PharmaCoNets of Clorazepic-acid (SPCN: 73.64 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Clorazepic-acidhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Clorazepic-acidhsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Clorazepic-acidhsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Clorazepic-acidhsa00670One carbon pool by folate1.32E-021P00374DHFRMore
Clorazepic-acidhsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Clorazepic-acidhsa00790Folate biosynthesis1.32E-021P00374DHFRMore
Clorazepic-acidhsa01523Antifolate resistance9.05E-056P41439, P41440, Q92820, P04818, P00374, P01375FOLR3, SLC19A1, GGH, TYMS, DHFR, TNFMore
Clorazepic-acidhsa01524Platinum drug resistance4.57E-021P20585MSH3More
Clorazepic-acidhsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Clorazepic-acidhsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Clorazepic-acidhsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Clorazepic-acidhsa03050Proteasome1.40E-021P55036PSMD4More
Clorazepic-acidhsa03430Mismatch repair3.93E-021P20585MSH3More
Clorazepic-acidhsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Clorazepic-acidhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Clorazepic-acidhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Clorazepic-acidhsa04064NF-kappa B signaling pathway2.98E-0413P10415, O00463, P14778, P19174, Q04759, Q9UDY8, Q16548, P06239, Q13315, P24522, P09341, P19875, Q06643BCL2, TRAF5, IL1R1, PLCG1, PRKCQ, MALT1, BCL2A1, LCK, ATM, GADD45A, CXCL1, CXCL2, LTBMore
Clorazepic-acidhsa04071Sphingolipid signaling pathway1.19E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Clorazepic-acidhsa04072Phospholipase D signaling pathway5.37E-038P42338, P61586, P43657, P25024, P25025, P19174, O14986, P63092PIK3CB, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, GNASMore
Clorazepic-acidhsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Clorazepic-acidhsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Clorazepic-acidhsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Clorazepic-acidhsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Clorazepic-acidhsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Clorazepic-acidhsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Clorazepic-acidhsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Clorazepic-acidhsa04142Lysosome3.65E-021Q99523SORT1More
Clorazepic-acidhsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Clorazepic-acidhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Clorazepic-acidhsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Clorazepic-acidhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Clorazepic-acidhsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Clorazepic-acidhsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Clorazepic-acidhsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Clorazepic-acidhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Clorazepic-acidhsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Clorazepic-acidhsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Clorazepic-acidhsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Clorazepic-acidhsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Clorazepic-acidhsa04613Neutrophil extracellular trap formation4.93E-028O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, P21730TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, C5AR1More
Clorazepic-acidhsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Clorazepic-acidhsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Clorazepic-acidhsa04640Hematopoietic cell lineage2.18E-039P14778, P27930, P11215, P25063, P07766, P01732, P01730, P06127, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD4, CD5, CD7More
Clorazepic-acidhsa04650Natural killer cell mediated cytotoxicity2.28E-0615P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Clorazepic-acidhsa04657IL-17 signaling pathway1.14E-037P07900, O00463, Q16539, P49841, P14780, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, MMP9, TNF, IL1BMore
Clorazepic-acidhsa04658Th1 and Th2 cell differentiation7.66E-0712Q04759, P07766, P20963, P09693, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Clorazepic-acidhsa04659Th17 cell differentiation8.48E-0511Q04759, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Clorazepic-acidhsa04660T cell receptor signaling pathway1.09E-0412Q9UDY8, Q04759, P42338, P10747, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239MALT1, PRKCQ, PIK3CB, CD28, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Clorazepic-acidhsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Clorazepic-acidhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Clorazepic-acidhsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Clorazepic-acidhsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Clorazepic-acidhsa04722Neurotrophin signaling pathway2.32E-021Q99523SORT1More
Clorazepic-acidhsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Clorazepic-acidhsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Clorazepic-acidhsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Clorazepic-acidhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Clorazepic-acidhsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Clorazepic-acidhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Clorazepic-acidhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Clorazepic-acidhsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Clorazepic-acidhsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Clorazepic-acidhsa04932Non-alcoholic fatty liver disease9.70E-034P18848, P01584, P13073, O15239ATF4, IL1B, COX4I1, NDUFA1More
Clorazepic-acidhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Clorazepic-acidhsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Clorazepic-acidhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Clorazepic-acidhsa04979Cholesterol metabolism8.29E-031Q99523SORT1More
Clorazepic-acidhsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Clorazepic-acidhsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Clorazepic-acidhsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Clorazepic-acidhsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Clorazepic-acidhsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Clorazepic-acidhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Clorazepic-acidhsa05134Legionellosis6.38E-046P01584, P11215, P68104, P11142, P09341, P19875IL1B, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2More
Clorazepic-acidhsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Clorazepic-acidhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Clorazepic-acidhsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Clorazepic-acidhsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Clorazepic-acidhsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Clorazepic-acidhsa05163Human cytomegalovirus infection2.55E-0310P01375, P62873, P61586, P49841, P14778, P25025, Q16539, P63092, O00463, P61769TNF, GNB1, RHOA, GSK3B, IL1R1, CXCR2, MAPK14, GNAS, TRAF5, B2MMore
Clorazepic-acidhsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Clorazepic-acidhsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Clorazepic-acidhsa05171Coronavirus disease - COVID-193.15E-049P01584, P62753, P25398, Q9UHA3, P36578, P32969, P18077, P62829, O14786IL1B, RPS6, RPS12, RSL24D1, RPL4, RPL9, RPL35A, RPL23, NRP1More
Clorazepic-acidhsa05200Pathways in cancer3.23E-022P17301, P20585ITGA2, MSH3More
Clorazepic-acidhsa05202Transcriptional misregulation in cancer2.90E-029Q12778, Q13315, P14780, Q16548, O15550, P05164, P08246, Q9C0K0, P24522FOXO1, ATM, MMP9, BCL2A1, UTX, MPO, ELA2, BCL11B, GADD45AMore
Clorazepic-acidhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Clorazepic-acidhsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Clorazepic-acidhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer6.79E-049P42338, P19174, P07766, P20963, P09693, P06239, O60603, P10747, Q04759PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQMore
Clorazepic-acidhsa05321Inflammatory bowel disease1.17E-035O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Clorazepic-acidhsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Clorazepic-acidhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Clorazepic-acidhsa05332Graft-versus-host disease3.49E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Clorazepic-acidhsa05410Hypertrophic cardiomyopathy2.63E-021P17301ITGA2More
Clorazepic-acidhsa05412Arrhythmogenic right ventricular cardiomyopathy1.98E-021P17301ITGA2More
Clorazepic-acidhsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore
Clorazepic-acidhsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Clorazepic-acid (SDC: 5.25)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)