E-03

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Clotiazepam

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Clotiazepam

hsa04380

Osteoclast differentiation

1.02E-02

Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2

Clotiazepam

hsa04510

Focal adhesion

4.07E-02

O14986, P61586, Q16363

PIP5K1B, RHOA, LAMA4

Clotiazepam

hsa04520

Adherens junction

1.38E-04

P19784, P67870, P61586

CSNK2A2, CSNK2B, RHOA

Clotiazepam

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Clotiazepam

hsa04612

Antigen processing and presentation

3.22E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Clotiazepam

hsa04613

Neutrophil extracellular trap formation

4.52E-06

P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778

Clotiazepam

hsa04621

NOD-like receptor signaling pathway

5.93E-05

Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P59665, P59666, P12838

MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P08246	ELA2	Neutrophil elastase	Q9H1Y0	ATG5	Autophagy protein 5	-0.759
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P08246	ELA2	Neutrophil elastase	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.702
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P08246	ELA2	Neutrophil elastase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.734
P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	P01375	TNF	Tumor necrosis factor	0.753
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.708
P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	P59666	DEFA3	Neutrophil defensin 3	0.708
P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	P12838	DEFA4	Neutrophil defensin 4	0.8
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709

Clotiazepam

hsa04623

Cytosolic DNA-sensing pathway

3.15E-02

P01568, P25963

IFNA21, NFKBIA

Clotiazepam

hsa04625

C-type lectin receptor signaling pathway

3.87E-02

Q9ULY5, P20749, P01375, Q16539

CLEC4E, BCL3, TNF, MAPK14

Clotiazepam

hsa04640

Hematopoietic cell lineage

4.95E-02

P01730, P06127, P09564

CD4, CD5, CD7

Clotiazepam

hsa04650

Natural killer cell mediated cytotoxicity

2.80E-04

P16298, P50591, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O75015, P26717, P26715

PPP3CB, TNFSF10, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Clotiazepam

hsa04657

IL-17 signaling pathway

1.47E-04

P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Clotiazepam

hsa04658

Th1 and Th2 cell differentiation

1.94E-06

Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765

PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q9UL17	TBX21	T-box transcription factor TBX21	-0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Clotiazepam

hsa04659

Th17 cell differentiation

4.24E-04

Q04759, Q16539, P06239, P13765, P14778, Q9UL17, P23771, P09693, P20963

PRKCQ, MAPK14, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3G, CD247

Clotiazepam

hsa04660

T cell receptor signaling pathway

1.84E-05

P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841

TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75

Clotiazepam

hsa04664

Fc epsilon RI signaling pathway

3.98E-02

P01375, Q16539, Q9UQC2

TNF, MAPK14, GAB2

Clotiazepam

hsa04668

TNF signaling pathway

1.83E-03

P01375, O00463, Q13489, Q16539, P25963, P20749, Q13077, P14780

TNF, TRAF5, BIRC3, MAPK14, NFKBIA, BCL3, TRAF1, MMP9

Clotiazepam

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Clotiazepam

hsa04713

Circadian entrainment

4.94E-02

P62873, P63092

GNB1, GNAS

Clotiazepam

hsa04720

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Clotiazepam

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Clotiazepam

hsa04723

Retrograde endocannabinoid signaling

4.94E-02

P48169, P62873

GABRA4, GNB1

Clotiazepam

hsa04724

Glutamatergic synapse

3.65E-02

P63092, P62873

GNAS, GNB1

Clotiazepam

hsa04726

Serotonergic synapse

2.52E-02

P63092, P62873

GNAS, GNB1

Clotiazepam

hsa04914

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Clotiazepam

hsa04920

Adipocytokine signaling pathway

4.49E-02

P25963, P33121, Q04759, P01375

NFKBIA, ACSL1, PRKCQ, TNF

Clotiazepam

hsa04922

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Clotiazepam

hsa04924

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Clotiazepam

hsa04928

Parathyroid hormone synthesis, secretion and action

4.23E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Clotiazepam

hsa04932

Non-alcoholic fatty liver disease

9.70E-03

P18848, P01584, P13073, O15239

ATF4, IL1B, COX4I1, NDUFA1

Clotiazepam

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Clotiazepam

hsa04970

Salivary secretion

4.49E-02

P22694, Q14643, P17252, P49913

PRKACB, ITPR1, PRKCA, CAMP

Clotiazepam

hsa04972

Pancreatic secretion

3.65E-02

P63092, P61586

GNAS, RHOA

Clotiazepam

hsa05012

Parkinson disease

2.53E-02

O15239, P13073, P05141, P18848, Q13557

NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D

Clotiazepam

hsa05016

Huntington disease

8.98E-04

O15239, P13073, Q9GZM3, P30876, P62487, P52435, P05141, P55036

NDUFA1, COX4I1, POLR2J2, POLR2B, POLR2G, POLR2J, SLC25A5, PSMD4

Clotiazepam

hsa05020

Prion disease

3.37E-03

P13591, P01584, P11142, O15239, P13073, P18848, P05141

NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5

Clotiazepam

hsa05022

Pathways of neurodegeneration - multiple diseases

3.80E-02

O15239, P13073, P18848, P05141, P01584, Q13557

NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2D

Clotiazepam

hsa05032

Morphine addiction

9.04E-05

P62873, P48169, P78334, P63092, P32298

GNB1, GABRA4, GABRE, GNAS, GRK4

Clotiazepam

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Clotiazepam

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Clotiazepam

hsa05132

Salmonella infection

2.98E-02

P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509

IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3

Clotiazepam

hsa05134

Legionellosis

1.28E-02

P01584, P68104, P11142

IL1B, EEF1A1, HSPA8

Clotiazepam

hsa05140

Leishmaniasis

4.29E-05

P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, IRAK1, NCF4

Clotiazepam

hsa05142

Chagas disease

2.26E-02

P01375, P30679, P48023

TNF, GNA15, FASLG

Clotiazepam

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Clotiazepam

hsa05144

Malaria

1.44E-02

P60033, O60603, P35443, P26718

CD81, TLR2, THBS4, KLRK1

Clotiazepam

hsa05145

Toxoplasmosis

3.07E-02

P51617, P25963, P01375, P10415, Q13489, P13765, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2

Clotiazepam

hsa05146

Amoebiasis

3.91E-02

P09341, P27930, P01375, O60603, P05089, P22694, P08311

CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Clotiazepam

hsa05150

Staphylococcus aureus infection

1.83E-02

P59665, P59666, P12838

DEFA1; DEFA1B, DEFA3, DEFA4

Clotiazepam

hsa05152

Tuberculosis

2.07E-02

Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Clotiazepam

hsa05161

Hepatitis B

2.33E-02

P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765

PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4

Clotiazepam

hsa05162

Measles

4.02E-02

P11142, P01584, Q9NP90

HSPA8, IL1B, RAB9B

Clotiazepam

hsa05163

Human cytomegalovirus infection

2.55E-03

P01375, P62873, P61586, P49841, P14778, P25025, Q16539, P63092, O00463, P61769

TNF, GNB1, RHOA, GSK3B, IL1R1, CXCR2, MAPK14, GNAS, TRAF5, B2M

Clotiazepam

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Clotiazepam

hsa05168

Herpes simplex virus 1 infection

3.38E-03

P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212

Clotiazepam

hsa05169

Epstein-Barr virus infection

4.41E-02

P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963

HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247

Clotiazepam

hsa05170

Human immunodeficiency virus 1 infection

2.58E-05

Q02750, P62879, P16298, P01375, Q05397, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5, P20333

MAP2K1, GNB2, PPP3CB, TNF, PTK2, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1B

Clotiazepam

hsa05171

Coronavirus disease - COVID-19

3.15E-04

P01584, P62753, P25398, Q9UHA3, P36578, P32969, P18077, P62829, O14786

IL1B, RPS6, RPS12, RSL24D1, RPL4, RPL9, RPL35A, RPL23, NRP1

Clotiazepam

hsa05202

Transcriptional misregulation in cancer

2.75E-06

Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522

FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Clotiazepam

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Clotiazepam

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Clotiazepam

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Clotiazepam

hsa05222

Small cell lung cancer

2.79E-02

Q13489, P10415, P25963, Q13077, O00463, P24522

BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Clotiazepam

hsa05226

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Clotiazepam

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

3.07E-03

P20963, P09693, P06239, O60603, P10747, Q04759, Q16539

CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14

Clotiazepam

hsa05310

Asthma

3.11E-03

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Clotiazepam

hsa05321

Inflammatory bowel disease

7.75E-07

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Clotiazepam

hsa05322

Systemic lupus erythematosus

2.09E-04

P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455

ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB

Clotiazepam

hsa05323

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Clotiazepam

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Clotiazepam

hsa05332

Graft-versus-host disease

1.80E-06

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Clotiazepam

hsa05415

Diabetic cardiomyopathy

1.49E-03

P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q13557, P04406

PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, CAMK2D, GAPDH

Clotiazepam

hsa05418

Fluid shear stress and atherosclerosis

1.08E-03

Q16539, Q14145, P10599, P14780, P01375, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2

Community members of Clotiazepam (S_DC: 6.44)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

GABRA4

GammaNoneaminobutyric acid receptor subunit alphaNone4

Reported

0.3253

0.565

0.1579

1.4506

P28472

GABRB3

GammaNoneaminobutyric acid receptor subunit betaNone3

Reported

0.1559

0.4387

0.1695

1.1248

P78334

GABRE

GammaNoneaminobutyric acid receptor subunit epsilon

Reported

0.1394

0.4097

0.1579

1.0469

P42330

AKR1C3

AldoNoneketo reductase family 1 member C3

Predicted

0.4017

0.8348

0.1748

2.0453

P02768

ALB

Albumin

Predicted

0.2848

0.9111

0.0857

2.0502

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

P14780

MMP9

Matrix metalloproteinaseNone9

Predicted

0.1696

0.8424

0.7315

2.5012

P98170

BIRC4

E3 ubiquitinNoneprotein ligase XIAP

Predicted

0.2974

0.2298

0.79

1.3984

P05186

ALPL

Alkaline phosphatase, tissueNonenonspecific isozyme

Predicted

0.3064

0.4143

0.1992

1.181

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P08246

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

P04818

TYMS

Thymidylate synthase

Predicted

0.4553

0.2706

0.1893

0.9582

O15164

TRIM24

Transcription intermediary factor 1Nonealpha

Predicted

0.2807

0.1055

0.3514

PharmaCoNets of Clotiazepam (SPCN: 97.20 )

Clotiazepam regulated-network (SDN: 15.09)

Community members of Clotiazepam (SDC: 6.44)

PharmaCoNets of Clotiazepam (S_PCN: 97.20 )

Clotiazepam regulated-network (S_DN: 15.09)

Community members of Clotiazepam (S_DC: 6.44)