PharmaCoNets of Clomifene (SPCN: 40.67 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Clomifenehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Clomifenehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Clomifenehsa00220Arginine biosynthesis1.97E-022P15104, P49448GLUL, GLUD2More
Clomifenehsa00250Alanine, aspartate and glutamate metabolism3.72E-043Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Clomifenehsa00270Cysteine and methionine metabolism3.39E-022Q96RQ9, P40926IL4I1, MDH2More
Clomifenehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Clomifenehsa00561Glycerolipid metabolism1.12E-023Q8NEB5, P14550, Q86XP1PPAPDC1B, AKR1A1, DGKHMore
Clomifenehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Clomifenehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Clomifenehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Clomifenehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Clomifenehsa00900Terpenoid backbone biosynthesis1.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Clomifenehsa00910Nitrogen metabolism1.97E-022P15104, P49448GLUL, GLUD2More
Clomifenehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Clomifenehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Clomifenehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Clomifenehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Clomifenehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Clomifenehsa03020RNA polymerase9.86E-072Q9GZM3, P52435POLR2J2, POLR2JMore
Clomifenehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Clomifenehsa04020Calcium signaling pathway2.41E-025Q96DU7, Q13557, P21860, P26678, P63092ITPKC, CAMK2D, ERBB3, PLN, GNASMore
Clomifenehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Clomifenehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Clomifenehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Clomifenehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Clomifenehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Clomifenehsa04151PI3K-Akt signaling pathway3.96E-028P43657, P09603, Q9GZP0, P63218, P50151, P13612, O15335, Q13751P2RY5, CSF1, PDGFD, GNG5, GNG10, ITGA4, CHAD, LAMB3More
Clomifenehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Clomifenehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Clomifenehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Clomifenehsa04330Notch signaling pathway1.12E-023Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Clomifenehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Clomifenehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Clomifenehsa04512ECM-receptor interaction3.88E-035Q13751, P07359, P13612, P08514, O15335LAMB3, GP1BA, ITGA4, ITGA2B, CHADMore
Clomifenehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Clomifenehsa04610Complement and coagulation cascades3.52E-022P09871, P20023C1S, CR2More
Clomifenehsa04611Platelet activation5.13E-044P08514, Q15746, Q8WYR1, P07359ITGA2B, MYLK, PIK3R5, GP1BAMore
Clomifenehsa04613Neutrophil extracellular trap formation1.49E-0411P16109, P04908, Q99878, Q93077, P62807, O60814, P68431, P08514, P07359, O43315, Q16539SELP, H2AC4; H2AC8, H2AC14, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ITGA2B, GP1BA, AQP9, MAPK14More
Clomifenehsa04622RIG-I-like receptor signaling pathway3.39E-022Q12933, P10145TRAF2, IL8More
Clomifenehsa04640Hematopoietic cell lineage2.84E-037P07359, P08514, P21926, P20023, P07766, P01730, P09564GP1BA, ITGA2B, CD9, CR2, CD3E, CD4, CD7More
Clomifenehsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Clomifenehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Clomifenehsa04662B cell receptor signaling pathway4.53E-033P20023, Q8WV28, P11912CR2, BLNK, CD79AMore
Clomifenehsa04713Circadian entrainment1.75E-024Q13557, Q02153, P61952, P63092CAMK2D, GUCY1B3, GNG11, GNASMore
Clomifenehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Clomifenehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Clomifenehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Clomifenehsa04724Glutamatergic synapse9.51E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Clomifenehsa04727GABAergic synapse2.33E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Clomifenehsa04728Dopaminergic synapse2.41E-025P63092, P61952, Q99941, Q13557, O15516GNAS, GNG11, CREBL1, CAMK2D, CLOCKMore
Clomifenehsa04730Long-term depression3.72E-022Q14344, P07948GNA13, LYNMore
Clomifenehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Clomifenehsa04911Insulin secretion4.88E-023P63092, Q99941, Q13557GNAS, CREBL1, CAMK2DMore
Clomifenehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Clomifenehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Clomifenehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Clomifenehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Clomifenehsa04934Cushing syndrome1.75E-024Q99941, P63092, O15169, Q13557CREBL1, GNAS, AXIN1, CAMK2DMore
Clomifenehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Clomifenehsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Clomifenehsa05010Alzheimer disease4.39E-026O15399, Q9NZJ5, Q13564, Q71U36, P09603, P21796GRIN2D, EIF2AK3, APPBP1, TUBA1A, CSF1, VDAC1More
Clomifenehsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Clomifenehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Clomifenehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Clomifenehsa05031Amphetamine addiction4.88E-023Q13557, P63092, Q99941CAMK2D, GNAS, CREBL1More
Clomifenehsa05032Morphine addiction1.34E-024P63218, P50151, Q07343, P43250GNG5, GNG10, PDE4B, GRK6More
Clomifenehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Clomifenehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Clomifenehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Clomifenehsa05150Staphylococcus aureus infection4.83E-022P09871, P16109C1S, SELPMore
Clomifenehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Clomifenehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Clomifenehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Clomifenehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Clomifenehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Clomifenehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Clomifenehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Clomifenehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Clomifenehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Clomifenehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-024P07766, P06239, Q9HC35, P01730CD3E, LCK, EML4, CD4More
Clomifenehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Clomifenehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Clomifenehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Clomifenehsa05340Primary immunodeficiency9.68E-055P01730, P11912, Q8WV28, P07766, P06239CD4, CD79A, BLNK, CD3E, LCKMore
Clomifenehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Clomifene (SDC: 4.51)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q6PL18ATAD2ATPase family AAA domainNonecontaining protein 2Predicted00.19630.051200.2006
P11511CYP19A1AromatasePredicted00.815610.15882.5666
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)